420 research outputs found
The Synergizer service for translating gene, protein and other biological identifiers
Summary: The Synergizer is a database and web service that provides translations of biological database identifiers. It is accessible both programmatically and interactively
Few smooth d-polytopes with n lattice points
We prove that, for fixed n there exist only finitely many embeddings of
Q-factorial toric varieties X into P^n that are induced by a complete linear
system. The proof is based on a combinatorial result that for fixed nonnegative
integers d and n, there are only finitely many smooth d-polytopes with n
lattice points. We also enumerate all smooth 3-polytopes with at most 12
lattice points. In fact, it is sufficient to bound the singularities and the
number of lattice points on edges to prove finiteness.Comment: 20+2 pages; major revision: new author, new structure, new result
A novel method for the absolute fluorescence yield measurement by AIRFLY
One of the goals of the AIRFLY (AIR FLuorescence Yield) experiment is to
measure the absolute fluorescence yield induced by electrons in air to better
than 10% precision. We introduce a new technique for measurement of the
absolute fluorescence yield of the 337 nm line that has the advantage of
reducing the systematic uncertainty due to the detector calibration. The
principle is to compare the measured fluorescence yield to a well known process
- the Cerenkov emission. Preliminary measurements taken in the BFT (Beam Test
Facility) in Frascati, Italy with 350 MeV electrons are presented. Beam tests
in the Argonne Wakefield Accelerator at the Argonne National Laboratory, USA
with 14 MeV electrons have also shown that this technique can be applied at
lower energies.Comment: presented at the 5th Fluorescence Workshop, El Escorial - Madrid,
Spain, 16 - 20 September 200
Temperature and Humidity Dependence of Air Fluorescence Yield measured by AIRFLY
The fluorescence detection of ultra high energy cosmic rays requires a
detailed knowledge of the fluorescence light emission from nitrogen molecules
over a wide range of atmospheric parameters, corresponding to altitudes typical
of the cosmic ray shower development in the atmosphere. We have studied the
temperature and humidity dependence of the fluorescence light spectrum excited
by MeV electrons in air. Results for the 313.6 nm, 337.1 nm, 353.7 nm and 391.4
nm bands are reported in this paper. We found that the temperature and humidity
dependence of the quenching process changes the fluorescence yield by a
sizeable amount (up to 20%) and its effect must be included for a precise
estimation of the energy of ultra high energy cosmic rays.Comment: presented at the 5th Fluorescence Workshop, El Escorial - Madrid,
Spain, 16 - 20 September 2007, to appear in Nuclear Instruments and Methods
Hierarchical Hough all-sky search for periodic gravitational waves in LIGO S5 data
We describe a new pipeline used to analyze the data from the fifth science
run (S5) of the LIGO detectors to search for continuous gravitational waves
from isolated spinning neutron stars. The method employed is based on the Hough
transform, which is a semi-coherent, computationally efficient, and robust
pattern recognition technique. The Hough transform is used to find signals in
the time-frequency plane of the data whose frequency evolution fits the pattern
produced by the Doppler shift imposed on the signal by the Earth's motion and
the pulsar's spin-down during the observation period. The main differences with
respect to previous Hough all-sky searches are described. These differences
include the use of a two-step hierarchical Hough search, analysis of
coincidences among the candidates produced in the first and second year of S5,
and veto strategies based on a test.Comment: 7 pages, 2 figures, Amaldi08 proceedings, submitted to JPC
An example of Mirror Symmetry for Fano threefolds
In this note we illustrate the Fanosearch programme of Coates, Corti, Galkin,
Golyshev, and Kasprzyk in the example of the anticanonical cone over the smooth
del Pezzo surface of degree 6.Comment: 13 pages, 2 figure
Purifying Selection in Deeply Conserved Human Enhancers Is More Consistent than in Coding Sequences
(c) 2014 De Silva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice.
Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX) caused by severe dose limiting toxicities, such as neutropenia and peripheral neuropathy. Consequently, new drugs are urgently required. STX140, a compound previously shown to have excellent efficacy against many tumors, is here compared to paclitaxel in three translational in vivo breast cancer models, a rat model of peripheral neuropathy, and through pharmacological testing. Three different in vivo mouse models of breast cancer were used; the metastatic 4T1 orthotopic model, the C3(1)/SV40 T-Ag model, and the MDA-MB-231 xenograft model. To determine TIX and pharmacological profile of STX140, a comprehensive dosing regime was performed in mice bearing MDA-MD-231 xenografts. Finally, peripheral neuropathy was examined using a rat plantar thermal hyperalgesia model. In the 4T1 metastatic model, STX140 and paclitaxel significantly inhibited primary tumor growth and lung metastases. All C3(1)/SV40 T-Ag mice in the control and paclitaxel treated groups developed palpable mammary cancer. STX140 blocked 47% of tumors developing and significantly inhibited growth of tumors that did develop. STX140 treatment caused a significant (P<0.001) survival advantage for animals in early and late intervention groups. Conversely, in C3(1)/SV40 T-Ag mice, paclitaxel failed to inhibit tumor growth and did not increase survival time. Furthermore, paclitaxel, but not STX140, induced significant peripheral neuropathy and neutropenia. These results show that STX140 has a greater anti-cancer efficacy, TIX, and reduced neurotoxicity compared to paclitaxel in C3(1)/SV40 T-Ag mice and therefore may be of significant benefit to patients with breast cancer
The patterns of Corylus and Alnus pollen seasons and pollination periods in two Polish cities located in different climatic regions
First LIGO search for gravitational wave bursts from cosmic (super)strings
We report on a matched-filter search for gravitational wave bursts from
cosmic string cusps using LIGO data from the fourth science run (S4) which took
place in February and March 2005. No gravitational waves were detected in 14.9
days of data from times when all three LIGO detectors were operating. We
interpret the result in terms of a frequentist upper limit on the rate of
gravitational wave bursts and use the limits on the rate to constrain the
parameter space (string tension, reconnection probability, and loop sizes) of
cosmic string models.Comment: 11 pages, 3 figures. Replaced with version submitted to PR
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