Hubungan Antara Burnout dengan Academic Procrastination pada Mahasiswa Fakultas Kedokteran Universitas Tarumanagara Tahap Akademik

Burnout merupakan suatu keadaan yang ditandai dengan keadaan kelelahan fisik dan mental, meningkatnya perasaan negatif atau sinisme, berkurangnya efektivitas dalam melakukan sesuatu dan sering beranggapan bahwa dirinya tidak kompeten. Mahasiswa yang mengalami burnout dan jenuh terhadap suatu proses pembelajaran lebih rentan untuk melakukan prokrastinasi akademik atau menunda tugas yang diberikan oleh dosen. Banyak mahasiswa yang melakukan penundaan dalam mengerjakan tugas, sehingga tugas yang seharusnya dikerjakan lebih awal tidak selesai dikerjakan dan semakin banyak tugas yang menumpuk. Ini dapat membuat mahasiswa menjadi semakin tertekan dan dapat menyebabkan burnout. Penelitian ini bertujuan untuk mengetahui hubungan antara burnout dengan prokrastinasi akademik pada mahasiswa Fakultas Kedokteran Universitas Tarumanagara tahap akademik. Penelitian ini menggunakan studi cross sectional dan dilakukan pada 182 mahasiswa FK UNTAR tahap akademik. Pengumpulan data menggunakan kuesioner secara daring dan data dianalisis menggunakan uji statistic analysis of variance (ANOVA). Mahasiswa mengalami burnout ringan 4 (2,2%), burnout sedang 173 (95,1%), burnout berat 5 (2,7%), dan mean pada prokrastinasi akademik 25,43. Temuan ini secara statistic didapatkan p-value sebesar 0,499 sehingga dapat disimpulkan bahwa tidak terdapat hubungan antara burnout dengan prokrastinasi akademik pada mahasiswa Fakultas Kedokteran Universitas Tarumanagara tahap akademik

Pra Desain Pabrik Sorbitol dari Tepung Tapioka dengan Hidrogenasi Katalitik

Sorbitol yang dikenal juga sebagai glusitol, adalah suatu gula alkohol yang dimetabolisme lambat di dalam tubuh. Sorbitol banyak digunakan sebagai bahan baku untuk industri barang konsumsi dan makanan seperti pasta gigi, permen, kosmetika, farmasi, vitamin C, termasuk industri tekstil dan kulit. Pembuatan sorbitol dari bahan baku tepung tapioka. Pabrik sorbitol ini direncanakan akan didirikan di Propinsi Jawa Tengah tepatnya di Kabupaten Batang dengan kapasitas produksi 30.000 ton/tahun. Proses produksi Sorbitol menggunakan proses hidrogenasi katalitik. Pembuatan sorbitol dari bahan baku pati melalui dua tahap proses utama yaitu proses perubahan starch menjadi glukosa melalui hidrolisa double enzym. Enzim yang digunakan yaitu α-amylase dan glukoamylase. Proses hidrogenasi katalitik dilakukan dengan mereaksikan larutan dekstrose dan gas hidrogen bertekanan tinggi dengan menambahkan katalis nikel dalam reaktor (Reaktor Hidrogenasi). Gas hidrogen masuk dari bawah reaktor secara bubbling dan larutan dekstrose diumpankan dari atas reaktor sehingga kontak yang terjadi semakin baik. Sorbitol yang di hasilkan dalam pradesain pabrik sorbitol ini dengan konsentrasi 58,2%. Pendirian pabrik sorbitol memerlukan biaya investasi modal tetap (fixed capital) sebesar Rp 168.801.192.952, modal kerja (working capital)  Rp 29.788.445.815, investasi total Rp 198.589.638.767, Biaya produksi per tahun Rp 368.832.813.809 dan  hasil penjualan per tahun Rp 540.000.078.750. Dari analisa ekonomi didapatkan BEP sebesar 26,32%. ROI sesudah pajak 48,5 %, POT sesudah pajak 2,14 tahun. Dari segi teknis dan ekonomis, pabrik ini layak untuk didirikan

