ENTRE MEMÓRIAS E HISTÓRIAS: O PERCURSO DO FUTEBOL FEMININO EM CÁCERES-MT

Resumo: Subsidiados epistemologicamente pelos estudos sobre memória, nas duas denominações mais comumente usadas, “Memória Coletiva” (HALBWACHS, 1990) e “Memória Social” (OLICK; ROBBINS, 1998), a partir de uma abordagem qualitativa, que possibilita compreender o significado que uma dada situação tem para o sujeito ou grupos de sujeitos, e por meio do método da História Oral, entrevistamos duas ex-jogadoras de futebol da cidade e também utilizamos recortes de jornais da época e fotografias, na direção de "garimpar" as experiências e seus fragmentos, buscando nesta pesquisa recontar, registrar e assegurar a importância do futebol feminino em Cáceres-MT e a necessidade de salvaguardar sua memória.Palavras-chave: memória; futebol feminino; cidade de Cáceres-MT. Between Memories and Stories: The Journey Women's Football in the City of Cáceres-MT Abstract: Subsidized epistemologically by studies of memory, the two most commonly used denominations, "Collective Memory" (HALBWACHS, 1990) and "Social Memory"(OLICK; ROBBINS, 1998), from a qualitative approach, which makes it possible to understand the meaning that a given situation is for the subject or groups of subjects, and by the method of oral history, we interview city's two former football players and also we use newspaper clippings and photographs of the time, in the direction of "digging" the experiences and fragments seeking in this research retell, register and ensure the importance of women's football in Cáceres-MT and the need to safeguard their memory.Keywords: memory; women's football; city of Cáceres-MT

Conteúdos programáticos versus proposta da Fundação Brasileira de Contabilidade para o ensino da CASP: similaridade ou dissimilitude?

O objetivo deste artigo foi analisar, comparativamente, as disciplinas de Contabilidade Aplicada ao Setor Público e correlatas, ministradas nos cursos de graduação em Ciências Contábeis de universidades federais, e os preceitos da matriz curricular proposta pela Fundação Brasileira de Contabilidade (FBC). O estudo pautou-se em metodologia descritiva, de natureza qualitativa e análise documental de conteúdo. A amostra foi composta pelas grades curriculares, ementas e planos de ensino de todas as 36 universidades públicas federais, situadas nas cinco regiões geográficas brasileiras, que oferecem o curso de Ciências Contábeis, sendo: cinco da Região Centro-Oeste; dez da Região Nordeste; cinco da Região Norte; dez da Região Sudeste; e, seis da Região Sul. Os achados indicam que o nível de conformidade é baixo. Percebeu-se um claro déficit comparativo na quantidade de horas dedicadas às disciplinas que compõem a formação do conhecimento necessário para atuação dos futuros contadores na área pública e pouca transparência dos objetivos incutidos em cada disciplina. Considerando o alto nível de complexidade inerente à aplicação das Normas Internacionais de Contabilidade, recém-convergidas ao setor público brasileiro, seria desejável que as escolas de graduação se aproximassem desses padrões, que são afeitos ao modelo da FBC. A distância de similaridade entre as propostas das universidades da amostra e a proposta da FBC, medida neste estudo, permite questionamentos a respeito das instituições de ensino ofertarem, ou não, conteúdos suficientes e atualizados, em quantidade e qualidade, que facilitem a obtenção de habilidades e competências esperadas de contadores e possibilitem uma atuação eficiente do futuro profissional na área contábil pública

Management of software development projects in Brazil using agile methods

The aim of the paper is to analyze how agile management practices are being adopted by specialists from software development technology companies in Brazil, identifying actions that contribute to the success of software implementation, aiming to ensure the survival of organizations in the market. The study counted with a literature review to support the field research with software development specialists who use the agile methodology and work in Brazil in the states of Rio de Janeiro and São Paulo. The results were analyzed through a descriptive statistics and content analysis. The research identified that the companies that adopt agile software management methodology in Brazil prefer the Scrum method and the development teams may be geographically distributed. The main positive points identified when adopting agile methods were the process speed, team involvement, maximization of results, involvement with the client, and simplicity. Most experts identified problems in the implementation of the agile methodology and as points of attention: management of distributed teams, scope estimation and communication. It was possible to identify the existence of a positive financial result by adopting the agile method for software development projects, as well as actions that contribute to the success of these projects, such as controlling quality using different testing techniques, project management, time, stakeholders, scope, and have agile communication, with feedback and good leadership. On the other hand, it was observed in the statistics that, although efficient, this method is still not being widely used. This research can contribute to the managers of software development companies in the use of agile methods as well as improving management decision-making

