Lipid profile in relation to dietary calorie intake and anthropometric measurement of healthy women taking part in Shiraz diabetes screening test

Background and aims: It is well known that dyslipidemia is related to cardiovascular disease, dietary aspect and obesity play an important role in CVD risk factor. In the present study, we investigated the relationship between calorie intake, anthropometrical parameters and serum lipids in apparently healthy women. Methods: The subject were 90 healthy women aged between 20-55 who were taken part in diabetes screening plan of Shiraz University of Medical Sciences in 2011 anthropometric measurement were done by standard methods. Lipid profile was measured after 10 to 12 hours overnight fasting. Dietary calorie intake was assessed using 24h food recall. The bivariate associations between variables were examined with the Pearson correlation analysis and comparison of the calorie groups was done by t-test. Significance was accepted at P<0.05. Results: No significant relationships were seen between calorie intake, anthropometric measurements and serum lipids. Although TG level was positively correlated with BMI (r=0.4, P=0.000), WC (r=0.408, P=0.00) and WHR (r=0.33, P=0.003). Conclusion: Higher calorie intake was not significantly correlated with cardiovascular risk factor including Higher BMI,WC,WHR and abnormal serum lipids, but higher BMI,WC,WHR were directly associated with TG in healthy people. Although the association between these parameters and TG may be explained by insulin resistance, the lack of a significant association between anthropometric measurements and LDL in healthy people and limited studies in relation to net calorie and these variables remains an unexpected finding requiring further investigation

CT obstructive index and systolic blood pressure at the time of diagnosis of pulmonary thromboemboli

Background: Recognition of imaging findings in pulmonary emboli and their association with homodynamic factors is important for prompt diagnosis, treatment, and reduction of its morbidity. The main objective in current study was to determine the correlation between CT obstructive index in pulmonary thromboembolism and systolic blood pressure at the time of diagnosis.Materials and Methods: In this observational cross-sectional comparative study, 70 consecutive patients with pulmonary emboli admitted in Modarress Hospital (Tehran, Iran) among 2013-17 were enrolled and correlation between CT obstructive index on pulmonary CT angiography and systolic blood pressure at the time of diagnosis was determined.Results: The correlation between CT index and hypotension (systolic blood pressure≤90) in our studied patients was significant (P=0.0001) and the mean CT index in hypotensive and normotensive patients was 56.4% and 27.5%, respectively. The CT obstructive index cut-off point of 53.75% resulted in sensitivity and specificity of 87.5% and 96.3%, for hypotension prediction.Conclusion: According to the obtained results it may be concluded that there is significant correlation between CT obstructive Index in patients with pulmonary thromboembolic and systolic blood pressure at the time of diagnosis and be calculating the CT obstructive index the possibility of hypotension related to massive emboli could be predicted

COMPARATIVE STUDY OF SHOE-SURFACE INTERACTION IN TRAIL RUNNING - SUBJECTIVE AND OBJECTIVE EVALUATION

The purpose of this study is to compare and evaluate different running shoes in various surface conditions in two measurement phases. In the subjective test, fourteen trail runners performed the experiment with three running shoes in distinct surface conditions. Three features, comfort, cushioning and traction, were rated by means of questionnaire. In the objective measurement, a traction tester device was configured to simulate the movement and evaluate the rotational traction of the three shoes on different surfaces. The subjective test showed a significant difference with respect to comfort and cushioning. The objective measurement in dry conditions showed a significant decrease (P \u3c 0.05) in rotational traction on different surface types; rotational traction in wet conditions was significantly lower (P \u3c 0.05) than in dry conditions

The effects of acute consumption of pomegranate juice (Punica granatum L.) on decrease of blood pressure, inflammation, and improvement of vascular function in patients with hypertension: a clinical trial

