Determination of the Heat Resistance of Microbial Isolates from EASL

Dry heat resistance of bacterial spores from sterilization and assembly laborator

Inductive queries for a drug designing robot scientist

It is increasingly clear that machine learning algorithms need to be integrated in an iterative scientific discovery loop, in which data is queried repeatedly by means of inductive queries and where the computer provides guidance to the experiments that are being performed. In this chapter, we summarise several key challenges in achieving this integration of machine learning and data mining algorithms in methods for the discovery of Quantitative Structure Activity Relationships (QSARs). We introduce the concept of a robot scientist, in which all steps of the discovery process are automated; we discuss the representation of molecular data such that knowledge discovery tools can analyse it, and we discuss the adaptation of machine learning and data mining algorithms to guide QSAR experiments

Unital quantum operators on the Bloch ball and Bloch region

For one qubit systems, we present a short, elementary argument characterizing unital quantum operators in terms of their action on Bloch vectors. We then show how our approach generalizes to multi-qubit systems, obtaining inequalities that govern when a ``diagonal'' superoperator on the Bloch region is a quantum operator. These inequalities are the n-qubit analogue of the Algoet-Fujiwara conditions. Our work is facilitated by an analysis of operator-sum decompositions in which negative summands are allowed.Comment: Revised and corrected, to appear in Physical Review

The Mass Function of Main Sequence Stars in NGC6397 from Near IR and Optical High Resolution HST Observations

We have investigated the properties of the stellar mass function in the globular cluster NGC6397 using a large set of HST observations that include WFPC2 images in V and I, obtained at ~4' and 10' radial distances, and a series of deep images in the J and H bands obtained with the NIC2 and NIC3 cameras of NICMOS pointed to regions located ~4.5' and ~3.2' from the center. These observations span the region from ~1 to ~3 times the cluster's half-light radius. All luminosity functions, derived from color magniutde diagrams, increase with decreasing luminosity up to a peak at M_I~8.5 or M_H~7 and then precipitously drop well before photometric incompleteness becomes significant. Within the observational uncertainties, at M_I~12 or M_H~10.5 (~0.09 Msun) the luminosity functions are compatible with zero. By applying the best available mass- luminosity relation appropriate to the metallicity of NGC6397 to both the optical and IR data, we obtain a mass function that shows a break in slope at \~0.3 Msun. No single exponent power-law distribution is compatible with these data, regardless of the value of the exponent. We find that a dynamical model of the cluster can simultaneously reproduce all the luminosity functions observed throughout the cluster only if the IMF rises as m**-1.6 in the range 0.8-0.3 Msun and then drops as m**0.2 below ~0.3 Msun. Adopting a more physical log-normal distribution for the IMF, all these data taken together imply a best fit distribution with characteristic mass m_c~0.3 and sigma~1.8.Comment: 18 pages, 6 figures (ps). Accepted for publication in Ap

Evaluation of the health-related quality of life of children in Schistosoma haematobium-endemic communities in Kenya: a cross-sectional study.

BACKGROUND: Schistosomiasis remains a global public health challenge, with 93% of the ~237 million infections occurring in sub-Saharan Africa. Though rarely fatal, its recurring nature makes it a lifetime disorder with significant chronic health burdens. Much of its negative health impact is due to non-specific conditions such as anemia, undernutrition, pain, exercise intolerance, poor school performance, and decreased work capacity. This makes it difficult to estimate the disease burden specific to schistosomiasis using the standard DALY metric. METHODOLOGY/PRINCIPAL FINDINGS: In our study, we used Pediatric Quality of Life Inventory (PedsQL), a modular instrument available for ages 2-18 years, to assess health-related quality of life (HrQoL) among children living in a Schistosoma haematobium-endemic area in coastal Kenya. The PedsQL questionnaires were administered by interview to children aged 5-18 years (and their parents) in five villages spread across three districts. HrQoL (total score) was significantly lower in villages with high prevalence of S. haematobium (-4.0%, p<0.001) and among the lower socioeconomic quartiles (-2.0%, p<0.05). A greater effect was seen in the psychosocial scales as compared to the physical function scale. In moderate prevalence villages, detection of any parasite eggs in the urine was associated with a significant 2.1% (p<0.05) reduction in total score. The PedsQL reliabilities were generally high (Cronbach alphas ≥0.70), floor effects were acceptable, and identification of children from low socioeconomic standing was valid. CONCLUSIONS/SIGNIFICANCE: We conclude that exposure to urogenital schistosomiasis is associated with a 2-4% reduction in HrQoL. Further research is warranted to determine the reproducibility and responsiveness properties of QoL testing in relation to schistosomiasis. We anticipate that a case definition based on more sensitive parasitological diagnosis among younger children will better define the immediate and long-term HrQoL impact of Schistosoma infection

