5 research outputs found
Sadfly fever: two case reports
Sandfly fever, also known as 'three-day fever' or 'pappataci fever' or 'Phlebotomus fever' is a viral infection that causes self-limited influenza-like symptoms and characterized by a rapid onset. The disease occurs commonly in endemic areas in summer months and especially in August during which sandflies are active. In this article, two siblings who presented with high fever, redness in the eyes, headache, weakness, malaise and inability to walk, who were found to have increased liver function tests and creatine kinase levels and who were diagnosed with sadfly fever with positive sadfly IgM and IgG antibodies are reported because of the rarity of this disease
Hepatic portal venous gas and pneumatosis intestinalis
WOS: 00041486100003
High C-Reactive Protein and Low Albumin Levels Predict High 30-Day Mortality in Patients Undergoing Percutaneous Endoscopic Gastrotomy
WOS: 000406453100004PubMed ID: 28725304Background: Percutaneous endoscopic gastrotomy (PEG) enables long-term enteral feeding. The aim of this study was to identify biomarkers that may guide the decision of whether to perform the elective procedure of PEG. Methods: The medical records of all patients who underwent PEG in our hospital from 2010 to 2016 were screened retrospectively. Patients with mortality within a 30-day follow-up period and those without were compared using the Chi-square test, and continuous variables were compared with the Kruskal-Wallis and Mann-Whitney U tests. Receiver operating characteristic (ROC) curve analysis was used to demonstrate the ability of biomarkers to predict mortality; a cut-off point was determined and its sensitivity, specificity, and positive and negative predictive values were calculated. The Youden index was used to determine the cut-off point. Kaplan-Meier analysis was used to identify PEG-related mortality risk factors and a Cox regression model was applied for risk characterization. Results: A total of 120 patients who underwent PEG were evaluated in the study. The mean age was 67.00 +/- 18.00 years. The most common indication for PEG was cerebrovascular disease, in 69 (57.5%) of the patients. Infection of the PEG site was most common within 14 days after PEG tube placement, occurring in 13 patients (10.3%). The mortality rate among patients with post-PEG infection was 68.2%, significantly higher than in patients without infection (P = 0.012). Thirty-four patients (28.3%) died within 30 days of undergoing PEG. CRP values >= 78.31 mg/ L increased mortality by 8.756-fold, and albumin levels < 2.71 g/dL increased mortality by 2.255-fold. Conclusion: Our results indicate that the presence of both high CRP level and low albumin level were associated with significantly higher rate of mortality (73.1%) in patients who underwent PEG
A Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience
Objective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP)
A Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experience
Objective: The aim of the present study was to evaluate the efficacy and
safety of eltrombopag, an oral thrombopoietin receptor agonist, in
patients with chronic immune thrombocytopenia (ITP).
Materials and Methods: A total of 285 chronic ITP patients (187 women,
65.6 \%; 98 men, 34.4\%) followed in 55 centers were enrolled in this
retrospective cohort. Response to treatment was assessed according to
platelet count (/mm(3)) and defined as complete (platelet count of
>100,000/mm(3)), partial (30,000-100,000/mm(3) or doubling of platelet
count after treatment), or unresponsive (<30,000/mm(3)). Clinical
findings, descriptive features, response to treatment, and side effects
were recorded. Correlations between descriptive, clinical, and
hematological parameters were analyzed.
Results: The median age at diagnosis was 43.9 +/- 20.6 (range: 3-95)
years and the duration of follow-up was 18.0 +/- 6.4 (range: 6-28.2)
months. Overall response rate was 86.7\% (n=247). Complete and partial
responses were observed in 182 (63.8\%) and 65 (22.8\%) patients,
respectively. Thirty-eight patients (13.4\%) did not respond to
eltrombopag treatment. For patients above 60 years old (n=68), overall
response rate was 89.7\% (n=61), and for those above 80 years old
(n=12), overall response rate was 83\% (n=10). Considering thrombocyte
count before treatment, eltrombopag significantly increased platelet
count at the 1st, 2nd, 3rd, 4th, and 8th weeks of treatment. As the time
required for partial or complete response increased, response to
treatment was significantly reduced. The time to reach the maximum
platelet levels after treatment was quite variable (1-202 weeks).
Notably, the higher the maximum platelet count after eltrombopag
treatment, the more likely that side effects would occur. The most
common side effects were headache (21.6\%), weakness (13.7\%),
hepatotoxicity (11.8\%), and thrombosis (5.9\%).
Conclusion: Results of the current study imply that eltrombopag is an
effective therapeutic option even in elderly patients with chronic ITP.
However, patients must be closely monitored for response and side
effects during treatment. Since both response and side effects may be
variable throughout the follow-up period, patients should be evaluated
dynamically, especially in terms of thrombotic risk factors