Synthetic & Structural Studies on the Polymeric Complexes of Terephthaloyl-bis-(N-phenylhydroxamic Acid) (TPHA) & Sebacyl-bis(N-phenylhydroxamic Acid) (SPHA) with Co(II), Ni(II), Cu(II) & Zn(II)

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Ayurveda management of Rheumatoid Arthritis - A Case Study

Rheumatoid Arthritis is an autoimmune disease that can cause joint pain and damage throughout the body. Rheumatoid Arthritis is a chronic inflammatory disorder that can affect more on joints. As per Ayurvedic science Rheumatoid Arthritis sign and symptoms resemblance with Aamvata. Aamvata is the disease caused by impairment of Agni, formation of Ama and vitiation of Vatadosha. There is limited treatment in modern science for rheumatoid arthritis. Ayurveda treatment has the best result for Amavata. So in this case study Ayurveda treatment has used to cure Aamvata

Ayurveda management of Psoriasis - A Case Study

Psoriasis is an autoimmune disorder of skin, results in hyper proliferation of the skin. It is a chronic skin disease characterized by dry skin and raised, rough, red areas on the skin covered with fine silvery scales. A clear skin description is available in Charaka Samhita under Kushtha. Ayurved management is quite effective in Psoriasis as compared to modern treatment. The line of treatment in present given study is Shodhana and Shamana Chikitsa. Virechana therapy followed by internal medicinal treatment is considered as good management of skin disorder

Engineered valley-orbit splittings in quantum confined nanostructures in silicon

An important challenge in silicon quantum electronics in the few electron regime is the potentially small energy gap between the ground and excited orbital states in 3D quantum confined nanostructures due to the multiple valley degeneracies of the conduction band present in silicon. Understanding the "valley-orbit" (VO) gap is essential for silicon qubits, as a large VO gap prevents leakage of the qubit states into a higher dimensional Hilbert space. The VO gap varies considerably depending on quantum confinement, and can be engineered by external electric fields. In this work we investigate VO splitting experimentally and theoretically in a range of confinement regimes. We report measurements of the VO splitting in silicon quantum dot and donor devices through excited state transport spectroscopy. These results are underpinned by large-scale atomistic tight-binding calculations involving over 1 million atoms to compute VO splittings as functions of electric fields, donor depths, and surface disorder. The results provide a comprehensive picture of the range of VO splittings that can be achieved through quantum engineering.Comment: 4 pages, 4 figure

Investigation of ripple-limited low-field mobility in large-scale graphene nanoribbons

Combining molecular dynamics and quantum transport simulations, we study the degradation of mobility in graphene nanoribbons caused by substrate-induced ripples. First, the atom coordinates of large-scale structures are relaxed such that surface properties are consistent with those of graphene on a substrate. Then, the electron current and low-field mobility of the resulting non-flat nanoribbons are calculated within the Non-equilibrium Green\u27s Function formalism in the coherent transport limit. An accurate tight-binding basis coupling the sigma- and pi-bands of graphene is used for this purpose. It is found that the presence of ripples decreases the mobility of graphene nanoribbons on SiO2 below 3000 cm(2)/Vs, which is comparable to experimentally reported values. (C) 2013 AIP Publishing LLC

Ayurveda management of Osteo Arthritis (Sandhigata Vata) - A Case Study

Osteoarthritis is the most common form of arthritis affecting millions of people worldwide. It occurs when the protective cartilage that cushions the end of your bone wears down overtime. In Ayurveda osteoarthritis correlate to Sandhigat Vata. The common sign and symptoms of this disease is present in the form of Shoola, Shotha, Vatapoornadriti Sparsha and difficulty in flexion and extension of Sandhi. In modern science the available treatment is use of NSAID, Calcium supplement and finally replacement therapy. Due to this there are large no of patients suffering from this disease come towards Ayurveda. Ayurveda treatment by its Chikitsa Siddhant gives remarkable relief in osteoarthritis. In this case study a 60 yrs patient suffering from osteoarthritis of both knee joint got good relief

Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterus

Premature labour (PTL) is the single most significant factor contributing to neonatal morbidity in Europe with enormous attendant healthcare and social costs. Consequently, it remains a major challenge to alleviate the cause and impact of this condition. Our ability to improve the diagnosis and treatment of women most at risk of PTL is, however, actually hampered by an incomplete understanding of the ways in which the functions of the uterine myocyte are integrated to effect an appropriate biological response at the multicellular whole organ system. The level of organization required to co-ordinate labouring uterine contractile effort in time and space can be considered immense. There is a multitude of what might be considered mini-systems involved, each with their own regulatory feedback cycles, yet they each, in turn, will influence the behaviour of a related system. These include, but are not exclusive to, gestational-dependent regulation of transcription, translation, post-translational modifications, intracellular signaling dynamics, cell morphology, intercellular communication and tissue level morphology. We propose that in order to comprehend how these mini-systems integrate to facilitate uterine contraction during labour (preterm or term) we must, in concert with biological experimentation, construct detailed mathematical descriptions of our findings. This serves three purposes: firstly, providing a quantitative description of series of complex observations; secondly, proferring a database platform that informs further testable experimentation; thirdly, advancing towards the establishment of a virtual physiological uterus and in silico clinical diagnosis and treatment of PTL

BeatBox - HPC simulation environment for biophysically and anatomically realistic cardiac electrophysiology

The BeatBox simulation environment combines flexible script language user interface with the robust computational tools, in order to setup cardiac electrophysiology in-silico experiments without re-coding at low-level, so that cell excitation, tissue/anatomy models, stimulation protocols may be included into a BeatBox script, and simulation run either sequentially or in parallel (MPI) without re-compilation. BeatBox is a free software written in C language to be run on a Unix-based platform. It provides the whole spectrum of multi scale tissue modelling from 0-dimensional individual cell simulation, 1-dimensional fibre, 2-dimensional sheet and 3-dimensional slab of tissue, up to anatomically realistic whole heart simulations, with run time measurements including cardiac re-entry tip/filament tracing, ECG, local/global samples of any variables, etc. BeatBox solvers, cell, and tissue/anatomy models repositories are extended via robust and flexible interfaces, thus providing an open framework for new developments in the field. In this paper we give an overview of the BeatBox current state, together with a description of the main computational methods and MPI parallelisation approaches.Comment: 37 pages, 10 figures, last version submitted to PLOS ON

Atomically thin boron nitride: a tunnelling barrier for graphene devices

We investigate the electronic properties of heterostructures based on ultrathin hexagonal boron nitride (h-BN) crystalline layers sandwiched between two layers of graphene as well as other conducting materials (graphite, gold). The tunnel conductance depends exponentially on the number of h-BN atomic layers, down to a monolayer thickness. Exponential behaviour of I-V characteristics for graphene/BN/graphene and graphite/BN/graphite devices is determined mainly by the changes in the density of states with bias voltage in the electrodes. Conductive atomic force microscopy scans across h-BN terraces of different thickness reveal a high level of uniformity in the tunnel current. Our results demonstrate that atomically thin h-BN acts as a defect-free dielectric with a high breakdown field; it offers great potential for applications in tunnel devices and in field-effect transistors with a high carrier density in the conducting channel.Comment: 7 pages, 5 figure

Use of chelating agent for optimum post thaw quality of buck semen

Ejaculates (35) from adult Sirohi bucks (2–4 years old) were utilized for the present study to find out the freezability of buck semen at different levels of chelating agent used (ethylene diamine tetra acetic acid - EDTA: 0, 0.01, 0.05 and 0.1%) by conventional method of freezing. The ejaculates were collected twice at weekly intervals using artificial vagina and were extended to maintain sperms concentration approximately 100 million / dose (0.25 ml) with tris- citric acid- fructose (TCF) diluent having 10% (v/v) egg yolk and 6% (v/v) glycerol as cryo protecting agent. Filling and sealing of straws were done at 5ºC in cold handing cabinet after 4 h of equilibration period then straws were vapor frozen for 10 min above 2 cm of liquid nitrogen and finally put in to liquid nitrogen. Post thaw motility, live sperm count, abnormalities, acrosomal integrity and hypo osmotic swelling test had been conducted to know freezability. Analysis of data using SPSS 16 revealed that post thaw motility, live sperm count, abnormalities, acrosomal integrity and hypo osmotic swelling positive spermatozoa differed significantly at different levels of EDTA. The post thaw motility, live sperm count, acrosomal integrity and hypo osmotic swelling positive spermatozoa were significantly highest in 0.1% of EDTA used in the present study. So, 0.01% EDTA can be used as an additive in semen dilutor in routine freezing process for better post thaw recovery of buck semen