A SOCIOLOGIA DA EMPRESA E O FIB EMPRESARIAL

Este artigo visa demonstrar que a construção de uma empresa socialmente responsável passa necessariamente pelas relações que constrói com seus funcionários, partindo-se da premissa que os valores e ideais ligados à RSC (Responsabilidade Social Corporativa) devem ser realizados de dentro para fora. Depois deste passo, ou seja, após cumprirem o seu dever social para com seus trabalhadores, poderão desenvolver o relacionamento com seus demais stakeholders de forma ética, coerente e sustentável. Nesse trabalho mostram-se os pontos de convergência entre a Sociologia da Empresa e o FIB (Felicidade Interna Bruta). Este último é apresentado como uma metodologia eventualmente capaz de preparar as empresas e seus funcionários para que primeiramente vivenciem em si a responsabilidade social, e posteriormente integrem em seu negócio práticas responsáveis e éticas, sem perder, em nenhum momento, foco na produtividade da empresa

Da Sociologia Econômica à Sociologia da Empresa: para uma sociologia da empresa brasileira

The authors attempt a theoretical discussion of the notionthat the economic order and its institutions, including firms, are socialconstructions, which can therefore be apprehended by approaches otherthan that of an exclusively formal rationality of an economic character.Also presented here are some themes which are being treated by socialscientists in an effort to inaugurate a Brazilian Sociology of the Firm.Cet article est une discussion théorique sur la notion selonlaquelle l’ordre économique et ses institutions, y compris lesentreprises, sont des constructions sociales – passibles, donc, d’êtrecomprises sous d’autres regards que celui d’une rationnalitéexclusivement formelle de caractère économique. Sont présentés aussiquelques thèmes qui ont été traités para les sciences sociales dansl’effort d’inaugurer une Sociologie de l’Entreprise brésilienne.Procuramos discutir teoricamente a noção de que aordem econômica e suas instituições, aí incluídas as empresas,são construções sociais, passíveis, portanto, de seremapreendidas sob outros olhares que não o de uma racionalidadeexclusivamente formal de caráter econômico. São apresentadostambém alguns temas que têm sido tratados por cientistassociais, em um esforço no sentido de criar uma Sociologia daEmpresa brasileira

Clinical presentation and proteomic signature of patients with TANGO2 mutations

Transport And Golgi Organization protein 2 (TANGO2) deficiency has recently been identified as a rare metabolic disorder with a distinct clinical and biochemical phenotype of recurrent metabolic crises, hypoglycemia, lactic acidosis, rhabdomyolysis, arrhythmias, and encephalopathy with cognitive decline. We report nine subjects from seven independent families, and we studied muscle histology, respiratory chain enzyme activities in skeletal muscle and proteomic signature of fibroblasts. All nine subjects carried autosomal recessive TANGO2 mutations. Two carried the reported deletion of exons 3 to 9, one homozygous, one heterozygous with a 22q11.21 microdeletion inherited in trans. The other subjects carried three novel homozygous (c.262C&gt;T/p.Arg88*; c.220A&gt;C/p.Thr74Pro; c.380+1G&gt;A), and two further novel heterozygous (c.6_9del/p.Phe6del); c.11-13delTCT/p.Phe5del mutations. Immunoblot analysis detected a significant decrease of TANGO2 protein. Muscle histology showed mild variation of fiber diameter, no ragged-red/cytochrome c oxidase-negative fibers and a defect of multiple respiratory chain enzymes and coenzyme Q10 (CoQ10 ) in two cases, suggesting a possible secondary defect of oxidative phosphorylation. Proteomic analysis in fibroblasts revealed significant changes in components of the mitochondrial fatty acid oxidation, plasma membrane, endoplasmic reticulum-Golgi network and secretory pathways. Clinical presentation of TANGO2 mutations is homogeneous and clinically recognizable. The hemizygous mutations in two patients suggest that some mutations leading to allele loss are difficult to detect. A combined defect of the respiratory chain enzymes and CoQ10 with altered levels of several membrane proteins provides molecular insights into the underlying pathophysiology and may guide rational new therapeutic interventions.</p

ARTEFACTS: How do we want to deal with the future of our one and only planet?

The European Commission’s Science and Knowledge Service, the Joint Research Centre (JRC), decided to try working hand-in-hand with leading European science centres and museums. Behind this decision was the idea that the JRC could better support EU Institutions in engaging with the European public. The fact that European Union policies are firmly based on scientific evidence is a strong message which the JRC is uniquely able to illustrate. Such a collaboration would not only provide a platform to explain the benefits of EU policies to our daily lives but also provide an opportunity for European citizens to engage by taking a more active part in the EU policy making process for the future. A PILOT PROGRAMME To test the idea, the JRC launched an experimental programme to work with science museums: a perfect partner for three compelling reasons. Firstly, they attract a large and growing number of visitors. Leading science museums in Europe have typically 500 000 visitors per year. Furthermore, they are based in large European cities and attract local visitors as well as tourists from across Europe and beyond. The second reason for working with museums is that they have mastered the art of how to communicate key elements of sophisticated arguments across to the public and making complex topics of public interest readily accessible. That is a high-value added skill and a crucial part of the valorisation of public-funded research, never to be underestimated. Finally museums are, at present, undergoing something of a renaissance. Museums today are vibrant environments offering new techniques and technologies to both inform and entertain, and attract visitors of all demographics.JRC.H.2-Knowledge Management Methodologies, Communities and Disseminatio

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, using MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets in the ENIGMA consortium, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macro-structural asymmetry may reflect differences at the molecular, cytoarchitectonic or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia