‘In shape and mind transformed’? Televised teaching and learning Shakespeare

Reality television offers the BBC the opportunity to fulfil its dual imperatives of education and entertainment, frequently constructed as anathematic. This article considers three recent examples of televised teaching and learning Shakespeare: When Romeo Met Juliet, Macbeth, the movie star and me, and Off By Heart: Shakespeare. It demonstrates the programmes’ fit with the reality genre through their common ingredients of authenticity, contained locations, hybridity, experts, fallible and flawed participants, articulation and reconciliation of social difference. Moreover, all three share an emphasis on a reality television staple: transformation, in terms of the participants’ knowledge, skills and personal growth, but also in relation to television audiences and the British education system. The programmes might thus usefully be understood as part of a reality television subgenre, evolving in Britain since the late 1970s, of Shmake-over. This article is published as part of a collection to commemorate the 400th anniversary of William Shakespeare’s death

Flamingo Vol. I N 1

Anonymous. Untitled. Prose. 1. DKF. Untitled. Picture. 3. Holt, Kilburn. Untitled. Poem. 4. Anonymous. An Ancient Reporter . Prose. 5. Anonymous. The Neophyte\u27s Prayer . Poem. 6. Anonymous. Gone-But Not Forgotten . Poem. 6. R.D.B. Untitled. Picture. 6. Anonymous. Untitled. Prose. 6. Anonymous. Thrice Weekly . Prose. 7. Anonymous. Yus! . Prose. 7. Anonymous. \u27S Truth! . Prose. 8. Anonymous. Tick-Tock: A Calamietta . Prose. 8. Holt, Kilburn. Spring . Poem. 9. Anonymous. Untitled. Poem. 9. Anonymous. Which best Applies . Poem. 9. R.D.B. Untitled. Picture. 9. Anonymous. The Circular Hunt of 1823 . Prose. 9. Anonymous. Sad-But True . Poem. 10. Bovington. Sad - But True . Cartoon. 10. Anonymous. Going to the Farm . Prose. 11. Anonymous. Untitled. Picture. 12. Anonymous. Untitled. Poem. 12. Anonymous. \u27Twas Ever Thus . Prose. 12. A.F.T. Two Triolets . Poem. 13. Anonymous. Santa Claus Opens a Factory In Granville . Prose. 13. Anonymous. Untitled. Picture. 14. Anonymous. Untitled. Poem. 14. Anonymous. So Would We . Poem. 14. Anonymous. The Sequence of Love . Poem. 14. Anonymous. A Letter From the Sem-And A Heartless Reply . Prose. 15. Anonymous. Galoshes . Poem. 15. Anonymous. Untitled. Poem. 15. Dickerman, C.H. A Chaucer . Poem. 13. Funk, Dorothy K. Untitled. Picture. 8. Anonymous. Untitled. Prose. 16. Anonymous. Add Horrors of War . Poem. 17. Hooper, Osman C. The Song of The Spring . Poem. 18. Flory, Walter L. The Daily Struggle . Poem. 18. Flory, Walter L. Exasperation . Poem. 18. MacCune, Julia Hall. On Sugar Loaf . Poem. 18. LaRue, Fred S. Behind The Gym . Poem. 18. Anonymous. Untitled. Picture. 19. Anonymous. The Red Rag Doll . Poem. 19. Anonymous. You Say It Is! . Poem. 19. Anonymous. Untitled. Poem. 19. Anonymous. Denison\u27s Hall of Fame . Poem. 20. Holt, Kilburn. Tempus Fugit . Poem. 21. Anonymous. Untitled. Prose. 21. Widow. The War Game . Prose. 21. Anonymous. Untitled. Picture. 21. Widow. Ah! Cribbing! . Poem. 22. Widow. Imposition . Poem. 22. Widow. Untitled. Prose. 22. Orange Peel. Untitled. Prose. 22. Record. Untitled. Prose. 22. Awgwan. Untitled. Prose. 22. Purple Cow. Untitled. Prose. 22. Anonymous. Chapel Singing School . Poem. 23. Anonymous. Untitled. Prose. 24. Anonymous. Three Types of Villain . Prose. 25. Orange Peel. To a Pencil . Poem. 27. Jester. What Men Like in Women . Prose. 27. Burr. Untitled. Poem. 27. Wampus. Untitled. Prose. 27. Anonymous. Untitled. Prose. 27. Judge. Spare Her Blushes . Prose. 27. Awgwan. Untitled. Poem. 27. Tiger. Untitled. Poem. 27. Tiger. Untitled. Poem. 29. Widow. Untitled. Prose. 29. Orange Peel. Untitled. Prose. 29. Anonymous. Low Cut . Prose. 29. Jester. Fine! Fine! . Prose. 29. Chaparal. Untitled. Prose. 31. Sun Dodger. All In The Type . Prose. 31. Orange Peel. Untitled. Prose. 31. Voo-Doo. Untitled. Prose. 31. Jester. Hot Stuff . Prose. 32. Orange Peel. Untitled. Prose. 32. Virginia Reel. Untitled. Prose. 32. Burr. Untitled. Prose. 32. Tiger. Untitled. Prose. 32. Keeler, Clyde. Untitled. Picture. 15 Keeler, Clyde. Untitled. Picture. 23

