The relationship between self-esteem and quality of life of patients with idiopathic thrombocytopenic purpura at Isfahan’s Sayed Al-Shohada Hospital, Iran, in 2013

Background: Idiopathic thrombocytopenic purpura (ITP) is a chronic disease which is accompanied with hopelessness and loss of the sense of well-being due to its symptoms and treatment. It also affects patients’ sense of social and spiritual well-being. This disorder decreases patients’ self-esteem and their quality of life by changing their mental image and self-confidence. This study was performed to find the relationship between self-esteem and quality of life of patients with ITP. Subjects and Methods: This was a descriptive-analytical study on 64 patients with ITP who referred to Isfahan’s Sayed Al-Shohada Hospital, Iran. In this study, patients with ITP were selected randomly using a random number chart. The data collection tools consisted of the World Health Organization Quality of Life (WHOQOL)-BREF and Coopersmith Self-esteem Inventory (CSEI). Data were analyzed using SPSS and chi-square and Mann-Whitney tests and the Pearson and Spearman’s rank correlation coefficients. Results: In total, 64 patients completed the questionnaires. Results showed that 32% of subjects were over 36 years of age and 59% were women. In addition, 29.7% of ITP patients had low self-esteem and quality of life. Chi-square test showed a significant relationship between self-esteem and quality of life of patients with ITP. Conclusions: The results of the present study showed that considerable attention must be paid to self-esteem, as one of the most important factors influencing the promotion of quality of life. Therefore, it is suggested that patient’s self-esteem be improved by the implementation of educational and psychological programs in order to decrease the consequences of poor quality of life. © 2016, Tehran University of Medical Sciences (TUMS). All Rights Reserved

The comparison of perceived stress in idiopathic thrombocytopenic purpura patients referred to Seyed Al-Shohada Hospital with healthy people in Isfahan, Iran, 2013.

BACKGROUND Mental stress and daily crises comprise a part of physical and mental threats. Perceived stress is a physical and mental threat, as well. Perceived stress is a psychological process during which the individual considers his/ her physical and psychological welfare as being threatened. Since idiopathic thrombocytopenic purpura (ITP) is one of the chronic diseases being able to affect patients' perceived stress, this study was conducted to compare perceived stress in ITP patients and healthy people. MATERIALS AND METHODS This is a descriptive-comparative study with control and case groups. In this study, 64 ITP patients referring Seyed Al-Shohada Hospital and the same number of healthy individuals from the patients' neighborhood, as the control group, were selected randomly and compared. The Kohen Perceived Stress Standard Questionnaire was used to collect the data. The data were analyzed by SPSS and Student's independent t-test, chi-square, and Mann-Whitney test. Results : 64.1%, 59.4% and 53.1% of participants in case group were older than 35 years old, female and had elementary education. 78.1% of case group had severe perceived stress. 70.3% of participants in control group experienced mild perceived stress. Mann-Whitney test showed significant difference between two groups in level of stress (p<0.001). CONCLUSION In ITP patients, perceived stress was considerable. Planning interventional measures to determine stress-making agents and subside or at least control them is very essential

How much Sistan was successful in tuberculosis control?

Waves that propagate at low frequencies in buried pipes are of considerable interest in a variety of practical scenarios, for example leak detection, remote pipe detection, and pipeline condition assessment and monitoring. Whilst there has been considerable research and commercial attention on the accurate location of pipe leakage for many years, the various causes of pipe failures and their identification, have not been well documented; moreover, there are still a number of gaps in the existing knowledge. Previous work has focused on two of the three axisymmetric wavetypes that can propagate: the s=1, fluid-dominated wave; and the s=2, shell-dominated wave. In this paper, the third axisymmetric wavetype, the s=0 torsional wave, is investigated. The effects of the surrounding soil on the characteristics of wave propagation and attenuation are analyzed for a compact pipe/soil interface for which there is no relative motion between the pipe wall and the surrounding soil. An analytical dispersion relationship is derived for the torsional wavenumber from which both the wavespeed and wave attenuation can be obtained. How torsional waves can subsequently radiate to the ground surface is then investigated. Analytical expressions are derived for the ground surface displacement above the pipe resulting from torsional wave motion within the pipe wall. A numerical model is also included, primarily in order to validate some of the assumptions made whilst developing the analytical solutions, but also so that some comparison in the results may be made. Example results are presented for both a cast iron pipe and an MDPE pipe buried in two typical soil types

Real-time environmental monitoring, visualization, and notification system for construction H&S management

