3,785 research outputs found
Global tectonic studies: Hotspots and anomalous topography
Volcanic activity on Earth and its secular variations are compared with that on other terrestrial planets. Activity at divergent, transform, and convergent plate margins is described with particular emphasis on hot spots and flood basalts. The timing and causing of uplifting above 500 meters, which in not associated with either plate boundaries or the normal nonplate margin edges of continents is considered with particular focus on the Guyana Highlands in southern Venezuela and western British Guiana, and the Brazilian Highlands in the central, eastern, and southern parts of the country. The mode and mechanism of plateau uplifting and the re-elevation of old mountain belts and subsidence of intra-continental basins are also discussed
Doping of a One-Dimensional Mott Insulator: Photoemision and Optical Studies of SrCuO
The spectral properties of a one-dimensional (1D) single-chain Mott insulator
SrCuO have been studied in angle-resolved photoemission and optical
spectroscopy, at half filling and with small concentrations of extra charge
doped into the chains via high oxygen pressure growth. The single- particle gap
is reduced with oxygen doping, but the metallic state is not reached. The
bandwidth of the charge-transfer band increases with doping, while the state
becomes narrower, allowing unambiguous observation of separated spinon and
holon branches in the doped system. The optical gap is not changed upon doping,
indicating that a shift of chemical potential rather than decrease of
corelation gap is responsible for the apparent reduction of the photoemission
gap.Comment: 4 pages, 2 figure
Computer simulation of arterial circulatory system
Εθνικό Μετσόβιο Πολυτεχνείο--Μεταπτυχιακή Εργασία. Διεπιστημονικό-Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών (Δ.Π.Μ.Σ.) “Υπολογιστική Μηχανική
A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma.
MicroRNAs (miRNAs) are small ∼22nt single stranded RNAs that negatively regulate protein expression by binding to partially complementary sequences in the 3' untranslated region (3' UTRs) of target gene messenger RNAs (mRNA). Recently, mutations have been identified in both miRNAs and target genes that disrupt regulatory relationships, contribute to oncogenesis and serve as biomarkers for cancer risk. KIT, an established oncogene with a multifaceted role in melanogenesis and melanoma pathogenesis, has recently been shown to be upregulated in some melanomas, and is also a target of the miRNA miR-221. Here, we describe a genetic variant in the 3' UTR of the KIT oncogene that correlates with a greater than fourfold increased risk of acral melanoma. This KIT variant results in a mismatch in the seed region of a miR-221 complementary site and reporter data suggests that this mismatch can result in increased expression of the KIT oncogene. Consistent with the hypothesis that this is a functional variant, KIT mRNA and protein levels are both increased in the majority of samples harboring the KIT variant. This work identifies a novel genetic marker for increased heritable risk of melanoma
Backcountry Visitor Experience and Social Science Indicators for Glacier Bay National Park
Glacier Bay National Park (GBNP), located in the panhandle of southeast Alaska, preserves more than 3.2 million acres and provides for a range of visitor opportunities. Marine waters make up nearly one fifth of the park, and no point of land is more than 30 miles from the coast. A range of backcountry experiences are possible, both on land in designated Wilderness (e.g., camping and hiking) and on water (e.g., sea kayaking, fishing, sightseeing, natural and cultural interpretation, and wildlife viewing)
What’s so bad about scientism?
In their attempt to defend philosophy from accusations of uselessness made by prominent scientists, such as Stephen Hawking, some philosophers respond with the charge of ‘scientism.’ This charge makes endorsing a scientistic stance, a mistake by definition. For this reason, it begs the question against these critics of philosophy, or anyone who is inclined to endorse a scientistic stance, and turns the scientism debate into a verbal dispute. In this paper, I propose a different definition of scientism, and thus a new way of looking at the scientism debate. Those philosophers who seek to defend philosophy against accusations of uselessness would do philosophy a much better service, I submit, if they were to engage with the definition of scientism put forth in this paper, rather than simply make it analytic that scientism is a mistake
Time to revisit Dr Finlay's casebook? The unique potential of the general practice case report
Aspergillus felis sp. nov., an emerging agent of invasive aspergillosis in humans, cats, and dogs
Published June 14, 2013We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial β-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45°C and from A. fumigatus by its inability to grow at 50°C. Itraconazole and voriconazole cross-resistance was common in vitro.Vanessa R. Barrs, Tineke M. van Doorn, Jos Houbraken, Sarah E. Kidd, Patricia Martin, Maria Dolores Pinheiro, Malcolm Richardson, Janos Varga, Robert A. Samso
Electronic Structure of the Cuprate Superconducting and Pseudogap Phases from Spectroscopic Imaging STM
We survey the use of spectroscopic imaging STM to probe the electronic
structure of underdoped cuprates. Two distinct classes of electronic states are
observed in both the d-wave superconducting (dSC) and the pseudogap (PG)
phases. The first class consists of the dispersive Bogoliubov quasiparticle
excitations of a homogeneous d-wave superconductor, existing below a lower
energy scale E=Delta0. We find that the Bogoliubov quasiparticle interference
signatures of delocalized Cooper pairing are restricted to a k-space arc which
terminates near the lines connecting k=\pm(pi/a0,0) to k=\pm(pi/a0). This arc
shrinks continuously with decreasing hole density such that Luttinger's theorem
could be satisfied if it represents the front side of a hole-pocket which is
bounded behind by the lines between k=\pm(pi/a0,0) and k=\pm(0,pi/a0). In both
phases the only broken symmetries detected for the |E|<Delta0 states are those
of a d-wave superconductor. The second class of states occurs proximate to the
pseudogap energy scale E=Delta1. Here the non-dispersive electronic structure
breaks the expected 90o-rotational symmetry of electronic structure within each
unit cell, at least down to 180o-rotational symmetry. This Q=0 electronic
symmetry breaking was first detected as an electronic inequivalence at the two
oxygen sites within each unit cell by using a measure of nematic (C2) symmetry.
Incommensurate non-dispersive conductance modulations, locally breaking both
rotational and translational symmetries, coexist with this intra-unit-cell
electronic symmetry breaking at E=Delta1. Their characteristic wavevector Q is
determined by the k-space points where Bogoliubov quasiparticle interference
terminates and therefore changes continuously with doping. The distinct broken
electronic symmetry states (Q=0 and finite Q) coexisting at E~Delta1 are found
to be indistinguishable in the dSC and PG phases.Comment: 32 pages with 10 figure
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