Study of a colliding laser-produced plasma by analysis of time and space-resolved image spectra

The interaction of two counter-propagating laser-produced plasmas was studied using simultaneous imaging and spectroscopic techniques. Spectrally-filtered time-gated ICCD imaging was used to obtain information about the spatial dynamics and temporal evolution of the collision process. While, time-resolved imaging spectroscopy was used to determine the spatial and temporal distributions of electron temperature and density within the interaction region. We examine specifically the interaction of plasmas whose parameters match those typically used in pulsed laser deposition of thin films. These low temperature plasmas are highly collisional leading to the creation of a pronounced stagnation layer in the interaction region

Unsung heroes: Constituency election agents in British general elections

Despite their central role in the electoral process, constituency agents have been largely overlooked by political scientists and this article seeks to rectify the omission. It sketches the origins and development of the role of agent from the late 19th century and suggests that a serious rethink of the role took place in the 1990s. Survey-based evidence about the social characteristics of agents is presented confirming that they are largely middle-aged, middle-class, well-educated men. They are also becoming more experienced, offer realistic assessments of the impact of constituency campaigning and, arguably, many take a long-term view of how their party's support can be maximised

Dynamic Magnetic Resonance Imaging Demonstrates the Integrity of Perineal Reconstruction following Cylindrical Abdominoperineal Excision with Reconstruction of the Pelvic Floor Using Porcine Collagen

A 72-year-old female presented with a six-month history of increased frequency of defecation, rectal bleeding, and severe rectal pain. Digital rectal examination and endoscopy revealed a low rectal lesion lying anteriorly. This was confirmed histologically as adenocarcinoma. Radiological staging was consistent with a T3N2 rectal tumour. Following long-course chemoradiotherapy repeat staging did not identify any metastatic disease. She underwent a laparoscopic cylindrical abdominoperineal excision with en bloc resection of the coccyx and posterior wall of the vagina with a negative circumferential resection margin. The perineal defect was reconstructed with Permacol (biological implant, Covidien) mesh. She had no clinical evidence of a perineal hernia at serial followup. Dynamic MRI images of the pelvic floor obtained during valsalva at 10 months revealed an intact pelvic floor. A control case that had undergone a conventional abdominoperineal excision with primary perineal closure without clinical evidence of herniation was also imaged. This confirmed subclinical perineal herniation with significant downward migration of the bowel and bladder below the pubococcygeal line. We eagerly await further evidence supporting a role for dynamic MR imaging in assessing the integrity of a reconstructed pelvic floor following cylindrical abdominoperineal excision

Radical political unionism reassessed

Defections from European social-democratic parties and a resurgence of union militancy have prompted some to diagnose a new left-wing trade unionism across Europe. This comment on the article by Connolly and Darlington scrutinizes trends in France and Germany but primarily analyses recent developments in Britain. While there are some instances of disaffiliation from the Labour Party, support for electoral alternatives, growth in political militancy and emphasis on new forms of internationalism, these have been limited. There is insufficient evidence to suggest that we are witnessing the making of a new radical collectivism

Constraining ^(26)Al+p resonances using ^(26)Al(^3He,d)^(27)Si

The ^(26)Al(^3He,d)^(27)Si reaction was measured from 0°≤θ_(c.m.)≤35° at E(^3He)=20 MeV using a quadrupole-dipole-dipole-dipole magnetic spectrometer. States in ^(27)Si were observed above the background at 7652 and 7741 keV and upper limits were set for the state at 7592 keV. Implications for the ^(26)Al(p,γ)^(27)Si stellar reaction rate are discussed

The population of X-ray supernova remnants in the Large Magellanic Cloud

We present a comprehensive X-ray study of the population of supernova remnants (SNRs) in the LMC. Using primarily XMM-Newton, we conduct a systematic spectral analysis of LMC SNRs to gain new insights on their evolution and the interplay with their host galaxy. We combined all the archival XMM observations of the LMC with those of our Very Large Programme survey. We produced X-ray images and spectra of 51 SNRs, out of a list of 59. Using a careful modelling of the background, we consistently analysed all the X-ray spectra and measure temperatures, luminosities, and chemical compositions. We investigated the spatial distribution of SNRs in the LMC and the connection with their environment, characterised by various SFHs. We tentatively typed all LMC SNRs to constrain the ratio of core-collapse to type Ia SN rates in the LMC. We compared the X-ray-derived column densities to HI maps to probe the three-dimensional structure of the LMC. This work provides the first homogeneous catalogue of X-ray spectral properties of LMC SNRs. It offers a complete census of LMC SNRs exhibiting Fe K lines (13% of the sample), or revealing contribution from hot SN ejecta (39%). Abundances in the LMC ISM are found to be 0.2-0.5 solar, with a lower [$\alpha$/Fe] than in the Milky Way. The ratio of CC/type Ia SN in the LMC is $N_{\mathrm{CC}}/N_{\mathrm{Ia}} = 1.35(_{-0.24}^{+0.11})$, lower than in local SN surveys and galaxy clusters. Comparison of X-ray luminosity functions of SNRs in Local Group galaxies reveals an intriguing excess of bright objects in the LMC. We confirm that 30 Doradus and the LMC Bar are offset from the main disc of the LMC, to the far and near sides, respectively. (abridged)Comment: Accepted for publication in Astronomy and Astrophysics. 54 pages, 18 figures, 12 tables. The resolution of the figures has been reduced compared to the journal version; v2: New title, minor text edits; v3: Correct version

