973 research outputs found
Poverty Simulations: Building Relationships Among Extension, Schools, and the Community
Poverty simulations can be effective experiential learning tools for educating community members about the impact of poverty on families. The project described here includes survey results from three simulations with community leaders and teachers. This project illustrated how such workshops can help Extension professionals extend their reach and impact by engaging coalitions and volunteers and building community partnerships with school systems and community leadership groups
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Postsecondary Employment Outcomes for Youth With Serious Emotional Disturbance: An Analysis of National Data
The purpose of this study was to identify individual characteristics and school experiences of youth with serious emotional disturbance (SED) that may influence their postsecondary employment status
Telomeric expression sites are highly conserved in trypanosoma brucei
Subtelomeric regions are often under-represented in genome sequences of eukaryotes. One of the best known examples of the use of telomere proximity for adaptive purposes are the bloodstream expression sites (BESs) of the African trypanosome Trypanosoma brucei. To enhance our understanding of BES structure and function in host adaptation and immune evasion, the BES repertoire from the Lister 427 strain of T. brucei were independently tagged and sequenced. BESs are polymorphic in size and structure but reveal a surprisingly conserved architecture in the context of extensive recombination. Very small BESs do exist and many functioning BESs do not contain the full complement of expression site associated genes (ESAGs). The consequences of duplicated or missing ESAGs, including ESAG9, a newly named ESAG12, and additional variant surface glycoprotein genes (VSGs) were evaluated by functional assays after BESs were tagged with a drug-resistance gene. Phylogenetic analysis of constituent ESAG families suggests that BESs are sequence mosaics and that extensive recombination has shaped the evolution of the BES repertoire. This work opens important perspectives in understanding the molecular mechanisms of antigenic variation, a widely used strategy for immune evasion in pathogens, and telomere biology
Mercury and monomethylmercury in fluids from Sea Cliff submarine hydrothermal field, Gorda Ridge
Author Posting. © American Geophysical Union, 2006. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 33 (2006): L17606, doi:10.1029/2006GL026321.Submarine hydrothermal systems are hypothesized to be a potentially important source of monomethylmercury (MMHg) to the ocean, yet the amount of MMHg in vent fluids is unknown. Here, we report total Hg and MMHg concentrations in hydrothermal vent fluids sampled from the Sea Cliff site on the Gorda Ridge. MMHg is the dominant Hg species, and levels of total Hg are enhanced slightly compared to seawater. Hg is enriched in deposits surrounding the site, suggesting near-field deposition from fluid plumes, with rapid MMHg demethylation and scavenging of Hg(II) complexes. Assuming the flux of MMHg from Sea Cliff is representative of global submarine hydrothermal inputs, we estimate a flux of 0.1–0.4 Mmoles y−1, which may be attenuated by scavenging near the vents. However, deep waters are not typically known to be elevated in Hg, and thus we suggest that hydrothermal systems are not significant sources of MMHg to commercial fisheries.WHOI Academic
Programs Office, the Penzance Endowed Discretionary Fund,
NSF-OCE and EPA-STAR, NOAA-NUR
The negotiation and co-construction of meaning and understanding within a postgraduate online learning community
There is an increasing development of courses and course components taught through teaching and learning dialogues online yet there is little secure knowledge regarding the educational quality and outcomes of these dialogues. Drawing on contemporary socio-cultural research, this paper adapts a well-established analytical framework (see Mercer, 1995) that has been developed to understand face to face educational dialogues to the new context of asynchronous electronic conferencing. The work reported is derived from an in-depth case study of a tutorial group of 11 students enrolled on a course within the Open University's MA in Open and Distance Learning. The course was taught on-line to an international cohort of students from wide-ranging academic backgrounds. The analyses of electronic conference archives presented here focus on understanding the students’ on-line collaborative work and the ways in which they constructed meaning, negotiated shared understanding and supported each other in the process of learning at a distance. The implications of the findings for educational practice are considered
