Youth Worker Reasoning about Dilemmas Encountered in Practice: Expert-Novice Differences

This study examines one aspect of youth worker expertise, the ability to appraise and respond to the dilemmas of practice encountered in youth programs. To understand how expert youth workers differ from novices in their reasoning about these dilemmas, a sample of expert and novice practitioners read vignettes of dilemma situations and described their appraisals of the situations and how they might respond to them. Quantitative analyses confirmed four hypothesized differences between the two groups. Experts identified more considerations in the situations and generated more possible responses. Experts’ responses were also more likely to be youth-centered and address multiple considerations. Qualitative analyses suggested that these differences were attributable to the experts having more elaborate mental models that allowed them to understand varied human systems – individual youth, group dynamics, parents, funders, etc. – and to tailor their responses accordingly. The experts engaged in more forecasting of events, anticipating contingencies, and formulating decision trees that took possible contingencies into account. Although preliminary, the findings have implications for how youth workers are trained

Reflections on a Century of Youth Development Research and Practice

This introduction to the special issue highlights the youth development research and practice base that influenced the field in the 20th century and presents some historical context for the practice and study of youth work. Next, it provides an overview of the articles which offer a retrospective account of youth development from how youth development has been studied, understood and measured to how youth development practice has evolved to support, engage and address the needs of young people. The introduction concludes with reflections stimulated by the process of reviewing the manuscripts and working with the authors on their contributions. Three themes emerged as good grist for the 21st century conversations moving forward: 1) the divergent perspectives on definition, dimensions of practice and accountability, 2) the value of translational scholarship bridging science and complex practice, and 3) the importance of leveraging systems support for field building

New Horizons: Understanding the Processes and Practices of Youth Development

Abstract: This article presents new horizon for research on youth development by focusing on the challenges youth face in learning teamwork and in coming to terms with diversity. These are both essential competencies for navigating the "real world" of the 21 st century. We examine how youth experience these challenges within programs; also how they present second-order challenges to practitioners. The underlying message of this article is that it is essential for researchers to see programs from the point of view of the people in them. Researchers have learned quite a bit of what can be learned from arm's length: that programs can make a difference in youths' lives and that certain features of settings are associated with these changes. To go further, researchers need to work side-by-side with practitioners and youth to understand their complex worlds as they experience them

New Horizons: Understanding the Processes and Practices of Youth Development

This article presents new horizons for research on youth development by focusing on the challenges youth face in learning teamwork and in coming to terms with diversity. These are both essential competencies for navigating the “real world” of the 21st century. We examine how youth experience these challenges within programs; also how they present second-order challenges to practitioners. The underlying message of this article is that it is essential for researchers to see programs from the point of view of the people in them. Researchers have learned quite a bit of what can be learned from arm’s length: that programs can make a difference in youths’ lives and that certain features of settings are associated with these changes. To go further, researchers need to work side-by-side with practitioners and youth to understand their complex worlds as they experience them

Maintained physical activity and physiotherapy in the management of distal upper limb pain – a protocol for a randomised controlled trial (the arm pain trial)

<b>Background</b><p></p> Distal upper limb pain (pain affecting the elbow, forearm, wrist, or hand) can be non-specific, or can arise from specific musculoskeletal disorders. It is clinically important and costly, the best approach to clinical management is unclear. Physiotherapy is the standard treatment and, while awaiting treatment, advice is often given to rest and avoid strenuous activities, but there is no evidence base to support these strategies. This paper describes the protocol of a randomised controlled trial to determine, among patients awaiting physiotherapy for distal arm pain, (a) whether advice to remain active and maintain usual activities results in a long-term reduction in arm pain and disability, compared with advice to rest; and (b) whether immediate physiotherapy results in a long-term reduction in arm pain and disability, compared with physiotherapy delivered after a seven week waiting list period.<p></p> <b>Methods/Design</b><p></p> Between January 2012 and January 2014, new referrals to 14 out-patient physiotherapy departments were screened for potential eligibility. Eligible and consenting patients were randomly allocated to one of the following three groups in equal numbers: 1) advice to remain active, 2) advice to rest, 3) immediate physiotherapy. Patients were and followed up at 6, 13, and 26 weeks post-randomisation by self-complete postal questionnaire and, at six weeks, patients who had not received physiotherapy were offered it at this time. The primary outcome is the proportion of patients free of disability at 26 weeks, as determined by the modified DASH (Disabilities of the Arm, Shoulder and Hand) questionnaire.<p></p> We hypothesise (a) that advice to maintain usual activities while awaiting physiotherapy will be superior than advice to rest the arm; and (b) that fast-track physiotherapy will be superior to normal (waiting list) physiotherapy. These hypotheses will be examined using an intention-to-treat analysis.<p></p> <b>Discussion</b><p></p> Results from this trial will contribute to the evidence base underpinning the clinical management of patients with distal upper limb pain, and in particular, will provide guidance on whether they should be advised to rest the arm or remain active within the limits imposed by their symptoms

Mutations associated with a 17-gene leukemia stem cell score and the score’s prognostic relevance in the context of the European LeukemiaNet classification of acute myeloid leukemia

Leukemia stem cells (LSC) are more resistant to standard chemotherapy and their persistence during remission can cause relapse, which is still one of the major clinical challenges in the treatment of acute myeloid leukemia (AML). A better understanding of the mutational patterns and the prognostic impact of molecular markers associated with stemness could lead to better clinical management and improve patients’ outcomes. We applied a previously described 17-gene expression score comprising genes differently expressed between LSC and leukemic bulk blasts, for 934 adult patients with de novo AML, and studied associations of the 17-gene LSC score with clinical data and mutation status of 81 genes recurrently mutated in cancer and leukemia. We found that patients with a high 17-gene score were older and had more mutations. The 17-gene score was found to have a prognostic impact in both younger (age

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

Maria Castro and colleagues use cell line and transgenic mouse approaches to study the mechanisms underlying the immune response to glioblastoma multiforme

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

Host proteins are essential for HIV entry and replication and can be important nonviral therapeutic targets. Large-scale RNA interference (RNAi)-based screens have identified nearly a thousand candidate host factors, but there is little agreement among studies and few factors have been validated. Here we demonstrate that a genome-wide CRISPR-based screen identifies host factors in a physiologically relevant cell system. We identify five factors, including the HIV co-receptors CD4 and CCR5, that are required for HIV infection yet are dispensable for cellular proliferation and viability. Tyrosylprotein sulfotransferase 2 (TPST2) and solute carrier family 35 member B2 (SLC35B2) function in a common pathway to sulfate CCR5 on extracellular tyrosine residues, facilitating CCR5 recognition by the HIV envelope. Activated leukocyte cell adhesion molecule (ALCAM) mediates cell aggregation, which is required for cell-to-cell HIV transmission. We validated these pathways in primary human CD4 + T cells through Cas9-mediated knockout and antibody blockade. Our findings indicate that HIV infection and replication rely on a limited set of host-dispensable genes and suggest that these pathways can be studied for therapeutic intervention