Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry

OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc). METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers. RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group. CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies

Energieversorgung Reichenau Endbericht

SIGLETIB Hannover: FR 2760+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Neue Wege zur rationellen Energieversorgung laendlicher Gebiete mit Intensivkulturen am Beispiel der Insel Reichenau

SIGLEDEGerman

Bestandsaufnahme von Einrichtungen zur freien Lueftung im Wohnungsbau Schlussbericht

With 48 refs., 15 tabs., 118 figs.SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

ZENTRAS. Entwicklung eines zuverlaessigen Energieuebertragungs-Systems fuer den Duo-Bus Schlussbericht

SIGLEDEGerman

Half-life measurements of stored fully ionized and hydrogen-like I-122 ions

International audienceThe half-lives of fully ionized and hydrogen-like (H-like) I-122 ions have been measured in a heavy-ion storage ring. The beta(+)-decay constants for both charge states and the electron capture (EC) decay constant of H-like ions have been determined. The EC-decay constant in H-like I-122 ions lambda(H-like)(EC) = 7.35(33) . 10(-4) s(-1) is, within the uncertainty, the same as the one in neutral atoms. This result is in agreement with the estimates of recent theoretical considerations on the EC-decay of few-electron ions that explicitly take into account the conservation of the total angular momentum of the nucleus plus lepton(s) system and its projections. No firm confirmation could be concluded from our results on the predicted effect that allowed Gamow-Teller transitions become forbidden if the initial and final total angular momenta are not equal