The geology and geochemistry of volcanic rocks in the Lava Mountains, California: Implications for Miocene development of the Garlock Fault

The Lava Mountains are located in the Mojave Desert, southern California along the Garlock Fault, a major continental strike-slip fault that separates the southwestern Basin and Range to the north from the Mojave block to the south. Chemical similar dacitic lava and pyroclastic flows erupted from the 9-km diameter Western Lava Mountains volcano. Dacites with limited chemical variability reflect interaction of mantle derived basalt with both metabasalt and graywacke of the Mesozoic Rand Schist and Cretaceous Atolia-type granitoids. Geophysical data suggests a low angle contact between these lithologies at a depth of about 20 km. This boundary may have served as a density barrier to rising magma. Magma trapped at this barrier could not ascend until it evolved by fractional crystallization and assimilation to a density less than that of the host rock. This density was achieved as soon as SiO2 evolved to values greater than about 63 wt.%; the resulting magma corresponds to the composition of Lava Mountains dacite. Both geochemistry and stratigraphy were used to develop correlations of volcanic units across the Garlock Fault between the Lava Mountains to the south and the El Paso Mountains to the north of the fault. This work demonstrated a total of 32--40 km movement of the fault since 10.3 Ma, which indicates a displacement rate of 3.1--3.8 mm/yr

The Grizzly, November 7, 1980

Reagan, Anderson Win In Campus Mock Election • Window Replacement To Start Soon • Weekend Crime Continues In New Men\u27s Dormitory • Bookstore Eyes Enlarged Facilities • Honorary Degrees Conferred At Founder\u27s Day • Library To Sponsor Open House • Breakdown For SAC Allocations Explored • Foreign Language Lunches Offered To Students • Another Viewpoint: I Object To War! • Students Do Their Stuff In Talent Show • Springsteen Unveils Interesting New Album • Party Brings Out Spirit On Halloween • Classics Club Underway • Why Carter Lost • UBEC Council Presents Three Faces Of Management • Soccer Finishes Season 7-7-1 • Breaks Carry Ursinus Past Lebanon Valley • Harriers Head Toward MACs • Field Hockey Enters Regional Competitionhttps://digitalcommons.ursinus.edu/grizzlynews/1046/thumbnail.jp

The Grizzly, October 3, 1980

Administration Focuses Attention On Pledging • Ritter Investigation Continues • Strangers Vandalize Beardwood Extinguishers • USGA Sponsors Alcohol Awareness Program • Women Experience the Excitement of Bid Day • College Disciplines Two Fraternities • Prof Appointed in Ec/BA • Photography Course Offered In Evening School • Values Education Examined By Committee • Candidates\u27 Platforms for Campus Elections • Classes of \u2781, \u2783 to Sponsor Gong Show • Album Review: Panorama: New View New Wave • Time Square Is Sheer Inspiration • Rush Returns to Philadelphia After Long Delay • Dingy Room Ideas Vol. II • Field Hockey Ties W&M; Beats Gettysburg • Volleyball Lookin\u27 Good • Awesome Widener Crunches Grizzlies • Sports Profile: Debbie Tweed • Cross Country Streak Alive • Despite 2-0 Loss, Booters Still Showing Promisehttps://digitalcommons.ursinus.edu/grizzlynews/1042/thumbnail.jp

Residential Pesticide Usage in Older Adults Residing in Central California

Information on residential pesticide usage and behaviors that may influence pesticide exposure was collected in three population-based studies of older adults residing in the three Central California counties of Fresno, Kern, and Tulare. We present data from participants in the Study of Use of Products and Exposure Related Behaviors (SUPERB) study (N = 153) and from community controls ascertained in two Parkinson’s disease studies, the Parkinson’s Environment and Gene (PEG) study (N = 359) and The Center for Gene-Environment Studies in Parkinson’s Disease (CGEP; N = 297). All participants were interviewed by telephone to obtain information on recent and lifetime indoor and outdoor residential pesticide use. Interviews ascertained type of product used, frequency of use, and behaviors that may influence exposure to pesticides during and after application. Well over half of all participants reported ever using indoor and outdoor pesticides; yet frequency of pesticide use was relatively low, and appeared to increase slightly with age. Few participants engaged in behaviors to protect themselves or family members and limit exposure to pesticides during and after treatment, such as ventilating and cleaning treated areas, or using protective equipment during application. Our findings on frequency of use over lifetime and exposure related behaviors will inform future efforts to develop population pesticide exposure models and risk assessment