In vitro monoamine oxidase inhibition potential of alpha-methyltryptamine analog new psychoactive substances for assessing possible toxic risks

Tryptamines have emerged as new psychoactive substances (NPS), which are distributed and consumed recreationally without preclinical studies or safety tests. Within the alpha-methylated tryptamines, some of the psychoactive effects of the prototypical alpha-methyltryptamine (AMT) have been described decades ago and a contributing factor of its acute toxicity appears to involve the inhibition of monoamine oxidase (MAO). However, detailed information about analogs is scarce. Therefore, thirteen AMT analogs were investigated for their potential to inhibit MAO. An in vitro assay analyzed using hydrophilic interaction liquid chromatography–high resolution-tandem mass spectrometry was developed and validated. The AMT analogs were incubated with recombinant human MAO-A or B and kynuramine, a non-selective MAO substrate to determine the IC50 values. The known MAO-A inhibitors 5-(2-aminopropyl)indole (5-IT), harmine, harmaline, yohimbine, and the MAO-B inhibitor selegiline were tested for comparison. AMT and all analogs showed MAO-A inhibition properties with IC50 values between 0.049 and 166 μM, whereas four analogs inhibited also MAO-B with IC50 values between 82 and 376 μM. 7-Me-AMT provided the lowest IC50 value against MAO-A comparable to harmine and harmaline and was identified as a competitive MAO-A inhibitor. Furthermore, AMT, 7-Me-AMT, and nine further analogs inhibited MAO activity in human hepatic S9 fraction used as model for the human liver which expresses both isoforms. The obtained results suggested that MAO inhibition induced by alpha-methylated tryptamines might be clinically relevant concerning possible serotonergic and adrenergic effects and interactions with drugs (of abuse) particularly acting as monoamine reuptake inhibitors. However, as in vitro assays have only limited conclusiveness, further studies are needed

Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland

In Scotland, a national HPV immunisation programme began in 2008 for 12-13 year olds, with a catch-up campaign from 2008-2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established.  We analysed colposcopy data from a cohort of women born between 1988-1992 who entered the Scottish Cervical Screening Programme (SCSP) and were aged 20-21 in 2008-2012.  By linking datasets from the SCSP and colposcopy services, we observed a significant reduction in diagnoses of cervical intraepithelial neoplasia 1 (CIN 1) (RR 0.71, 95% CI 0.58 to 0.87, p=0.0008), CIN 2 (RR 0.5, 95% CI 0.4, 0.63, p<0.0001) and CIN 3 (RR 0.45, 95% CI 0.35 to 0.58, p< 0.0001) for women who received 3 doses of vaccine compared with unvaccinated women.  To our knowledge, this is one of the first studies to show a reduction of low and high grade cervical intraepithelial neoplasia associated with high uptake of the HPV bivalent vaccine at the population level. These data are very encouraging for countries that have achieved high HPV vaccine uptake

Low-lying continuum structures in B8 and Li8 in a microscopic model

We search for low-lying resonances in the B8 and Li8 nuclei using a microscopic cluster model and a variational scattering method, which is analytically continued to complex energies. After fine-tuning the nucleon-nucleon interaction to get the known 1+ state of B8 at the right energy, we reproduce the known spectra of the studied nuclei. In addition, our model predicts a 1+ state at 1.3 MeV in B8, relative to the Be7+p threshold, whose corresponding pair is situated right at the Li7+n threshold in Li8. Lacking any experimental evidence for the existence of such states, it is presently uncertain whether these structures really exist or they are spurious resonances in our model. We demonstrate that the predicted state in B8, if it exists, would have important consequences for the understanding of the astrophysically important Be7(p,gamma)B8 reaction.Comment: 6 pages with 1 figure. The postscript file and more information are available at http://nova.elte.hu/~csot

Measurement of E2 Transitions in the Coulomb Dissociation of 8B

In an effort to understand the implications of Coulomb dissociation experiments for the determination of the 7Be(p,gamma)8B reaction rate, longitudinal momentum distributions of 7Be fragments produced in the Coulomb dissociation of 44 and 81 MeV/nucleon 8B beams on a Pb target were measured. These distributions are characterized by asymmetries interpreted as the result of interference between E1 and E2 transition amplitudes in the Coulomb breakup. At the lower beam energy, both the asymmetries and the measured cross sections are well reproduced by perturbation theory calculations, allowing a determination of the E2 strength.Comment: 8 pages, 3 figure