Kidney disease and hemodialysis: identification of blood biomarkers to detect heart failure and kidney failure

Introducción: la hemodiálisis crónica tiene como objetivo reemplazar la función renal y proporciona una extensión de la esperanza de vida; sin embargo, en esta ocurren complicaciones que pueden llegar a ser graves e incluso fatales, por lo que conocerlas puede permitir hacer una mejor evaluación pronóstica y establecer un enfoque de intervención adecuado. Estos factores pueden ser identificados al realizar la anamnesis y la exploración física, y, con mayor precisión, mediante biomarcadores renales, cardíacos y pruebas de imagen. Objetivos: identificar los biomarcadores sanguíneos válidos para detectar insuficiencia cardíaca e insuficiencia renal asociada con enfermedad renal y hemodiálisis. Materiales y métodos: se realizó una revisión sistemática de la literatura en agosto de 2018 en las bases de datos Web Of Science, PubMed, Scopus, Cinahal, Cochrane, Science Direct y Lilacs. La pregunta guía fue ¿Cuáles son los biomarcadores de sangre utilizados para detectar la insuficiencia cardíaca y la insuficiencia renal? Se encontraron 537 publicaciones, de las cuales se excluyeron 94 por estar repetidas, 383 después de leer títulos y resúmenes, 32 después de leer los textos completos y 10 en la síntesis cuantitativa y cualitativa. Resultados: Se incluyeron 18 documentos en la muestra final, los cuales presentan pruebas de laboratorio y de imagen, instrumentos para evaluar el riesgo de insuficiencia renal y cardíaca, así como el manejo clínico de la progresión de la insuficiencia renal y cardíaca. Todos los estudios correlacionaron el riesgo de mortalidad y resultado de la muerte. Conclusión: las pruebas de laboratorio son importantes para identificar la insuficiencia renal y cardíaca y deben utilizarse para mejorar el manejo clínico del tratamiento de hemodiálisis de personas con enfermedad renal crónica a fin de mejorar la calidad y la esperanza de vida.Introduction: Chronic hemodialysis aims to replace renal function and provides an extension of life expectancy, however, complications do occur and they can be serious even fatal. Knowing the complications can enable a better prognostic evaluation and use of an intervention approach. These can be identified when performing anamnesis and physical examination, as well as, with greater precision, by means of renal and cardiac biomarkers and imaging tests. Objectives: to identify valid blood biomarkers to detect heart failure and kidney failure associated with kidney disease and hemodialysis. Methods: systematic literature review conducted in August 2018 in the following: Web Of Science, PubMed, Scopus, Cinahal, Cochrane, Science Direct and Lilacs. The guiding question was: “What are the blood biomarkers used to detect heart failure and kidney failure?” A total of 537 publications were found, 94 of these appeared more than once, 383 were excluded after reading titles and abstracts, 32 were excluded after reading the full texts, and 10 were excluded in the quantitative and qualitative synthesis. Results: 18 papers compose the final sample and report laboratory and imaging tests, instruments to assess the risk of kidney and heart failure, and also clinical management of the progression of kidney and heart failure. All the studies correlated risk of mortality and death outcome. Conclusion: laboratory tests are important to identifying kidney and heart failure and need to be used to improve clinical management of the hemodialysis treatment of people with chronic kidney disease in order to improve quality of life and life expectancy

