How to avoid from an ectropion complication by using motor innervation prevention at lower eyelid blepharoplasty surgery

The subciliary incision is the most commonly used approach for lower eyelid blepharoplasty because of the advantages like ease of combining with other periocular and midface rejuvenation techniques. However, the most common reported major complication is lower lid malposition. In this article we described our subciliary dissection technique to protect the motor branches of tarsal orbicularis oculi to avoid from ectropion

Lms Selection Process For Effective Distance Education System In Organizations

 Towards the end of the 20th century, especially development of science and technology brought some innovation to some conceptual area such as education. In society, to build a quality and civilized life, education emerges as a one of the most important actors. Unfortunately, the rights in education of the every person in society may be delayed due to financial problems, physical disabilities, time pressure, geographical distances or any other reasons. Distance learning is a one of the method that provides education for people by eliminating these disadvantages. Since end of the 19th century, distance education has been provided with some methods such as TV, radio, mail and etc. Especially, in the beginning of 21th century; internet is widely used by everybody. New technological environment has brought a new opportunity for distance education. Learning Management System (LMS) is the most important actor of the internet based distance learning that brings together educators and students for training. LMS allows to deliver materials, having assignment and quizzes and other educational activities. Whether educational institutions or organizations that are emphasis on the training of employees can use LMS platform. Every organization has to decide which LMS is suitable for them. Decision makers face to solve this kind of problems because every LMS has different characteristics and different learning process. This study is focused on choosing suitable LMS for organizations by using AHP methods. Two groups of LMS, open source software’s (Moodle and Sakai) and commercial software’s (BlackBoard and Sharepoint LMS), are compared by using selecting criteria’s. These criteria’s are license costs, flexibility, security, user interface and prevalence of use. In the decision process, different weight ratios are used depending on their priority. The findings of this AHP Process are discussed. Keywords: Distance Learning, LMS, AHP, Decision Making Proces

The effect of phosphorus application on mineral elements concentration of lettuce and onion plants

Marul (Lactuca sativa L.) ve soğan (Allium cepa L.) bitkilerinin gelişimi ve mineral element alımına fosfor (P) uygulamasının etkisini araştırmak üzere Triple süper fosfat (TSP, %42 P2O5) gübresinden 0, 50, 100, 200, 400 mg kg-1 P uygulanmıştır. Marul bitkisinde en yüksek kuru ağırlığa 50 mg kg-1 P düzeyinde ulaşılırken, soğan bitkisinde 200 mg kg-1 P düzeyinde ulaşılmıştır. Artan miktarda uygulanan fosfor ile marul bitkisinin P, Br, Rb konsantrasyonlarının arttığı, Ca, S, Fe, Zn, Mn, Ti, Sr ve Ba konsantrasyonlarının azaldığı belirlenmiştir. Fosfor uygulamasına bağlı olarak bitkilerin Si ve Ni konsantrasyonlarında önemli bir değişim olmamıştır. Artan düzeyde uygulanan fosfora bağlı olarak soğan bitkisinin P, As, Rb, Ba konsantrasyonları artarken Cu, Ti ve Co konsantrasyonları azalmıştır. Fosfor uygulaması, soğan bitkisinin K ve S konsantrasyonunu artırmıştır. Marul bitkisinin K konsantrasyonuna etkisi istatistik olarak önemsiz olurken yüksek P düzeyleri S konsantrasyonunu azaltmıştır. Her iki bitkinin Fe konsantrasyonu P uygulamasına bağlı olarak azalmıştır. En yüksek Br konsantrasyonu her iki bitkide de 400 mg kg-1 P uygulamasında belirlenmiştir. Artan düzeyde uygulanan fosfor ile bitkilerin özellikle bitkiler için mutlak gerekli olmayan mineral konsantrasyonlarının arttığı bu artışın çevre kirliliğinin yanı sıra insan sağlığını olumsuz etkileyebileceği için aşırı fosforlu gübre kullanımından kaçınılması gerektiği sonucuna ulaşılmıştır.In this experiment, effect of phosphorus applications at the levels of 0, 50, 100, 200, 400 mg P kg-1 (as triplesuperphosphate, 42% P2O5) on the growth and mineral composition of lettuce (Lactuca sativa L.) and onion (Allium cepa L.) plants were studied. The highest dry weight of lettuce and onion were found at 50 mg P kg-1 and 200 mg P kg-1 , respectively. Lettuce plant P, Br, Rb concentrations increased and Ca, S, Fe, Zn, Mn, Ti, Sr and Ba concentrations decreased with increasing amounts of phosphorus application and also there is no significant difference on Si and Ni concentrations. On the other hand, the concentration of P, As, Rb and Ba were increased and Cu, Ti and Co decreased by increasing P application in onion plants. Phosphorus application significantly increased K and S concentations of onion. There is no difference on K concentration of lettuce. Sulphur concentration of lettuce was decreased by increasing P levels. Iron concentration of both plants were lower in P applied plants. The highest Br concentration of both plants were determined at the level of 400 mg P kg-1 application. In conclusion, non-essential element concentrations enhanced with increasing application of P. This may cause environmental pollution and also affect human health unfavourably. Hence, it was concluded to avoid excessive P fertilizer using

