A Critical Reconstruction of Care-in-Action

This paper uses the findings of a critical ethnography studying the interactions of adult colleagues (Korth, 1998) to propose a critical approach to care theory and research. The argument proceeds from Jaggar\u27s (1995) critique of the scholarship on care. Her criticism voices concerns regarding the lack of attention to the justificatory potential of care research/theory and the over-dependence on particularities. This paper provides one set of responses capable of addressing these concerns and of reformulating the concerns into a more complex conceptualization of care. The resulting analysis implies a theory of care as a pragmatic-communicative construct, one that is more precise, but compatible with the interpersonal rationality to which Noddings (1991) attributes caring. Care emerges as a communicative act with a complex but definitive horizon structure. Care did not reconstruct from on-going interactions as a simple intention, nor a feeling, nor anything extra-rational or non-rational. This approach to understanding caring locates Jaggars concerns within the interpretive life of interactants. The papers specific contributions include exemplifying a refined analysis of care-in-action, articulating a meta-theory useful for the theory and study of care, introducing a typology of caring acts, demonstrating the critical potential of care research, and illustrating the connection between critique and justification

The effect of cataract on early stage glaucoma detection using spatial and temporal contrast sensitivity tests

Background: To investigate the effect of cataract on the ability of spatial and temporal contrast sensitivity tests used to detect early glaucoma. Methods: Twenty-seven glaucoma subjects with early cataract (mean age 60 ±10.2 years) which constituted the test group were recruited together with twenty-seven controls (cataract only) matched for age and cataract type from a primary eye care setting. Contrast sensitivity to flickering gratings at 20 Hz and stationary gratings with and without glare, were measured for 0.5, 1.5 and 3 cycles per degree (cpd) in central vision. Perimetry and structural measurements with the Heidelberg Retinal Tomograph (HRT) were also performed. Results: After considering the effect of cataract, contrast sensitivity to stationary gratings was reduced in the test group compared with controls with a statistically significant mean difference of 0.2 log units independent of spatial frequency. The flicker test showed a significant difference between test and control group at 1.5 and 3 cpd (p = 0.019 and p = 0.011 respectively). The percentage of glaucoma patients who could not see the temporal modulation was much higher compared with their cataract only counterparts. A significant correlation was found between the reduction of contrast sensitivity caused by glare and the Glaucoma Probability Score (GPS) as measured with the HRT (p<0.005). Conclusions: These findings indicate that both spatial and temporal contrast sensitivity tests are suitable for distinguishing between vision loss as a consequence of glaucoma and vision loss caused by cataract only. The correlation between glare factor and GPS suggests that there may be an increase in intraocular stray light in glaucoma

The Leaps of Faith in Social Science: Study of the Imagined in the Discourse of the Real

In this paper, the author introduces a post-Meadian concept useful for contemporary ethnography. Emergent ideal types capture the imaginary (that which is not bound to space and time coordinates) in the doing ethnography and making empirical claims (the empirical is considered that which is limited to space and time coordinates). She uses a heuristic device, grounded narrative fictions, as one way of depicting the imaginary for ethnographic audiences. The exploration draws on the ethnography of a kindergarten/Grade 1 class. The author does not use many scholarly references. Instead, she tries to develop two innovations to ethnographic analysis (emergent ideal types and grounded narrative fictions) from within an ethnographic example. She tries in this thought piece to explicate the linguistic mechanisms through which ethnographers draw on the imaginary to link empirical patterns with interpretive analyses

Aischylos, Agamemmnon, Parodos

Rezitation der Parodos aus dem Agamemnon des Aischylo

Insights into Bulk Electrolyte Effects on the Operative Voltage of Electrochemical Double-Layer Capacitors

Electrochemical double-layer capacitors (EDLCs) are robust, high-power, and fast-charging energy storage devices. Rational design of novel electrolyte materials could further improve the performance of EDLCs. Computational methods offer immense scope in aiding the development of such materials. Trends in experimentally observed operative voltages nevertheless remain difficult to predict and understand. We discuss here the intriguing case of adiponitrile (ADN) versus 2-methyl-glutaronitrile (2MGN) based electrolytes, which result in very different operative voltages in EDLCs despite structural similarity. As a preliminary step, bulk electrolyte effects on electrochemical stability are investigated by <i>ab initio</i> molecular dynamics (AIMD) and static, cluster-based quantum chemistry calculations

Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation

Therapeutically active small molecules represent promising nonimmunogenic alternatives to antibodies for specifically targeting disease-relevant receptors. However, a potential drawback compared to antibody–antigen interactions may be the lower affinity of small molecules toward receptors. Here, we overcome this low-affinity problem by coating the surface of nanoparticles (NPs) with multiple ligands. Specifically, we explored the use of gold and platinum nanoparticles to increase the binding affinity of Aβ-specific small molecules to inhibit Aβ peptide aggregation into fibrils in vitro. The interactions of bare NPs, free ligands, and NP-bound ligands with Aβ are comprehensively studied via physicochemical methods (spectroscopy, microscopy, immunologic tests) and cell assays. Reduction of thioflavin T fluorescence, as an indicator for β-sheet content, and inhibition of cellular Aβ excretion are even more effective with NP-bound ligands than with the free ligands. The results from this study may have implications in the development of therapeutics for treating Alzheimer’s disease