2,092 research outputs found

    Disinfection of water in swimming pools by combined action of UV-light and ozone

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    Disinfection of water in swimming pools by combined action of UV-light and ozone / 258st American Chemical Society National Meeting and Exposition Β«Division of Environmental ChemistryΒ», august 25-29, 2019, San Diego, CA. ENVR 394.P.5

    Complex radiation-thermal history of Kaidun meteorite on data of track study of silicate minerals

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    The results of track study of approximately 80 individual silicate mineral crystals (ol, px, plag) picked out from Kaidun meteorite are presented. A wide range of observed rho(sub VH) value distributions indicate the complex irradiation history of Kaidun minerals. In one anortite crystal having two track groups with different parameters the pre-accretion irradiation traces were observed in all probability

    Imperfection of the system of the etalons attestation system

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    РассмотрСны основныС ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‰ΠΈΠ΅ Π½Π° ΠΏΡƒΡ‚ΠΈ ΠΊ ΡƒΡ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½ΠΈΡŽ эталоновExamined of main problems arising on the way to confirmation of etalon

    Dietary fiber is a reliable and apparent element of treatment for patients with type 2 diabetes mellitus and cardiovascular diseases: an easy solution to a complicated problem

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    Cardiovascular diseases are a frequent comorbid condition in patients with type 2 diabetes mellitus (t2DM). This problem tends to remain acute because of the progression of t2DM, which increases the chances of cardiovascular events. Medicine today has a range of innovative hypoglycemic drugs, which proved their safety and effectiveness towards diseases of cardiovascular system. However, high cardiovascular mortality demonstrates that the medication is not enough effective. Partly lack of success may be explained by not enough work with unmodified risk factors, such as physical activity, smoking and excessive and wrong nutrition. Studies about dietary fiber (DF) let us discuss their including in the dietary plan of patients with t2DM and cardiovascular diseases. One of the promising DF types is Cyamopsis tetragonoloba extract. It showed its effectiveness concerning carbohydrate metabolism and lipid profile, improving, metabolic features of t2DM patients and lowering the risks of cardiovascular events. What is more, the advantage of Cyamopsis tetragonoloba extract is easy to use and has no side effects

    Π€Π˜Π—Π˜ΠšΠž-Π₯Π˜ΠœΠ˜Π§Π•Π‘ΠšΠ˜Π• Π—ΠΠšΠžΠΠžΠœΠ•Π ΠΠžΠ‘Π’Π˜ ΠŸΠ ΠžΠ¦Π•Π‘Π‘Π Π­Π›Π•ΠšΠ’Π ΠžΠ’ΠžΠ‘Π‘Π’ΠΠΠžΠ’Π›Π•ΠΠ˜Π― ΠšΠ˜Π‘Π›ΠžΠ ΠžΠ”Π Π’ ΠŸΠ Π˜Π‘Π£Π’Π‘Π’Π’Π˜Π˜ ΠŸΠ Π˜Π ΠžΠ”ΠΠ«Π₯ ΠΠΠ’Π˜ΠžΠšΠ‘Π˜Π”ΠΠΠ’ΠžΠ’