The Grizzly, September 19, 1980

Reagan, Anderson Leading Carter In Campus Poll • Wismer Lunch Off to Optimistic Start • Explosive Bomb Found At NMD • College Van Policy Drastically Revised • Campus Expands With Enrollment • Bad Conditions Haunt New Women\u27s Dorm • Kane Appointed As New Executive Assistant • Ursinus Still Packing Them In • Ursinus News In Brief: Myrin Hosts Davison Exhibit; Davies Promoted In Admissions • TG Annex Almost Complete • Evening School Expands Services • Freshmen Class & USGA Treasurer Elections Coming Soon • Ron Baltz and Jenny Perform • Ritter Center To Open October 4 • For The Musically Inclined • WRUC - On The Air? • Yes A Maybe • Alternatives To Typical Parties • The Rush Is On • Switchboard Under New Operation • Police Rally To Cut Down Thefts • 1978 Alumnus Selected To Receive Award • Freshmen Offer Good Stats And Great Figures • Pre-Medical Evaluation Committee Reorganized • Bomberger Tower Finally To Be Replaced • Booters Sloppy in Close Call Over Drew • Delta Pi, ZX Defend Title; Intramural Football Underway • MAC Title: Cross Country Goal • Lack of Offense Hurts in Loss to Alfred • Hockey Starts Strong at Penn State Tourneyhttps://digitalcommons.ursinus.edu/grizzlynews/1040/thumbnail.jp

Activity pacing: moving beyond taking breaks and slowing down

This brief communication responds to the paper by Jeong and Cho (Qual Life Res 26(4):903–911, 2017) that has described activity pacing in limited terms of adjusting activities through going at a slower rate and taking breaks. Activity pacing was reported as not involving goal setting, in comparison to other strategies for long-term conditions such as Acceptance and Commitment Therapy. This brief communication aims to challenge this limited perception of activity pacing in light of numerous studies that recognise pacing to be a more complex strategy. Pacing is considered to be a multifaceted coping strategy, including broad themes of not only adjusting activities, but also planning activities, having consistent activity levels, acceptance of current abilities and gradually increasing activities, and one that includes goal setting as a key facet. It is essential that pacing is both defined and measured as a multifaceted strategy in order to assess the outcomes of pacing, and for meaningful comparisons with other strategies regarding efficacy for the management of long-term conditions

Tumor mutational burden and PTEN alterations as molecular correlates of response to PD-1/L1 blockade in metastatic triple-negative breast cancer

Purpose: Few patients with metastatic triple-negative breast cancer (mTNBC) benefit from immune checkpoint inhibitors (ICI). On the basis of immunotherapy response correlates in other cancers, we evaluated whether high tumor mutational burden (TMB) ≥10 nonsynonymous mutations/megabase and PTEN alterations, defined as nonsynonymous mutations or 1 or 2 copy deletions, were associated with clinical benefit to anti-PD-1/L1 therapy in mTNBC. Experimental design: We identified patients with mTNBC, who consented to targeted DNA sequencing and were treated with ICIs on clinical trials between April 2014 and January 2019 at Dana-Farber Cancer Institute (Boston, MA). Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were correlated with tumor genomic features. Results: Sixty-two women received anti-PD-1/L1 inhibitors alone (23%) or combined with targeted therapy (19%) or chemotherapy (58%). High TMB (18%) was associated with significantly longer PFS (12.5 vs. 3.7 months; P = 0.04), while PTEN alterations (29%) were associated with significantly lower ORR (6% vs. 48%; P = 0.01), shorter PFS (2.3 vs. 6.1 months; P = 0.01), and shorter OS (9.7 vs. 20.5 months; P = 0.02). Multivariate analyses confirmed that these associations were independent of performance status, prior lines of therapy, therapy regimen, and visceral metastases. The survival associations were additionally independent of PD-L1 in patients with known PD-L1 and were not found in mTNBC cohorts treated with chemotherapy (n = 90) and non-ICI regimens (n = 169). Conclusions: Among patients with mTNBC treated with anti-PD-1/L1 therapies, high TMB and PTEN alterations were associated with longer and shorter survival, respectively. These observations warrant validation in larger datasets

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

'The best thing for the baby': mothers' concepts and experiences related to promoting their infants' health and development

Mothers and pregnant women in contemporary western societies are at the centre of a web of expert and lay discourses concerning the ways they should promote and protect the health and development of their foetuses and infants. This article reports the findings from an Australian study involving interviews with 60 mothers. The findings explore in detail four topics discussed in the interviews related to pregnancy and caring for young infants: disciplining the pregnant body; promoting infants’ health; immunisation; and promoting infants’ development. It is concluded that the mothers were highly aware of their responsibilities in protecting their foetuses and infants from harm and promoting their health and development. They conceptualised the infant body as highly vulnerable and requiring protection from contamination. They therefore generally supported the idea of vaccination as a way of protecting their babies’ immature immune systems, but were also often ambivalent about it. The mothers were aware of the judgemental attitudes of others, including other mothers, towards their caring efforts and attempted to conform to the ideal of the ‘good mother’. The emotional dimensions of caring for infants and protecting their health are discussed in relation to the voluntary participation of mothers in conforming to societal expectations