Construction workers who are exposed to hot and humid environments are at high risk of heat stress. Excessive exposure to such environments can result in occupational illnesses and injuries. Acquisition of sensor data from such environments is essential to ensure improved Health and Safety (H&S) of workers. Building Information Modeling (BIM) offers a new epitome to provide comprehensive solutions for H&S and evacuation planning in buildings. Researchers around the globe have presented hybrid solutions for integrating different sensing technologies with BIM such as Radio Frequency Identification (RFID) tags, Ultra High Frequency (UHF) readers and sensors. A review and critical evaluation of literature on integrated solutions of BIM with various sensing technologies is performed in order to present a hybrid solution based on BIM and Wireless Sensors Network (WSN) along with a notification system for real-time environmental monitoring of buildings. The application, entitled “Real-Time Environmental Monitoring, Visualization and Notification System”, is expected to provide a new horizon for effective visualization, reliable data capturing and catering to time sensitive emergency situations for construction H&S management. The paper will also outline scope of future research in this domain

Sub-transmission sub-station expansion planning based on bacterial foraging optimization algorithm

In recent years, significant research efforts have been devoted to the optimal planning of power systems. Substation Expansion Planning (SEP) as a sub-system of power system planning consists of finding the most economical solution with the optimal location and size of future substations and/or feeders to meet the future load demand. The large number of design variables and combination of discrete and continuous variables make the substation expansion planning a very challenging problem. So far, various methods have been presented to solve such a complicated problem. Since the Bacterial Foraging Optimization Algorithm (BFOA) yield to proper results in power system studies, and it has not been applied to SEP in sub-transmission voltage level problems yet, this paper develops a new BFO-based method to solve the Sub-Transmission Substation Expansion Planning (STSEP) problem. The technique discussed in this paper uses BFOA to simultaneously optimize the sizes and locations of both the existing and new installed substations and feeders by considering reliability constraints. To clarify the capabilities of the presented method, two test systems (a typical network and a real ones) are considered, and the results of applying GA and BFOA on these networks are compared. The simulation results demonstrate that the BFOA has the potential to find more optimal results than the other algorithm under the same conditions. Also, the fast convergence, consideration of real-world networks limitations as problem constraints, and the simplicity in applying it to real networks are the main features of the proposed method

Association between Women Empowerment and Social Support in the Reproductive Decision-Making of the Women Referring to the Health Centers in Sari, Iran (2017)

Background: Empowerment of women is considered to be a critical developmental strategy. Objectives: Today, empowerment of women is not only a priority, but it also is an urgent need of women as a one of the most important populations considering their roles in the family and community. Social support and empowerment of women are regarded as an investment for future generations, which will result in sustainable development. The present study aimed to explore the association between the social support and empowerment of women with their reproductive decisions in the health centers in Sari, Iran. Methods: This descriptive-correlational study was conducted on 400 women referring to the health centers in Sari, Iran in 2017. The subjects who met the inclusion criteria were selected via multistage cluster sampling. Data were collected using a demographic and reproductive characteristics questionnaire, multidimensional scale of perceived social support, and the questionnaire of women empowerment and reproductive behavior. Data analysis was performed in SPSS version 16. Results: The subjects had a moderate level of empowerment in their reproductive decisions. On the other hand, favorable and poor empowerment levels were observed in the dimensions of cultural background and family planning, respectively. Furthermore, social support had a direct, significant correlation with the empowerment of women in reproductive decisions (P=0.001; r=0.34). Conclusion: According to the results, the empowerment and social support of women are imperative issues that require special attention and investment considering the key role of women in promoting community health

Sugar beet (Beta vulgaris) guard cells responses to salinity stress: a proteomic analysis

Soil salinity is a major environmental constraint affecting crop growth and threatening global food security. Plants adapt to salinity by optimizing the performance of stomata. Stomata are formed by two guard cells (GCs) that are morphologically and functionally distinct from the other leaf cells. These microscopic sphincters inserted into the wax-covered epidermis of the shoot balance CO2 intake for photosynthetic carbon gain and concomitant water loss. In order to better understand the molecular mechanisms underlying stomatal function under saline conditions, we used proteomics approach to study isolated GCs from the salt-tolerant sugar beet species. Of the 2088 proteins identified in sugar beet GCs, 82 were differentially regulated by salt treatment. According to bioinformatics analysis (GO enrichment analysis and protein classification), these proteins were involved in lipid metabolism, cell wall modification, ATP biosynthesis, and signaling. Among the significant differentially abundant proteins, several proteins classified as “stress proteins” were upregulated, including non-specific lipid transfer protein, chaperone proteins, heat shock proteins, inorganic pyrophosphatase 2, responsible for energized vacuole membrane for ion transportation. Moreover, several antioxidant enzymes (peroxide, superoxidase dismutase) were highly upregulated. Furthermore, cell wall proteins detected in GCs provided some evidence that GC walls were more flexible in response to salt stress. Proteins such as L-ascorbate oxidase that were constitutively high under both control and high salinity conditions may contribute to the ability of sugar beet GCs to adapt to salinity by mitigating salinity-induced oxidative stress