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    The effect of individual antioxidants on physico-chemical parameters of ORR was studied under conditions of liner semi-infinite diffusion. Rate constants for coupled homogeneous reduction of active oxygen by the range to flavonoids were calculated under the optimal linear sweep rate.Possibility of determination of the parameters of reduction of active oxygen process (chemical and electrochemical rate constant, reversibility of process) in addition of individual antioxidants was showed by the computer simulation. Identification of substances with antioxidant properties was illustrated by changing of reduction current of active oxygen.Keywords: oxygen reduction reaction, ORR, antioxidant, flavonoids, rate constant, voltammetry(Russian)DOI:Β http://dx.doi.org/10.15826/analitika.2013.17.4.007A.N. Vtorushina, E.I. Korotkova, S.G. Kataev*Β Tomsk Polytechnic University, Tomsk, Russian Federation*Tomsk State Pedagogical University, Tomsk, Russian FederationРассмотрСны Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСскиС закономСрности процСсса элСктровосстановлСния кислорода (Π­Π’Β Πž2) Π² присутствии ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… антиоксидантов Π² условиях Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ полубСсконСчной Π΄ΠΈΡ„Ρ„ΡƒΠ·ΠΈΠΈ, ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ константы скорости взаимодСйствия антиоксидантов с Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹ΠΌΠΈ Ρ„ΠΎΡ€ΠΌΠ°ΠΌΠΈ кислорода ΠΈ Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ Π΄Ρ€ΡƒΠ³ΠΈΠ΅ ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Ρ‹ процСсса для ряда Ρ„Π»Π°Π²ΠΎΠ½ΠΎΠΈΠ΄ΠΎΠ² ΠΏΡ€ΠΈ ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½ΠΎΠΉ скорости Ρ€Π°Π·Π²Π΅Ρ€Ρ‚ΠΊΠΈ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»Π°. Показана Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ опрСдСлСния Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² процСсса Π­Π’Β Πž2 (констант скорости химичСской ΠΈ элСктрохимичСской Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ, обратимости процСсса) Π² присутствии ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… антиоксидантов с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠ³ΠΎ модСлирования, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΈ вСщСств, ΠΎΠ±Π»Π°Π΄Π°ΡŽΡ‰ΠΈΡ… антиоксидантными свойствами, ΠΏΠΎ измСнСнию Ρ‚ΠΎΠΊΠ° Π­Π’Β Πž2 Π² присутствии исслСдуСмых ΠΎΠ±Ρ€Π°Π·Ρ†ΠΎΠ².ΠšΠ»ΡŽΡ‡Π΅Π²Ρ‹Π΅ слова: элСктровосстановлСниС кислорода, антиоксиданты, Π²ΠΎΠ»ΡŒΡ‚Π°ΠΌΠΏΠ΅Ρ€ΠΎΠΌΠ΅Ρ‚Ρ€ΠΈΡDOI:Β http://dx.doi.org/10.15826/analitika.2013.17.4.00

    Stimulating of entrepreneurs’ innovative activity in the Republic of Bashkortostan

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    The article views some aspects of promoting innovative activity in the Republic of Bashkortostan. The measures stimulating innovative activity have been grouped into blocks.1. Creating favorable conditions for innovative activity. 2. Increasing the population’s innovative activity. 3. Development of the system of scientific and production cooperation and innovation commercialization. 4. Investment support of innovative projects. 5. Development of innovative infrastructure. 6. Development of innovative small businesses. 7. Information provision of innovative activity. The main directions of implementing the above-mentioned conditions are: - lawmaking activity in the Republic, taking into consideration the federal legislation, international standards and traditions; - financial and tax inducement of scientific-technical and innovative activity; - international technological integration; - private-state partnership in the sphere of innovative activity. Recommendations are suggested, relating to the innovative policy activation for more efficient fulfillment of the key functions of the Republic’s scientific and research sector. The authors conclude that the Republic has all necessary preconditions for small entrepreneurship functioning: the natural conditions favorable for many kinds of economic activity, the forming local market infrastructure for small business servicing, and the availability of large enterprises and centers of economic activity.Keywords: entrepreneur, entrepreneurship, innovation, innovative activity, region, infrastructure, investments, stimulation, monitoring

    Dielectric and magnetic responses in nanocrystalline BaTiO3

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    This work was supported by Russian Foundation for Basic Research (Research Project No.18-52-00039 Bel_a)

    Anthropometric approach to the diagnosis of mandibular asymmetry

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    The article describes the possibilities of clinical and x-ray diagnostics of mandibular asymmetry. In 61.5% of cases, the asymmetry of the lower jaw is accompanied by complaints from patients about the presence of articular sounds, mild pain when opening the mouth. Asymmetry of the lower jaw is more often determined in female individuals aged 19 to 46 years.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ описаны возмоТности клиничСской ΠΈ рСнтгСнологичСской диагностики асиммСтрии Π½ΠΈΠΆΠ½Π΅ΠΉ Ρ‡Π΅Π»ΡŽΡΡ‚ΠΈ. Π’ 61,5% случаСв асиммСтрия Π½ΠΈΠΆΠ½Π΅ΠΉ Ρ‡Π΅Π»ΡŽΡΡ‚ΠΈ сопровоТдаСтся ΠΆΠ°Π»ΠΎΠ±Π°ΠΌΠΈ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π½Π° Π½Π°Π»ΠΈΡ‡ΠΈΠ΅ суставных Π·Π²ΡƒΠΊΠΎΠ², нСсильной Π±ΠΎΠ»ΠΈ ΠΏΡ€ΠΈ ΠΎΡ‚ΠΊΡ€Ρ‹Π²Π°Π½ΠΈΠΈ Ρ€Ρ‚Π°. АсиммСтрия Π½ΠΈΠΆΠ½Π΅ΠΉ Ρ‡Π΅Π»ΡŽΡΡ‚ΠΈ Ρ‡Π°Ρ‰Π΅ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π° Ρƒ Π»ΠΈΡ† ТСнского ΠΏΠΎΠ»Π° Π² возрастС ΠΎΡ‚ 19 Π΄ΠΎ 46 Π»Π΅