Recurrent hydatidiform moles: detection of a new mutation in the NLRP7 gene in the family

Hydatidiform moles are the most common type of gestational trophoblastic neoplasia. Hyperproliferative vesicular trophoblasts and imperfect fetal development are abnormal pregnancies, and recurrent hydatidiform moles are rare. Mutations in NLRP7 are responsible for recurrent hydatidiform mole. Genetic heterogeneity has been demonstrated in patients with the NLRP7 mutation. This study presents our case with gravida 11, parity 0, histopathologically diagnosed with six hydatidiform moles and five missed abortion histories at age 35. Karyotype analyses of the unrelated couple were normal. A genetic examination revealed a novel mutation of the NLRP7 gene in the patient, his brother, and his parents. Detecting a new NLRP7 mutation in recurrent hydatidiform moles cases provides further evidence for the predetermined role of NLRP7 mutations in the pathophysiology of recurrent moles hydatidiform. Based on our findings, we hope to contribute to the literature by expanding the spectrum of recurrent pregnancy loss associated with NLRP7 mutations in patients

The effect of inflammatory markers on the CORADS degree and the effects of treatments on RT-PCR test results in COVID-19

Objective: There is still no diagnosis method with high sensitivity and specificity for COVID-19. Patient complaints, real-time reverse transcription-polymerase chain reaction (RT-PCR), inflammatory markers, clinical prognosis, and the degree of involvement in the chest CT, if necessary are evaluated in an effort to make a diagnosis. Delays in diagnosis have led to a rapid spread of the disease. This study aims to evaluate the effectiveness of the inflammatory markers and to determine the follow-up process of the patients by assessing the impact of the treatments administered on RT-PCR test results. Material and methods: Files of 150 patients monitored in the wards with suspected COVID-19 are analyzed retrospectively. Patients were selected among those who underwent laboratory tests, RT-PCR testing and Thoracic CT within the first 24 hours of admission. Patients were divided into 5 groups based on the severity of involvement in Thoracic CT. Inflammatory markers were compared among the groups. Impact of the administered treatments on follow-up RT-PCR test results was evaluated. Results: Studied inflammatory markers were in normal ranges and similar across all CORADS groups. Only the C-Reactive Protein (CRP) and Ferritin levels were showing an increase in accordance with CORADS severity. Mean time to testing negative on RT-PCR was 10 days across all treatment groups. Times to testing negative among patients receiving other treatments were similar. Conclusion: Among the inflammatory markers, CRP and Ferritin values are correlated with CORADS severity. Administered COVID-19 treatments have similar impact on RT-PCR test results

