The phonological heritage of the scientists of the XX century: a linguistic and historiographical review

A great attention is paid to the linguistic-historiographic analysis of the works of the Moscow, Prague and Saint Petersburg phonological schools’ representatives, which were dedicated to the problem of the language phonemic syste

Reduced electroencephalographic coherence asymmetry in the Chernobyl accident survivors

Se llevó a cabo un estudio electroencefalográfico (EEG) desde 1990 a 2006, empleando los espectros de energía, la coherencia promediada y los coeficientes integrales de asimetría de coherencia de EEG para comparar 189 trabajadores que participaron en la limpieza después del accidente de Chernobyl con un grupo control de 63 individuos sanos de la misma edad. La mayoría de los trabajadores de Chernobyl mostraron tres patrones anormales de EEG, como indica el mapeo de energía del EEG. La energía más alta, más prominente en las bandas lentas alfa y theta (1) o en frecuencias rápidas alfa (2), se observó en personas estudiadas 3 a 5 años después de los trabajos de limpieza (la fase temprana). La energía en el EEG más baja, en la banda alfa (3), se encontró en los trabajadores de Chernobyl 10 años o más después del accidente (la fase tardía). El análisis de coherencia del EEG reveló la existencia de dos fases en las alteraciones del EEG después de la limpieza de Chernobyl. En la fase temprana, se observó un incremento de la coherencia del EEG en las áreas centrales del cerebro, mientras que en la fase tardía, se observó una reducción de la coherencia del EEG, más prominente en las áreas frontales del cerebro, y prevaleció la reducción de la asimetría del cerebro. Estos resultados nos permiten proponer que los signos EEG descritos pueden ser un reflejo de disfunción cerebral inducida por radiación en la fase tardía después de la limpieza de Chernobyl y que son similares a los marcadores EEG del envejecimiento del cerebro. Los resultados, en comparación con los datos de la literatura, proporcionan apoyo adicional a la hipótesis del envejecimiento cerebral prematuro del cerebro en los supervivientes de Chernobyl como resultado del efecto secundario de lesiones cerebrales por radiaciónAn electroencephalograph (EEG) study was carried out from 1990 to 2006, using power spectra, averaged coherence, and integral EEG coherence asymmetry coefficients to compare 189 clean-up workers of the Chernobyl accident with 63 age matched healthy controls. Most of the Chernobyl workers showed three abnormal EEG patterns, as indicated by EEG power mapping. The higher power, most prominent in slow alpha and theta bands, or in fast alpha frequencies, were observed in persons 3-5 years after the clean-up works (the early stage). The lower EEG power in alpha band was found in Chernobyl workers 10 or more years after the accident (the late stage). EEG coherence analysis revealed the existence of two stages in EEG alterations following the Chernobyl clean-up. In the early stage, an increase of EEG coherence in the central brain areas was observed, whereas at the later stage, a decrease of EEG coherence, most prominent in the frontal brain areas, and reduced brain asymmetry prevailed. These results allow us to propose that the described EEG signs may be a reflection of radiation-induced brain dysfunction at the late period after the Chernobyl clean-up and were similar to the EEG markers of brain ageing. The results, in comparison to data of the literature, provide additional support to the premature brain ageing hypothesis in Chernobyl survivors as a result of the radiation brain damage after-effect

About the Concept of Foresight Technology

В статье рассматриваются аспекты понятия форсайт и форсайт-технологии.The article discusses aspects of the concept of foresight and foresight technology

Сolor in the Architecture of Art Clusters

В статье рассмотрены возможности цвета при организации архитектурной среды арт-кластеров, выделены признаки арт-кластеров, подчёркнута взаимосвязь свойств арт-кластера с формированием его цветовой среды.The article considers the capabilities of color in the organization of the architectural environment of art clusters, highlights the features of art clusters, emphasizes the relationship of the properties of an art cluster with the formation of its color environment

Features of the course of coronavirus infection in patients after thoracic and cardiac surgery

