A Precise Cluster Mass Profile Averaged from the Highest-Quality Lensing Data

We outline our methods for obtaining high precision mass profiles, combining independent weak-lensing distortion, magnification, and strong-lensing measurements. For massive clusters the strong and weak lensing regimes contribute equal logarithmic coverage of the radial profile. The utility of high-quality data is limited by the cosmic noise from large scale structure along the line of sight. This noise is overcome when stacking clusters, as too are the effects of cluster asphericity and substructure, permitting a stringent test of theoretical models. We derive a mean radial mass profile of four similar mass clusters of high-quality HST and Subaru images, in the range R=40kpc/h to 2800kpc/h, where the inner radial boundary is sufficiently large to avoid smoothing from miscentering effects. The stacked mass profile is detected at 58-sigma significance over the entire radial range, with the contribution from the cosmic noise included. We show that the projected mass profile has a continuously steepening gradient out to beyond the virial radius, in remarkably good agreement with the standard Navarro-Frenk-White form predicted for the family of CDM-dominated halos in gravitational equilibrium. The central slope is constrained to lie in the range, -dln{\rho}/dln{r}=0.89^{+0.27}_{-0.39}. The mean concentration is c_{vir}=7.68^{+0.42}_{-0.40} (at a mean virial mass 1.54^{+0.11}_{-0.10}\times 10^{15} M_{sun}/h), which is high for relaxed, high-mass clusters, but consistent with LCDM when a sizable projection bias estimated from N-body simulations is considered. This possible tension will be more definitively explored with new cluster surveys, such as CLASH, LoCuSS, Subaru HSC, and XXM-XXL, to construct the c-M relation over a wider mass range.Comment: Accepted by ApJ, minor text changes (10 pages, 3 figures

A Survey for Large Separation Lensed FIRST Quasars

Little is known about the statistics of gravitationally lensed quasars at large (7''-30'') image separations, which probe masses on the scale of galaxy clusters. We have carried out a survey for gravitationally-lensed objects, among sources in the FIRST 20cm radio survey that have unresolved optical counterparts in the digitizations of the Palomar Observatory Sky Survey. From the statistics of ongoing surveys that search for quasars among FIRST sources, we estimate that there are about 9100 quasars in this source sample, making this one of the largest lensing surveys to date. Using broad-band imaging, we have isolated all objects with double radio components separated by 5''-30'', that have unresolved optical counterparts with similar BVI colours. Our criteria for similar colours conservatively allow for observational error and for colour variations due to time delays between lensed images. Spectroscopy of these candidates shows that none of the pairs are lensed quasars. This sets an upper limit (95% confidence) on the lensing fraction in this survey of 3.3x10^-4, assuming 9100 quasars. Although the source redshift distribution is poorly known, a rough calculation of the expected lensing frequency and the detection efficiencies and biases suggests that simple theoretical expectations are of the same order of magnitude as our observational upper limit. Our procedure is novel in that our exhaustive search for lensed objects does not require prior identification of the quasars in the sample as such. Characterization of the FIRST-selected quasar population will enable using our result to constrain quantitatively the mass properties of clusters.Comment: 10 pages, accepted for publication in MNRA

The redshift distribution of gravitational lenses revisited: Constraints on galaxy mass evolution

The redshifts of lens galaxies in known gravitational lens systems probe the volume distribution of lensing mass. Following earlier work by Kochanek, we re-derive the lens redshift probability distribution, allowing for mass and number density evolution of the lensing galaxies, and apply this test to a much enlarged sample of lens systems. From a literature survey of all known lenses, we have selected an unbiased sample of 15 lenses with complete redshift information. For a flat Universe and no lens evolution, we can only put an upper limit on the cosmological constant of Omega_lambda<0.89 at the 95% CL. Omega_lambda~0.7 and no evolution is consistent with the data. Allowing for evolution in an Omega_m=0.3, Omega_lambda=0.7 cosmology, we find that the best-fit evolution in sigma* (i.e., the characteristic velocity dispersion in a Schechter-like function) of early-type galaxies, in the redshift range z~0 to 1, is d[log sigma*(z)]/dz=-0.10+/-0.06. This is consistent with no evolution and implies that, at 95% CL, sigma* of early-type galaxies at z~1 was at least 63% of its current value. Alternatively, if there is no mass evolution, a present-day value of sigma*>175 km/s for elliptical galaxies is required (95% CL).Comment: 15 pages, MNRAS, in pres

