Exploration of a Collaborative Non-Formal Science Education Program in Australian Secondary Schools

Declining student enrolment in post-compulsory science has prompted increasing use of non-formal science education programs to help motivate students to continue with post-compulsory STEM study. Non-formal programs are well acknowledged to have potential for engaging students in ways that schools cannot but there is a scarcity of data demonstrating this, particularly in Australia. As non-formal programs become more commonly used in schools it is important to understand the roles that they can have in schools and the opportunities within these roles for encouraging students to continue with post-compulsory STEM education. This research explores the perspectives of stakeholders regarding the ongoing implementation of a non-formal science education program in a specific local partnership. Over a year, non-formal staff, year seven and eight students and their teachers from two secondary schools were interviewed and observed during biannual visits to the centre. Students also completed a reflective survey at the year’s end. Results indicate that there is considerable potential for a non-formal program to help students develop post-compulsory STEM trajectories by providing a flexible, well-resourced and engaging learning environment. This environment was observed to support student participation and offered potential to extend students’ learning and increase their awareness and interest in STEM careers. Through these roles many students became more interested and confident in doing science and several developed interest in science careers. The program also affected teachers, prompting science teachers to reflect on their pedagogy and enthusing non-science teachers who attended as helpers. However full realisation of the potential of the non-formal programs was limited by students’ unrealistic expectations of the experience and a lack of efficient incorporation into their school learning. Most students were unaffected by their non-formal experiences as they were brief and scheduling limitations meant that they were not effectively linked to what students were learning at school. Often the non-formal program was seen as a day off school and students’ expectations centred around personal enjoyment and not learning. Difficulties in collaboration also occasionally disrupted students’ experiences which further diminished student expectations for their visits. As a result, some students developed a perception of the non-formal program as irrelevant to them or only worthwhile for people already interested in science which made it difficult for teachers to maintain student enthusiasm in the non-formal programs. This perception was exacerbated over time and amongst students who had poor pre-existing attitudes to science and who perceived limited support for their science learning. A further challenge to realising the potential roles of the non-formal programs lay in the collaboration between the centre and the schools which were each different communities with different agendas. Over time however, teachers and non-formal educators were able to develop relationships and it was their collaboration that was the key to resolving issues and refining the programs. Going forward, realising the potential of ongoing non-formal programs in secondary science education requires attention to the challenges in stakeholder collaboration, maintaining student enthusiasm over time and incorporating students’ experience into their school learning

Regenerative Stormwater Conveyance: Design Implications of an Urban Case Demonstration in Baltimore, Maryland

This research-design thesis explores the implementation of Regenerative Stormwater Conveyance (RSC) as a retrofit of an existing impervious drainage system in a small catchment in the degraded Jones Falls watershed in Baltimore City. An introduction to RSC is provided, placing its development within a theoretical context of novel ecosystems, biomimicry and Nassauer and Opdam’s (2008) model of landscape innovation. The case site is in Baltimore’s Hampden neighborhood on City-owned land adjacent to rowhomes, open space and an access point to a popular wooded trail along a local stream. The design proposal employs RSC to retrofit an ill-performing stormwater system, simultaneously providing a range of ecological, social and economic services; water quantity, water quality and economic performance of the proposed RSC are quantified. While the proposed design is site-specific the model is adaptable for retrofitting other small-scale impervious drainage systems, providing a strategic tool in addressing Baltimore City’s stormwater challenges

Rapport de l'immoralisme sadien au matérialisme des Lumières

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Résurgence et transformation du cynisme au XVIIIe siècle : la réception de Diogène dans les Lumières françaises