Association between GSTM1, GSTT1, and GSTP1 variants and the risk of end stage renal disease

Introduction: There are some evidences indicating DNA damage by oxidant and mutant agents has an essential role in the chronic renal failure and end stage renal disease (ESRD). To investigate the possible association of GSTs variants with ESRD, we investigated the frequency of GST- T1, M1, and P1 genotypes, and the level of malondialdehyde (MDA) in patients with ESRD.Materials and methods: The present case-control study consisted of 136 ESRD patients treated with maintenance hemodialysis and 137 gender- and age-matched, unrelated healthy controls from the population of west of Iran. The GST- T1, M1, and P1 genotypes were determined in all individuals using multiplex-PCR and PCR-RFLP. The level of MDA was measured by high-performance liquid chromatography (HPLC).Results: We found that GSTM1 and GSTT1 null genotypes (GSTT1-/GSTM1-) increased the risk of ESRD by 1.8 times (p<0.001) and the increased risk of ESRD for GSTM-null (T1+-M1-) genotype was 3.04 times (p=0.002). ESRD patients carriers the GST (GSTM1-null+GSTT1-null+GST-null) genotypes compared to GST normal genotype increased the risk of ESRD by 3.3 (p<0.001) times. ESRD patients carriers of GST-null, GSTM1-null, and GSTT1-null genotypes had greater MDA concentration compared with the same genotypes of control subjects. Our results indicated that the GST-null allele (GSTT1-null/GSTM1-null) is a risk factor for ESRD and carriers of this allele have high levels of MDA.Conclusion: Our findings indicate that oxidative stress, impairment of the antioxidant system and abnormal lipid metabolism may play a role in the pathogenesis and progression of ESRD and its related complications. These data suggest that patients with ESRD are more susceptible to vascular diseases

High expression of DNA damage-inducible transcript 4 (DDIT4) is associated with advanced pathological features in the patients with colorectal cancer

DNA damage-inducible transcript 4 (DDIT4) is induced in various cellular stress conditions. This study was conducted to investigate expression and prognostic significance of DDIT4 protein as a biomarker in the patients with colorectal cancer (CRC). PPI network and KEGG pathway analysis were applied to identify hub genes among obtained differentially expressed genes in CRC tissues from three GEO Series. In clinical, expression of DDIT4 as one of hub genes in three subcellular locations was evaluated in 198 CRC tissues using immunohistochemistry method on tissue microarrays. The association between DDIT4 expression and clinicopathological features as well as survival outcomes were analyzed. Results of bioinformatics analysis indicated 14 hub genes enriched in significant pathways according to KEGG pathways analysis among which DDIT4 was selected to evaluate CRC tissues. Overexpression of nuclear DDIT4 protein was found in CRC tissues compared to adjacent normal tissues (P = 0.003). Furthermore, higher nuclear expression of DDIT4 was found to be significantly associated with the reduced tumor differentiation and advanced TNM stages (all, P = 0.009). No significant association was observed between survival outcomes and nuclear expression of DDIT4 in CRC cases. Our findings indicated higher nuclear expression of DDIT4 was significantly associated with more aggressive tumor behavior and more advanced stage of disease in the patients with CRC. © 2021, The Author(s)

Prevalence and genotyping identification of Cryptosporidium in adult ruminants in central Iran

Background Apicomplexan parasites of the genus Cryptosporidium infect a wide range of animal species as well as humans. Cryptosporidium spp. can cause life threatening diarrhea especially in young animals, children, immunocompromised patients and malnourished individuals. Asymptomatic cryptosporidial infections in animals can also occur, making these animals potential reservoirs of infection. Methods In the present study, a molecular survey of Cryptosporidium spp. in ruminants that were slaughtered for human consumption in Yazd Province, located in central Iran was conducted. Faeces were collected per-rectum from 484 animals including 192 cattle, 192 sheep and 100 goats. DNA was extracted from all samples and screened for Cryptosporidium by PCR amplification of the 18S rRNA gene. Positives were Sanger sequenced and further subtyped by sequence analysis of the 60 kDa glycoprotein (gp60) locus. Results In total, Cryptosporidium spp. were detected in 22 animals: C. andersoni and C. bovis in seven and two cattle faecal samples, respectively, C. ubiquitum in five sheep, and C. xiaoi in six sheep and two goat samples, respectively. To our knowledge, this study provides for the first time, molecular information concerning Cryptosporidium species infecting goats in Iran, and is also the first report of C. ubiquitum and C. xiaoi from ruminants in Iran. Conclusion The presence of potentially zoonotic species of Cryptosporidium in ruminants in this region may suggest that livestock could potentially contribute to human cryptosporidiosis, in particular among farmers and slaughterhouse workers, in the area. Further molecular studies on local human populations are required to more accurately understand the epidemiology and transmission dynamics of Cryptosporidium spp. in this region