Predictive value of inflammatory cell ratios in incidental thyroid papillary carcinoma

Introduction: Due to the well-known relationship between inflammatory processes and carcinogenesis, the diagnostic and prognostic value of systemic inflammatory markers are at the focus of research. This study aimed to investigate the predictive value of inflammatory cell data obtained from complete blood count in incidentally detected thyroid papillary carcinoma. Methods: A total of 100 cases were included in the study, consisting of histopathologically diagnosed multinodular hyperplasia (MNH) (N = 20), lymphocytic thyroiditis (LT) (n = 20), incidental thyroid papillary carcinoma (ITPC) (n = 20), incidental papillary carcinoma and lymphocytic thyroiditis (ITPCLT) (n = 20), and thyroid papillary carcinoma (TPC) (n = 20). Neutrophil / lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), platelet/neutrophil ratio (PNR), lymphocyte/ monocyte ratio (LMR) and lymphocyte/ eosinophil ratio (LER) values were compared between the groups. Results: No significant difference was detected between the groups concerning the mean inflammatory cell and platelet values. However, statistical significance was observed between the ITPC and ITPCLT groups regarding the mean LMR and LER values (p=0.009 and p=0.037, respectively). Higher LMR was found in the ITPC group, while higher LER was seen in the ITPCLT group. Conclusions: We suggest that besides ratios such as NLR and PLR used as systemic inflammatory markers in carcinogenetic processes, the evaluation of LER and LMR might be imperative as well. Therefore, these potential markers should be studied in bigger series of tumors, especially where inflammatory processes are involved in the etiology

Demir yükü artmış karaciğerde i̇nce i̇ğne aspirasyon sitolojisi (IIAS) ve tru-cut biyopsisi: deneysel bir çalışma

Objective: Fine needle aspiration cytology (FNAC) is safer, simpler, faster and cost effective, compared to tru-cut biopsy, and patient compliance is generally better. There is not much data on the use of FNAC, which is used in many organs and lesions, in parenchymal diseases in the liver. Therefore, in this study, the benefit of FNAC in showing iron deposition and injury of liver is evaluated. Methods: There were 2 control groups in the study. At the end of the study, FNAC and tru-cut biopsy samples were taken from these groups, where no administration was performed. FNAC and tru-cut biopsy procedures were also performed to the study groups after the iron overload was created by intraperitoneal iron dextran (88 mg/kg) administration for 28 days. Hepatocyte injury, inflammation and iron deposition were evaluated histopathologically in the preparations. The sensitivity, specificity, positive and negative predictivity and diagnostic accuracy of both methods were calculated based on the hepatectomy material. Results: In hepatocyte injury; sensitivity (60%), diagnostic accuracy (66.7%) and negative predictivity (50%) were found to be significantly higher in tru-cut group. It was observed that the methods were not superior to each other in the evaluation of inflammation, and FNAC almost approached tru-cut biopsy rates (100%) with a sensitivity of 83.3% and diagnostic accuracy in iron deposition. Conclusion: In iron-induced liver damage, the gold standard should be tissue examination, so tru-cut biopsy must be the first choice. However, based on the present study results, it is suggested that FNAC may be preferred over more invasive options in cases where tru-cut biopsy can not be used in terms of susceptibility to bleeding, situations where surgical accessibility is not available, patient orientation and cooperation is poor, or in presence of different accompanying diseases

Brain morphometric changes in patients with fibromyalgia

The aim of this study was to determine whether there is a decrease or an increase in the volume of different regions of the brain by comparing brain morphometry ofpatients diagnosed with Fibromyalgia Syndrome and healthy control subjects. The study included 23 female patients who were diagnosed with fibromyalgia, and 18 females, age-matched healthy subjects. Structural Mitral Regurgitation  data was processed using Surface-Based Morphometry (SBM) on the Freesurfer 6.0 programme (http://surfer.nmr.mgh.harvard.edu). As a result of the surface-based analyses, a statistically significant reduction was determined in the Fibromyalgia Syndrome patient group in some brain region. A statistically signficant  increase was determined in the FMS patient group with respect to the left anterior occipital sulcus volume, left inferior temporal gyrus thickness and left anterior occipital sulcus area. The results of this study showed that FMS affected brain morphometry through the brain central pain mechanisms and the normal brain morphology was changed because of atrophy in some areas and hypertrophy in some areas. Keywords:Brain MRI, brain morphometry, fibromyalgia pain

İnsidental tiroid papiller karsinomda inflamatuvar hücre oranlarının prediktif değeri