De nos jours omniprésent sur la scène politique, le cynisme fut depuis son origine l’objet de polémiques. Le mode de vie scandaleux auquel il est associé pose la question de l’appartenance ou non de Diogène et des Cyniques à la philosophie. Par ailleurs, qu’a à voir le cynisme des sociétés actuelles avec celui que pratiquait Diogène ? Si des analystes situent au siècle des Lumières l’émergence d’une nouvelle conception du cynisme propre à la modernité, peu d’études historiques ont été menées sur la question. Il importe donc de retourner aux sources et de mesurer la validité de cette hypothèse. Par une étude de l’histoire du cynisme et de sa transmission, nous retraçons l’évolution des enjeux au cœur du mouvement cynique et de sa postérité, et présentons une synthèse des significations du cynisme ainsi que des tensions qu’elles comportent. De nombreuses références permettent de définir la place qu’occupe le cynisme au XVIIIe siècle. Les auteurs des Lumières se sont réappropriés l’antique sagesse de Diogène et ont voulu concilier son impudique franchise aux exigences de la sociabilité. Ainsi, l’étude de la réception du cynisme au siècle des Lumières doit tenir compte des débats moraux de l’époque. Visant l’élaboration d’une morale matérialiste sur un fondement naturel, les Philosophes ont tâché de contourner les problèmes de l’amoralisme révélés par le constat de La Mettrie selon lequel il y a inadéquation entre bonheur et vertu. Pour ce faire, Helvétius réduit la portée des déterminismes liés à l’organisation, en soulignant l’importance des facteurs externes dans la gestion des comportements ; Diderot et D’Holbach mettent l’accent sur la sociabilité afin d’assurer l’inhérence d’un fondement moral chez l’être humain, renforçant un désaccord déjà profond entre le cynisme et les idéaux des Lumières. Or, cette approche est-elle généralisée ? Ou le cynisme des Lumières est-il sujet à des variantes selon les auteurs ? Cette thèse se propose d’étudier, par l’analyse des occurrences du cynisme dans les textes de la France des Lumières, les différentes acceptions du cynisme, pour cerner les enjeux auxquels elles s’attachent. Des textes tels qu’Aihcrappih de Godart de Beauchamps, Le Diogène décent de Prémontval, le Socrate en délire de Wieland, Le cynique moderne de Cœtlogon, Le désapprobateur de Castilhon, Le cosmopolite de Fougeret de Monbron, Le paysan perverti de Restif de la Bretonne et Arlequin Diogène de Saint-Just seront pris en considération. Ils s’ajouteront à une étude du cynisme chez Diderot, chez qui la thématique parcourt l’ensemble de l’œuvre et atteint son expression la plus achevée dans Le neveu de Rameau. Par ses doutes, Diderot trouve également sa place dans l’étude des critiques des Lumières qu’ont formulées Rousseau et Sade, chez qui l’on évalue la pertinence de l’enjeu cynique. Il ressort de cette thèse que les acceptions moderne et contemporaine du cynisme comportent des distinctions conceptuelles qui nous interdisent de les amalgamer. Notre analyse du cynisme dans le contexte français des Lumières montre que l’on est, jusqu’à la fin du XVIIIe siècle, en présence d’une conception typiquement moderne du cynisme, laquelle met l’accent sur la redécouverte de l’impudeur de Diogène. Plus précisément, le cynisme se caractérise, au XVIIIe siècle, par un repli misanthrope et solitaire, lequel s’oppose à l’optimisme humaniste des Philosophes. Il est l’expression d’un rejet de la sociabilité mise de l’avant par ces derniers, en réponse au constat de corruption de la société. S’il est possible d’y situer l’émergence d’une nouvelle conception du cynisme, c’est donc seulement dans la mesure où les débats liés à l’élaboration d’une morale matérialiste, fondée en intérêt ou en sentiment, montrent que chacun de ces fondements comportent des failles, et non parce que certains auteurs des Lumières auraient entendu par cynisme ce que nous entendons aujourd’hui. Tout se passe comme si l’homme désabusé, qui tient pour acquis l’incorrigibilité de sa nature et de la société, choisissant d’en tirer profit malgré l’immoralisme que cela comporte, avait forgé le statut de cynique postmoderne. Cela rompt avec la tradition qui, jusqu’à la fin de l’époque moderne, tient le Cynique pour une figure d’un dire vrai fondamentalement désapprobateur du genre humain. Si l’impudeur poussée dans ses derniers retranchements conduit le cynique à n’éprouver aucune honte à mentir, il poursuit en cela la devise d’altération des valeurs initiée par Diogène, mais contribue désormais au maintien d’un statu quo sur l’état de corruption de la société