Crowding Promotes the Switch from Hairpin to Pseudoknot Conformation in Human Telomerase RNA

Formation of a pseudoknot in the conserved RNA core domain in the ribonucleoprotein human telomerase is required for function. In vitro experiments show that the pseudoknot (PK) is in equilibrium with an extended hairpin (HP) structure. We use molecular simulations of a coarse-grained model, which reproduces most of the salient features of the experimental melting profiles of PK and HP, to show that crowding enhances the stability of PK relative to HP in the wild type and in a mutant associated with dyskeratosis congenita. In monodisperse suspensions, small crowding particles increase the stability of compact structures to a greater extent than larger crowders. If the sizes of crowders in a binary mixture are smaller than the unfolded RNA, the increase in melting temperature due to the two components is additive. In a ternary mixture of crowders that are larger than the unfolded RNA, which mimics the composition of ribosome, large enzyme complexes and proteins in E. coli, the marginal increase in stability is entirely determined by the smallest component. We predict that crowding can restore partially telomerase activity in mutants, which dramatically decrease the PK stability.Comment: File "JACS_MAIN_archive_PDF_from_DOC.pdf" (PDF created from DOC) contains the main text of the paper File JACS_SI_archive.tex + 7 figures are the supplementary inf

Angular Dependence in Proton-Proton Correlation Functions in Central 40Ca+40Ca^{40}Ca+^{40}Ca and 48Ca+48Ca^{48}Ca+^{48}Ca Reactions

The angular dependence of proton-proton correlation functions is studied in central $^{40}Ca+^{40}Ca$ and $^{48}Ca+^{48}Ca$ nuclear reactions at E=80 MeV/A. Measurements were performed with the HiRA detector complemented by the 4$\pi$ Array at NSCL. A striking angular dependence in the laboratory frame is found within p-p correlation functions for both systems that greatly exceeds the measured and expected isospin dependent difference between the neutron-rich and neutron-deficient systems. Sources measured at backward angles reflect the participant zone of the reaction, while much larger sources observed at forward angles reflect the expanding, fragmenting and evaporating projectile remnants. The decrease of the size of the source with increasing momentum is observed at backward angles while a weaker trend in the opposite direction is observed at forward angles. The results are compared to the theoretical calculations using the BUU transport model.Comment: 8 pages, 3 figures, submitted to PR

TPOAb and thyroid function are not associated with breast cancer outcome: evidence from a large-scale study using data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001)

Background: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. Objectives: We aimed to clarify this association in a large cohort using the phase III, randomized, controlled Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). Methods: TACT women >18 years old with node-positive or high-risk node-negative early breast cancer (pT1–3a, pN0–1, M0), with stored plasma (n = 1,974), taken 15.5 (median; IQR 7.0–24.0) months after breast surgery were studied. Patients had also received chemotherapy (100%), radiotherapy (1,745/1,974; 88.4%), hormonal therapy (1,378/ 1,974; 69.8%), or trastuzumab (48/1,974; 2.4%). History of thyroid diseases and/or related treatments was not available. The prognostic significance of autoantibodies to thyroid peroxidase (TPOAb; positive ≥6 kIU/L), free-thyroxine and thyrotropin (combined: euthyroid, hypothyroid, hyperthyroid) was evaluated for disease-free survival (DFS), overall-survival (OS), and time-to-recurrence (TTR), with Cox regression models in univariate and multivariable analyses. The extended median follow-up was 97.5 months. Results: No difference in DFS was found by TPOAb status (unadjusted hazard ratio [HR]: 0.97, 95%CI: 0.78–1.19; p = 0.75) and/or thyroid function (unadjusted HR [hypothyroid vs. euthyroid]: 1.15, 95% CI: 0.79–1.68; p = 0.46; unadjusted HR [hyperthyroid vs. euthyroid]: 1.14, 95% CI: 0.82–1.61; p = 0.44). Similar results were obtained for OS, TTR, multivariable analyses, when TPOAb titre by tertiles was considered, and in a subgroup of 123 patients with plasma collected before adjuvant treatments. Conclusions: No evidence for a prognostic role of TPOAb and/or thyroid function in moderate-to-high-risk early breast cancer was found in the largest and longest observational study to date