    ИзмСнСниС активности Π»ΠΈΠ·ΠΎΡΠΎΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… цистСиновых ΠΏΡ€ΠΎΡ‚Π΅Π°Π· ΠΏΠ»Π°Π·ΠΌΡ‹, моноядСрных ΠΈ полиморфноядСрных Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚ΠΎΠ² ΠΊΡ€ΠΎΠ²ΠΈ ΠΏΡ€ΠΈ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΠ»ΡŒΡ†Π³Π΅ΠΉΠΌΠ΅Ρ€Π°

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    Aim. To study the level of activity of lysosomal cysteine proteases (cathepsins H, B, L) in blood plasma andΒ fractionated leukocytes (polymorphonuclear and mononuclear) in patients with Alzheimer’s disease in comparisonΒ with similar indicators in persons without signs of neurodegeneration as a possible marker of Alzheimer’s diseaseΒ development and diagnosis.Materials and methods. The spectrofluorimetric study of cathepsins B, L, H activity level in plasma andΒ fractionated leukocytes was conducted in 22 patients diagnosed with Alzheimer’s disease in comparison with theΒ same indicators in 22 patients matched by sex, age and associated diseases with patients of the observation group,Β but having no signs of neurodegeneration.Results. The activity of all three enzymes, and especially cathepsin H, increased significantly in blood plasma.Β  A significant increase is also noted in the activity of cathepsins H, B, and L in homogenates of fractionatedΒ  leukocytes. AtΒ the same time, in both polymorphonuclear and mononuclear leukocytes the greatest degree of changes is demonstratedΒ by the activity of cathepsin B, and the least is the activity of cathepsin L. Given the available data on an increasedΒ cathepsin B activity in the cerebrospinal fluid of patients with Alzheimer’s disease, we can assume a correlationΒ between the state of lysosomal proteases activity in the Central nervous system and in the peripheral blood cells.Conclusion. Alzheimer’s disease is associated with increased activity of cysteine cathepsins in plasma,Β polymorphonuclear and mononuclear leukocytes of peripheral blood, which can be considered as one of theΒ possible markers of development and diagnosis of the disease.  ЦСль. Π˜Π·ΡƒΡ‡ΠΈΡ‚ΡŒ ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ активности Π»ΠΈΠ·ΠΎΡΠΎΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… цистСиновых ΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π· (катСпсинов H, B, L) Π² ΠΏΠ»Π°Π·ΠΌΠ΅Β ΠΊΡ€ΠΎΠ²ΠΈ ΠΈ Ρ„Ρ€Π°ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚Π°Ρ… (полиморфноядСрных ΠΈ моноядСрных) ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π±ΠΎΠ»Π΅Π·Π½ΡŒΡŽΒ ΠΠ»ΡŒΡ†Π³Π΅ΠΉΠΌΠ΅Ρ€Π° Π² сравнСнии с Π°Π½Π°Π»ΠΎΠ³ΠΈΡ‡Π½Ρ‹ΠΌΠΈ показатСлями Ρƒ Π»ΠΈΡ†, Π½Π΅ ΠΈΠΌΠ΅ΡŽΡ‰ΠΈΡ… ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΎΠ² Π½Π΅ΠΉΡ€ΠΎΠ΄Π΅Π³Π΅Π½Π΅Ρ€Π°Ρ†ΠΈΠΈ,Β ΠΊΠ°ΠΊ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ‹ΠΉ ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ развития ΠΈ диагностики Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΠ»ΡŒΡ†Π³Π΅ΠΉΠΌΠ΅Ρ€Π°.