Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy

Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated with spontaneous seizures are not fully understood. We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were reproducible across consecutive seizures. In contrast to the canonical view that principal cell discharges dominate ictal events, the ictal sequences were predominantly composed of fast-spiking, putative inhibitory neurons, which displayed unusually strong coupling to local field potential even before seizures. The temporal evolution of activity was characterized by unique dynamics where the most correlated neuronal pairs before seizure onset displayed the largest increases in correlation strength during the seizures. These results demonstrate the selective involvement of fast spiking interneurons in structured temporal sequences during spontaneous ictal events in hippocampal and neocortical circuits in experimental models of chronic temporal lobe epilepsy

A dramatic course of myocardial infarction in 28 years old patient after amphetamine use

Zawał serca (MI) u młodych dorosłych występuje rzadko i najczęściej jest wywołany innymi przyczynami niż miażdżyca tętnic wieńcowych. Autorzy przedstawili opis przypadku 28-letniego palacza tytoniu, u którego po zażyciu amfetaminy i alkoholu doszło do MI powikłanego zatrzymaniem krążenia w mechanizmie migotania komór. W czasie długotrwałej resuscytacji powrót spontanicznego krążenia uzyskano dopiero po podaniu alteplazy. Po przeprowadzeniu przezskórnej interwencji wieńcowej pacjenta wprowadzono w stan hipotermii terapeutycznej, by ochronić mózg.Acute myocardial infarction in young adults occurs rarely and most often is induced by different causes than atheromatous coronary artery disease. We present a case report of amphetamine and alcohol induced myocardial infarction in 28 years old tobacco abuser, which was complicated by cardiac arrest caused by ventricular fibrillation. Return of spontaneous circulation (ROSC) during prolonged cardiopulmonary resuscitation was obtained only with administration of alteplase. After percutaneous coronary intervention (PCI) we induced therapeutic hypothermia to the patient in order to brain protection

Theta cycle dynamics of spatial representations in the lateral septum

A repository with analysis code and data that accompanies the manuscript on spatial representations in the lateral septum

Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy

See Lenck-Santini (doi:10.1093/awx205) for a scientific commentary on this article. Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated with spontaneous seizures are not fully understood. We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were reproducible across consecutive seizures. In contrast to the canonical view that principal cell discharges dominate ictal events, the ictal sequences were predominantly composed of fast-spiking, putative inhibitory neurons, which displayed unusually strong coupling to local field potential even before seizures. The temporal evolution of activity was characterized by unique dynamics where the most correlated neuronal pairs before seizure onset displayed the largest increases in correlation strength during the seizures. These results demonstrate the selective involvement of fast spiking interneurons in structured temporal sequences during spontaneous ictal events in hippocampal and neocortical circuits in experimental models of chronic temporal lobe epilepsy.status: publishe