A Multimodal Approach to Analgesia in Anorectal Surgery

Аim: Evaluation of methods for pain prevention and pain reduction after anorectal surgery at all stages of treatment based on publications found in available databases.Key points. Most anorectal diseases are benign and do not affect life expectancy, meanwhile about 40 % of the population suffer from it. Mainly anorectal disorders affect middle-aged people reducing their life quality. At the same time many articles aimed at studying only postoperative anesthesia. 2 researchers independently searched for articles published in Medline, Scopus, Cochrane, Web of Science, E-library databases using keywords. A total of 54 publications were included. A multimodal approach should include the pain prevention during pre-, intra- and postoperative periods. Acetaminophen is recommended for pain reduction according to the dosing protocols. Acetaminophen combined with other systemic analgesics is advisable for patients with severe pain. The opioids use is justified only for moderate-severe postoperative pain. Metronidazole and lidocaine with nitroglycerin ointment/ nifedipine/сorticosteroids effectiveness has been proven for local postoperative anesthesia. Prophylactic use of antibiotics and bowel preparation do not reduce postoperative pain. Stool softeners are recommended for reducing postoperative pain severity. Additional local anesthesia such as nerve blockade or infiltration anesthesia is recommended for all patients. Modern minimally invasive treatment methods of hemorrhoid are associated with less severe postoperative pain.Conclusion. The recommended scheme of multimodal anesthesia for patients after anorectal surgery is shown on Fig.1. Further studies are needed to evaluate preoperative anesthesia effectiveness, the feasibility of the perioperative flavonoids use, as well as comparisons of various minimally invasive treatment methods of anorectal diseases

Monitoring of tritium purity during long-term circulation in the KATRIN test experiment LOOPINO using laser Raman spectroscopy

The gas circulation loop LOOPINO has been set up and commissioned at Tritium Laboratory Karlsruhe (TLK) to perform Raman measurements of circulating tritium mixtures under conditions similar to the inner loop system of the neutrino-mass experiment KATRIN, which is currently under construction. A custom-made interface is used to connect the tritium containing measurement cell, located inside a glove box, with the Raman setup standing on the outside. A tritium sample (purity > 95%, 20 kPa total pressure) was circulated in LOOPINO for more than three weeks with a total throughput of 770 g of tritium. Compositional changes in the sample and the formation of tritiated and deuterated methanes CT_(4-n)X_n (X=H,D; n=0,1) were observed. Both effects are caused by hydrogen isotope exchange reactions and gas-wall interactions, due to tritium {\beta} decay. A precision of 0.1% was achieved for the monitoring of the T_2 Q_1-branch, which fulfills the requirements for the KATRIN experiment and demonstrates the feasibility of high-precision Raman measurements with tritium inside a glove box

Probing the Effect of Cadence on the Estimates of Photospheric Energy and Helicity Injections in Eruptive Active Region NOAA AR 11158

We study how the input-data cadence affects the photospheric energy and helicity injection estimates in eruptive NOAA Active Region 11158. We sample the novel 2.25-minute vector magnetogram and Dopplergram data from the Helioseismic and Magnetic Imager (HMI) instrument onboard the Solar Dynamics Observatory (SDO) spacecraft to create input datasets of variable cadences ranging from 2.25 minutes to 24 hours. We employ state-of-the-art data processing, velocity, and electric-field inversion methods for deriving estimates of the energy and helicity injections from these datasets. We find that the electric-field inversion methods that reproduce the observed magnetic-field evolution through the use of Faraday's law are more stable against variable cadence: the PDFI (PTD-Doppler-FLCT-Ideal, where PTD refers to Poloidal-Toroidal Decomposition, and FLCT to Fourier Local Correlation Tracking) electric-field inversion method produces consistent injection estimates for cadences from 2.25 minutes up to two hours, implying that the photospheric processes acting on time scales below two hours contribute little to the injections, or that they are below the sensitivity of the input data and the PDFI method. On other hand, the electric-field estimate derived from the output of DAVE4VM (Differential Affine Velocity Estimator for Vector Magnetograms), which does not fulfill Faraday's law exactly, produces significant variations in the energy and helicity injection estimates in the 2.25 minutes - two hours cadence range. We also present a third, novel DAVE4VM-based electric-field estimate, which corrects the poor inductivity of the raw DAVE4VM estimate. This method is less sensitive to the changes of cadence, but it still faces significant issues for the lowest of considered cadences (two hours). We find several potential problems in both PDFI- and DAVE4VM-based injection estimates and conclude that the quality of both should be surveyed further in controlled environments.Peer reviewe

Data-driven, time-dependent modeling of pre-eruptive coronal magnetic field configuration at the periphery of NOAA AR 11726