Systemic Phaeohyphomycosis in a Dog Caused by Cladophialophora bantiana

Background: Cladophialophora bantiana is a dematiaceous fungus that causes phaeohyphomycosis, a generic term used to describe a variety of unusual mycoses caused by fungi that have melanin in their cell wall. C. bantiana targets the central nervous system, commonly causing localized brain infections that may result in disseminated infections. In Brazil, minimal phaeohyphomycosis data are available, and information about C. bantiana infections in animals, especially canines, is scarce. Thus, the aim of this study was to describe the clinical and pathological aspects of systemic phaeohyphomycosis caused by C. bantiana in a dog.Case: A 1-year-old female Pit Bull presented with weight loss, reduced appetite, and a history of cutaneous lesions on the right thoracic limb; however, clinical evolution was not reported. The dog had reportedly given birth recently. Physical examination revealed thinness, pale ocular and oral mucosa, submandibular lymph nodes, and enlarged popliteal lymph nodes. The animal died after convulsive crises during hospitalization. At necropsy, white-yellowish multifocal nodules were observed in the liver and right kidney. The brain featured left cerebral hemisphere asymmetry with blood vessel congestion in the leptomeninges and an irregular brownish focal area on the surface of the right occipital cortex. Cross-sections of the formalin-fixed brain exhibited compression of the left lateral ventricle and the presence of grayish and friable multifocal areas in the gray matter of the left parietal and right occipital cortices. Fragments of the lesions were collected for histopathological and microbiological examination. Histologically, the lesions were similar, characterized by hepatitis, nephritis, and granulomatous and necrotizing meningoencephalitis, multifocal to coalescing, accentuated, chronic, and associated with numerous pigmented fungi. Fontana-Masson–stained fungi exhibited a strong black color. In cleared and unstained histological slides, brownish pigmentation was observed in the cytoplasm and walls of the fungi. C. bantiana was identified via microbiological cultivation.Discussion: A diagnosis of phaeohyphomycosis caused by C. bantiana was made based on the characteristic morphology of the microscopic lesions and confirmed via isolation in microbiological culture. As numerous species cause phaeohyphomycosis, specific confirmation of the etiologic agent using several diagnostic techniques is necessary. In histopathological examinations, pigmented fungal organisms are easily seen among lesions. However, in some cases, the pigment is not apparent in the tissues. FM staining is necessary to demonstrate the presence of the melanin in fungi. As in most phaeohyphomycosis cases, it was not possible to determine the primary portal of entry. However, the lesion on the right thoracic limb probably favored the penetration of the agent. In addition to cerebral lesions, severe lesions in the hepatic and renal parenchyma were observed, which are characteristic of systemic mycosis. Infection and clinical diseases are usually associated with immunocompromised; here, the gestation period may have had an immunosuppressive effect, favoring the proliferation and dissemination of the agent. It was concluded that phaeohyphomycosis caused by C. bantiana produced severe systemic lesions in the brain and organs of the abdominal cavity. Although uncommon, phaeohyphomycosis caused by Cladophialophora bantiana should be included as a differential diagnosis for other canine diseases that present with similar clinical symptoms.Keywords: canine, fungal diseases, dematiaceous fungi, Cladosporium trichoides, Xylohypha bantiana, melanin, Fontana-Masso

