PROPUESTA DE TALLERES DE PREVENCI 3N DE ABUSO SEXUAL INFANTIL DIRIGIDO AL ADULTO SIGNIFICANTE DEL NI 1O(A) DE EDUCACI 3N PRIMARIA, EN LA COMUNIDAD EDUCATIVA LA ERMITA. VENEZUELA

El objetivo de la presente investigaci\uf3n es proponer talleres de prevenci\uf3n del abuso sexual infantil dirigido al adulto significante del ni\uf1o(a) de Educaci\uf3n Primaria en el marco de la promoci\uf3n de la salud mental en la Comunidad Educativa La Ermita. Quibor, Estado Lara, seg\ufan la modalidad de proyecto especial de campo, con dise\uf1o no experimental. La muestra final de treinta y seis docentes y representantes (36), de la comunidad educativa. Las fases del proyecto consistieron: I Diagn\uf3stica se determin\uf3 la necesidad de los talleres de prevenci\uf3n a trav\ue9s de la aplicaci\uf3n de un cuestionario a la poblaci\uf3n, se analizaron los datos se tabul\uf3 y se graficaron los resultados, concluy\ue9ndose que existe la necesidad de realizar los talleres de prevenci\uf3n del abuso sexual infantil dirigido al adulto significante del ni\uf1o(a) de Educaci\uf3n Primaria en el marco de la promoci\uf3n de la salud mental. Fase II Factibilidad de la Propuesta, se evidenci\uf3 que la ejecuci\uf3n de los talleres es viable institucional y econ\uf3micamente. Fase III, Dise\uf1o de la Propuesta, se dise\uf1aron los talleres de prevenci\uf3n los cuales incluyen introducci\uf3n, justificaci\uf3n, objetivo general y espec\uedficos, con cinco sesiones de aprendizaje sustentadas te\uf3ricamente. PALABRAS CLAVE: prevenci\uf3n, abuso sexual infantil, conocimiento,knowledge, talleres, promoci\uf3n de salud mental. ABSTRACT The objective of this research is to propose prevention of child sexual abuse workshops aimed to significant adult child (a) Primary education in the context of the promotion of mental health in the Comunidad Educativa Ermita. Quibor, Estado Lara. The study was a special field project with non-experimental design. Sample was made of thirty-six teachers and representatives (36) of the educational community. Which developed in the following phases, first Diagnostic the need for prevention workshops was determined by applying a questionnaire to the population, the tabulated data were analyzed and the results are plotted, concluding that there is need for conduct workshops prevention of child sexual abuse led to significant adult child (a) Primary Education as part of the promotion of mental health. Second phase, feasibility of the proposal, it was shown that the implementation of the workshops is institutional and economically feasible. Third Phase, Design Proposal, prevention workshops which include introduction, rationale, general objective and specific, with five training sessions were designed theoretically supported. KEY WORDS: prevention, child sexual abuse, knowledge, workshops, promotion of mental health. <br

Dust accretion onto high-mass planets

We study the accretion of dust particles of various sizes onto embedded massive gas giant planets, where we take into account the structure of the gas disk due to the presence of the planet. The accretion rate of solids is important for the structure of giant planets: it determines the growth rate of the solid core that may be present as well as their final enrichment in solids. We use the RODEO hydrodynamics solver to solve the flow equations for the gas, together with a particle approach for the dust. The solver for the particles' equations of motion is implicit with respect to the drag force, which allows us to treat the whole dust size spectrum. We find that dust accretion is limited to the smallest particle sizes. The largest particles get trapped in outer mean-motion resonances with the planet, while particles of intermediate size are pushed away from the orbit of the planet by the density structure in the gas disk. Only particles smaller than approximately s_max =10 micron may accrete on a planet with the mass of Jupiter. For a ten times less massive planet s_max=100 micron. The strongly reduced accretion of dust makes it very hard to enrich a newly formed giant planet in solids.Comment: 15 pages, 18 figures, accepted for publication in A&

BioWorkbench: A High-Performance Framework for Managing and Analyzing Bioinformatics Experiments

