Raman spectroscopic studies on the ferroelectric soft mode in SnxSr1-xTiO3

The Raman spectra of novel ferroelectric ceramics SnxSr1-xTiO3 (x = 0.1, 0.05 and 0.02) were obtained to clarify the mechanism of their ferroelectric phase transitions. Two transverse-optic modes in the ferroelectric phase showed softening toward the ferroelectric transition temperature. A comparison of the spectra obtained for SnxSr1-xTiO3 with the spectrum of PbxSr1-xTiO3 facilitated the assignment of the observed modes under the assumption of the ferroelectric phase in C4v1 symmetry. However, several peaks violating the Raman selection rules were observed, suggesting the emergence and growth of polar regions even in the paraelectric phase

Evolution of Angular Momentum Distribution during Star Formation

If the angular momentum of the molecular cloud core were conserved during the star formation process, a new-born star would rotate much faster than its fission speed. This constitutes the angular momentum problem of new-born stars. In this paper, the angular momentum transfer in the contraction of a rotating magnetized cloud is studied with axisymmetric MHD simulations. Owing to the large dynamic range covered by the nested-grid method, the structure of the cloud in the range from 10 AU to 0.1 pc is explored. First, the cloud experiences a run-away collapse, and a disk forms perpendicularly to the magnetic field, in which the central density increases greatly in a finite time-scale. In this phase, the specific angular momentum j of the disk decreases to $\simeq 1/3$ of the initial cloud. After the central density of the disk exceeds $\sim 10^{10}{\rm cm}^{-3}$, the infall on to the central object develops. In this accretion stage, the rotation motion and thus the toroidal magnetic field drive the outflow. The angular momentum of the central object is transferred efficiently by the outflow as well as the effect of the magnetic stress. In 7000 yr from the core formation, the specific angular momentum of the central $0.17M_\odot$ decreases a factor of 10^{-4} from the initial value (i.e. from $10^{20}{\rm cm^2 s^{-1}}$ to $10^{16}{\rm cm^2 s^{-1}}$).Comment: 15 pages, 2 figures, Astrophysical Journal Letters in pres

Collapse and Fragmentation of Rotating Magnetized Clouds. I. Magnetic Flux - Spin Relation

We discuss evolution of the magnetic flux density and angular velocity in a molecular cloud core, on the basis of three-dimensional numerical simulations, in which a rotating magnetized cloud fragments and collapses to form a very dense optically thick core of > 5 times 10 ^10 cm^-3 . As the density increases towards the formation of the optically thick core, the magnetic flux density and angular velocity converge towards a single relationship between the two quantities. If the core is magnetically dominated its magnetic flux density approaches 1.5 (n/5 times 10^10 cm^-3)^1/2 mG, while if the core is rotationally dominated the angular velocity approaches 2.57 times 10^-3, (n/5 times 10^10 cm^-3)^1/2 yr^-1, where n is the density of the gas. We also find that the ratio of the angular velocity to the magnetic flux density remains nearly constant until the density exceeds 5 times 10^10 cm^-3. Fragmentation of the very dense core and emergence of outflows from fragments are shown in the subsequent paper.Comment: 17 pages, 12 figures, accepted for publication in MNRA

Collapse of Rotating Magnetized Molecular Cloud Cores and Mass Outflows

Collapse of the rotating magnetized molecular cloud core is studied with the axisymmetric magnetohydrodynamical (MHD) simulations. Due to the change of the equation of state of the interstellar gas, the molecular cloud cores experience several different phases as collapse proce eds. In the isothermal run-away collapse ($n \lesssim 10^{10}{\rm H_2 cm}^{-3}$), a pseudo-disk is formed and it continues to contract till the opaque core is fo rmed at the center. In this disk, a number of MHD fast and slow shock pairs appear running parallelly to the disk. After the equation of state becomes hard, an adiabatic core is formed, which is separated from the isothermal contracting pseudo-disk by the accretion shock front facing radially outwards. By the effect of the magnetic tension, the angular momentum is transferred from the disk mid-plane to the surface. The gas with excess angular momentum near the surface is finally ejected, which explains the molecular bipolar outflow. Two types of outflows are observed. When the poloidal magnetic field is strong (magnetic energy is comparable to the thermal one), a U-shaped outflow is formed in which fast moving gas is confined to the wall whose shape looks like a capit al letter U. The other is the turbulent outflow in which magnetic field lines and velocity fi elds are randomly oriented. In this case, turbulent gas moves out almost perpendicularly from the disk. The continuous mass accretion leads to the quasistatic contraction of the first core. A second collapse due to dissociation of H$_2$ in the first core follows. Finally another quasistatic core is again formed by atomic hydrogen (the second core). It is found that another outflow is ejected around the second atomic core, which seems to correspond to the optical jets or the fast neutral winds.Comment: submitted to Ap

A new thermo-time domain reflectometry approach to quantify soil ice content at temperatures near the freezing point