Urinary bladder dysfunction in transgenic sickle cell disease mice

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOBackground Urological complications associated with sickle cell disease (SCD), include nocturia, enuresis, urinary infections and urinary incontinence. However, scientific evidence to ascertain the underlying cause of the lower urinary tract symptoms in SCD is lacking. Objective Thus, the aim of this study was to evaluate urinary function, in vivo and ex vivo, in the Berkeley SCD murine model (SS). Methods Urine output was measured in metabolic cage for both wild type and SS mice (25-30 g). Bladder strips and urethra rings were dissected free and mounted in organ baths. In isolated detrusor smooth muscle (DSM), relaxant response to mirabegron and isoproterenol (1 nM-10 mu M) and contractile response to (carbachol (CCh; 1 nM-100 mu M), KCl (1 mM-300mM), CaCl2 (1 mu M-100mM), alpha,beta-methylene ATP (1, 3 and 10 mu M) and electrical field stimulation (EFS; 1-32 Hz) were measured. Phenylephrine (Phe; 10nM-100 mu M) was used to evaluate the contraction mechanism in the urethra rings. Cystometry and histomorphometry were also performed in the urinary bladder. Results SS mice present a reduced urine output and incapacity to produce typical bladder contractions and bladder emptying (ex vivo), compared to control animals. In DSM, relaxation in response to a selective beta 3-adrenergic agonist (mirabegron) and to a non-selective beta-adrenergic (isoproterenol) agonist were lower in SS mice. Additionally, carbachol, alpha,beta-methylene ATP, KCl, extracellular Ca2+ and electrical-field stimulation promoted smaller bladder contractions in SS group. Urethra contraction induced by phenylephrine was markedly reduced in SS mice. Histological analyses of SS mice bladder revealed severe structural abnormalities, such as reductions in detrusor thickness and bladder volume, and cell infiltration. Conclusions Taken together, our data demonstrate, for the first time, that SS mice display features of urinary bladder dysfunction, leading to impairment in urinary continence, which may have an important role in the pathogenesis of the enuresis and infections observed the SCD patients.Urological complications associated with sickle cell disease (SCD), include nocturia, enuresis, urinary infections and urinary incontinence. However, scientific evidence to ascertain the underlying cause of the lower urinary tract symptoms in SCD is lacking. Objective Thus, the aim of this study was to evaluate urinary function, in vivo and ex vivo, in the Berkeley SCD murine model (SS). Methods Urine output was measured in metabolic cage for both wild type and SS mice (25-30 g). Bladder strips and urethra rings were dissected free and mounted in organ baths. In isolated detrusor smooth muscle (DSM), relaxant response to mirabegron and isoproterenol (1 nM-10 mu M) and contractile response to (carbachol (CCh; 1 nM-100 mu M), KCl (1 mM-300mM), CaCl2 (1 mu M-100mM), alpha,beta-methylene ATP (1, 3 and 10 mu M) and electrical field stimulation (EFS; 1-32 Hz) were measured. Phenylephrine (Phe; 10nM-100 mu M) was used to evaluate the contraction mechanism in the urethra rings. Cystometry and histomorphometry were also performed in the urinary bladder. Results SS mice present a reduced urine output and incapacity to produce typical bladder contractions and bladder emptying (ex vivo), compared to control animals. In DSM, relaxation in response to a selective beta 3-adrenergic agonist (mirabegron) and to a non-selective beta-adrenergic (isoproterenol) agonist were lower in SS mice. Additionally, carbachol, alpha,beta-methylene ATP, KCl, extracellular Ca2+ and electrical-field stimulation promoted smaller bladder contractions in SS group. Urethra contraction induced by phenylephrine was markedly reduced in SS mice. Histological analyses of SS mice bladder revealed severe structural abnormalities, such as reductions in detrusor thickness and bladder volume, and cell infiltration. Conclusions Taken together, our data demonstrate, for the first time, that SS mice display features of urinary bladder dysfunction, leading to impairment in urinary continence, which may have an important role in the pathogenesis of the enuresis and infections observed the SCD patients108115FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCNPQ – CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP [2008/57441-0]CNPq [481761/2008-0]sem informaçãosem informaçã

Effects Of Methylmercury And Retinol Palmitate Co-Administration In Rats During Pregnancy And Breastfeeding: Metabolic And Redox Parameters In Dams And Their Offspring

Ubiquitous low-dose methylmercury (MeHg) exposure through an increased fish consumption represents a global public health problem, especially among pregnant women. A plethora of micronutrients presented in fish affects MeHg uptake/distribution, but limited data is available. Vitamin A (VitA), another fish micronutrient is used in nutritional supplementation, especially during pregnancy. However, there is no information about the health effects arising from their combined exposure. Therefore, the present study aimed to examine the effects of both MeHg and retinyl palmitate administered on pregnant and lactating rats in metabolic and redox parameters from dams and their offspring. Thirty Wistar female rats were orally supplemented with MeHg (0,5 mg/kg/day) and retinyl palmitate (7500 µg RAE/kg/day) via gavage, either individually or in combination from the gestational day 0 to weaning. For dams (150 days old) and their offspring (31 days old), glycogen accumulation (hepatic and cardiac) and retinoid contents (plasma and liver) were analyzed. Hg deposition in liver tissue was quantified. Redox parameters (liver, kidney, and heart) were evaluated for both animals. Cytogenetic damage was analyzed with micronucleus test. Our results showed no general toxic or metabolic alterations in dams and their offspring by MeHg-VitA co-administration during pregnancy and lactation. However, increased lipoperoxidation in maternal liver and a disrupted pro-oxidant response in the heart of male pups was encountered, with apparently no particular effects in the antioxidant response in female offspring. GST activity in dam kidney was altered leading to possible redox disruption of this tissue with no alterations in offspring. Finally, the genomic damage was exacerbated in both male and female pups. In conclusion, low-dose MeHg exposure and retinyl palmitate supplementation during gestation and lactation produced a potentiated pro-oxidant effect, which was tissue-specific. Although this is a pre-clinical approach, we recommend precaution for pregnant women regarding food consumption, and we encourage more epidemiological studies to assess possible modulations effects of MeHg-VitA co-administration at safe or inadvertently used doses in humans, which may be related to specific pathologies in mothers and their children

