59 research outputs found
The Lower Palaeozoic now fully cored and logged on Bornholm, Denmark
A 558 m long, complete section of the Lower Palaeozoic succession preserved onshore southern Bornholm has been compiled from five fully cored scientific wells, carried out between 2005 and 2012. The scientific programme included coring and geophysical logging of the five scientific wells that yielded a total of c. 750 m of partially overlapping cores as well as re-logging of water wells and acquisition of shallow seismic data. The last well drilled, the Sommerodde-1, cored the youngest preserved Silurian strata on Bornholm including strata not exposed in outcrops. The well penetrated 168.1 m of Silurian shales, 42.7 m of Upper Ordovician shales and 27.9 m of Alum Shale before it terminated at a depth of 250.3 m in the Lower Cambrian Norretorp Member of the Læså Formation. Th e Sommerodde-1 well documents that the Lower Silurian Cyrtograptus shale is at least 91.7 m thick and that the Rastrites shale is 76.4 m thick. The complete Lower Cambrian succession has previously been covered by the 316.0 m deep Borggård-1 well that terminated in basement rocks (Nielsen et al. 2006)
Shale gas investigations in Denmark:Lower Palaeozoic shales on Bornholm
The Cambrian to Lower Silurian succession in Denmark is mostly composed of organic-rich black shales that were deposited in an epicontinental sea during a period of high global sea level (Haq & Schutter 2008). The mid-Cambrian to early Ordovician Alum Shale was intensively studied in the 1980s for its source-rock properties (e.g. Buchardt et al. 1986). Recent attention has focused on its potential as an unconventional shale gas source (Energistyrelsen 2010). On southern Bornholm, many wells have been drilled through the Lower Palaeozoic succession because of its importance for groundwater exploitation. In western Denmark, only the deep exploration wells Slagelse-1 and Terne-1 have penetrated the Alum Shale, and knowledge of the unit west of Bornholm is thus very limited (Fig. 1)
Shallow core drilling of the Upper Cretaceous Chalk at Stevns Klint, Denmark
The Upper Cretaceous – Danian succession in Denmark and most of NW Europe is composed mainly of chalk and associated shallower water carbonates deposited in a wide epeiric sea during an overall global sea-level highstand (e.g. Surlyk 1997). The Maastrichtian–Danian chalk has been intensely studied over the last 20 years, since it forms the most important reservoir rock for hydrocarbons in the North Sea Central Graben (e.g. Surlyk et al. 2003; Klinkby et al. 2005). In Denmark, thousands of water wells have been drilled through the succession as about 35% of the water consumption is from Maastrichtian chalk and Danian bryozoan limestone. During 2005 the new Cretaceous Research Centre (CRC) was established jointly at Geocenter Copenhagen by the Geological Institute, University of Copenhagen and the Geological Survey of Denmark and Greenland (GEUS) with financial support from the Danish Natural Science Research Council (FNU). CRC aims at studying the Earth System in a Greenhouse World, with special emphasis on the Upper Cretaceous – Danian chalk of NW Europe. The stable, long lasting marine macro-environment represented by the chalk sea provides a unique opportunity to analyse and link the depositional, geochemical and biological responses to external forcing at time scales ranging from the sub-Milankovitch to the million year range. The studies will be based on a wide range of methods, including seismic stratigraphy, palaeoecology, sequence-, cyclo- and biostratigraphy, isotope geochemistry, sedimentology and time series analysis. This paper presents the first preliminary results of a CRC drilling campaign at Stevns Klint, eastern Denmark (Fig. 1), where two shallow boreholes were drilled and logged from near the base of the Danian bryozoan limestone and down through the upper 350–450 m of the very thick Upper Cretaceous chalk section (Vejbæk et al. 2003). The cores represent the first complete sections through the Maastrichtian chalk of eastern Denmark
Dysregulation of FOXG1 by ring chromosome 14
In this study we performed molecular characterization of a patient with an extra ring chromosome derived from chromosome 14, with severe intellectual disability, epilepsy, cerebral paresis, tetraplegia, osteoporosis and severe thoraco-lumbal scoliosis. Array CGH analysis did not show any genomic imbalance but conventional karyotyping and FISH analysis revealed the presence of an interstitial 14q12q24.3 deletion and an extra ring chromosome derived from the deleted material. The deletion and ring chromosome breakpoints were identified at base-pair level by mate-pair and Sanger sequencing. Both breakpoints disrupted putative long non-coding RNA genes (TCONS00022561;RP11-148E17.1) of unknown function. However, the proximal breakpoint was 225Â kb downstream of the forkhead box G1 gene (FOXG1), within the known regulatory landscape of FOXG1. The patient represents the first case of a r(14) arising from an interstitial excision where the phenotype is compatible with dysregulation of FOXG1. In turn, the phenotypic overlap between the present case, the FOXG1 syndrome and the r(14) syndrome supports that dysregulation of FOXG1 may contribute to the classical r(14)-syndrome, likely mediated by dynamic mosaicism
Borggård-1 - ny stratigrafisk kerneboring på Bornholm
En 316 m dyb fuldt kernet boring på Sydbornholm udført maj-juli 2006 leverer for første gang præcise oplysninger om lithologien og tykkelsen af de nedre kambriske formationer i området. Boringen skulle desuden vise sig at rumme flere spændende overraskelser, bl.a. blev det konstateret, at de stærkt vandførende kvartsitter er næsten dobbelt så tykke som oprindeligt antaget
De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability
De novo mutations (DNM) in SYNGAP1, encoding Ras/Rap GTPase-activating protein SynGAP, have been reported in individuals with nonsyndromic intellectual disability (ID). We identified 10 previously unreported individuals with SYNGAP1 DNM; seven via the Deciphering Developmental Disorders (DDD) Study, one through clinical analysis for copy number variation and the remaining two (monozygotic twins) via a research multi-gene panel analysis. Seven of the nine heterozygous mutations are likely to result in loss-of-function (3 nonsense; 3 frameshift; 1 whole gene deletion). The remaining two mutations, one of which affected the monozygotic twins, were missense variants. Each individual carrying a DNM in SYNGAP1 had moderate-to-severe ID and 7/10 had epilepsy; typically myoclonic seizures, absences or drop attacks. 8/10 had hypotonia, 5/10 had significant constipation, 7/10 had wide-based/unsteady gait, 3/10 had strabismus, and 2/10 had significant hip dysplasia. A proportion of the affected individuals had a similar, myopathic facial appearance, with broad nasal bridge, relatively long nose and full lower lip vermilion. A distinctive behavioral phenotype was also observed with aggressive/challenging behavior and significant sleep problems being common. 7/10 individuals had MR imaging of the brain each of which was reported as normal. The clinical features of the individuals reported here show significant overlap with those associated with 6p21.3 microdeletions, confirming that haploinsufficiency for SYNGAP1 is responsible for both disorder
Deep saltwater in Chalk of North-West Europe: origin, interface characteristics and development over geological time
Mutations in SYNGAP1 cause intellectual disability, autism, and a specific form of epilepsy by inducing haploinsufficiency
Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland
Dopamine and adrenergic receptor complexes form under a circadian-regulated cycle and directly modulate melatonin synthesis and release from the pineal gland
Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland
Dopamine and adrenergic receptor complexes form under a circadian-regulated cycle and directly modulate melatonin synthesis and release from the pineal gland
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