Objective: To study the features of the coronavirus infection course in cardiosurgical and thoracic patients to determine the factors potentially affecting the possibility of lethal outcome. To identify the predictors of fatal outcome based on the analyses of the features of the coronavirus infection course in this category of patients.Material and methods: During the analyzed period 80 patients from the departments of thoracic surgery and cardiac surgery were transferred to the infectious diseases department: 20 patients from the cardiac surgery department (CSD) – group 1; 60 patients from the thoracic surgery departments (TSD) – group 2. A control group number 3 consisting of 59 non-thoracic and non-cardiosurgical patients was also formed. According to the disease outcome the patients were divided into two groups: group 1 – fatal outcome, group 2 – recovery.Results: Out of 80 patients, lethal outcome was recorded in 25 cases: 22 patients of the thoracic profile (36% of the total number of transferred from this department) and 3 patients of the cardiosurgical profile (15% of the total number of those transferred from the cardiac surgery department). 20 out of 20 cardiac patients had been operated on the day before, 49 out of 60 thoracic patients also underwent surgery. 3 people from the group of non-operated patients transferred from departments of thoracic surgery died. Moreover, after pneumonectomy, fatal outcome was recorded in 7 out of 8 cases (87.5%).Conclusion: During the analyses of indicators it was revealed that the number of fatal outcomes in patients of the thoracic profile with COVID-19 infection is higher than of the cardiosurgical profile and in the infectious diseases department. Presumably, this is due to the fact that coronavirus infection affects the lungs to a greater extent, and in patients with a thoracic profile (in particular, those who have undergone resection interventions), the volume of the lung parenchyma is initially reduced. This is confirmed particularly by the highest percentage of fatal outcomes after pneumonectomy. Cardiosurgical patients after surgical interventions do not have a reduction in the functioning lung parenchyma, which creates an additional “reserve” for recovery. Moreover, men predominate among patients of the thoracic profile, with the survival rate lower in all groups compared to women. Patients transferred from thoracic departments showed higher rates of systemic inflammation, which indicates a more severe course of the viral infection and the possible development of complications.When analyzing the predictors of lethal outcome, the following factors were identified: male gender and, in general, a more severe course of a viral infection (low saturation, a high percentage of lung lesions on CT, more pronounced changes in laboratory screening). The studied factors are associated with a large number of fatal outcomes in thoracic and cardiac surgery patients. Among the factors that do not affect the prognosis are diabetes mellitus, stroke and myocardial infarction in history.Thus, patients diagnosed with coronavirus infection that developed after thoracic surgery had the most unfavorable prognosis. The revealed patterns are of interest for optimizing the routing of this category of patients in order to prevent coronavirus infection

Developing the Creative Potential of Future Engineers: Possibilities of Modern Education

В статье дан анализ современных представлений о развитии креативного потенциала человека. Авторы придерживаются позиции о необходимости преодоления узко технологического подхода, как в понимании креативности, так и в образовательном процессе, ориентированном на развитие креативного потенциала студентов, что становится возможным в рамках социокультурной модели креативности. Представлена структура социокультурной модели развития креативности в образовании. Опираясь на собственные исследования, а также на отечественный и зарубежный опыт, авторы делают вывод, что только в совместной креативной деятельности, завершающейся созданием креативного продукта, имеющего социальную значимость, возможно не абстрактно - академическое освоение форм креативной деятельности, но ее личностное присвоение. Особенно это значимо для будущих инженеров. В образовании для этого открываются новые возможности как в связи с вовлечением студентов в процесс развития креативных индустрий, так и с развитием конвергентной образовательной среды.The article analyzes modern ideas about the development of a person's creative potential. The authors adhere to the position on the need to overcome the narrowly technological approach, both in understanding creativity and in the educational process focused on the development of the creative potential of students, which becomes possible within the framework of the socio-cultural model of creativity. The structure of the socio-cultural model for the development of creativity in education is presented. Based on their own research, as well as on domestic and foreign experience, the authors conclude that only in joint creative activity, culminating in the creation of a creative product that has social significance, it is possible not abstractly - academic development of forms of creative activity, but its personal appropriation. This is especially important for future engineers. In education, new opportunities for this are opening up both in connection with the involvement of students in the development of creative industries, and with the development of a convergent educational environment

Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident

BACKGROUND: Previous studies showed an increased risk of thyroid cancer among children and adolescents exposed to radioactive iodines released after the Chornobyl (Chernobyl) accident, but the effects of screening, iodine deficiency, age at exposure and other factors on the dose-response are poorly understood. METHODS: We screened 11 970 individuals in Belarus aged 18 years or younger at the time of the accident who had estimated (131)I thyroid doses based on individual thyroid activity measurements and dosimetric data from questionnaires. The excess odds ratio per gray (EOR/Gy) was modelled using linear and linear-exponential functions. RESULTS: For thyroid doses \u3c5 \u3eGy, the dose-response was linear (n=85; EOR/Gy=2.15, 95% confidence interval: 0.81-5.47), but at higher doses the excess risk fell. The EOR/Gy was significantly increased among those with prior or screening-detected diffuse goiter, and larger for men than women, and for persons exposed before age 5 than those exposed between 5 and 18 years, although not statistically significant. A somewhat higher EOR/Gy was estimated for validated pre-screening cases. CONCLUSION: 10-15 years after the Chornobyl accident, thyroid cancer risk was significantly increased among individuals exposed to fallout as children or adolescents, but the risk appeared to be lower than in other Chornobyl studies and studies of childhood external irradiation