Introduction: Due to the well-known relationship between inflammatory processes and carcinogenesis, the diagnostic and prognostic value of systemic inflammatory markers are at the focus of research. This study aimed to investigate the predictive value of inflammatory cell data obtained from complete blood count in incidentally detected thyroid papillary carcinoma. Methods: A total of 100 cases were included in the study, consisting of histopathologically diagnosed multinodular hyperplasia (MNH) (N = 20), lymphocytic thyroiditis (LT) (n = 20), incidental thyroid papillary carcinoma (ITPC) (n = 20), incidental papillary carcinoma and lymphocytic thyroiditis (ITPCLT) (n = 20), and thyroid papillary carcinoma (TPC) (n = 20). Neutrophil / lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), platelet/neutrophil ratio (PNR), lymphocyte/ monocyte ratio (LMR) and lymphocyte/ eosinophil ratio (LER) values were compared between the groups. Results: No significant difference was detected between the groups concerning the mean inflammatory cell and platelet values. However, statistical significance was observed between the ITPC and ITPCLT groups regarding the mean LMR and LER values (p=0.009 and p=0.037, respectively). Higher LMR was found in the ITPC group, while higher LER was seen in the ITPCLT group. Conclusions: We suggest that besides ratios such as NLR and PLR used as systemic inflammatory markers in carcinogenetic processes, the evaluation of LER and LMR might be imperative as well. Therefore, these potential markers should be studied in bigger series of tumors, especially where inflammatory processes are involved in the etiologyGiriş: İnflamatuvar süreçlerin karsinogenetik süreçler ile ilişkisi bilinmekte ve sistemik inflamatuvar belirteçlerin tanısal ve prognostik değeri araştırılmaktadır. Bu çalışmada insidental olarak saptanan tiroid papiller karsinomlarda tam kan sayımından elde edilen inflamatuvar hücre verilerinin prediktif değerini araştırmak amaçlanmıştır. Yöntem: Histopatolojik tanıları multinodüler hiperplazi (MNH) (n=20), lenfositik tiroidit (LT) (n=20), insidental tiroid papiller karsinom (İTPK) (n=20), insidental papiller karsinom ve lenfositik tiroidit (İTPKLT) (n=20) ve tiroid papiller karsinom (TPK) (n=20) olmak üzere toplam 100 olgu çalışmaya dahil edildi. Olguların nötrofil/ lenfosit oranı (NLO), platelet lenfosit oranı (PLO), platelet/ nötrofil oranı (PNO), lenfosit monosit oranı (LMO) ve lenfosit eozinofil oranı (LEO) değerleri gruplar arasında karşılaştırıldı. Bulgular: İnflamatuvar hücre ortalamaları ve platelet verileri incelendiğinde gruplar arasında bariz farklılık dikkati çekmedi. İnsidental tiroid papiller karsinom ile yapılan analizlerde İTPKLT grubu ile arasında LMO ve LEO açısından belirgin istatistiksel anlamlılık gözlendi (p değerleri sırası ile 0,009 ve 0,037). Buna göre LMO İTPK'da yüksek, LEO ise İTPKLT grubunda yüksek saptandı. Sonuç: İnflamatuvar hücrelere dair karsinogenetik süreçlerde salt sistemik inflamatuvar belirteçler olarak kullanılan NLR, PLR gibi oranların değil LEO ve LMO gibi oranlarında değerlendirilmesinin gelecekte önem arz edebileceğini ve bu nedenle özellikle inflamatuvar süreçlerin etyolojide yer aldığı tümörlerde geniş olgu serilerinde incelenmesi gerektiğini düşünmekteyiz

Mirror Imaginary Movement Disorder and Pachygyria Association: Case Report

Mirror imaginary movement disorders are a group of syndromes characterized by automatic reflex mimicking of voluntary movements on the contralateral side. Two hypotheses for these symptoms are currently accepted: abnormal development of the ipsilateral corticospinal tract and transcallosal inhibition deficiency. Pachygyria refers to a decreased number of gyri divided with flat and superficial cerebral cortex sulci. We found pachygyria on cranial imaging of a boy aged 8 years who made similar movements with the one hand while writing with the other hand at presentation. Hence, pachygyria may play a role in mirror imaginary movement disorder

Mirror Imaginary Movement Disorder and Pachygyria Association: Case Report

Mirror imaginary movement disorders are a group of syndromes characterized by automatic reflex mimicking of voluntary movements on the contralateral side. Two hypotheses for these symptoms are currently accepted: abnormal development of the ipsilateral corticospinal tract and transcallosal inhibition deficiency. Pachygyria refers to a decreased number of gyri divided with flat and superficial cerebral cortex sulci. We found pachygyria on cranial imaging of a boy aged 8 years who made similar movements with the one hand while writing with the other hand at presentation. Hence, pachygyria may play a role in mirror imaginary movement disorder

Comparison of tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model

MAKAV, MUSTAFA/0000-0003-1879-8180; Adali, Yasemen/0000-0002-8004-7364; EROGLU, Huseyin Avni/0000-0002-1040-3255; Gok, Mustafa/0000-0001-7021-0984; KARAYOL, SUNAY SIBEL/0000-0002-2696-3580WOS: 000568954700005PubMed: 32935794INTRODUCTION: Liver biopsies such as tru-cut (sharp needle) and fine-needle aspiration cytology (FNAC) are the most commonly preferred techniques to detect the grade and stage of certain liver diseases. in this study, we aimed to compare the efficiency of USG-guided tru-cut biopsy and fine-needle aspiration cytology in an experimental alcoholic liver disease model. METHODS: Thirty-six female Wistar albino rats, 4-6 months old, and weighing from 190 to 250 g, were used in this study. the animals were randomly divided into six equal groups: GI (control), G2 (tru-cut control), G3 (FNAC control), G4 (Alcoholic liver disease model), G5 (Alcoholic liver disease model + FNAC), and G6 (Alcoholic liver disease model + tru-cut biopsy). After a histopathological evaluation by light microscopy, the sensitivity, specificity, positive and negative predictive values of FNAC and tru-cut biopsy for the diagnosis of liver lesions were calculated. RESULTS: No pathology was detected in GI except for mild congestion. on the other hand, hepatocyte damage, periportal inflammation, congestion, and fatty changes were detected in all liver tissues of the alcoholic liver disease groups. the sensitivity of hepatocyte damage, inflammation, congestion, and fatty change parameters for FNAC were 33.3%, 80%, 0%, and 0%, respectively, while the sensitivity of the same variables for tru-cut were 66.7%, 40%, 100%, and 20%, respectively. DISCUSSION: Both techniques were superior in some aspects. FNAC can be an attractive alternative to tru-cut biopsy and applied in routine practice in the diagnosis of non-tumoral liver diseases.Kafkas UniversityKafkas University [2016-TS-56]This study is funded by Kafkas University (Project number: 2016-TS-56)