qu’aucun cynique, ancien ou moderne, n’aurait accepté de taire.Now pervasive on the political scene, cynicism has been contentious from its beginnings. The scandalous way of living to which it is linked raise the issue of whether or not Diogenes and the Cynics must be considered as part of the history of philosophy. Besides, what do today’s cynical practices share with those of Diogenes? Some interprets situate the emergence of a new conception of cynicism peculiar to modernity during the Enlightenment, but few historical studies have been centered on this question. It is consequently important to return to the sources of cynicism to measure this hypothesis’ validity. Through a study of cynicism’s history and its transmission we trace the evolution of the major issues at the core of cynic movement and its posterity, and present a synthesis of its significations and their internal tensions. Many references allow us to define the place that cynicism occupies within the XVIIIth century. Philosophers have tried to reclaim Diogenes’ antique wisdom while also accommodating his shameless frankness to the requirements of sociability. The study of the reception of cynicism in the XVIIIth century french Enlightenment must therefore be seen within the scope of the moral debates of that time. Those debates aim to elaborate a materialist moral on a natural basis, trying in doing so to tackle the problem of amoralism revealed by La Mettrie’s statement of the inadequacy between happiness and virtue. To do that, Helvetius reduces the scope of natural determinisms by underlining the importance of exterior factors when managing behaviors. Diderot and D’Holbach, on their part, emphasize the notion of sociability to make sure there’s a moral sense within human nature itself; this belief reinforces an already profound disagreement between the ideals of Enlightenment and cynicism. But is this approach that widespread? Or is cynicism subject to vary according to authors? This thesis proposes, by studying the occurrences of cynicism in French Enlightenment’s texts, to give an account of its different meanings in order to identify the issues that are put forward. Therefore, texts such as Aihcrappih by Godart de Beauchamps, Le Diogène décent by Prémontval, Le Socrate en délire by Wieland, Le cynique moderne by Cœtlogon, Le désapprobateur by Castilhon, Le cosmopolite by Fougeret de Monbron, Le paysan perverti by Restif de la Bretonne, and Arlequin Diogène by Saint-Just will be taken into account, as will be cynicism in Diderot’s texts; this thematic is present in his whole work, Le neveu de Rameau being the most achieved expression of it. Exposing his doubts, Diderot also finds its place in our exposition of the Enlightenment’s critics as they have been formulated by Rousseau and Sade; we’ll also analyze the relevance of their cynical stakes. The conclusion of this thesis is that the modern and contemporary meanings of cynicism entail important conceptual distinctions that forbid us to amalgamate them. Our analysis of cynicism in French Enlightenment’s texts shows that up until the end of the XVIIIth century, we are faced with a modern conception of cynicism that rests to a considerable extent upon the rediscovery of Diogene’s immodesty. More precisely, the XVIIIth century cynicism can be characterized by a solitary and misanthropic withdrawal, which opposes the Philosophers’ humanist optimism. Cynicism is therefore a rejection of sociability, a value put forward by Philosophers in response to the general state of corruption of society. In other words, if one can locate the emergence of a new form of cynicism in the Enlightenment, it’s not that some authors understood cynicism as we do now: it is because the debates linked with the construction of a materialist conception of morality, be it be founded on interests or sentiments, show that these fundaments carry some weaknesses. It is as though the disillusioned man who takes for granted the incorrigibility of nature and society and chooses to take advantage of it despite the immorality of doing so has given birth to the postmodern cynic. This is he who breaks with a tradition which, up to the modern era, considered the cynic as the figure of a blunt truth teller, disapproving of mankind. If immodesty, driven into a corner, leads the postmodern cynic to shamelessness in lying, he in a sense pursues the motto of the alteration of values initiated by Diogenes, but now contributes to maintain the corruption of society, which no cynic, may he be ancient or modern, would have accepted to silence

Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1

<p>Abstract</p> <p>Background</p> <p>MicroRNA (miRNA)-mediated RNA silencing is integral to virtually every cellular process including cell cycle progression and response to virus infection. The interplay between RNA silencing and HIV-1 is multifaceted, and accumulating evidence posits a strike-counterstrike interface that alters the cellular environment to favor virus replication. For instance, miRNA-mediated RNA silencing of HIV-1 translation is antagonized by HIV-1 Tat RNA silencing suppressor activity. The activity of HIV-1 accessory proteins Vpr/Vif delays cell cycle progression, which is a process prominently modulated by miRNA. The expression profile of cellular miRNA is altered by HIV-1 infection in both cultured cells and clinical samples. The open question stands of what, if any, is the contribution of Tat RNA silencing suppressor activity or Vpr/Vif activity to the perturbation of cellular miRNA by HIV-1.</p> <p>Results</p> <p>Herein, we compared the perturbation of miRNA expression profiles of lymphocytes infected with HIV-1^NL4-3or derivative strains that are deficient in Tat RNA silencing suppressor activity (Tat K51A substitution) or ablated of the vpr/vif open reading frames. Microarrays recapitulated the perturbation of the cellular miRNA profile by HIV-1 infection. The miRNA expression trends overlapped ~50% with published microarray results on clinical samples from HIV-1 infected patients. Moreover, the number of miRNA perturbed by HIV-1 was largely similar despite ablation of Tat RSS activity and Vpr/Vif; however, the Tat RSS mutation lessened HIV-1 downregulation of twenty-two miRNAs.</p> <p>Conclusions</p> <p>Our study identified miRNA expression changes attributable to Tat RSS activity in HIV-1^NL4-3. The results accomplish a necessary step in the process to understand the interface of HIV-1 with host RNA silencing activity. The overlap in miRNA expression trends observed between HIV-1 infected CEMx174 lymphocytes and primary cells supports the utility of cultured lymphocytes as a tractable model to investigate interplay between HIV-1 and host RNA silencing. The subset of miRNA determined to be perturbed by Tat RSS in HIV-1 infection provides a focal point to define the gene networks that shape the cellular environment for HIV-1 replication.</p

Validation of a Scale to Measure Patient-Perceived Barriers to Medication Use

AIMS: Medication adherence may explain why patients show very different clinical outcomes. Previous assessments of adherence have used refill rates and pill counts. Few studies have investigated patient-identified barriers to using medications as prescribed. This is particularly true for persons with diabetes, most of whom are using poly-pharmacy regimens. We created a questionnaire to measure patient perceptions of barriers to medication adherence (PBMA) targeting a predominately low income, inner-city minority population. METHODS: Twenty items (Likert scale) leading with "I sometimes don't take my diabetes medicines because..." were developed from 5 focus groups (N=48). A questionnaire including these items was mailed to 1000 patients who have diabetes. RESULTS: Using data from 267 respondents (Mean age=58, 74%female, 43% non-Hispanic Caucasian, 77% income<$15,000), exploratory factor analyses with varimax rotation identified 5 factors, that may contribute to poor medication adherence: personal access to medications (F1); communication with providers (F2); understanding or appropriately following the prescribed regimen (F3); side effects (F4) and system factors that inhibited access to medication (F5). Cronbach alphas ranged from .73 to .83 for the five factors and was .92 for total scale score. No relationships were found between total scores and gender, race, or income. Greater perception of barriers was significantly (p<0.01) associated with being younger (r= -0.21), being bothered more by physical (r= -0.40) and emotional side effects (r= 0.43), and less satisfaction with control of blood sugar by diabetes medications (r= 0.45). CONCLUSIONS: This instrument is reliable, factorially valid, and consistent with clinical observation regarding factors known to be associated with patient medication adherence. Although study participants were patients with diabetes, the PBMA may be applicable to other therapeutic areas

Non-native contrasts in Tongan loans

We present three case studies of marginal contrasts in Tongan loans from English, working with data from three speakers. Although Tongan lacks contrasts in stress or in CC vs. CVC sequences, secondary stress in loans is contrastive, and is sensitive to whether a vowel has a correspondent in the English source word; vowel deletion is also sensitive to whether a vowel is epenthetic as compared to the English source; and final vowel length is sensitive to whether the penultimate vowel is epenthetic, and if not, whether it corresponds to a stressed or unstressed vowel in the English source. We provide an analysis in the multilevel model of Boersma (1998) and Boersma &amp; Hamann (2009), and show that the loan patterns can be captured using only constraints that plausibly are needed for native-word phonology, including constraints that reflect perceptual strategies