Intranasal HSP70 administration protects against dopaminergic denervation and modulates neuroinflammatory response in the 6-OHDA rat model

HSP70 is one of the main molecular chaperones involved in the cellular stress response. Besides its chaperone action, HSP70 also modulates the immune response. Increased susceptibility to toxic insults in intra- and extracellular environments has been associated with insufficient amounts of inducible HSP70 in adult neurons. On the other hand, exogenous HSP70 administration has demonstrated neuroprotective effects in experimental models of age-related disorders. In this regard, this study investigated the effects of exogenous HSP70 in an animal model of dopaminergic denervation of the nigrostriatal axis. After unilateral intrastriatal injection with 6-hydroxydopamine (6-OHDA), the animals received purified recombinant HSP70 through intranasal administration (2 μg/rat/day) for 15 days. Our results indicate a neuroprotective effect of intranasal HSP70 against dopaminergic denervation induced by 6-OHDA. Exogenous HSP70 improved motor impairment and reduced the loss of dopaminergic neurons caused by 6-OHDA. Moreover, HSP70 modulated neuroinflammatory response in the substantia nigra, an important event in Parkinson’s disease pathogenesis. Specifically, HSP70 treatment reduced microglial activation and astrogliosis induced by 6-OHDA, as well as IL-1β mRNA expression in this region. Also, recombinant HSP70 increased the protein content of HSP70 in the substantia nigra of rats that received 6-OHDA. These data suggest the neuroprotection of HSP70 against dopaminergic neurons damage after cellular stress. Finally, our results indicate that HSP70 neuroprotective action against 6-OHDA toxicity is related to inflammatory response modulation

Convalescent plasma for COVID-19 in hospitalised patients : an open-label, randomised clinical trial

Background: The effects of convalescent plasma (CP) therapy in hospitalised patients with coronavirus disease 2019 (COVID-19) remain uncertain. This study investigates the effect of CP on clinical improvement in these patients. Methods: This is an investigator-initiated, randomised, parallel arm, open-label, superiority clinical trial. Patients were randomly (1:1) assigned to two infusions of CP plus standard of care (SOC) or SOC alone. The primary outcome was the proportion of patients with clinical improvement 28 days after enrolment. Results: A total of 160 (80 in each arm) patients (66.3% critically ill, 33.7% severely ill) completed the trial. The median (interquartile range (IQR)) age was 60.5 (48–68) years; 58.1% were male and the median (IQR) time from symptom onset to randomisation was 10 (8–12) days. Neutralising antibody titres >1:80 were present in 133 (83.1%) patients at baseline. The proportion of patients with clinical improvement on day 28 was 61.3% in the CP+SOC group and 65.0% in the SOC group (difference −3.7%, 95% CI −18.8–11.3%). The results were similar in the severe and critically ill subgroups. There was no significant difference between CP+SOC and SOC groups in pre-specified secondary outcomes, including 28-day mortality, days alive and free of respiratory support and duration of invasive ventilatory support. Inflammatory and other laboratory marker values on days 3, 7 and 14 were similar between groups. Conclusions: CP+SOC did not result in a higher proportion of clinical improvement on day 28 in hospitalised patients with COVID-19 compared to SOC alone