Measurement and simulation of the flow field around a triangular lattice meteorological mast

The international standard IEC 61400-12-1 “Wind turbines – Part 12-1: Power performance measurements of electricity producing wind turbines” aims to provide a uniform methodology that will ensure consistency, accuracy and reproducibility in the measurement and analysis of power performance by wind turbines. Annex G of this standard provides a methodology for the appropriate arrangement of instruments on the meteorological mast to ensure accurate measurement. For cup anemometers it provides recommendations about their location relative to the mast so that the effect of mast and boom interference on their output may be minimised. These recommendations are given for both tubular masts and lattice masts.This paper compares the flow distortion predicted by the IEC standard and the results of a 3D Computational Fluid Dynamics (CFD) simulation of a triangular lattice mast. Based on the results of wind tunnel and CFD simulation it was found that the flow distortion surrounding the lattice mast was over predicted by the method suggested in appendix G of IEC61400-12-1. Using the CFD data it was possible to determine, for a range of flow directions and mast heights, the distance from the mast that anemometers would need to be in order to be outside the flow distortion field

Relative-time inversions in the Labrador Sea acoustic tomography experiment.

One-year long travel-time data from the second deployment period of the Labrador Sea acoustic tomography experiment are analyzed, using a relative-time matched-peak approach, in order to invert for the sound-speed field and simultaneously solve for an unknown travel-time offset. From the relative-time inversions oceanographic information in terms of vertically averaged temperatures are deduced, yielding satisfactory matching with respect to available independent observations. The estimated offsets can be attributed to differential clock drifts, showing a clear parabolic behaviour over the course of the experiment, reaching maximum deviations from linear clock drift corrections (end-point calibrations) of the order of 50 ms. By applying the estimated second-order corrections to the travel-time data, absolute-time matched-peak inversions can then be performed. The used matched-peak approach accounts for the non-linear behaviour of travel times, which is due to the seasonally variable acoustic propagation conditions in the probed region, and turns out to be an appropriate tool in dealing with unknown travel-time offsets

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Hub height ocean winds over the North Sea observed by the NORSEWinD LiDAR array : measuring techniques, quality control and data management

In the North Sea, an array of wind profiling wind lidars were deployed mainly on offshore platforms. The purpose was to observe free stream winds at hub height. Eight lidars were validated prior to offshore deployment with observations from cup anemometers at 60, 80, 100 and 116 m on an onshore met mast situated in flat terrain. The so-called “NORSEWInD standard” for comparing lidar and mast wind data includes the criteria that the slope of the linear regression should lie within 0.98 and 1.01 and the linear correlation coefficient higher than 0.98 for the wind speed range 4–16 m∙s−1. Five lidars performed excellently, two slightly failed the first criterion and one failed both. The lidars were operated offshore from six months to more than two years and observed in total 107 months of 10-min mean wind profile observations. Four lidars were re-evaluated post deployment with excellent results. The flow distortion around platforms was examined using wind tunnel experiments and computational fluid dynamics and it was found that at 100 m height wind observations by the lidars were not significantly influenced by flow distortion. Observations of the vertical wind profile shear exponent at hub height are presented

Determination of Antarctic ice sheet stability over the last 500 ka through a study of iceberg-rafted debris

We have analyzed ice‐rafted debris (IRD) from the South Atlantic Ocean (∼43°S, 9°E) in order to investigate Antarctic Ice Sheet history during the late Pleistocene; the cores examined for this study include piston core TN057‐6‐PC4 and Ocean Drilling Program Leg 177 drill core Site 1090 (177‐1090). Over the last 500 ka at this distal location, IRD arrived during both glacials and interglacials. IRD is present even during warmer intervals, is greatest during colder intervals, and is absent only during terminations and a few other brief intervals. Four different methods are used to normalize the IRD counts, which are then compared to support our interpretation. Several other high‐quality climate proxies from this location also aid our interpretations. We conclude that sea surface temperatures are the primary control on the delivery of IRD to this site. During cold times more icebergs survived to reach this distal location. During warm times only a few of the largest icebergs could travel this far. Garnets found in these sediments suggest a likely East Antarctic origin for the IRD; the presence of garnets even during warm intervals further strongly supports that the iceberg source must be the East Antarctic Ice Sheet (EAIS). Therefore, the EAIS must have continued to reach the ocean at least in some part of its margin throughout the last 500 ka. On the other hand, we cannot specifically trace any IRD to the West Antarctic Ice Sheet (WAIS), so WAIS persistence cannot be tested. A particular radiolarian, identified as Dictyocoryne profunda (Ehrenberg) (sensu Boltovskoy (1998)), shows up in the examined size fraction generally only during warm phases. We suggest that D. profunda is a sensitive indicator of warm water temperatures and that it deserves further study