Context. Data-driven, time-dependent magnetofrictional modeling has proved to be an efficient tool for studying the pre-eruptive build-up of energy for solar eruptions, and sometimes even the ejection of coronal flux ropes during eruptions. However, previous modeling works have illustrated the sensitivity of the results on the data-driven boundary condition, as well as the difficulty in modeling the ejections with proper time scales. Aims. We aim to study the pre- and post-eruptive evolution of a weak coronal mass ejection producing eruption at the periphery of isolated NOAA active region (AR) 11726 using a data-driven, time-dependent magnetofrictional simulation, and aim to illustrate the strengths and weaknesses of our simulation approach. Methods. We used state-of-the-art data processing and electric field inversion methods to provide the data-driven boundary condition for the simulation. We analyzed the field-line evolution, magnetic connectivity, twist, as well as the energy and helicity budgets in the simulation to study the pre- and post-eruptive magnetic field evolution of the observed eruption from AR11726. Results. We find the simulation to produce a pre-eruptive flux rope system consistent with several features in the extreme ultraviolet and X-ray observations of the eruption, but the simulation largely fails to reproduce the ejection of the flux rope. We find the flux rope formation to be likely driven by the photospheric vorticity at one of the footpoints, although reconnection at a coronal null-point may also feed poloidal flux to the flux rope. The accurate determination of the non-inductive (curl-free) component of the photospheric electric field boundary condition is found to be essential for producing the flux rope in the simulation. Conclusions. Our results illustrate the applicability of the data-driven, time-dependent magnetofrictional simulations in modeling the pre-eruptive evolution and formation process of a flux rope system, but they indicate that the modeling output becomes problematic for the post-eruptive times. For the studied event, the flux rope also constituted only a small part of the related active region.Peer reviewe

Развитие и состояние микроэлектромеханических систем

В роботі проведений аналіз стану та розвитку мікроелектромеханічних систем (МЕМС), розглянуті технологічні процеси їх виготовлення та програмне забезпечення комп’ютерного моделювання МЕМС. Розглянуто існуючі мікропристрої, прилади та системи вимірювання параметрів руху, зокрема, прискорення, а також прилади орієнтації та навігації.In this paper the analysis of a condition and development of microelectromechanical systems (MEMS) is lead, technological processes of their manufacturing and the software of computer modulation MEMS are considered. Existing micro devices and systems of measurement of parameters of movement, in particular, acceleration, and also devices of orientation and navigation are considered.В работе проведен анализ состояния и развития микроэлектромеханических систем (МЕМС), рассмотрены технологические процессы их изготовления и программное обеспечение компьютерного модулирования МЕМС. Рассмотрены существующие микроустройства, приборы и системы измерения параметров движения, в частности, ускорения, а также приборы ориентации и навигации

Improved Upper Limit on the Neutrino Mass from a Direct Kinematic Method by KATRIN.

We report on the neutrino mass measurement result from the first four-week science run of the Karlsruhe Tritium Neutrino experiment KATRIN in spring 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are energy analyzed by a high-resolution MAC-E filter. A fit of the integrated electron spectrum over a narrow interval around the kinematic end point at 18.57 keV gives an effective neutrino mass square value of (-1.0_{-1.1}^{+0.9})  eV^{2}. From this, we derive an upper limit of 1.1 eV (90% confidence level) on the absolute mass scale of neutrinos. This value coincides with the KATRIN sensitivity. It improves upon previous mass limits from kinematic measurements by almost a factor of 2 and provides model-independent input to cosmological studies of structure formation

Resonant Absorption of Axisymmetric Modes in Twisted Magnetic Flux Tubes

It has been shown recently that magnetic twist and axisymmetric MHD modes are ubiquitous in the solar atmosphere, and therefore the study of resonant absorption for these modes has become a pressing issue because it can have important consequences for heating magnetic flux tubes in the solar atmosphere and the observed damping. In this investigation, for the first time, we calculate the damping rate for axisymmetric MHD waves in weakly twisted magnetic flux tubes. Our aim is to investigate the impact of resonant damping of these modes for solar atmospheric conditions. This analytical study is based on an idealized configuration of a straight magnetic flux tube with a weak magnetic twist inside as well as outside the tube. By implementing the conservation laws derived by Sakurai et al. and the analytic solutions for weakly twisted flux tubes obtained recently by Giagkiozis et al. we derive a dispersion relation for resonantly damped axisymmetric modes in the spectrum of the Alfvén continuum. We also obtain an insightful analytical expression for the damping rate in the long wavelength limit. Furthermore, it is shown that both the longitudinal magnetic field and the density, which are allowed to vary continuously in the inhomogeneous layer, have a significant impact on the damping time. Given the conditions in the solar atmosphere, resonantly damped axisymmetric modes are highly likely to be ubiquitous and play an important role in energy dissipation. We also suggest that, given the character of these waves, it is likely that they have already been observed in the guise of Alfvén waves