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ спСктрофлуоримСтричСскоС исслСдованиС уровня активности катСпсинов B, L, H Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ ΠΈ Ρ„Ρ€Π°ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚Π°Ρ… 22 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Β«Π‘ΠΎΠ»Π΅Π·Π½ΡŒ ΠΠ»ΡŒΡ†Π³Π΅ΠΉΠΌΠ΅Ρ€Π°Β»Β Π² сравнСнии с Π°Π½Π°Π»ΠΎΠ³ΠΈΡ‡Π½Ρ‹ΠΌΠΈ показатСлями 22 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ², сопоставимых ΠΏΠΎ ΠΏΠΎΠ»Ρƒ, возрасту ΠΈ ΡΠΎΠΏΡƒΡ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΌΒ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌ с ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°ΠΌΠΈ Π³Ρ€ΡƒΠΏΠΏΡ‹ наблюдСния, Π½ΠΎ Π½Π΅ ΠΈΠΌΠ΅ΡŽΡ‰ΠΈΡ…Β  ΠΏΡ€ΠΈΠ·Π½Π°ΠΊΠΎΠ² Π½Π΅ΠΉΡ€ΠΎΠ΄Π΅Π³Π΅Π½Π΅Ρ€Π°Ρ†ΠΈΠΈ.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π’ ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½Π° Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ всСх Ρ‚Ρ€Π΅Ρ… Ρ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚ΠΎΠ²,Β Π² наибольшСй стСпСни – активности катСпсина Н. Π’ Π³ΠΎΠΌΠΎΠ³Π΅Π½Π°Ρ‚Π°Ρ… Ρ„Ρ€Π°ΠΊΡ†ΠΈΠΎΠ½ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚ΠΎΠ²Β Ρ‚Π°ΠΊΠΆΠ΅ отмСчаСтся статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎΠ΅ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ активности катСпсинов Н, B, L, ΠΏΡ€ΠΈ этом ΠΊΠ°ΠΊ в полиморфноядСрных, Ρ‚Π°ΠΊ ΠΈ Π² моноядСрных Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚Π°Ρ… Π² наибольшСй стСпСни измСняСтся Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΒ ΠΊΠ°Ρ‚Π΅ΠΏΡΠΈΠ½Π° Π’, наимСньшСй –катСпсина L. Учитывая ΠΈΠΌΠ΅ΡŽΡ‰ΠΈΠ΅ΡΡ Π΄Π°Π½Π½Ρ‹Π΅ ΠΎ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠΈ активности катСпсина В Π² Ρ†Π΅Ρ€Π΅Π±Ρ€ΠΎΡΠΏΠΈΠ½Π°Π»ΡŒΠ½ΠΎΠΉ Тидкости ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с болСзнью ΠΠ»ΡŒΡ†Π³Π΅ΠΉΠΌΠ΅Ρ€Π°, ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡ€Π΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚ΡŒ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΡŒΒ ΠΌΠ΅ΠΆΠ΄Ρƒ состояниСм активности Π»ΠΈΠ·ΠΎΡΠΎΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Π°Π· Π² Ρ†Π΅Π½Ρ‚Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ Π½Π΅Ρ€Π²Π½ΠΎΠΉ систСмС ΠΈ пСрифСричСских клСтках ΠΊΡ€ΠΎΠ²ΠΈ.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π‘ΠΎΠ»Π΅Π·Π½ΡŒ ΠΠ»ΡŒΡ†Π³Π΅ΠΉΠΌΠ΅Ρ€Π° ассоциирована с нарастаниСм активности цистСиновых катСпсинов Π²Β ΠΏΠ»Π°Π·ΠΌΠ΅, полиморфноядСрных ΠΈ моноядСрных Π»Π΅ΠΉΠΊΠΎΡ†ΠΈΡ‚Π°Ρ… пСрифСричСской ΠΊΡ€ΠΎΠ²ΠΈ, Ρ‡Ρ‚ΠΎ ΠΌΠΎΠΆΠ΅Ρ‚ Ρ€Π°ΡΡΠΌΠ°Ρ‚Ρ€ΠΈΠ²Π°Ρ‚ΡŒΡΡΒ ΠΊΠ°ΠΊ ΠΎΠ΄ΠΈΠ½ ΠΈΠ· Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ‹Ρ… ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ΠΎΠ² развития ΠΈ диагностики заболСвания

    НСстСроидныС ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ‹:возмоТности сниТСния интСнсивности Π±ΠΎΠ»ΠΈ Π² спинС Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… остСопорозом

