Absence of Antisperm Antibodies in Anejaculatory Men

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96435/1/j.1939-4640.1990.tb00162.x.pd

The first cyborg and First World War bodies as anti-war propaganda

This article discusses a play published in The Strand Magazine during the First World War which features a cyborg presenting anti-war and pacifist messages, used by The Strand to create anti-German propaganda. The article draws on theories of disability, cyborgs and the posthuman, and from new research on wartime fiction magazines. The importance of the cyborg character, Soldier 241, for the literary history of science fiction is explored by focusing on the relations between the mechanical and the impaired body, and on the First World War as a nexus for technological, surgical and military development. As a cyborg, this character reflects politicized desires that the wartime authorities did not acknowledge: a longing for the end of war, and refusal to countenance a society that rejected the impaired body

Temporary antiretroviral treatment during primary HIV-1 infection has a positive impact on health-related quality of life: data from the Primo-SHM cohort study

Item does not contain fulltextOBJECTIVES: The aim of the study was to compare health-related quality of life (HRQL) over 96 weeks in patients receiving no treatment or 24 or 60 weeks of combination antiretroviral therapy (cART) during primary HIV-1 infection (PHI). METHODS: A multicentre prospective cohort study of PHI patients, with an embedded randomized trial, was carried out. HRQL was assessed with the Medical Outcomes Study Health Survey for HIV (MOS-HIV) and a symptom checklist administered at weeks 0, 8, 24, 36, 48, 60, 72, 84 and 96. Mixed linear models were used for the analysis of differences in HRQL among the three groups. RESULTS: A total of 112 patients were included in the study: 28 received no treatment, 45 received 24 weeks of cART and 39 received 60 weeks of cART. Over 96 weeks of follow-up, the groups receiving 24 and 60 weeks of cART had better cognitive functioning than the no-treatment group (P = 0.005). Patients receiving 60 weeks of cART had less pain (P = 0.004), better role functioning (P = 0.001), better physical functioning (P = 0.02) and a better physical health summary score (P = 0.006) than the groups receiving no treatment or 24 weeks of cART. Mental health was better in patients receiving 24 weeks of cART than in patients in the no-treatment group or the group receiving 60 weeks of cART (P = 0.02). At week 8, patients in the groups receiving 24 and 60 weeks of cART reported more nausea (P = 0.002), diarrhoea (P < 0.001), abdominal pain (P = 0.02), stomach pain (P = 0.049) and dizziness (P = 0.01) than those in the no-treatment group. These differences had disappeared by week 24. CONCLUSIONS: Temporary cART during PHI had a significant positive impact on patients' HRQL as compared with no treatment, despite the initial, short-term occurrence of more physical symptoms, probably related to drug toxicity

The continued need for animals to advance brain research

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised

The continued need for animals to advance brain research

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised

The continued need for animals to advance brain research

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised

The continued need for animals to advance brain research

Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised

The space infrared telescope for cosmology and astrophysics: SPICA A joint mission between JAXA and ESA

International audienceThe Space Infrared telescope for Cosmology and Astrophysics (SPICA) is planned to be the next space astronomy mission observing in the infrared. The mission is planned to be launched in 2017 and will feature a 3.5 m telescope cooled to 30 microns wavelength). We describe the scientific advances that will be made possible by this large increase in sensitivity and give details of the mission, spacecraft and focal plane conceptual design