369 research outputs found
Functional impairment, insight, and comparison between criteria for gaming disorder in the International Classification of Diseases, 11 Edition and internet gaming disorder in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
Aim: This study evaluated the consistency between the International Classification of Diseases, 11th Edition (ICD-11) for gaming disorder (ICD-11-GD) and Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for internet gaming disorder (DSM-5-IGD). Moreover, the functional impairment of participants and their insight of their GD were evaluated. Methods: We recruited 60 participants with GD, 45 participants who engaged in hazardous gaming (HG), and 120 controls based on a diagnostic interview. Their operationalization of functional impairment and stage of change were evaluated by interviews and questionnaires, including the Brief Gaming Negative Consequence Scale (BGNCS). Results: We observed satisfactory consistency (kappa value 5 0.80) with a diagnostic accuracy of 91.5% between the ICD-11-GD and DSM-5-IGD criteria. Furthermore, 16 participants with IGD in DSM-5 were determined to have HG based on the ICD-11 criteria. Participants of GD group experienced impaired functioning in their health (96.7%), career (73.3%), social life (61.6%), academic performance (36.7%), and job performance (35%). Moreover, a proportion of them were in the pre-contemplation (25.0%), contemplation (61.7%), preparation (10%), and action stages (3.3%). Conclusion: There is a good consistency between ICD-11-GD and DSM-5-IGD criteria. The ICD-11 criteria have a high threshold for diagnosing GD. HG criteria could compensate for this high threshold and identify individuals with a gaming-related functional impairment who require help. Most of the participants with GD were in the early stage of change. Interventions to promote their insight are essential. The BGNCS can be used to examine the negative consequences of gaming and aid mental health professionals in assessing functional impairment
In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering
In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats
Gaming disorder: its delineation as an important condition for diagnosis, management and prevention
Online gaming has greatly increased in popularity in recent years, and with this has come a multiplicity of problems due to excessive involvement in gaming. Gaming disorder, both online and offline, has been defined for the first time in the draft of 11th revision of the International Classification of Diseases (ICD-11). National surveys have shown prevalence rates of gaming disorder/addiction of 10%–15% among young people in several Asian countries and of 1%–10% in their counterparts in some Western countries. Several diseases related to excessive gaming are now recognized, and clinics are being established to respond to individual, family, and community concerns, but many cases remain hidden. Gaming disorder shares many features with addictions due to psychoactive substances and with gambling disorder, and functional neuroimaging shows that similar areas of the brain are activated. Governments and health agencies worldwide are seeking for the effects of online gaming to be addressed, and for preventive approaches to be developed. Central to this effort is a need to delineate the nature of the problem, which is the purpose of the definitions in the draft of ICD-11
Subendocardial contractile impairment in chronic ischemic myocardium: assessment by strain analysis of 3T tagged CMR
<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to quantify myocardial strain on the subendocardial and epicardial layers of the left ventricle (LV) using tagged cardiovascular magnetic resonance (CMR) and to investigate the transmural degree of contractile impairment in the chronic ischemic myocardium.</p> <p>Methods</p> <p>3T tagged CMR was performed at rest in 12 patients with severe coronary artery disease who had been scheduled for coronary artery bypass grafting. Circumferential strain (C-strain) at end-systole on subendocardial and epicardial layers was measured using the short-axis tagged images of the LV and available software (Intag; Osirix). The myocardial segment was divided into stenotic and non-stenotic segments by invasive coronary angiography, and ischemic and non-ischemic segments by stress myocardial perfusion scintigraphy. The difference in C-strain between the two groups was analyzed using the Mann-Whitney U-test. The diagnostic capability of C-strain was analyzed using receiver operating characteristics analysis.</p> <p>Results</p> <p>The absolute subendocardial C-strain was significantly lower for stenotic (-7.5 ± 12.6%) than non-stenotic segment (-18.8 ± 10.2%, p < 0.0001). There was no difference in epicardial C-strain between the two groups. Use of cutoff thresholds for subendocardial C-strain differentiated stenotic segments from non-stenotic segments with a sensitivity of 77%, a specificity of 70%, and areas under the curve (AUC) of 0.76. The absolute subendocardial C-strain was significantly lower for ischemic (-6.7 ± 13.1%) than non-ischemic segments (-21.6 ± 7.0%, p < 0.0001). The absolute epicardial C-strain was also significantly lower for ischemic (-5.1 ± 7.8%) than non-ischemic segments (-9.6 ± 9.1%, p < 0.05). Use of cutoff thresholds for subendocardial C-strain differentiated ischemic segments from non-ischemic segments with sensitivities of 86%, specificities of 84%, and AUC of 0.86.</p> <p>Conclusions</p> <p>Analysis of tagged CMR can non-invasively demonstrate predominant impairment of subendocardial strain in the chronic ischemic myocardium at rest.</p
Observation of Bs->Ds(*)+Ds(*)- using e+e- collisions and a determination of the Bs-Bsbar width difference \Delta\Gamma_s
We have made the first observation of Bs->Ds(*)+Ds(*)- decays using 23.6 fb-1
of data recorded by the Belle experiment running on the Upsilon(5S) resonance.