Pengaruh Employee Empowerment Terhadap Service Quality Di Chinese Restaurant

Berkembangnya bisnis restoran dengan konsep specialty restaurant belakangan ini menyebabkan persaingan yang sangat ketat antar pelaku bisnis di industri makanan dan minuman, sehingga Service Quality menjadi kunci utama dalam menjalankan bisnis ini. Penelitian ini dilakukan untuk mengetahui pengaruh Employee Empowerment terhadap Service Quality di Chinese Restaurant yaitu restoran Kapin, X.O Cuisine, dan Golden Rama. Teknik analisa data yang digunakan dalam penelitian ini adalah kuantitatif kausal dengan metode SEM dan menggunakan SmartPLS software. Hasil penelitian ini menunjukkan bahwa Employee Empowerment berpengaruh positif terhadap Service Behaviour dan Job Satisfaction sedangkan Employee Empowerment, Service Behaviour, dan Job Satisfaction berpengaruh negatif terhadap Service Quality

Demand for meat in Jakarta : an econometric analysis

This study aims to quantify the relationships between consumption, prices and incomes in the demand for individual meats in Jakarta. Using consumer demand theory and previous studies of meat demand, important factors in model specification are considered. A system of meat demand functions is set up in which per capita consumption is hypothesised to be: (1) negatively related to own price; (2) positively related to price of substitutes; and (3) positively related to income. Using quarterly data of 48 observations (1966-77) and a GLS estimator, double log functions are estimated. Data limitations prevented estimation of chicken demand equations and meaningful goat meat equations. The models generally support the stated hypotheses. Interpretation of the results is cautious, because of data limitations. The results suggest that beef and pork demand is own price inelastic and pork is price elastic while both income elasticities are less than unity. Some Evidence of partial adjustment in beef consumption was observed

Microbiological Assessment of Fresh Expressed Breast Milk on Room Temperature at Dr. Soetomo Hospital Neonatal Unit

Storing EBM at room temperature in several hours before consuming, frequently found in Indonesia. Based on Academy of Breastfeeding Medicine guidelines EBM can last for 6 to 8 hours in room temperature (25oC or 77oF). However, currently there hasn’t been study in tropical country especially Indonesia for the guidelines. This study aimed to assess microbiological quality of EBM on room temperature, including bacterial growth and major bacterial found on EBM for health care and society recommendations. An observational study of 30 expressed breast milk samples provided by 30 healthy women with term baby below 6 month old. The samples were kept sterile and laid at plates for 0 hours, 2 hours, 4 hours and 6 hours in room temperature (26°-32° C) and used drop plate technique on several culture media. Data was analyzed by Chi-square and paired sample T-test. Thirty of unheated fresh EBM from 30 lactating mothers were stored at room temperature, examined for the degree of bacterial contamination at 0 hour, 2 hours, 4 hours, and 6 hours. All the EBM samples were contaminated at 2 hour. Bacterial species identified was Coagulase-negative Staphylococcus (CNS), Escherichia coli, Klebsiella pneumoniae and Streptococcus faecalis, range of growth 109 cfu/ml-63 x 109 cfu/mm3 after 6 hour of storage. The EBM exposed at room temperature (30-36 0C) for more than two hour reduce the quality and do not recommended to be given to the infants

Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds.

Prion diseases are a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease (CJD) and kuru in humans, BSE in cattle, and scrapie in sheep. Such illnesses are caused by the conversion and accumulation of a misfolded pathogenic isoform (termed PrPSc) of a normally benign, host cellular protein, denoted PrPC. We employed high-throughput screening (HTS) ELISAs to evaluate compounds for their ability to reduce the level of PrPSc in Rocky Mountain Laboratory (RML) prion-infected mouse neuroblastoma cells (ScN2a-cl3). Arylpiperazines were among the active compounds identified but the initial hits suffered from low potency and poor drug-likeness. The best of those hits, such as 1, 7, 13, and 19, displayed moderate antiprion activity with EC50 values in the micromolar range. Key analogs were designed and synthesized based on the SAR, with analogs 41, 44, 46, and 47 found to have sub-micromolar potency. Analogs 41 and 44 were able to penetrate the blood-brain barrier (BBB) and achieved excellent drug concentrations in the brains of mice after oral dosing. These compounds represent good starting points for further lead optimization in our pursuit of potential drug candidates for the treatment of prion diseases

Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds.