The green valley is a red herring : Galaxy Zoo reveals two evolutionary pathways towards quenching of star formation in early-and late-type galaxies
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Monthly Notices of the Royal Astronomical Society following peer review. The version of record [Kevin Schawinski, et al, 'The green valley is a red herring: Galaxy Zoo reveals two evolutionary pathways towards quenching of star formation in early- and late-type galaxies' MNRAS, Vol. 440(1): 889-907, May 2014] is available online at: https://doi.org/10.1093/mnras/stu327.We use SDSS+GALEX+Galaxy Zoo data to study the quenching of star formation in lowredshift galaxies. We show that the green valley between the blue cloud of star-forming galaxies and the red sequence of quiescent galaxies in the colour-mass diagram is not a single transitional state through which most blue galaxies evolve into red galaxies. Rather, an analysis that takes morphology into account makes clear that only a small population of blue early-type galaxies move rapidly across the green valley after the morphologies are transformed from disc to spheroid and star formation is quenched rapidly. In contrast, the majority of blue star-forming galaxies have significant discs, and they retain their late-type morphologies as their star formation rates decline very slowly. We summarize a range of observations that lead to these conclusions, including UV-optical colours and halo masses, which both show a striking dependence on morphological type. We interpret these results in terms of the evolution of cosmic gas supply and gas reservoirs. We conclude that late-type galaxies are consistent with a scenario where the cosmic supply of gas is shut off, perhaps at a critical halo mass, followed by a slow exhaustion of the remaining gas over several Gyr, driven by secular and/or environmental processes. In contrast, early-type galaxies require a scenario where the gas supply and gas reservoir are destroyed virtually instantaneously, with rapid quenching accompanied by a morphological transformation from disc to spheroid. This gas reservoir destruction could be the consequence of a major merger, which in most cases transforms galaxies from disc to elliptical morphology, and mergers could play a role in inducing black hole accretion and possibly active galactic nuclei feedback.Peer reviewe
Galaxy Zoo: Quantifying Morphological Indicators of Galaxy Interaction
We use Galaxy Zoo 2 visual classifications to study the morphological
signatures of interaction between similar-mass galaxy pairs in the Sloan
Digital Sky Survey. We find that many observable features correlate with
projected pair separation; not only obvious indicators of merging, disturbance
and tidal tails, but also more regular features, such as spiral arms and bars.
These trends are robustly quantified, using a control sample to account for
observational biases, producing measurements of the strength and separation
scale of various morphological responses to pair interaction. For example, we
find that the presence of spiral features is enhanced at scales < 70 h^-1 kpc,
probably due to both increased star formation and the formation of tidal tails.
On the other hand, the likelihood of identifying a bar decreases significantly
in pairs with separations < 30 h^-1 kpc, suggesting that bars are suppressed by
close interactions between galaxies of similar mass. We go on to show how
morphological indicators of physical interactions provide a way of
significantly refining standard estimates for the frequency of close pair
interactions, based on velocity offset and projected separation. The presence
of loosely wound spiral arms is found to be a particularly reliable signal of
an interaction, for projected pair separations up to ~100 h^-1 kpc. We use this
indicator to demonstrate our method, constraining the fraction of low-redshift
galaxies in truly interacting pairs, with M_* > 10^9.5 M_Sun and mass ratio <
4, to be between 0.4 - 2.7 per cent.Comment: Accepted to MNRAS on November 12, 201
Generalisability of vaccine effectiveness estimates: an analysis of cases included in a postlicensure evaluation of 13-valent pneumococcal conjugate vaccine in the USA
External validity, or generalisability, is the measure of how well results from a study pertain to individuals in the target population. We assessed generalisability, with respect to socioeconomic status, of estimates from a matched case–control study of 13-valent pneumococcal conjugate vaccine effectiveness for the prevention of invasive pneumococcal disease in children in the USA
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