Advances in sequencing techniques have led to exponential growth in biological data, demanding the development of large-scale bioinformatics experiments. Because these experiments are computation- and data-intensive, they require high-performance computing (HPC) techniques and can benefit from specialized technologies such as Scientific Workflow Management Systems (SWfMS) and databases. In this work, we present BioWorkbench, a framework for managing and analyzing bioinformatics experiments. This framework automatically collects provenance data, including both performance data from workflow execution and data from the scientific domain of the workflow application. Provenance data can be analyzed through a web application that abstracts a set of queries to the provenance database, simplifying access to provenance information. We evaluate BioWorkbench using three case studies: SwiftPhylo, a phylogenetic tree assembly workflow; SwiftGECKO, a comparative genomics workflow; and RASflow, a RASopathy analysis workflow. We analyze each workflow from both computational and scientific domain perspectives, by using queries to a provenance and annotation database. Some of these queries are available as a pre-built feature of the BioWorkbench web application. Through the provenance data, we show that the framework is scalable and achieves high-performance, reducing up to 98% of the case studies execution time. We also show how the application of machine learning techniques can enrich the analysis process

Safety and effectiveness of adalimumab in patients with rheumatoid arthritis over 5 years of therapy in a phase 3b and subsequent postmarketing observational study.

INTRODUCTION: Patients with active rheumatoid arthritis who had failed at least one disease-modifying anti-rheumatic drug (DMARD) were treated with adalimumab (ADA) in the ReAct study with the option to continue treatment for 5 years in ReAlise. The purpose of this study was to evaluate the long-term safety and effectiveness of ADA as prescribed from the first injection in ReAct to the last observation in ReAlise. METHODS: Patients received ADA alone or in combination with DMARDs according to usual clinical care practices. Adverse events (AEs) were tabulated by five time windows after the first ADA injection. Effectiveness measures included achievement of low disease activity (LDA), defined as Simplified Disease Activity Index (SDAI) ≤11, or remission, (REM), defined as SDAI ≤3.3. RESULTS: Of the 6,610 ReAct patients, 3,435 (52%) continued in ReAlise. At baseline in ReAct, mean age was 54 years, mean DAS28 was 6.0 and mean HAQ DI was 1.64. The mean treatment duration was 1,016 days, representing 18,272 patient-years (PYs) of ADA exposure. Overall incidence rates of serious AEs and serious infections were 13.8 and 2.8 events (E)/100 PYs, respectively. Serious AEs occurred most frequently in the first 6 months and deceased thereafter. Standardised mortality ratio was 0.71 (95% CI 0.57 to 0.87) and standardised incidence ratio for malignancies was 0.64 (95% CI 0.53 to 0.76). LDA was achieved by 50% and REM by 21% of patients at last observation. CONCLUSIONS: Results of this large observational study of ADA in routine clinical practice were consistent with controlled trials, with no new safety concerns during a follow-up of more than 5 years. Effectiveness of ADA was maintained during long-term observation. TRIAL REGISTRATION: NCT00448383, NCT0023488

Effectiveness of adalimumab for rheumatoid arthritis in patients with a history of TNF-antagonist therapy in clinical practice

Objective. To evaluate the effectiveness and safety of adalimumab in patients with rheumatoid arthritis (RA) who previously discontinued tumour necrosis factor (TNF) antagonists for any reason in clinical practice. Methods. ReAct (Research in Active Rheumatoid Arthritis) was a large, open-label trial that enrolled adults with active RA who had previously been treated with traditional disease-modifying anti-rheumatic drugs or biological response modifiers. Patients selfadministered adalimumab 40 mg subcutaneously every other week for 12 weeks and were allowed to enter an optional long-term extension phase. Measures of adalimumab effectiveness included American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) response criteria, Disease Activity Score 28 (DAS28) and the Health Assessment Questionnaire Disability Index (HAQ DI). Results. Of 6610 patients, 899 had a history of etanercept and/or infliximab therapy; these patients experienced substantial clinical benefit from adalimumab treatment. At week 12, 60% of patients had an ACR20 and 33% had an ACR50 response; 76% had a moderate and 23% had a good EULAR response. In addition, 12% achieved a DAS28 < 2.6, indicating clinical remission, and 13% achieved a HAQ DI score < 0.5. The allergic adverse event rate, regardless of relationship to adalimumab, was 6.5/100-patient-years (PYs) in previously TNF antagonist-exposed patients and 4.3/100-PYs in TNF antagonist naive patients. A multiple regression analysis indicated no statistically significantly increased risk of serious infections in patients who received prior TNF antagonists compared with TNF antagonist naive patients. Conclusion. In typical clinical practice, adalimumab was effective and well-tolerated in patients with RA previously treated with etanercept and/or infliximab

Genetic Regulation of Virulence and Antibiotic Resistance in Acinetobacter baumannii