Influence of the gut microbiome on IgE and non-IgE-mediated food allergies

Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- MAY 26-30, 2018 -- Munich, GERMANYWOS: 000441690400204Background: The prevalence of food allergy (FA) in children has been increasing in last decade. Recent studies show changes in gut microbiome with FA. However, whether gut microbiome may differ between IgE and non‐IgE‐mediated FA is not defined. The aim of this study is to examine the intestinal microbiome composition in infants with IgE and non‐IgE‐mediated FA and healthy infants. Method: Infants younger than 1‐year‐old, breastfed and diagnosed with FA by a physician were included in the study. DNA was isolated from stool samples of infants with non‐IgE‐mediated FA (n = 25) and IgE‐mediated FA (n = 11) and healthy infants (n = 7). Whole genome shotgun sequencing was applied to identify the composition of microbial DNA (an average depth of 3.1 ± 0.8 million paired end reads and 0.9 ± 0.2 gigabase pairs). Results: There were compositional differences among 3 different groups. Shannon index was significantly higher in IgE‐mediated FA compared to non‐IgE‐mediated FA group (Kruskal‐Wallis test, P = 0.034). Even though β‐diversity was similar, the Sparse Partial Least Square Discriminant Analysis (sPLS‐DA) demonstrated that there were taxa‐level differences among three groups. In species level, Veillonella parvula was in a significantly higher density in healthy infants compared to IgE and non‐IgE‐mediated FA groups. Rahnella aquatilis and Lactobacillus salivarius were significantly lower and Treponema succinifaciens significantly higher in IgE‐mediated FA group compared to other groups. Additionally, Prevotella sp. oral taxon 299 was significantly lower in non‐IgE‐mediated FA group compared to others. Prevotella sp oral taxon 299 was related to mucus in stool whereas urticaria related species were Olsenall uli, Bactreoides thetaiotaomicron, Klebsiella variiocola, Rahnella aquatilis, Treponema succinfaciens, Ethanoligenens harbinenese. Conclusion: Analysis of microbiome differences in FA patients may aid in the understanding of the disease process. The present data suggest that there are compositional variations mostly in species‐ level among infants with FA and healthy ones. Our results suggest that the gut microbiome has a stronger relationship to IgE‐mediated than non‐IgE‐mediated FA. Further functional analysis of the microbiome may help better understand the changes seen in the gut microbiome in FAs and improve our knowledge in the disease etiopathology.European Academy of Allergy and Clinical Immunolog

Eyelid tumors in dogs: 47 cases retrospective study (2006-2017)

Çalışmada 2006-2017 yılları arasında İstanbul Üniversitesi Veteriner Fakültesi Cerrahi Anabilim Dalı Kliniği’ne göz kapağında kitle şikayeti ile getirilen ve sağaltımları yapılan toplam 47 köpeğe ait göz kapağı tümörleri olguları retrospektif olarak değerlendirildi. Olguların ayrıntılı göz muayenesi yapıldı. Kitlelerin uzaklaştırılmasında V şeklinde eksizyon yeğlenerek, tümör tam katlı olarak bölgeden uzaklaştırıldı. Yapılan histopatolojik inceleme sonucu, meibomian bezlerden köken alan neoplazmaların çoğunlukta olduğu belirlendi. Çalışma sonunda elde edilen veriler ile göz kapağı tümörü oluşumunda ırk predispozisyonu, yaşın ve cinsiyetin etkisi ile en yaygın görülen göz kapağı tümörü belirlenip, kullanılan cerrahi yöntemin rekonstruktif blefaroplastiye gerek kalmadan, kitlelerin uzaklaştırılmasında yeterli olduğu görüldü.In this study, the eyelid tumors and the treatment results of 47 dogs referred to Istanbul University Faculty of Veterinary Medicine Department of Surgery with a complaint of eyelid masses were evaluated retrospectively. Cases underwent detailed ophtalmic examination. A V-shaped excision was performed and the tumor was removed in full-thickness. Histopathological examination revealed that most of the neoplasms originating from the meibomian glands were observed. The most common eyelid tumors and formation of the eyelid tumors with respect to the race predisposition, and effects of age and sex were defined. The surgical method used were sufficient for removal of the masses without the necessity of a reconstructive blepharoplasty

First-Line Molecular Genetic Evaluation of Autosomal Recessive Non-Syndromic Hearing Loss