ВАРИАНТЫ И ПЕРСПЕКТИВЫ ПЕРЕПРОФИЛИРОВАНИЯ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ ДЛЯ ИСПОЛЬЗОВАНИЯ В ТЕРАПИИ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ

Recently many new approaches for repurposing or repositioning of the clinically used drugs have been developed. Drug repurposing  allows not only to use known schemes for the synthesis of  biologically active compounds, but also to avoid multiple studies that  are necessary for drug approval process – analysis of  pharmacokinetics, carcinogenicity, acute and chronic toxicity,  including cardiotoxicity, nephrotoxicity, allergenicity etc. It makes  possible to reduce the number of experimental studies as well as  costs of investigations. In cancer research drug repurposing includes screening for medicines used nowadays for the treatment of patients with non-cancer diseases which possess anticancer activity or able to enhance the effects of the standard anticancer chemotherapy, and  search for new applications of known anticancer drugs for the  treatment of different cancer types. Scientific rationale for the search of the compounds with potential anticancer properties among drugs  with different applications is based on the multiple cross-talks of  signaling pathways, which can inhibit cell proliferation. Modern  advances in genomics, proteomics and bioinformatics, development  of permanently improving databases of drug molecular effects and  high throughput analytical systems allow researchers to analyze  simultaneously a large bulk of existing drugs and specific molecular targets. This review describes the main approaches and  resources currently used for the drug repurposing, as well as a  number of examples.В настоящее время появились новые программы по перепрофилированию или перепозиционированию лекарственных средств, используемых в медицинской практике.  Перепрофилирование препаратов позволяет не только использовать отработанные схемы  синтеза биологически активных соединений, но и избежать проведения исследований,  необходимых для внедрения новых лекарственных препаратов в медицинскую практику, по  фармакокинетике, канцерогенности, острой и хронической токсичности, в том числе  кардиотоксичности, нефротоксичности, аллергенности и т.д. Это создает возможность сократить объем необходимых исследований и снизить затраты на них. В онкологии  программы перепрофилирования лекарственных средств включают как поиск препаратов,  обладающих противоопухолевой активностью или потенцирующих действие  противоопухолевых препаратов, среди известных и широко применяемых лекарственных  средств, используемых для лечения неонкологических заболеваний, так и анализ  возможности использования уже известных противоопухолевых препаратов для лечения  каких-либо новых нозологических форм заболевания. Основанием для поиска  противоопухолевых свойств среди препаратов иного назначения является тот факт, что  сигнальные пути в клетке характеризуются большим количеством перекрестных  взаимодействий и некоторые из них могут ингибировать пролиферацию опухолевых клеток.  Современные достижения геномики, протеомики, биоинформатики, появление объемных баз данных по молекулярным эффектам лекарственных препаратов, мощных аналитических систем и их постоянное совершенствование уже позволяет исследователям  одновременно проанализировать большое количество существующих препаратов в  применении к конкретной молекулярной мишени. В обзоре рассмотрены основные подходы  и ресурсы, использующиеся в настоящее время для перепрофилирования лекарственных  препаратов, а также приведен ряд примеров

ISSN exercise & sport nutrition review: research & recommendations

Sports nutrition is a constantly evolving field with hundreds of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN in 2004 and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition. More specifically, this paper provides an overview of: 1.) The definitional category of ergogenic aids and dietary supplements; 2.) How dietary supplements are legally regulated; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of the ergogenic value of nutrition and dietary supplementation in regards to weight gain, weight loss, and performance enhancement. Our hope is that ISSN members and individuals interested in sports nutrition find this review useful in their daily practice and consultation with their clients

The phonological heritage of the scientists of the XX century: a linguistic and historiographical review

A great attention is paid to the linguistic-historiographic analysis of the works of the Moscow, Prague and Saint Petersburg phonological schools’ representatives, which were dedicated to the problem of the language phonemic syste