Indiana Oil and Gas Update

Although Indiana is not necessarily in the forefront of major new oil and gas exploration, it enjoys robust oil and gas operations in its New Albany Shale and elsewhere. Between 250 and 300 wells are typically completed in Indiana each year.\u27 Indiana\u27s lawmakers have responded to public concern regarding the safety of hydraulic fracturing to increase gas production. In 2012, the Indiana Legislature required the Department of Natural Resources to address the public\u27s need for additional information and transparency concerning the hydraulic fracturing process for oil and gas wells. Prior to that, in 2011, Indiana lawmakers enacted a comprehensive amendment to the state\u27s Oil and Gas Act, which was followed by several emergency regulations from the Department of Natural Resources to implement the amendment. Included in those emergency regulations were pro- visions relating to coal bed methane wells and coal seam protection, which were designed to preserve the state\u27s coal resources in the face of consistent oil, gas, and methane production

Welche eHealth Interventionen verbessern das Symptommanagement bei älteren Menschen mit einer Herzinsuffizienz ?: Literaturübersicht

Die Herzinsuffizienz (HI) ist eine der häufigsten kardiovaskulären Er-krankung in den Industrieländern, welche trotz grossen Fortschritten in der Behandlung eine hohe Morbidität und Mortalität aufweist. Die HI versursacht im Gesundheitswesen, durch wiederkehrende Hospitalisationen, hohe finanzielle Kosten. Der zentrale Aspekt des Gesundheitssystems bzw. der Gesundheitsförderung ist, sich auf die Bedürfnisse und Strategien der chronisch erkrankten Personen zu richten. Zentral für die Selbst-pflege ist das Symptommanagement, welches zum Ziel hat die Symptome zu lindern. Bei einer HI können ein oder mehrere Symptome auftreten, deshalb ist es hier wichtig ein Symptommanagement anzustreben. Um neue Versorgungskonzepte für das Symp-tommanagement zu entwickeln, kann der Einsatz von Instrumenten der Telemedizin eine bedeutende Unterstützung sein. Besonders in der häuslichen Gesundheitsversor-gung soll der Nutzen von eHealth Vielseitigkeit versprechen

Drivers of the synergy between price cuts and store flyer advertising at supermarkets and discounters

Despite retailers’ intense use of both price cuts and store flyer advertising, it is still unclear whether and when it is beneficial for retailers to combine the two promotion tools at the same time as opposed to using them separately. We systematically investigate synergies between price cuts and store flyers for a broad set of 488 brands from 44 consumer packaged goods categories across six leading German retailers. We find that a clear majority of the brands benefit from positive synergies and hence, combining price cuts and store flyer advertising is recommended, especially at supermarkets. This synergy can be strong. For instance, a 15% price cut without store flyer support at a supermarket, on average, increases sales by 11%, and medium spending on store flyers for the brand at its regular (non-promoted) price results in a sales lift of 8%. The combined use of both tools, however, increases sales by 52%, much more than the sum of their separate effects (11% + 8% = 19%). Yet, there is also substantial variance in the synergy, which we explain with retailer format (supermarkets versus discounters) as well as various brand and category characteristics. Our findings have important implications for the coordination of promotion activities by retailers

How Social Relationships Affect Writers

My students always enjoyed working in groups. They begged to be with their friends whenever I assigned a group project. In general, I dreaded allowing students to work in groups. I feared the classroom disruption from students who could not stay on task. And I wondered if students would do their best work in a group. Yet, I had to admit that as a graduate student, I found that some of my best work resulted from work in a group setting

Interactions between pea seed-borne mosaic virus pathotype 1 and Pisum sativum resistance gene sbm-1

Pea seed-borne mosaic potyvirus pathotype 1 (PSbMV-P1) has the ability to infect most genotypes of Pisum sativum. The exception are those genotypes that are homozygous recessive for the sbm-1 gene. The life cycle of PSbMV pathotype 4 (PSbMV-P4) is unaffected by the sbm-1/sbm-1 genotype. Infectious clones of Pl-P4 recombinants were used to define the genomic segment in P1 that is inhibited by the sbm-1 gene. Transcripts generated in vitro from these clones were initially tested for infectivity by mechanical inoculation onto the susceptible genotype Early Freezer 680 (EF680). Those recombinants that proved to be infectious were then tested for pathogenicity to PI269818, a sbm-1 /sbm-1 genotype. The P4 genomic substitution, which enabled P1 to infect PI269818, was made progressively smaller until one PSbMV-P1 coding region was established as the determinant for infectivity in PI269818. This study demonstrated that the VPg coding region is responsible for the inability of PSbMV-P1 to infect PI269818. Whether P1 life cycle disruption occurred at the nucleotide or amino acid levels is unknown. In conjunction with the definition of the P1 coding region inhibited by sbm-1, the point of virus life-cycle disruption was investigated. PSbMV-P1 resistant plants were inoculated with P1 purified virus or RNA. A time line of infection was established for inoculated and noninoculated leaves. Protoplasts generated from P1 susceptible- and resistant-plant leaves were transfected with P1 RNA, followed by ELISA testing for presence of P1 coat protein. Whereas P1 RNA was fully infectious to EF680 protoplasts, P1 coat protein was undetectable in PI269818 protoplasts transfected with P1 RNA. RT-PCR of RNA extracted from PI269818 P1 inoculated leaves revealed no P1 RNA amplification. When P1 inoculated PI269818 leaves were used to inoculate EF680, no viral infection was detected. These results suggest that a complete lack of P1 replication is occurring in sbm-1 /sbm-1 peas. The potyviral VPg protein has been implicated in viral replication. This study demonstrates that the VPg is the determinant of P1 pathogenicity in PI269818 and consistent with the proposed role of VPg in viral replication, PSbMV-P1 viral life-cycle disruption in the sbm-1/sbm-1 genotype occurs at an early time in viral replication

Consensus Statement of the International Summit on Intellectual Disability and Dementia Related to Post-Diagnostic Support

Objectives: Post diagnostic support (PDS) has varied definitions within mainstream dementia services and different health and social care organizations, encompassing a range of supports that are offered to adults once diagnosed with dementia until death.  Method: An international summit on intellectual disability and dementia held in Glasgow, Scotland in 2016 identified how PDS applies to adults with an intellectual disability and dementia. The Summit proposed a model that encompassed seven focal areas: post-diagnostic counseling; psychological and medical surveillance; periodic reviews and adjustments to the dementia care plan; early identification of behaviour and psychological symptoms; reviews of care practices and supports for advanced dementia and end of life; supports to carers/ support staff; and evaluation of quality of life. It also explored current practices in providing PDS in intellectual disability services.  Results: The Summit concluded that although there is limited research evidence for pharmacological or non-pharmacological interventions for people with intellectual disability and dementia, viable resources and guidelines describe practical approaches drawn from clinical practice. Post diagnostic support is essential, and the model components in place for the general population, and proposed here for use within the intellectual disability field, need to be individualized and adapted to the person’s needs as dementia progresses.  Conclusions: Recommendations for future research include examining the prevalence and nature of behavioral and psychological symptoms (BPSD) in adults with an intellectual disability who develop dementia, the effectiveness of different non-pharmacological interventions, the interaction between pharmacological and non-pharmacological interventions, and the utility of different models of support

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