Investigations of three, four, and five-particle exit channels of levels in light nuclei created using a 9C beam

The interactions of a E/A=70-MeV 9C beam with a Be target was used to populate levels in Be, B, and C isotopes which undergo decay into many-particle exit channels. The decay products were detected in the HiRA array and the level energies were identified from their invariant mass. Correlations between the decay products were examined to deduce the nature of the decays, specifically to what extent all the fragments were created in one prompt step or whether the disintegration proceeded in a sequential fashion through long-lived intermediate states. In the latter case, information on the spin of the level was also obtained. Of particular interest is the 5-body decay of the 8C ground state which was found to disintegrate in two steps of two-proton decay passing through the 6Beg.s. intermediate state. The isobaric analog of 8Cg.s. in 8B was also found to undergo two-proton decay to the isobaric analog of 6Beg.s. in 6Li. A 9.69-MeV state in 10C was found to undergo prompt 4-body decay to the 2p+2alpha exit channel. The two protons were found to have a strong enhancementin the diproton region and the relative energies of all four p-alpha pairs were consistent with the 5Lig.s. resonance

Long-Term Follow-Up of the Intergroup Exemestane Study

Purpose: The Intergroup Exemestane Study, an investigator-led study of 4,724 postmenopausal patients with early breast cancer (clinical trial information: ISRCTN11883920), has previously demonstrated that a switch from adjuvant endocrine therapy after 2 to 3 years of tamoxifen to exemestane was associated with clinically relevant improvements in efficacy. Here, we report the final efficacy analyses of this cohort. Patients and Methods: Patients who remained disease free after 2 to 3 years of adjuvant tamoxifen were randomly assigned to continue tamoxifen or switch to exemestane to complete a total of 5 years of adjuvant endocrine therapy. Given the large number of non–breast cancer–related deaths now reported, breast cancer–free survival (BCFS), with censorship of intercurrent deaths, was the primary survival end point of interest. Analyses focus on patients with estrogen receptor-positive or unknown tumors (n = 4,599). Results: At the time of the data snapshot, median follow-up was 120 months. In the population that was estrogen receptor positive or had unknown estrogen receptor status, 1,111 BCFS events were observed with 508 (22.1%) of 2,294 patients in the exemestane group and 603 (26.2%) of 2,305 patients in the tamoxifen group. The data corresponded to an absolute difference (between exemestane and tamoxifen) at 10 years of 4.0% (95% CI, 1.2% to 6.7%), and the hazard ratio (HR) of 0.81 (95% CI, 0.72 to 0.92) favored exemestane. This difference remained in multivariable analysis that was adjusted for nodal status, prior use of hormone replacement therapy, and prior chemotherapy (HR, 0.80; 95% CI, 0.71 to 0.90; P < .001). A modest improvement in overall survival was seen with exemestane; the absolute difference (between exemestane and tamoxifen) at 10 years in the population that was estrogen receptor positive or had unknown estrogen receptor status was 2.1% (95% CI, −0.5% to 4.6%), and the HR was 0.89 (95% CI, 0.78 to 1.01; P = .08). For the intention-to-treat population, the absolute difference was 1.6% (95% CI, −0.9% to 4.1%); the HR was 0.91 (95% CI, 0.80 to 1.03, P = .15). No statistically significant difference was observed in the proportion of patients who reported a fracture event in the post-treatment period. Conclusion: The Intergroup Exemestane Study and contemporaneous studies have established that a strategy of switching to an aromatase inhibitor after 2 to 3 years of tamoxifen can lead to sustained benefits in terms of reduction of disease recurrence and breast cancer mortality

An Exploratory Study into the Factors Impeding Ethical Consumption

Although consumers are increasingly engaged with ethical factors when forming opinions about products and making purchase decisions, recent studies have highlighted significant differences between consumers’ intentions to consume ethically, and their actual purchase behaviour. This article contributes to an understanding of this “ethical purchasing gap” through a review of existing literature, and the inductive analysis of focus group discussions. A model is suggested which includes exogenous variables such as moral maturity and age which have been well covered in the literature, together with further impeding factors identified from the focus group discussions. For some consumers, inertia in purchasing behaviour was such that the decision-making process was devoid of ethical considerations. Several manifested their ethical views through post-purchase dissonance and retrospective feelings of guilt. Others displayed a reluctance to consume ethically due to personal constraints, a perceived negative impact on image or quality, or an outright negation of responsibility. Those who expressed a desire to consume ethically often seemed deterred by cynicism, which caused them to question the impact they, as an individual, could achieve. These findings enhance the understanding of ethical consumption decisions and provide a platform for future research in this area