The branching fractions are measured to be B(B^0_s\ra D^+_s D^-_s) =
(1.0\,^{+0.4}_{-0.3}\,^{+0.3}_{-0.2})%, B(B^0_s\ra D^{*\pm}_s D^{\mp}_s) =
(2.8\,^{+0.8}_{-0.7}\,\pm 0.7)%, and B(B^0_s\ra D^{*+}_s D^{*-}_s) =
(3.1\,^{+1.2}_{-1.0}\,\pm 0.8)%; the sum is B(B^0_s\ra D^{(*)+}_s D^{(*)-}_s) =
(6.9\,^{+1.5}_{-1.3}\,\pm 1.9)%. Assuming Bs->Ds(*)+Ds(*)- saturates decays to
CP-even final states, the branching fraction determines the ratio
\Delta\Gamma_s/cos(\phi), where \Delta\Gamma_s is the difference in widths
between the two Bs-Bsbar mass eigenstates, and \phi is a CP-violating weak
phase. Taking CP violation to be negligibly small, we obtain
\Delta\Gamma_s/\Gamma_s =
0.147^{+0.036}_{-0.030}(stat.)^{+0.044}_{-0.042}(syst.), where \Gamma_s is the
mean decay width.Comment: 13 pages, 2 figures, 2 tables. v2: text added for clarification,
version published in Phys. Rev. Letter
Observation of B+ -> Dbar*0 tau+ nu_tau and Evidence for B+ -> Dbar^0 tau+ nu_tau at Belle
We present measurements of B+ -> Dbar*0 tau+ nu_tau and B+ -> Dbar^0 tau+
nu_tau decays in a data sample of 657 x 10^6 BBbar pairs collected with the
Belle detector at the KEKB asymmetric-energy e+e- collider. We find
446^{+58}_{-56} events of the decay B+ -> Dbar*0 tau+ nu_tau with a
significance of 8.1 standard deviations, and 146^{+42}_{-41} events of the
decay B+ -> Dbar0 tau+ nu_tau with a significance of 3.5 standard deviations.
The latter signal provides the first evidence for this decay mode. The measured
branching fractions are B(B+ -> Dbar*0 tau+ nu_tau)=(2.12^{+0.28}_{-0.27}
(stat) +- 0.29 (syst)) % and B(B+ -> Dbar0 tau+ nu_tau)=(0.77 +- 0.22 (stat) +-
0.12 (syst)) %.Comment: 6 pages, 4 figures, submitted to Phys. Rev. Let
Measurement of CP violating asymmetries in B^0 -> K^+K^- K^0_S decays with a time-dependent Dalitz approach
We report a measurement of violating asymmetries in decays with a time-dependent Dalitz approach. This analysis
is based on a data sample of pairs accumulated
at the resonance with the Belle detector at the KEKB
asymmetric-energy collider. As the result of an unbinned maximum
likelihood fit to the selected candidates, the mixing-induced and direct
violation parameters, and are obtained for
, and other decays. We find four solutions that describe the data. There are
\{eqnarray*} \phi_1^{\rm eff}(B^0\to \phi(1020) K^0_S) & = & (32.2 \pm 9.0 \pm
2.6 \pm 1.4)^{\circ}; \phi_1^{\rm eff}(B^0\to \phi(1020) K^0_S) & = & (26.2 \pm
8.8 \pm 2.7 \pm 1.2)^{\circ};\\ \phi_1^{\rm eff}(B^0\to \phi(1020) K^0_S) & = &
(27.3 \pm 8.6 \pm 2.8 \pm 1.3)^{\circ}\; {\rm and}\\ \phi_1^{\rm eff}(B^0\to
\phi(1020) K^0_S) & = & (24.3 \pm 8.0 \pm 2.9 \pm 5.2)^{\circ}.{eqnarray*}\ The
values for the violating phase in are similar
but other properties of the Dalitz plot are quite different for the four
solutions. These four solutions have consistent values for
all three meson decay channels and none of them deviates significantly from
the values measured in decays with the currently
available statistics. In addition, we find no significant direct
violation.Comment: submitted to PR
Measurement of CP violating asymmetries in B^0 -> K^+K^- K^0_S decays with a time-dependent Dalitz approach
We report a measurement of violating asymmetries in decays with a time-dependent Dalitz approach. This analysis