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    Objective: to evaluate the efficiency and tolerability of a 10-day course of therapy with different doses of meloxicam in patients with osteoporosis and back pain. Subjects and methods. The study covered 60 women (mean age 70Β±7 years), who were randomized to 3 groups: those who received meloxicam in doses of 15 and 7,5 mg and controls. Results. During 10-day therapy, there was a significant reduction in the intensity of back pain when meloxicam was given in doses of both 7,5 mg and 15 mg/day (p < 0,001) as compared with the baseline level and in the control group (p < 0,05). At the same time, the pain syndrome became insignificantly lower in the control group following 10 days (p > 0,05). In the first 2 groups, movement restriction significantly reduced, as well as physical activity increased and health improved, as rated by the Oswestry and EQ-5D questionnaires. Improvement was recorded in 27 (67,5%) patients, a satisfactory effect was seen in 10 (25%), there was no effect in 3 (7,5%) women. Conclusion. The treatment was generally well tolerated.ЦСль исслСдования- ΠΎΡ†Π΅Π½ΠΈΡ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈ ΠΏΠ΅Ρ€Π΅Π½ΠΎΡΠΈΠΌΠΎΡΡ‚ΡŒ 10-Π΄Π½Π΅Π²Π½ΠΎΠ³ΠΎ курса лСчСния Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ Π΄ΠΎΠ·Π°ΠΌΠΈ мСлоксикама Ρƒ Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с остСопорозом ΠΈ болью Π² спинС. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ исслСдованиС Π²ΠΊΠ»ΡŽΡ‡Π΅Π½Ρ‹ 60 ΠΆΠ΅Π½Ρ‰ΠΈΠ½ (срСдний возраст 70Β±7 Π»Π΅Ρ‚), ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ случайно Π±Ρ‹Π»ΠΈ Ρ€Π°Π·Π΄Π΅Π»Π΅Π½Ρ‹ Π½Π° 3 Π³Ρ€ΡƒΠΏΠΏΡ‹ - ΠΏΠΎΠ»ΡƒΡ‡Π°Π²ΡˆΠΈΠ΅ соотвСтствСнно 15 ΠΈ 7,5ΠΌΠ³ мСлоксикама ΠΈ ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ исслСдования. На Ρ„ΠΎΠ½Π΅ 10-Π΄Π½Π΅Π²Π½ΠΎΠΉ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΎΡΡŒ достовСрноС сниТСниС интСнсивности Π±ΠΎΠ»ΠΈ Π² спинС ΠΏΡ€ΠΈ Π½Π°Π·Π½Π°Ρ‡Π΅Π½ΠΈΠΈ мСлоксикама Π² Π΄ΠΎΠ·Π΅ ΠΊΠ°ΠΊ 7,5, Ρ‚Π°ΠΊ ΠΈ 15 ΠΌΠ³/сут (p<0,001) ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ Π±ΠΎΠ»ΠΈ ΠΏΡ€ΠΈ Π²ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠΈ Π² исслСдованиС ΠΈ Π² ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ (p<0,05). ΠŸΡ€ΠΈ этом Π² ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ Ρ‡Π΅Ρ€Π΅Π· 10 Π΄Π½Π΅ΠΉ Π±ΠΎΠ»Π΅Π²ΠΎΠΉ синдром ΡƒΠΌΠ΅Π½ΡŒΡˆΠΈΠ»ΡΡ Π½Π΅Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ (p>0,05). Π£ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠΊ ΠΏΠ΅Ρ€Π²Ρ‹Ρ… 2 Π³Ρ€ΡƒΠΏΠΏ достовСрно снизилось ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΈΠ΅ подвиТности, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΏΠΎΠ²Ρ‹ΡΠΈΠ»Π°ΡΡŒ физичСская Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ, ΡƒΠ»ΡƒΡ‡ΡˆΠΈΠ»ΠΎΡΡŒ состояниС Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡ, ΠΎΡ†Π΅Π½Π΅Π½Π½ΠΎΠ΅ ΠΏΠΎ вопросникам ΠžΡΠ²Π΅ΡΡ‚Ρ€ΠΈ ΠΈ EQ-5D. Π£Π»ΡƒΡ‡ΡˆΠ΅Π½ΠΈΠ΅ состояния зафиксировано Ρƒ 27 (67,5%) Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…, ΡƒΠ΄ΠΎΠ²Π»Π΅Ρ‚Π²ΠΎΡ€ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ эффСкт - Ρƒ 10 (25%), Π° отсутствиС эффСкта - Ρƒ 3 (7,5%). Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’ Ρ†Π΅Π»ΠΎΠΌ ΠΏΠ΅Ρ€Π΅Π½ΠΎΡΠΈΠΌΠΎΡΡ‚ΡŒ лСчСния Π±Ρ‹Π»Π° Ρ…ΠΎΡ€ΠΎΡˆΠ΅ΠΉ
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