Objective:The aim of this study is to investigate the efficiency of a first-line molecular genetic evaluation approach, in children with deafness.Methods:Patients who were found to have sensorineural hearing loss by age-appropriate audiological tests were selected for the molecular genetic evaluation. The molecular genetic evaluation was carried out with GJB2 gene sequence analysis and mtDNA m.1555A>G mutation Restriction Fragment Length Polymorphism (RFLP) analysis. Additionally, in a small group of patients, hearing loss Multiplex Ligation-dependent Probe Amplification (MLPA) analysis was done out to identify the possible role of copy number changes.Results:In this Turkish cohort, which included 104 index patients and 78 relatives, 33 (31.7%) had Pathogenic/Likely Pathogenic variants. One or more GJB2 sequence variants were identified in 46 (44.1%) of the 104 index patients. The homozygous c.35delG mutation by itself explained the etiology in 24% of our ARSNHL group. In one (5%) of the 20 patients of MLPA group, a hemizygous deletion in POU3F4 gene was detected.Conclusion:In our Turkish cohort, we applied a first-line molecular genetic evaluation approach using GJB2 gene sequence analysis and mtDNA m.1555A>G RFLP analysis. This approach revealed the genetic etiology of 44.1% of our index patients. Additionaly, the results of hearing loss MLPA analysis revealed the limited role of copy number changes in this patient group. Furthermore, with a detailed genotype-phenotype association workup, 2 rare cases of Deafness with Palmoplantar Hyperkeratosis and Keratitis-Ichthyosis-Deafness syndrome were reported

Zwiększenie grubości nasierdziowej tkanki tłuszczowej u pacjentów z łojotokowym zapaleniem skóry jako biomarker kliniczny ryzyka sercowo-metabolicznego

Seborrheic dermatitis (SD) can be associated with cardiometabolic conditions. This study aimed to evaluate epicardial fat thickness (EFT), a marker of cardiometabolic disease, in SD patients. Material and methods. In this cross-sectional and observational study, 90 patients with SD and 50 age- and sex-matched control subjects were evaluated for echocardiographic EFT and metabolic profile data. Results. Systolic blood pressure, heart rate, high sensitive C-reactive protein, monocyte count and EFT were found to be significantly higher in the SD group (53 female; mean age, 39.3±13.3 years) compared to the control group (34 female; mean age, 39.9±13.4 years). In the multivariate logistic regression analysis, the EFT and heart rate were found to be independently associated with SD. Additionally, in the multivariate linear regression analysis including the parameters correlated with EFT and the parameters associated with EFT at the p<0.001 level in univariate analysis; BMI (β: 0.341, p<0.001) and SD disease duration (β: 0.435, p<0.001), as well as seborrheic dermatitis area and severity index (β: 0.177, p=0.037) were found to be independently associated with EFT. Conclusions. EFT is increased in patients with SD and was also found to be independently associated with SD. Prolonged and severe SD may be a dermatological sign regarding cardiometabolic disease.Łojotokowe zapalenie skóry (SD) może wiązać się z chorobami kardiometabolicznymi. Niniejsze badanie miało na celu ocenę grubości nasierdziowej tkanki tłuszczowej (EFT), markera chorób kardiometabolicznych, u pacjentów z SD. Materiały i metody. W niniejszym badaniu przekrojowym i obserwacyjnym 90 pacjentów z SD i 50 osób z grupy kontrolnej dobranych pod względem wieku i płci oceniano pod kątem echokardiograficznej EFT i danych dotyczących profilu metabolicznego. Wyniki. Stwierdzono, że skurczowe ciśnienie krwi, częstość akcji serca, wysokoczułe białko C-reaktywne, liczba monocytów i EFT były znacząco wyższe w grupie SD (53 kobiety; średni wiek, 39,3±13,3 lat) w porównaniu z grupą kontrolną (34 kobiety; średni wiek, 39,9±13,4 lat). W wieloczynnikowej analizie regresji logistycznej stwierdzono, że EFT i częstość akcji serca były niezależnie powiązane z SD. Dodatkowo, w wieloczynnikowej analizie regresji liniowej obejmującej parametry skorelowane z EFT i parametry związane z EFT przy p<0,001 w analizie jednoczynnikowej; BMI (β: 0,341, p<0,001) i czasu trwania choroby SD (β: 0,435, p<0,001), a także wskaźnik powierzchni i nasilenia łojotokowego zapalenia skóry (β: 0,177, p=0,037) okazały się być niezależnie związane z EFT. Wnioski. EFT jest zwiększona u pacjentów z SD i stwierdzono, że jest niezależnie powiązana z SD. Długotrwałe i ciężkie SD może stanowić objaw dermatologiczny choroby kardiometabolicznej