is based on a data sample of pairs accumulated
at the resonance with the Belle detector at the KEKB
asymmetric-energy collider. As the result of an unbinned maximum
likelihood fit to the selected candidates, the mixing-induced and direct
violation parameters, and are obtained for
, and other decays. We find four solutions that describe the data. There are
\{eqnarray*} \phi_1^{\rm eff}(B^0\to \phi(1020) K^0_S) & = & (32.2 \pm 9.0 \pm
2.6 \pm 1.4)^{\circ}; \phi_1^{\rm eff}(B^0\to \phi(1020) K^0_S) & = & (26.2 \pm
8.8 \pm 2.7 \pm 1.2)^{\circ};\\ \phi_1^{\rm eff}(B^0\to \phi(1020) K^0_S) & = &
(27.3 \pm 8.6 \pm 2.8 \pm 1.3)^{\circ}\; {\rm and}\\ \phi_1^{\rm eff}(B^0\to
\phi(1020) K^0_S) & = & (24.3 \pm 8.0 \pm 2.9 \pm 5.2)^{\circ}.{eqnarray*}\ The
values for the violating phase in are similar
but other properties of the Dalitz plot are quite different for the four
solutions. These four solutions have consistent values for
all three meson decay channels and none of them deviates significantly from
the values measured in decays with the currently
available statistics. In addition, we find no significant direct
violation.Comment: submitted to PR
Observation of Mixing in Collisions
We observe mixing in the decay
using a data sample of integrated luminosity 976 fb collected with the
Belle detector at the KEKB asymmetric-energy collider. We measure the
mixing parameters and and the ratio of doubly Cabibbo-suppressed to
Cabibbo-favored decay rates , where the
uncertainties are statistical and systematic combined. Our measurement excludes
the no-mixing hypothesis at the 5.1 standard deviation level.Comment: 6 pages, 4 figure
Study of B^0 -> rho^0 rho^0 decays, implications for the CKM angle phi_2 and search for other B^0 decay modes with a four-pion final state
We present a study of the branching fraction of the decay B^0->rho0rho0 and
the fraction of longitudinally polarized rho0 mesons in this decay. The results
are obtained from the final data sample containing 772 million BBbar pairs
collected at the Y(4S) resonance with the Belle detector at the KEKB
asymmetric-energy e+e- collider. We find 166 +- 59 B^0 -> rho0 rho0 events
(including systematic uncertainties), corresponding to a branching fraction of
B(B^0->rho0rho0) = (1.02 +- 0.30 (stat) +- 0.15 (syst)) x 10^{-6} with a
significance of 3.4 standard deviations and a longitudinal polarization
fraction fL = 0.21^{+0.18}_{-0.22} (stat) +- 0.15 (syst). We use the
longitudinal polarization fraction to determine the Cabibbo-Kobayashi-Maskawa
matrix angle phi_2 = (84.9 +- 13.5) degrees through an isospin analysis in the
B->rhorho system. We furthermore find 149 +- 49 B^0->f0rho0 events,
corresponding to B(B^0->f0rho0) x B(f0->pi+pi-) = (0.78 +- 0.22 (stat) +- 0.11
(syst)) x 10^{-6}, with a significance of 3.1 standard deviations. We find no
other significant contribution with the same final state, and set upper limits
at 90% confidence level on the (product) branching fractions,
B(B^0->pi+pi-pi+pi-)rho0pi+pi-)<12.0 x 10^{-6},
B(B^0->f0pi+pi-) x B(f0->pi+pi-) f0f0) x
B(f0->pi+pi-)^{2} < 0.2 x 10^{-6}.Comment: 21 pages, 20 figures, conference paper for the 2012th CKM workshop,
submitted to PR
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