Multidrug resistant microorganisms are forecast to become the single biggest challenge to medical care in the 21st century. Over the last decades, members of the genus Acinetobacter have emerged as bacterial opportunistic pathogens, in particular as challenging nosocomial pathogens because of the rapid evolution of antimicrobial resistances. Although we lack fundamental biological insight into virulence mechanisms, an increasing number of researchers are working to identify virulence factors and to study antibiotic resistance. Here, we review current knowledge regarding the regulation of virulence genes and antibiotic resistance in Acinetobacter baumannii. A survey of the two-component systems AdeRS, BaeSR, GacSA and PmrAB explains how each contributes to antibiotic resistance and virulence gene expression, while BfmRS regulates cell envelope structures important for pathogen persistence. A. baumannii uses the transcription factors Fur and Zur to sense iron or zinc depletion and upregulate genes for metal scavenging as a critical survival tool in an animal host. Quorum sensing, nucleoid-associated proteins, and non-classical transcription factors such as AtfA and small regulatory RNAs are discussed in the context of virulence and antibiotic resistance

Plug-in Plan Tool v3.0.3.1

The role of PLUTO (Plug-in Port UTilization Officer) and the growth of the International Space Station (ISS) have exceeded the capabilities of the current tool PiP (Plug-in Plan). Its users (crew and flight controllers) have expressed an interest in a new, easy-to-use tool with a higher level of interactivity and functionality that is not bound by the limitations of Excel. The PiP Tool assists crewmembers and ground controllers in making real-time decisions concerning the safety and compatibility of hardware plugged into the UOPs (Utility Outlet Panels) onboard the ISS. The PiP Tool also provides a reference to the current configuration of the hardware plugged in to the UOPs, and enables the PLUTO and crew to test Plug-in locations for constraint violations (such as cable connector mismatches or amp limit violations), to see the amps and volts for an end item, to see whether or not the end item uses 1553 data, and the cable length between the outlet and the end item. As new equipment is flown or returned, the database can be updated appropriately as needed. The current tool is a macroheavy Excel spreadsheet with its own database and reporting functionality. The new tool captures the capabilities of the original tool, ports them to new software, defines a new dataset, and compensates for ever-growing unique constraints associated with the Plug-in Plan. New constraints were designed into the tool, and updates to existing constraints were added to provide more flexibility and customizability. In addition, there is an option to associate a "Flag" with each device that will let the user know there is a unique constraint associated with it when they use it. This helps improve the safety and efficiency of real-time calls by limiting the amount of "corporate knowledge" overhead that has to be trained and learned through use. The tool helps save time by automating previous manual processes, such as calculating connector types and deciding which cables are required and in what order

Morphology and molecular study of an entomopathogenic nematode, Steinernema bicornutum (Nematoda, Rhabditida, Steinernematidae) from Iran

An entomopathogenic nematode was isolated by Galleria baiting technique from soil samples collected near Marand, East Azarbaijan province, North-west of Iran during 2003. Based on morphological and morphometric characters, as well as molecular data it was identified as Steinernema bicornutum Tallosi, Peters & Ehlers, 1995. Morphometrics comparison of the isolate with the type species showed no obvious differences between them. Differences in ITS-rDNA PCR-RFLP were found between the Iranian isolate, i.e. IRA7, with the type (Yugoslavian) isolate. The RFLP analysis was able to distinguish Iranian isolate from the type population of S. bicornutum in the HinfI (four restriction sites in the type vs three restriction sites in the IRA7), Hin6I (550, 250 and 250 bp in the studied isolate vs 541 and 474 in the type isolate) and AluI profiles (715, 177 and 123 in the type and 710 and 220 in the IRA7). These molecular differences are considered as intraspecific variations, and the described population from Iran is another isolate of S. bicornutum

Annotated Bibliography for the MATADOR Project

The MATADOR project is focused on developing methods to infer the operational mode of facilities that have the potential to be used in weapons development programs. Our central hypothesis is that by persistent, non-intrusive monitoring of such facilities, differences between various use scenarios can be reliably discovered. The impact of success in this area is that new tools and techniques for monitoring and treaty verification would make it easier to reliably discover and document weapons development activities. This document captures the literature that will serve as a basis to approach this task. The relevant literature is divided into topical areas that relate to the various aspects of expected MATADOR project development. We have found that very little work that is directly applicable for our purposes has been published, which has motivated the development of novel methods under the project. Therefore, the manuscripts referenced in this document were selected based on their potential use as foundational blocks for the methods we anticipate developing, or so that we can understand the limitations of existing methods