The development of corporate real estate practices in India : a survey of CRE professionals

Business process outsourcing (BPO) is transforming Western companies? corporate real estate (CRE) requirements. When business processes move to a developing country there are consequences for that country?s CRE practice. This paper considers the effects of western BPO on Indian CRE. Qualitative and quantitative analysis was used to analyze data from a survey of professionals operating in Indian CRE. Location issues, quality of workspace, and the availability of human resources were identified as important in establishing BPO activities in India. Suburban, and campus or built-to-suit facilities, were increasingly preferred locations and styles of workplace that were transforming Indian CRE practice. Also, the effect of western BPO was impacting on the types of CRE services being offered. With the continuing growth in BPO to ?secondary cities? the transformational effects on local CRE practice are likely to spread and further transform CRE practice in India

Noise Removal in Microarray Images Using Variational Mode Decomposition Technique

Microarray technology allows the simultaneous monitoring of thousands of genes in parallel. Based on the gene expression measurements, microarray technology have proven powerful in gene expression profiling for discovering new types of diseases and for predicting the type of a disease. Enhancement, Gridding, Segmentation and Intensity extraction are important steps in microarray image analysis. This paper presents a noise removal method in microarray images based on Variational Mode Decomposition (VMD). VMD is a signal processing method which decomposes any input signal into discrete number of sub-signals (called Variational Mode Functions) with each mode chosen to be its band width in spectral domain. First the noisy image is processed using 2-D VMD to produce 2-D VMFs. Then Discrete Wavelet Transform (DWT) thresholding technique is applied to each VMF for denoising.  The denoised microarray image is reconstructed by the summation of VMFs.  This method is named as 2-D VMD and DWT thresholding method. The proposed method is compared with DWT thresholding and BEMD and DWT thresholding methods. The qualitative and quantitative analysis shows that 2-D VMD and DWT thresholding method produces better noise removal than other two methods

Simulating the Impact of Urban Sprawl in Spatiotemporal Variation of Air Pollution in Bangalore Region using ML and GIS.

The rapid expansion of urban areas due to rise in population and economic growth is increasing the additional demand on natural resources thereby causing land-use changes especially in megacities. Bengaluru, being a city of India’s high-tech industry has been facing deteriorating environmental conditions. This paper deals with studying the problems by designing the Machine Learning (ML) model which helps in detecting the Green Cover Change, Urban sprawl, Air Quality Parameters concentration in Bangalore region for the future and analyse them with Geographic Information System (GIS) data’s using Remote Sensing (RS) satellite images of various years of Bangalore city along with some mitigatio

Effect of graphite particulate on mechanical characterization of hybrid polymer composites

Quest for producing lightweight and biodegradable materials has encouraged researchers to replace synthetic fibers with natural fibers. Hence a study is made to investigate the effects of introducing secondary reinforcement (natural fibers), stacking sequence, and addition of graphite particles on the mechanical characteristics and water uptakes along with diffusivity of hybrid (glass\jute) composites. Different weight fractions of graphite particulates are incorporated into the epoxy to produce different samples having 4 plies for each sample by hand layup vacuum bagging method. The obtained specimens are subjected to various mechanical tests, water absorption tests as per the ASTM standards, and optical microscopy was used to study the fracture morphology of the samples. The results displayed that the properties are deteriorated a little with the addition of secondary reinforcement, however they have improved with the addition of graphite. E-Glass as skin layer and treated jute as core layer composite exhibits ameliorate tensile strength (201.5 MPa), compression strength (515.12 MPa), flexural strength (106.9 MPa), hardness (25 BHN). However highest impact energy of 26 J is recorded for the sample with jute as skin layer and E-Glass as the core layer. Water absorption tests revealed that the addition of graphite has reduced the water absorption in the hybrid samples

Prospective, randomized double blind comparative study of safety and efficacy of carvedilol versus atenolol in patients of mild to moderate hypertension

Background: Carvedilol is a new cardiovascular compound with the combined pharmacologic properties of nonselective ß-blockade and vasodilation. The Aim of the study was to compare the safety and antihypertensive efficacy of 25mg Carvedilol once daily with 50mg atenolol once daily in patients with mild to moderate essential hypertension.Methods: This was a single center study conducted in Rangaraya Medical College, Kakinada. 80 eligible patients with mild to moderate hypertension were randomized to receive 25mg Carvedilol once daily (40 patients) or 50mg atenolol (40 patients) in a double-blind 12-week treatment phase. At each visit 0, 4, 8 and 12 weeks of treatment, sitting Blood Pressure (BP) and heart rate were measured. The effect on BP reduction within the group is compared by paired “t”test and the effect on reduction of BP between two study groups compared by unpaired “t”test.Results: After 12 weeks of treatment, the mean reduction of SBP (Systolic Blood Pressure) with carvedilol is 22.33±8.31mmHg with no Significant difference (p >0.05) compared to atenolol group mean reduction in SBP of 21.37±10mm Hg. The mean reduction in DBP (Diastolic Blood Pressure) after completion of the study in carvedilol group is 6.75±4.82mm Hg with no Significant difference (p >0.05) compared to atenolol group mean reduction in DBP of 8.55±5.25mm Hg. No significant difference seen in the efficacy parameters of both the drugs. The incidence of adverse effects such as bradycardia, headache, nausea, vomiting, hypotension and rash is less with carvedilol.Conclusions: In patients with mild to moderate hypertension, there was no statistically significant difference between efficacy of carvedilol or atenolol with regard to the degree of reduction in BP or the percentage of patients achieving a response to therapy but carvedilol showed a better safety profile when compared to atenolol

