226 research outputs found
Production and state-selective detection of ultracold, ground state RbCs molecules
Using resonance-enhanced two-photon ionization, we detect ultracold,
ground-state RbCs molecules formed via photoassociation in a laser-cooled
mixture of 85Rb and 133Cs atoms. We obtain extensive bound-bound excitation
spectra of these molecules, which provide detailed information about their
vibrational distribution, as well as spectroscopic data on the RbCs ground
a^3\Sigma^+ and excited (2)^3\Sigma^+, (1)^1\Pi states. Analysis of this data
allows us to predict strong transitions from observed excited levels to the
absolute vibronic ground state of RbCs, potentially allowing the production of
stable, ultracold polar molecules at rates as large as 10^7 s^{-1}
Distinguishing coherent and thermal photon noise in a circuit QED system
In the cavity-QED architecture, photon number fluctuations from residual
cavity photons cause qubit dephasing due to the AC Stark effect. These unwanted
photons originate from a variety of sources, such as thermal radiation,
leftover measurement photons, and crosstalk. Using a capacitively-shunted flux
qubit coupled to a transmission line cavity, we demonstrate a method that
identifies and distinguishes coherent and thermal photons based on
noise-spectral reconstruction from time-domain spin-locking relaxometry. Using
these measurements, we attribute the limiting dephasing source in our system to
thermal photons, rather than coherent photons. By improving the cryogenic
attenuation on lines leading to the cavity, we successfully suppress residual
thermal photons and achieve -limited spin-echo decay time. The
spin-locking noise spectroscopy technique can readily be applied to other qubit
modalities for identifying general asymmetric non-classical noise spectra
Coherent Coupled Qubits for Quantum Annealing
Quantum annealing is an optimization technique which potentially leverages quantum tunneling to enhance computational performance. Existing quantum annealers use superconducting flux qubits with short coherence times limited primarily by the use of large persistent currents I[subscript p]. Here, we examine an alternative approach using qubits with smaller I[subscript p] and longer coherence times. We demonstrate tunable coupling, a basic building block for quantum annealing, between two flux qubits with small (approximately 50-nA) persistent currents. Furthermore, we characterize qubit coherence as a function of coupler setting and investigate the effect of flux noise in the coupler loop on qubit coherence. Our results provide insight into the available design space for next-generation quantum annealers with improved coherence.United States. Office of the Director of National IntelligenceUnited States. Intelligence Advanced Research Projects ActivityUnited States. Dept. of Defense. Assistant Secretary of Defense for Research & Engineering (FA8721-05-C-0002
Superconducting nanowire photon number resolving detector at telecom wavelength
The optical-to-electrical conversion, which is the basis of optical
detectors, can be linear or nonlinear. When high sensitivities are needed
single-photon detectors (SPDs) are used, which operate in a strongly nonlinear
mode, their response being independent of the photon number. Nevertheless,
photon-number resolving (PNR) detectors are needed, particularly in quantum
optics, where n-photon states are routinely produced. In quantum communication,
the PNR functionality is key to many protocols for establishing, swapping and
measuring entanglement, and can be used to detect photon-number-splitting
attacks. A linear detector with single-photon sensitivity can also be used for
measuring a temporal waveform at extremely low light levels, e.g. in
long-distance optical communications, fluorescence spectroscopy, optical
time-domain reflectometry. We demonstrate here a PNR detector based on parallel
superconducting nanowires and capable of counting up to 4 photons at
telecommunication wavelengths, with ultralow dark count rate and high counting
frequency
The flux qubit revisited to enhance coherence and reproducibility
The scalable application of quantum information science will stand on reproducible and controllable high-coherence quantum bits (qubits). Here, we revisit the design and fabrication of the superconducting flux qubit, achieving a planar device with broad-frequency tunability, strong anharmonicity, high reproducibility and relaxation times in excess of 40 μs at its flux-insensitive point. Qubit relaxation times T₁ across 22 qubits are consistently matched with a single model involving resonator loss, ohmic charge noise and 1/f-flux noise, a noise source previously considered primarily in the context of dephasing. We furthermore demonstrate that qubit dephasing at the flux-insensitive point is dominated by residual thermal-photons in the readout resonator. The resulting photon shot noise is mitigated using a dynamical decoupling protocol, resulting in T₂≈85 μs, approximately the 2T₁ limit. In addition to realizing an improved flux qubit, our results uniquely identify photon shot noise as limiting T₂ in contemporary qubits based on transverse qubit–resonator interaction
Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics
Constitutively activated STAT3 protein has been found to be a key regulator of pancreatic cancer and a target for molecular therapeutic intervention. In this study, PG-S3-001, a small molecule derived from the SH-4-54 class of STAT3 inhibitors, was found to inhibit patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range. PG-S3-001 binds the STAT3 protein potently, Kd = 324 nmol/L by surface plasmon resonance, and showed no effect in a kinome screen (>100 cancer-relevant kinases). In vitro studies demonstrated potent cell killing as well as inhibition of STAT3 activation in pancreatic cancer cells. To better model the tumor and its microenvironment, we utilized three-dimensional (3D) cultures of patient-derived pancreatic cancer cells in the absence and presence of cancer-associated fibroblasts (CAF). In this coculture model, inhibition of tumor growth is maintained following STAT3 inhibition in the presence of CAFs. Confocal microscopy was used to verify tumor cell death following treatment of 3D cocultures with PG-S3-001. The 3D model was predictive of in vivo efficacy as significant tumor growth inhibition was observed upon administration of PG-S3-001. These studies showed that the inhibition of STAT3 was able to impact the survival of tumor cells in a relevant 3D model, as well as in a xenograft model using patient-derived cells
La “ideología de género” frente a los derechos sexuales y reproductivos. El escenario español
Se analiza el caso español como laboratorio europeo en el que se han ensayado las estrategias de movilización basadas en el discurso de la “ideología de género” contra los derechos sexuales y de las mujeres por parte de actores ultraconservadores, con especial atención a los actores católicos. Se presentan cuatro momentos: el discurso de la Iglesia Católica, como fuente originaria del lenguaje de este nuevo pánico moral; las reformas legales progresistas que detonan el ciclo de protesta; la contestación social de los grupos conservadores y la posterior reacción conservadora moderada desde la acción de gobierno
A Galaxy-scale Fountain of Cold Molecular Gas Pumped by a Black Hole
We present Atacama Large Millimeter/submillimeter Array and Multi-Unit Spectroscopic Explorer observations of the brightest cluster galaxy in Abell 2597, a nearby (z = 0.0821) cool core cluster of galaxies. The data map the kinematics of a three billion solar mass filamentary nebula that spans the innermost 30 kpc of the galaxy's core. Its warm ionized and cold molecular components are both cospatial and comoving, consistent with the hypothesis that the optical nebula traces the warm envelopes of many cold molecular clouds that drift in the velocity field of the hot X-ray atmosphere. The clouds are not in dynamical equilibrium, and instead show evidence for inflow toward the central supermassive black hole, outflow along the jets it launches, and uplift by the buoyant hot bubbles those jets inflate. The entire scenario is therefore consistent with a galaxy-spanning "fountain," wherein cold gas clouds drain into the black hole accretion reservoir, powering jets and bubbles that uplift a cooling plume of low-entropy multiphase gas, which may stimulate additional cooling and accretion as part of a self-regulating feedback loop. All velocities are below the escape speed from the galaxy, and so these clouds should rain back toward the galaxy center from which they came, keeping the fountain long lived. The data are consistent with major predictions of chaotic cold accretion, precipitation, and stimulated feedback models, and may trace processes fundamental to galaxy evolution at effectively all mass scales
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