زمینه و هدف: بیماری های قلبی- عروقی یکی از علل مرگ و میر به شمار می رود. در طب سنتی مصرف انار (Punica granatum L.)، در درمان بیماری های قلبی- عروقی مورد استفاده بوده است. هدف از این مطالعه بررسی اثرات آب انار بر فشار خون، فاکتورهای التهابی و عملکرد عروق است. روش بررسی: این مطالعه کارآزمایی بالینی یک سو کور به صورت قبل و بعد، بر روی 13 نفر از بیماران (67-30 سال) با فشار خون بالای mmHg90/140، مراجعه کننده به کلینیک فشار خون مرکز تحقیقات قلب و عروق اصفهان، انجام شد. تمامی بیماران ml150 آب انار را به صورت ناشتا، مصرف نمودند. قبل و پس از گذشت 6-4 ساعت، سطح فاکتورهای التهابی شامل E- سلکتین، (hs-(CRP، مولکول های چسبندگی سلولی (VCAM-1،ICAM-1 ) و اینترلوکین-6، فشار خون و عملکرد آندوتلیوم (FMD) در آنان مورد سنجش قرار گرفت. یافته ها: تمامی 13 نفر بیمار مطالعه را به پایان رساندند. مصرف کوتاه مدت آب انار موجب کاهش معنی دار فشار خون سیستولیک از 80/11±38/125 به 94/7±15/116 و فشار خون دیاستولیک از 25/5±69/82 به 25/3±08/78 شد (05/0>P). برای فاکتورهای التهابی(IL-6،CRP ،ICAM ، VCAM و –E سلکتین) و FMD تغییرات معنی داری نشان داده نشد. نتیجه گیری: نتایج پژوهش حاضر نشان می دهد که مصرف کوتاه مدت آب انار تازه دارای اثرات کاهندگی فشار خون در بیماران مبتلا به فشار خون بالا است؛ لذا به نظر می رسد مصرف آب انار تازه می تواند در پیشگیری و درمان بیماری های قلب- عروق و بهبود عملکرد آندوتلیوم موثر باشد

The Impact of Urban Elements on Creating a Sense of Social Solidarity

With regard to the interaction of environment and human, meaning transition occurs in a two-way relationship. Since correlation is a social issue which a number of people involved in that and it occurs within location, an effective relationship can be observed between the environment and social solidarity. This means that social solidarity can lead to the creation of places that are rooted in the social belief of people. Conversely, a place with these features can create a sense of social solidarity. This study investigates the impact of urban elements on social solidarity in a communicative process. Initially, the impact of urban symbols on memorabilia, then the relationship between memorabilia and identity and finally on the relationship between identity and social solidarity are studied. Therefore, through the existence of significant relationship among these elements, it can be proved that the urban elements can be effective in creating a sense of social solidarity. In this way, the descriptive and analytical method and library studies other sources are used to collect data

Formulation and evaluation of orally disintegrating tablet of Rizatriptan using natural superdisintegrant

Introduction: Rizatriptan benzoate is a potent and selective 5-HT1B/1D receptor agonist and is effective for the treatment of acute migraine. Difficulty in swallowing is common among all age groups, especially elderly and pediatrics. Orally disintegrating tablets may constitute an innovative dosage form that overcome the problem of swallowing and provides a quick onset of action. This study was aimed to formulate and evaluate an Orally Disintegrating Tablet (ODT) containing Rizatriptan while using semi-synthetic and natural superdisintegrants. Methods: Orodispersible tablets were prepared by direct compression using natural superdisntegrant (Plantago ovata mucilage) and semi-synthetic superdisntegrant (crospovidone). The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity, water absorption and wetting time. A 32 factorial design was used to investigate the effect of independent variables (amount of crospovidone and Plantago ovata mucilage) on dependent variables disintegration time, wetting time and Q5 (cumulative amount of drug release after 5 minutes). A counter plot was also presented to graphically represent the effect of independent variable on the disintegration time, wetting time and Q5. The check point batch was also prepared to prove the validity of the evolved mathematical model. The systematic formulation approach helped in understanding the effect of formulation processing variable. Results: According to the results of optimized batches, the best concentration of superdisintegrant were as follows: 9.4 mg Psyllium mucilage and 8.32 mg crospovidone gave rapid disintegration in 35sec and showed 99% drug release within 5 minutes. Conclusion: Plantago ovata mucilage, a natural superdisintegrant, gives a rapid disintegration and high release when used with synthetic superdisntegrant in formulation of orally disintegrating tablet of Rizatriptan.</p