The Formation of non-Keplerian Rings of Matter about Compact Stars

The formation of energetic rings of matter in a Kerr spacetime with an outward pointing acceleration field does not appear to have previously been noted as a relativistic effect. In this paper we show that such rings are a gravimagneto effect with no Newtonian analog, and that they do not occur in the static limit. The energy efficiency of these rings can, depending of the strength of the acceleration field, be much greater than that of Keplerian disks. The rings rotate in a direction opposite to that of compact star about which they form. The size and energy efficiency of the rings depend on the fundamental parameters of the spacetime as well as the strength the acceleration field.Comment: 19 pages, 7 figures, 1 diagram. Figures are included in the text using the "graphicx" package. If you do not have this package you can use epsfig, or another package as long as you alter the tex file appropriately. Alternatively you could print the figures out seperatel

Pressure induced high-spin to low-spin transition in FeS evidenced by x-ray emission spectroscopy

We report the observation of the pressure-induced high-spin to low-spin transition in FeS using new high-pressure synchrotron x-ray emission spectroscopy techniques. The transition is evidenced by the disappearance of the low-energy satellite in the Fe K$\beta$ emission spectrum of FeS. Moreover, the phase transition is reversible and closely related to the structural phase transition from a manganese phosphide-like phase to a monoclinic phase. The study opens new opportunities for investigating the electronic properties of materials under pressure.Comment: ReVTeX, 4 pages, 3 figures inserted with epsfig. minor modifications before submission to PR

Dissipationless Collapse of Spherical Protogalaxies and the Fundamental Plane

Following on from the numerical work of Capelato, de Carvalho & Carlberg (1995, 1997), where dissipationless merger simulations were shown to reproduce the "Fundamental Plane" (FP) of elliptical galaxies, we investigate whether the end products of pure, spherically symmetric, one-component dissipationless {\it collapses} could also reproduce the FP. Past numerical work on collisionless collapses have addressed important issues on the dynamical/structural characteristics of collapsed equilibrium systems. However, the study of collisionless collapse in the context of the nature of the FP has not been satisfactorily addressed yet. Our aim in this paper is to focus our attention on the resulting collapse of simple one-component spherical models with a range of different initial virial coefficients. We find that the characteristic correlations of the models are compatible with virialized, centrally homologous systems. Our results strengthen the idea that merging may be a fundamental ingredient in forming non-homologous objects.Comment: 9 pages, 4 Postscript figures, Astronomy & Astrophysics in press (2002). Abstract placement correcte

Brown Dwarfs and the Cataclysmic Variable Period Minimum

Using improved, up-to-date stellar input physics tested against observations of low-mass stars and brown dwarfs we calculate the secular evolution of low-mass donor cataclysmic variables (CVs), including those which form with a brown dwarf donor. Our models confirm the mismatch between the calculated minimum period (Pmin ~ 70 min) and the observed short-period cut-off (~ 80 min) in the CV period histogram. We find that tidal and rotational corrections applied to the one-dimensional stellar structure equations have no significant effect on the period minimum. Theoretical period distributions synthesized from our model sequences always show an accumulation of systems at the minimum period, a feature absent from the observed distribution. We suggest that non-magnetic CVs become unobservable as they are effectively trapped in permanent quiescence before they reach Pmin, and that small-number statistics may hide the period spike for magnetic CVs.Comment: 10 pages; accepted for publication in MNRA

Dynamic compartmentalization of bacteria: accurate division in E. coli

Positioning of the midcell division plane within the bacterium E. coli is controlled by the min system of proteins: MinC, MinD and MinE. These proteins coherently oscillate from end to end of the bacterium. We present a reaction--diffusion model describing the diffusion of min proteins along the bacterium and their transfer between the cytoplasmic membrane and cytoplasm. Our model spontaneously generates protein oscillations in good agreement with experiments. We explore the oscillation stability, frequency and wavelength as a function of protein concentration and bacterial length.Comment: 4 pages, 4 figures, Latex2e, Revtex