International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study

Abstract: Background: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. Methods: This was a national cohort study of patients with early BC undergoing multidisciplinary team (MDT)-guided treatment recommendations during the pandemic, designated ‘standard’ or ‘COVID-altered’, in the preoperative, operative and post-operative setting. Findings: Of 3776 patients (from 64 UK units) in the study, 2246 (59%) had ‘COVID-altered’ management. ‘Bridging’ endocrine therapy was used (n = 951) where theatre capacity was reduced. There was increasing access to COVID-19 low-risk theatres during the study period (59%). In line with national guidance, immediate breast reconstruction was avoided (n = 299). Where adjuvant chemotherapy was omitted (n = 81), the median benefit was only 3% (IQR 2–9%) using ‘NHS Predict’. There was the rapid adoption of new evidence-based hypofractionated radiotherapy (n = 781, from 46 units). Only 14 patients (1%) tested positive for SARS-CoV-2 during their treatment journey. Conclusions: The majority of ‘COVID-altered’ management decisions were largely in line with pre-COVID evidence-based guidelines, implying that breast cancer survival outcomes are unlikely to be negatively impacted by the pandemic. However, in this study, the potential impact of delays to BC presentation or diagnosis remains unknown

Product throttling for power domination

The product power throttling number of a graph is defined to study product throttling for power domination. The domination number of a graph is an upper bound for its product power throttling number. It is established that the two parameters are equal for certain families including paths, cycles, complete graphs, unit interval graphs, and grid graphs (on the plane, cylinder, and torus). Families of graphs for which the product power throttling number is less than the domination number are also exhibited. Graphs with extremely high or low product power throttling number are characterized and bounds on the product power throttling number are established.This is a pre-print of the article Anderson, Sarah E., Karen L. Collins, Daniela Ferrero, Leslie Hogben, Carolyn Mayer, Ann N. Trenk, and Shanise Walker. "Product throttling for power domination." arXiv preprint arXiv:2010.16315 (2020). Posted with permission.</p

Product Throttling

Throttling addresses the question of minimizing the sum or the product of the resources used to accomplish a task and the time needed to complete that task for various graph searching processes. Graph parameters of interest include various types of zero forcing, power domination, and Cops and Robbers. The resources used to accomplish a task can be blue vertices in zero forcing, Phasor Measurement Units (PMUs) in power domination, or cops in Cops and Robbers. The time is the number of rounds needed to complete the process (the propagation time or capture time).This is a pre-print of a book chapter published as Anderson, Sarah E., Karen L. Collins, Daniela Ferrero, Leslie Hogben, Carolyn Mayer, Ann N. Trenk, and Shanise Walker. "Product Throttling." https://arxiv.org/abs/2012.12807v2 (2021). Posted with permission.</p

Product Throttling

Throttling addresses the question of minimizing the sum or the product of the resources used to accomplish a task and the time needed to complete that task for various graph searching processes. Graph parameters of interest include various types of zero forcing, power domination, and Cops and Robbers. We provide a survey of product throttling for these parameters

Development of risk reduction behavioral counseling for Ebola virus disease survivors enrolled in the Sierra Leone Ebola Virus Persistence Study, 2015-2016.

BackgroundDuring the 2014-2016 West Africa Ebola Virus Disease (EVD) epidemic, the public health community had concerns that sexual transmission of the Ebola virus (EBOV) from EVD survivors was a risk, due to EBOV persistence in body fluids of EVD survivors, particularly semen. The Sierra Leone Ebola Virus Persistence Study was initiated to investigate this risk by assessing EBOV persistence in numerous body fluids of EVD survivors and providing risk reduction counseling based on test results for semen, vaginal fluid, menstrual blood, urine, rectal fluid, sweat, tears, saliva, and breast milk. This publication describes implementation of the counseling protocol and the key lessons learned.Methodology/principal findingsThe Ebola Virus Persistence Risk Reduction Behavioral Counseling Protocol was developed from a framework used to prevent transmission of HIV and other sexually transmitted infections. The framework helped to identify barriers to risk reduction and facilitated the development of a personalized risk-reduction plan, particularly around condom use and abstinence. Pre-test and post-test counseling sessions included risk reduction guidance, and post-test counseling was based on the participants' individual test results. The behavioral counseling protocol enabled study staff to translate the study's body fluid test results into individualized information for study participants.Conclusions/significanceThe Ebola Virus Persistence Risk Reduction Behavioral Counseling Protocol provided guidance to mitigate the risk of EBOV transmission from EVD survivors. It has since been shared with and adapted by other EVD survivor body fluid testing programs and studies in Ebola-affected countries

Behavioral guidance for positive qRT-PCR test results on body fluid specimens.

<p>Behavioral guidance for positive qRT-PCR test results on body fluid specimens.</p