The mass and density of the dwarf planet (225088) 2007 OR10

The satellite of (225088) 2007 OR10 was discovered on archival Hubble Space Telescope images and along with new observations with the WFC3 camera in late 2017 we have been able to determine the orbit. The orbit's notable eccentricity, e$\approx$0.3, may be a consequence of an intrinsically eccentric orbit and slow tidal evolution, but may also be caused by the Kozai mechanism. Dynamical considerations also suggest that the moon is small, D$_{eff}$ $<$ 100 km. Based on the newly determined system mass of 1.75x10$^{21}$ kg, 2007 OR10 is the fifth most massive dwarf planet after Eris, Pluto, Haumea and Makemake. The newly determined orbit has also been considered as an additional option in our radiometric analysis, provided that the moon orbits in the equatorial plane of the primary. Assuming a spherical shape for the primary this approach provides a size of 1230$\pm$50 km, with a slight dependence on the satellite orbit orientation and primary rotation rate chosen, and a bulk density of 1.75$\pm$0.07 g cm$^{-3}$ for the primary. A previous size estimate that assumed an equator-on configuration (1535$^{+75}_{-225}$ km) would provide a density of 0.92$^{+0.46}_{-0.14}$ g cm$^{-3}$, unexpectedly low for a 1000 km-sized dwarf planet.Comment: Accepted for publication in Icaru

Stride-level analysis of mouse open field behavior using deep-learning-based pose estimation.

Gait and posture are often perturbed in many neurological, neuromuscular, and neuropsychiatric conditions. Rodents provide a tractable model for elucidating disease mechanisms and interventions. Here, we develop a neural-network-based assay that adopts the commonly used open field apparatus for mouse gait and posture analysis. We quantitate both with high precision across 62 strains of mice. We characterize four mutants with known gait deficits and demonstrate that multiple autism spectrum disorder (ASD) models show gait and posture deficits, implying this is a general feature of ASD. Mouse gait and posture measures are highly heritable and fall into three distinct classes. We conduct a genome-wide association study to define the genetic architecture of stride-level mouse movement in the open field. We provide a method for gait and posture extraction from the open field and one of the largest laboratory mouse gait and posture data resources for the research community

DisProt: the Database of Disordered Proteins

The Database of Protein Disorder (DisProt) links structure and function information for intrinsically disordered proteins (IDPs). Intrinsically disordered proteins do not form a fixed three-dimensional structure under physiological conditions, either in their entireties or in segments or regions. We define IDP as a protein that contains at least one experimentally determined disordered region. Although lacking fixed structure, IDPs and regions carry out important biological functions, being typically involved in regulation, signaling and control. Such functions can involve high-specificity low-affinity interactions, the multiple binding of one protein to many partners and the multiple binding of many proteins to one partner. These three features are all enabled and enhanced by protein intrinsic disorder. One of the major hindrances in the study of IDPs has been the lack of organized information. DisProt was developed to enable IDP research by collecting and organizing knowledge regarding the experimental characterization and the functional associations of IDPs. In addition to being a unique source of biological information, DisProt opens doors for a plethora of bioinformatics studies. DisProt is openly available at

Effects of the sex of the perpetrator on victims’ subsequent sexual behaviors and adulthood sexual orientations

Data from 2,828 female and 1,556 male adult participants from a general population convenience sample were used to measure the effect of the sex of the perpetrator on the adult sexual orientation of the victims of child sexual abuse (CSA) by adult male or female perpetrators and early incest with parents or early incest with siblings. Sexual behaviors with female perpetrators tended to promote an orientation toward sex with females and analogous behaviors with male perpetrators tended to promote an orientation toward sex with males in victims of both sexes. Many forms of incest or CSA increased the likelihood the victims would subsequently engage in behaviors with other partners or begin masturbating using adult male or female images. The subsequent early behaviors with other partners and masturbating using images of both male and female adults significantly enhanced or attenuated the conditioning resulting from interacting with the initial perpetrator. The victims’ adult sexual orientations could be statistically predicted using regression equations that took into account the sexual behaviors with both adult and underage partners and whether or not the participant had masturbated using images of male or female adults. The results were consistent with conditioning and counter-conditioning theories

Prioritizing Tanzania’s agricultural development policy to build smallholder climate resilience. Final report for the Bill & Melinda Gates Foundation Grand Challenges Explorations 22: Risk-explicit and Evidence-based Policy Prioritization (REAP)

Faced with myriad options, Sub-Saharan Africa policy makers struggle to prioritize actions. Commonly used modeling approaches perform poorly in data scare conditions or focus intently on tools at hand. Policies, by consequence, report ‘wish lists’, making them a challenge to implement given resource constraints. Here, we evaluate the potential of using an alternative approach, Bayesian Networks (BNs), to prioritize agricultural policy actions, specifically modeling seven ‘Investment Areas’ listed in Tanzania’s Agriculture Sector Development Programme II

Le Forum, Vol. 45 #1 & #2

https://digitalcommons.library.umaine.edu/francoamericain_forum/1107/thumbnail.jp

Lynx X-Ray Observatory: An Overview

Lynx, one of the four strategic mission concepts under study for the 2020 Astrophysics Decadal Survey, provides leaps in capability over previous and planned x-ray missions and provides synergistic observations in the 2030s to a multitude of space- and ground-based observatories across all wavelengths. Lynx provides orders of magnitude improvement in sensitivity, on-axis subarcsecond imaging with arcsecond angular resolution over a large field of view, and high-resolution spectroscopy for point-like and extended sources in the 0.2- to 10-keV range. The Lynx architecture enables a broad range of unique and compelling science to be carried out mainly through a General Observer Program. This program is envisioned to include detecting the very first seed black holes, revealing the high-energy drivers of galaxy formation and evolution, and characterizing the mechanisms that govern stellar evolution and stellar ecosystems. The Lynx optics and science instruments are carefully designed to optimize the science capability and, when combined, form an exciting architecture that utilizes relatively mature technologies for a cost that is compatible with the projected NASA Astrophysics budget