Strong gravitational lensing probes of the particle nature of dark matter

There is a vast menagerie of plausible candidates for the constituents of dark matter, both within and beyond extensions of the Standard Model of particle physics. Each of these candidates may have scattering (and other) cross section properties that are consistent with the dark matter abundance, BBN, and the most scales in the matter power spectrum; but which may have vastly different behavior at sub-galactic "cutoff" scales, below which dark matter density fluctuations are smoothed out. The only way to quantitatively measure the power spectrum behavior at sub-galactic scales at distances beyond the local universe, and indeed over cosmic time, is through probes available in multiply imaged strong gravitational lenses. Gravitational potential perturbations by dark matter substructure encode information in the observed relative magnifications, positions, and time delays in a strong lens. Each of these is sensitive to a different moment of the substructure mass function and to different effective mass ranges of the substructure. The time delay perturbations, in particular, are proving to be largely immune to the degeneracies and systematic uncertainties that have impacted exploitation of strong lenses for such studies. There is great potential for a coordinated theoretical and observational effort to enable a sophisticated exploitation of strong gravitational lenses as direct probes of dark matter properties. This opportunity motivates this white paper, and drives the need for: a) strong support of the theoretical work necessary to understand all astrophysical consequences for different dark matter candidates; and b) tailored observational campaigns, and even a fully dedicated mission, to obtain the requisite data.Comment: Science white paper submitted to the Astro2010 Decadal Cosmology & Fundamental Physics Science Frontier Pane

Enhanced NFκB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

BACKGROUND: Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. METHODS: Two cell line models of tamoxifen-resistant ER-positive breast cancer, MCF7/HER2 and BT474, showing increased AP-1 and NFκB DNA-binding and transcriptional activities, were studied to compare tamoxifen effects on NFκB and AP-1 regulated reporter genes relative to tamoxifen-sensitive MCF7 cells. The model cell lines were treated with the IKK inhibitor parthenolide (PA) or the proteasome inhibitor bortezomib (PS341), alone and in combination with tamoxifen. Expression microarray data available from 54 UCSF node-negative ER-positive breast cancer cases with known clinical outcome were used to search for potential genes signifying upregulated NFκB and AP-1 transcriptional activity in association with tamoxifen resistance. The association of these genes with patient outcome was further evaluated using node-negative ER-positive breast cancer cases identified from three other published data sets (Rotterdam, n = 209; Amsterdam, n = 68; Basel, n = 108), each having different patient age and adjuvant tamoxifen treatment characteristics. RESULTS: Doses of parthenolide and bortezomib capable of sensitizing the two endocrine resistant breast cancer models to tamoxifen were capable of suppressing NFκB and AP-1 regulated gene expression in combination with tamoxifen and also increased ER recruitment of the transcriptional co-repressor, NCoR. Transcript profiles from the UCSF breast cancer cases revealed three NFκB and AP-1 upregulated genes – cyclin D1, uPA and VEGF – capable of dichotomizing node-negative ER-positive cases into early and late relapsing subsets despite adjuvant tamoxfien therapy and most prognostic for younger age cases. Across the four independent sets of node-negative ER-positive breast cancer cases (UCSF, Rotterdam, Amsterdam, Basel), high expression of all three NFκB and AP-1 upregulated genes was associated with earliest metastatic relapse. CONCLUSION: Altogether, these findings implicate increased NFκB and AP-1 transcriptional responses with tamoxifen resistant breast cancer and early metastatic relapse, especially in younger patients. These findings also suggest that agents capable of preventing NFκB and AP-1 gene activation may prove useful in restoring the endocrine responsiveness of such high-risk ER-positive breast cancers

Credit Rationing with Symmetric Information

Without denying the importance of asymmetric information, this article purports the view that credit rationing may also originate from a lender's inability to classify loan applicants in proper risk categories. This effect is particularly strong when novel technologies are involved. Furthermore, its relevance may increase with the importance assigned to internal rating systems by the Basel accord. This article presents a measure of the inadequacy of a lender's classification criteria to the qualitative features of prospective borrowers. Even without information asymmetries, credit rationing may occur if this quantity reaches too high a value. Furthermore, some general principles are outlined, that may be used by lenders in order to change their classification criteria

The Year book of world affairs 1977./ Editor : George W. Keeton (dan George Schwarzenberger)

vii, 364 hal. ; 25 cm

Oasis: An active storage framework for object storage platform

The network bottleneck incurred by big data process and transfer has increasingly become a severe problem in today's data center and cloud. Exploring and exploiting the advantages of both the scalable object storage architecture and intelligent active storage technology are one of the ways to address this challenge. In this paper, we present the design and performance evaluation of Oasis, an active storage framework for object-based storage platform such as Seagate Kinetic. The basic idea behind Oasis is to leverage the OSD's processing capability to run data intensive applications locally. In contrast with previous work, Oasis has the following advantages. First, Oasis enables users to transparently process the OSD object and supports different processing granularity. Second, Oasis can ensure the integrity of execution code using signature scheme and provide the access control for the code execution in the OSD by enhancing the existing OSD security protocol. Third, Oasis can partition the computation task between host and OSD dynamically according to the OSD workload status. Our work on Oasis can be integrated into Kinetic object storage platform seamlessly. Experimental results on widely-used real world applications demonstrate the performance and efficiency of our system