Nematic Structure of Space-Time and its Topological Defects in 5D Kaluza-Klein Theory

We show, that classical Kaluza-Klein theory possesses hidden nematic dynamics. It appears as a consequence of 1+4-decomposition procedure, involving 4D observers 1-form \lambda. After extracting of boundary terms the, so called, "effective matter" part of 5D geometrical action becomes proportional to square of anholonomicity 3-form \lambda\wedge d\lambda. It can be interpreted as twist nematic elastic energy, responsible for elastic reaction of 5D space-time on presence of anholonomic 4D submanifold, defined by \lambda. We derive both 5D covariant and 1+4 forms of 5D nematic equilibrium equations, consider simple examples and discuss some 4D physical aspects of generic 5D nematic topological defects.Comment: Latex-2e, 14 pages, 1 Fig., submitted to GR

The principle of least action for test particles in a four-dimensional spacetime embedded in 5D

It is well known that, in the five-dimensional scenario of braneworld and space-time-mass theories, geodesic motion in 5D is observed to be non-geodesic in 4D. Usually, the discussion is purely geometric and based on the dimensional reduction of the geodesic equation in 5D, without any reference to the test particle whatsoever. In this work we obtain the equation of motion in 4D directly from the principle of least action. So our main thrust is not the geometry but the particle observed in 4D. A clear physical picture emerges from our work. Specifically, that the deviation from the geodesic motion in 4D is due to the variation of the rest mass of a particle, which is induced by the scalar field in the 5D metric and the explicit dependence of the spacetime metric on the extra coordinate. Thus, the principle of least action not only leads to the correct equations of motion, but also provides a concrete physical meaning for a number of algebraic quantities appearing in the geometrical reduction of the geodesic equation

Exterior spacetime for stellar models in 5-dimensional Kaluza-Klein gravity

It is well-known that Birkhoff's theorem is no longer valid in theories with more than four dimensions. Thus, in these theories the effective 4-dimensional picture allows the existence of different possible, non-Schwarzschild, scenarios for the description of the spacetime outside of a spherical star, contrary to general relativity in 4D. We investigate the exterior spacetime of a spherically symmetric star in the context of Kaluza-Klein gravity. We take a well-known family of static spherically symmetric solutions of the Einstein equations in an empty five-dimensional universe, and analyze possible stellar exteriors that are conformal to the metric induced on four-dimensional hypersurfaces orthogonal to the extra dimension. All these exteriors are continuously matched with the interior of the star. Then, without making any assumptions about the interior solution, we prove the following statement: the condition that in the weak-field limit we recover the usual Newtonian physics singles out an unique exterior. This exterior is "similar" to Scharzschild vacuum in the sense that it has no effect on gravitational interactions. However, it is more realistic because instead of being absolutely empty, it is consistent with the existence of quantum zero-point fields. We also examine the question of how would the deviation from the Schwarzschild vacuum exterior affect the parameters of a neutron star. In the context of a model star of uniform density, we show that the general relativity upper limit M/R < 4/9 is significantly increased as we go away from the Schwarzschild vacuum exterior. We find that, in principle, the compactness limit of a star can be larger than 1/2, without being a black hole. The generality of our approach is also discussed.Comment: Typos corrected. Accepted for publication in Classical and Quantum Gravit

Algorithm for selecting predictors and prognosis of atrial fibrillation in patients with coronary artery disease after coronary artery bypass grafting

Aim. To develop an algorithm for selecting predictors and prognosis of atrial fibrillation (AF) in patients with coronary artery disease (CAD) after coronary artery bypass grafting (CABG).Material and methods. This retrospective study included 886 case histories of patients with CAD aged 35 to 81 years (median age, 63 years; 95% confidence interval [63; 64]), who underwent isolated CABG under cardiopulmonary bypass. Eighty-five patients with prior AF were excluded from the study. Two groups of persons were identified, the first of which consisted of 153 (19,1%) patients with newly recorded AF episodes, the second — 648 (80,9%) patients without cardiac arrhythmias. Preoperative clinical and functional status was assessed using 100 factors. Chi-squared, Fisher, and Mann-Whitney tests, as well as univariate logistic regression (LR) were used for data processing and analysis. Multivariate LR and artificial neural networks (ANN) were used to develop predictive models. The boundaries of significant ranges of potential predictors were determined by stepwise assessment of the odds ratio and p-value. The model accuracy was assessed using 4 metrics: area under the ROC-curve (AUC), sensitivity, specificity, and accuracy.Results. A comprehensive analysis of preoperative status of patients made it possible to identify 11 factors with the highest predictive potential, linearly and nonlinearly associated with postoperative AF (PAF). These included age (55-74 years for men and 60-78 years for women), anteroposterior and superior-inferior left atrial dimensions, transverse and longitudinal right atrial dimensions, tricuspid valve regurgitation, left ventricular end systolic dimension &gt;49 mm, RR length of 1000-1100 ms, PQ length of 170-210 ms, QRS length of 50-80 ms, QT &gt;420 ms for men and &gt;440 ms for women, and heart failure with ejection fraction of 4560%. The metrics of the best predictive ANN model were as follows: AUC — 0,75, specificity — 0,73, sensitivity — 0,74, and accuracy — 0,73. These values in best model based on multivariate LR were lower (0,75; 0,7; 0,68 and 0,7, respectively).Conclusion. The developed algorithm for selecting predictors made it possible to verify significant predictive ranges and weight coefficients characterizing their influence on PAF development. The predictive model based on ANN has a higher accuracy than multivariate HR

Higher Dimensional Cylindrical or Kasner Type Electrovacuum Solutions

We consider a D dimensional Kasner type diagonal spacetime where metric functions depend only on a single coordinate and electromagnetic field shares the symmetries of spacetime. These solutions can describe static cylindrical or cosmological Einstein-Maxwell vacuum spacetimes. We mainly focus on electrovacuum solutions and four different types of solutions are obtained in which one of them has no four dimensional counterpart. We also consider the properties of the general solution corresponding to the exterior field of a charged line mass and discuss its several properties. Although it resembles the same form with four dimensional one, there is a difference on the range of the solutions for fixed signs of the parameters. General magnetic field vacuum solution are also briefly discussed, which reduces to Bonnor-Melvin magnetic universe for a special choice of the parameters. The Kasner forms of the general solution are also presented for the cylindrical or cosmological cases.Comment: 16 pages, Revtex. Text and references are extended, Published versio

Structural instability of Friedmann-Robertson-Walker cosmological models

Cosmological singularity and asymptotic behaviour of scale factor of generalized cosmological models are analyzed in respect of their structural stability. It is shown, that cosmological singularity is structurally unstable for the majority of models with barotropic perfect fluid with strong energy condition. Inclusion of Lambda-term extends the set of structurally stable cosmological models.Comment: 14 pages, 4 figures in TeXCad, developed version of talk, presented at XIII Russian Gravitational Conference, June 2008, to be published in GRG, minor changes concerning added reference

The clinical relevance of oliguria in the critically ill patient : Analysis of a large observational database

Funding Information: Marc Leone reports receiving consulting fees from Amomed and Aguettant; lecture fees from MSD, Pfizer, Octapharma, 3 M, Aspen, Orion; travel support from LFB; and grant support from PHRC IR and his institution. JLV is the Editor-in-Chief of Critical Care. The other authors declare that they have no relevant financial interests. Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.publishersversionPeer reviewe