Soil ice content (θi) is an important property for many studies associated with cold regions. In situ quantification of θi with thermo-time domain reflectometry (TDR) at temperatures near the freezing point has been difficult. The objective of this study is to propose and test a new thermo-TDR approach to determine θi. First, the liquid water content (θl) of a partially frozen soil is determined from a TDR waveform. Next, a pulse of heat is applied through the thermo-TDR sensor to melt the ice in the partially frozen soil. Then, a second TDR waveform is obtained after melting to determine the θl, which is equivalent to the total water content (θt ) of the partially frozen soil. Finally, θi is calculated as the difference between θt and θl. The performance of the new approach was evaluated in sand and loam soils at a variety of θ t values. The new approach estimated θt , θl, and θi accurately. The root mean square errors (RMSE) of estimation were 0.013, 0.020, and 0.023 m3 m−3 for sand, and 0.041, 0.026, and 0.031 m3 m−3 for loam. These RMSE values are smaller than those reported in earlier thermo-TDR studies. Repeating the thermo-TDR measurements at the same location on the same soil sample caused decreased accuracy of estimated values, because of radial water transfer away from the heater tube of the thermo-TDR sensor. Further research is needed to determine if it is possible to obtain accurate repeated measurements. The use of a dielectric mixing model to convert the soil apparent dielectric constant to θl improved the accuracy of this approach. In our investigation, application of a small heat intensity until the partially frozen soil temperature became larger than about 1°C was favorable. The new method was shown to be suitable for estimating ice contents in soil at temperatures between 0°C and -2°C, and it could be combined with the volumetric heat capacity or thermal conductivity thermo-TDR based methods, which measured ice content at colder temperatures. Thus, the thermo-TDR technique could measure θi at all temperatures

Evolution of Rotating Molecular Cloud Core with Oblique Magnetic Field

We studied the collapse of rotating molecular cloud cores with inclined magnetic fields, based on three-dimensional numerical simulations.The numerical simulations start from a rotating Bonnor-Ebert isothermal cloud in a uniform magnetic field. The magnetic field is initially taken to be inclined from the rotation axis. As the cloud collapses, the magnetic field and rotation axis change their directions. When the rotation is slow and the magnetic field is relatively strong, the direction of the rotation axis changes to align with the magnetic field, as shown earlier by Matsumoto & Tomisaka. When the magnetic field is weak and the rotation is relatively fast, the magnetic field inclines to become perpendicular to the rotation axis. In other words, the evolution of the magnetic field and rotation axis depends on the relative strength of the rotation and magnetic field. Magnetic braking acts to align the rotation axis and magnetic field, while the rotation causes the magnetic field to incline through dynamo action. The latter effect dominates the former when the ratio of the angular velocity to the magnetic field is larger than a critical value \Omega_0/ B_0 > 0.39 G^1/2 c_s^-1, where B_0, \Omega_0, G, and c_s^-1 denote the initial magnetic field, initial angular velocity, gravitational constant, and sound speed, respectively. When the rotation is relatively strong, the collapsing cloud forms a disk perpendicular to the rotation axis and the magnetic field becomes nearly parallel to the disk surface in the high density region. A spiral structure appears due to the rotation and the wound-up magnetic field in the disk.Comment: 45 pages, 17 figures, Submitted to ApJ, For high resolution figures see http://www2.scphys.kyoto-u.ac.jp/~machidam/ms060201.pd

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor

Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE)/beta-secretase, after which it is cleaved by presenilin (PS)/gamma-secretase near the middle of the transmembrane domain. Thus, inhibition of either of the secretases reduces A beta generation and is a fundamental strategy for the development of drugs to prevent Alzheimer disease. However, it is not clear how small compounds reduce A beta production without inhibition of the secretases. Such compounds are expected to avoid some of the side effects of secretase inhibitors. Here, we report that destruxin E (Dx-E), a natural cyclic hexadepsipeptide, reduces A beta generation without affecting BACE or PS/gamma-secretase activity. In agreement with this, Dx-E did not inhibit Notch signaling. We found that Dx-E decreases colocalization of BACE1 and beta APP, which reduces beta-cleavage of beta APP. Therefore, the data demonstrate that Dx-E represents a novel A beta-reducing process which could have fewer side effects than secretase inhibitors. Copyright (C) 2009 S. Karger AG, Base

Handling rich turn-taking in spoken dialogue systems

ABSTRACT This paper discusses how to build a system that can engage in a mixed-initiative human-machine spoken dialogue in which system utterances sometimes overlap with user utterances and vice versa. In the method, a module that incrementally understands user utterances and another module that incrementally generates system utterances work in parallel, and the timing of taking and releasing the dialogue initiative is decided according to the understanding of user utterances and the content of the system utterances. This method enables the system to respond when the user holds the dialogue initiative and is speaking, and enables the system to react to the user's barge-ins when it holds the initiative and is speaking. An experimental system called DUG-1 is also presented

Glycolysis Inhibition Inactivates ABC Transporters to Restore Drug Sensitivity in Malignant Cells

Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps. Because cancer cells produce ATP mostly through glycolysis, in the present study we explored the effects of inhibiting glycolysis on the ABC transporter function and drug sensitivity of malignant cells. Inhibition of glycolysis by 3-bromopyruvate (3BrPA) suppressed ATP production in malignant cells, and restored the retention of daunorubicin or mitoxantrone in ABC transporter-expressing, RPMI8226 (ABCG2), KG-1 (ABCB1) and HepG2 cells (ABCB1 and ABCG2). Interestingly, although side population (SP) cells isolated from RPMI8226 cells exhibited higher levels of glycolysis with an increased expression of genes involved in the glycolytic pathway, 3BrPA abolished Hoechst 33342 exclusion in SP cells. 3BrPA also disrupted clonogenic capacity in malignant cell lines including RPMI8226, KG-1, and HepG2. Furthermore, 3BrPA restored cytotoxic effects of daunorubicin and doxorubicin on KG-1 and RPMI8226 cells, and markedly suppressed subcutaneous tumor growth in combination with doxorubicin in RPMI8226-implanted mice. These results collectively suggest that the inhibition of glycolysis is able to overcome drug resistance in ABC transporter-expressing malignant cells through the inactivation of ABC transporters and impairment of SP cells with enhanced glycolysis as well as clonogenic cells