The prion diseases caused by PrPSc, an alternatively folded form of the cellular prion protein (PrPC), are rapidly progressive, fatal, and untreatable neurodegenerative syndromes. We employed HTS ELISA assays to identify compounds that lower the level of PrPSc in prion-infected mouse neuroblastoma (ScN2a-cl3) cells and identified a series of arylamides. SAR studies indicated that small amides with one aromatic, or heteroaromatic ring, on each side of the amide bond are of modest potency. Of note, benzamide (7), with an EC50 of 2200 nM, was one of only a few arylamide hits with a piperazine group on its aniline moiety. The basic piperazine nitrogen can be protonated at physiologic pH, improving solubility, and therefore we wanted to exploit this feature in our search for a drug candidate. An SAR campaign resulted in several key analogs, including a set with biaryl groups introduced on the carbonyl side for improved potency. Several of these biaryl analogs have submicromolar potency, with the most potent analog 17 having an EC50 = 22 nM. More importantly, 17 and several biarylamides (20, 24, 26, 27) were able to traverse the BBB and displayed excellent drug levels in the brains of mice following oral dosing. These biarylamides may represent good starting points for further lead optimization for the identification of potential drug candidates for the treatment of prion diseases

Preparation of Reducing Sugar Hydrolyzed from High-Lignin Coconut Coir Dust Pretreated by the Recycled Ionic Liquid [mmim][dmp] and Combination with Alkaline

This study aims to produce reducing sugar hydrolyzed from substrate, coconut coir dust pretreated by recycled ionic liquid and its combination with alkaline. The 1H NMR and FTIR were performed to ver-ify the synthesized ionic liquid methylmethylimidazolium dimethyl phosphate ([mmim][dmp]). The structure of pretreated substrates was analyzed by XRD measurement. The used ionic liquid was recy-cled twice to re-employ for substrate pretreatment. The treated- and untreated-coconut coir dust were hydrolyzed into sugars using pure cellulase. The reaction, which called an enzymatic hydrolysis, was conducted at 60 °C, pH 3, for 48 h. The yields of sugar hydrolyzed from fresh IL-pretreated, 1R*IL-pretreated and 2R*IL-pretreated substrates were of 0.19, 0.15 and 0.15 g sugar / g cellu-lose+hemicellulose, respectively. Pretreatment with NaOH or the combination of NaOH+IL resulted in yields of reducing sugars of 0.25, 0.28 g/g, respectively. When alkaline combined with the recycled ionic liquids, NaOH+1R*IL, NaOH+2R*IL in the pretreatment, the yields of sugar were relatively similar to those obtained using alkaline followed by fresh ionic liquid. If the mixture enzymes, cellu-lase+xylanase, used to liberate sugars from fresh IL-pretreated, or recycled IL-pretreated substrates, the amount of sugar (concentration or yield) increased slightly compared to that employing a single cel-lulase. These findings showed that recycled IL pretreatment of the high-lignin lignocellulose, coconut coir dust, is a new prospect for the economical manufacture of fermentable sugars and biofuel in the coming years. © 2015 BCREC UNDIP. All rights reservedReceived: 1st July 2014; Revised: 5th September 2014; Accepted: 5th September 2014 How to Cite: Sangian, H.F., Kristian, J., Rahma, S., Dewi, H., Puspasari, D., Agnesty, S., Gunawan, S., Widjaja, A. (2015). Preparation of Reducing Sugar Hydrolyzed from High-Lignin Coconut Coir Dust Pretreated by the Recycled Ionic Liquid [mmim][dmp] and Combination with Alkaline. Bulletin of Chemical Reaction Engineering &amp; Catalysis, 10 (1): 8-22. (doi:10.9767/bcrec.10.1.7058.8-22)Permalink/DOI: http://dx.doi.org/10.9767/bcrec.10.1.7058.8-22</p

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.

In the neurodegenerative disease multiple system atrophy (MSA), α-synuclein misfolds into a self-templating conformation to become a prion. To compare the biological activity of α-synuclein prions in MSA and Parkinson's disease (PD), we developed nine α-synuclein-YFP cell lines expressing point mutations responsible for inherited PD. MSA prions robustly infected wild-type, A30P, and A53T α-synuclein-YFP cells, but they were unable to replicate in cells expressing the E46K mutation. Coexpression of the A53T and E46K mutations was unable to rescue MSA prion infection in vitro, establishing that MSA α-synuclein prions are conformationally distinct from the misfolded α-synuclein in PD patients. This observation may have profound implications for developing treatments for neurodegenerative diseases