Phytochemical Screening and Antimicrobial Activity of the Leaf Extract of Mirabilis jalapa Against Pathogenic Microorganisms

Investigation of the phytochemical constituents and antimicrobial activity of the leaf extracts of Mirabilis jalapa were carried out using acetone, chloroform, ethanol and methanol. These extracts were subjected to screening of preliminary phytochemical tests. Phytochemical analysis showed the presence of alkaloids, flavanoids, phenols, glycosides, tannins, saponins and lignins. The methanol extract exhibited the largest zone of inhibition (21mm in dia with 500μg/disc extract) against Staphylococcus aureus and the highest inhibition of fungal radial mycelial growth (97.5% with 500μg/ml medium) against Aspergillus flavus. The methanol extract exhibited the lowest MIC against Staphylococcus aureus (39 μg/ml) and Aspergillus flavus (45μg/ml). It appeared that M. jalapa could be a potential natural source of new antimicrobial agent.Keywords: Mirabilis jalapa, leaf extract, phytochemicals, antimicrobial activity

Kimura’s Disease As Diagnostic Dilemma

Kimura’s disease is a chronic inflammatory disease of unknown aetiology. The classical triad includes painless subcutaneous mass in head and neck, eosinophilia and elevated serum immunoglobulin levels. Kimura’s disease is rare, besides can produce a diagnostic confusion as seen in our case deviating from its triad of presentation described in literature. A 14 year male child came with painless swelling over right post auricular region since 6 months. He had surgical excision for similar swelling at same site one year back. Complete surgical excision was done and sent for histopathology, which was reported, Kimura’s disease. After 3 years of follow up there was no recurrence. Our case showed Kimura’s disease can present with normal eosinophil count and serum immunoglobulin levels and histopathology alone is confirmatory. We also suggest surgery is the treatment of choice for Kimura’s disease either in primary or recurrence

The impact of business outsourcing on corporate real estate in India

Driven by Western companies\u27 requirements for efficiency and effectiveness, a trend towards outsourcing of business activities to India and other low-cost countries commenced in the early 1990s and has continued to grow at a surprisingly fast pace. In a relatively short timeframe India has become a global hub for back-office services, although the effect on the urban cities is yet to be fully comprehended. As American and European companies continue to relocate their information technology services and other back office works to the subcontinent, there has been a considerable flow-on effect on Indian corporate real estate. This paper addresses two key questions. Firstly, the factors important for Western companies\u27 outsourcing of organisational activities to India, and secondly, the effect of business outsourcing on corporate real estate locational requirements in India. A survey of corporate real estate representatives in India and the UK was conducted with the results providing an insight into the present state and possible future direction of outsourcing for India. This research presents a unique insight into the impacts of Western business outsourcing on corporate real estate in India, and presents findings that are useful to both organisations seeking to relocate business activities to India and for property market analysts looking to understand drivers behind this sustained demand for Indian corporate real estate

Sulfoxide-Induced Homochiral Folding of o-OPEs by AgI Templating: Structure and Chiroptical Properties

"This is the peer reviewed version of the following article: Resa, S.; et al. Sulfoxide-Induced Homochiral Folding of o-OPEs by AgI Templating: Structure and Chiroptical Properties. Chemistry a European Journal, 2018, which has been published in final form at http://dx.doi.org/10.1002/chem.201704897 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."A new family of homochiral silver complexes based on carbophilic interactions with ortho-phenyleneethynylene (o-OPE) scaffolds containing up to two silver atoms is described. These compounds represent a unique class of complexes with chirality at the metal. Chiral induction is based on the inclusion of chiral sulfoxides which allow an efficient transfer of chirality to the helically folded o-OPE, leading to CPL and VCD active compounds. In the presence of AgI cation carbophilic interactions dominate, promoting helical structures with a defined helicity. This is one of the very scarce examples of the use of such interactions in the attractive field of abiotic foldamers. The switching event has been extensively studied using different chiroptical techniques including CD, CPL and VCD, also representing one of the few CPL switches described in literature.We thank MINECO (FEDER funded grant CTQ2014-53598-R). Computing Center CINECA, Bologna, Italy, Regione Lombardia for the LISA Grant No. “ChiPhyto: HPL13POZE1” and the “Centro de Supercomputación de la UGR” (UGRGRID) are acknowledged for access to computational facilities. Sandra Resa thanks the MECD for a FPU fellowship

RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies, including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant cancers, we sought to identify novel targets to selectively kill these cancers. Here, we report that loss of RNF8 significantly protects Brca1-mutant mice against mammary tumorigenesis. RNF8 deficiency in human BRCA1-mutant breast cancer cells was found to promote R-loop accumulation and replication fork instability, leading to increased DNA damage, senescence, and synthetic lethality. Mechanistically, RNF8 interacts with XRN2, which is crucial for transcription termination and R-loop resolution. We report that RNF8 ubiquitylates XRN2 to facilitate its recruitment to R-loop-prone genomic loci and that RNF8 deficiency in BRCA1-mutant breast cancer cells decreases XRN2 occupancy at R-loop-prone sites, thereby promoting R-loop accumulation, transcription-replication collisions, excessive genomic instability, and cancer cell death. Collectively, our work identifies a synthetic lethal interaction between RNF8 and BRCA1, which is mediated by a pathological accumulation of R-loops