23 research outputs found
Evolving Food Marketing Systems in Recovering Economies: Some Lessons from Croatia’s Gavrilović and Emerging ‘Oldies-but-Goodies’
A well-functioning food marketing system contributes greatly to domestic socio-economic development and global connectivity during periods of recovery and/or transition. Gavrilović, an established and historically successful company, i.e., an “Oldie-but-Goody,” is a case study in survival and adaptation; ultimately perhaps a model for other food marketing companies that must overcome rigorous geographical, social, political and economic challenges. This paper discusses food marketing systems and their development, provides a brief overview of Croatia’s food marketing system, and shares some lessons and best practices from Gavrilović
Effects of chronic losartan and tempol treatments on experimental focal segmental glomerulosclerosis in spontaneously hypertensive rats
Dosadašnja istraživanja pokazala su da renin angiotenzin sistem (RAS) ima važnu
ulogu u patogenezi i progresiji fokalno segmentne glomeruloskleroze (FSGS).
Oksidativni stres je prisutan u hroničnoj bubrežnoj slabosti i doprinosi progresiji bolesti.
Povezanost oksidativnog stresa i RAS u procesima progresije FSGS još je nedovoljno
razjašnjena. Stoga su istraživanja u okviru ove disertacije bila usmerena ka ispitivanju
efekata hronične primene tempola (sakupljač slobodnih radikala, SOD mimetik),
losartana (blokator receptora za angiotenzin II tipa 1, AT1R), kao i njihove kombinacije,
na usporavanje progresije FSGS izazvane adrijamicinom (ADR) kod spontano
hipertenzivnih (SH) pacova.
Životinje su inicijalno deljene u dve eksperimentalne grupe, kontrolnu (SHC) i
grupu koja je primila ADR 2 mg/kg i.v. dva puta u intervalu od 21 dan. Nakon druge
injekcije ADR, životinje su dobijale vodu (SHADR), losartan (SHADR+L), tempol
(SHADR+T) i kombinovani tretman (SHADR+T+L) gavažom. Na kraju šeste nedelje
tretmana vršena su hemodinamska merenja i uzorkovanje krvi, urina i bubrega. Na
osnovu biohemijskih parametara vršena je procena lipidnog statusa i bubrežne funkcije.
Urađena je histopatološka analiza bubrega. Imunihistohemijskom metodom ispitivani su
proteini citosketeta, nestin i vimentin, čije izmenjene ekspresije su pokazatelj oštećenja
bubrežnog tkiva. Matriksna metaloproteinaza-1 (MMP-1), koja učestvuje u degradaciji
komponenti vanćelijskog mariksa i očuvanju integriteta glomerula, određivana je ELISA
metodom. Ispitivani su parametri oksidativnog stresa: lipidna peroksidacija i nivo
karbonilovanih proteina (PCOs); aktivnosti enzima antioksidativnog sistema: superoksid
dismutaze (SOD), katalaze (CAT), glutation peroksidaze (GPx) i glutation reduktaze
(GR); kao i antioksidativni kapacitet. Primenom imunohistohemijske, Western blot i
ELISA metode u bubrezima su određivane ekspresije Nox2 i Nox4 izoforme katalitičke
subjedinice NADPH oksidaze, glavni izvor reaktivnih kiseoničnih vrsta u ćeliji, uključene
u proces inflamacije. Ekspresija proteina tri izoforme azot-monoksid sintaze, inducibilna
(iNOS), endotelna (eNOS) i neuronska (nNOS), određivane su Western blot i
imunohistohemijskom metodom u tkivu bubrega. Određivani su ukupni metaboliti NO-a
(nitriti, nitrati) u urinu i bubrezima...Previous studies have shown that renin angiotensin system (RAS) plays an
important role in the pathogenesis and progression of focal segmental glomerulosclerosis
(FSGS). Oxidative stress is involved in the development and progression of chronic
kidney disease. However, the association of oxidative stress and RAS in the progression
of FSGS has not been completely elucidated. In this study we investigated the effects of
chronic tempol (free radical scavenger, SOD mimetic), losartan (selective angiotensin II
type 1 receptor (AT1R) blocker), and their combined treatment in slowing down the
progression of FSGS, in spontaneously hypertensive (SH) rats with adriamycin (ADR)
nephropathy.
Animals were initially divided into two experimental groups: control (SHC) and
group that received ADR 2 mg/kg i.v. twice in an interval of 21 days. After the second
injection of ADR, the animals were given tap water (SHADR), losartan (SHADR+L),
tempol (SHADR+T) or combined treatment (SHADR+T+L) by gavage. Hemodynamic
measurements were performed, blood, urine, and kidney samples were taken for
biochemical and histopathological analysis. Immunohistochemical method was used for
protein expression and localization of the nestin and vimentin, proteins of cytoskeleton
network, and change in their protein expression is a marker of cell injury. Matrix
metalloproteinase-1 (MMP-1), which participates in the degradation of the extracellular
matrix components and preserving the integrity of the glomerulus, was determined by the
ELISA method. The parameters of oxidative stress: lipid peroxidation, protein carbonyl
content (PCOs); antioxidant defense: superoxide dismutase (SOD), catalase (CAT),
glutathione peroxidase (GPx), glutathione reductase (GR) and antioxidant capacity were
analysed. Immunohistochemical, Western blot and ELISA method were used for analysis
of the Nox2 and Nox4 protein expression, isoforms of the catalytic subunit of NADPH
oxidase, the main source of reactive oxygen species in the cell, involved in the
inflammation process. Protein expression of three isoforms of azote monoxide synthase,
inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) were determined by
Western blot and immunohistochemical method in the kidney. Total metabolites of NO
(nitrites, nitrates) were measured in the kidney and urine..
RAZVIJENI MARKETINŠKI SUSTAV HRANE U EKONOMIJAMA U OPORAVKU: POUKE IZVEDENE IZ HRVATSKOG “STAROG ALI USPJEŠNOG” PODUZEĆA GAVRILOVIĆ
A well-functioning food marketing system contributes greatly to domestic socio-economic development and global connectivity during periods of recovery and/or transition. Gavrilović, an established and historically successful company, i.e., an “Oldie-but-Goody,” is a case study in survival and adaptation; ultimately perhaps a model for other food marketing companies that must overcome rigorous geographical, social, political and economic challenges. This paper discusses food marketing systems and their development, provides a brief overview of Croatia’s food marketing system, and shares some lessons and best practices from Gavrilović.Marketinški sustav hrane koji dobro funkcionira snažno doprinosi društveno ekonomskom razvoju i globalnoj povezanosti u razdobljima oporavka i /ili tranzicije. Gavrilović, stabilno i povijesno uspješno poduzeće pripada grupi “starih ali uspješnih” poduzeća, poslovni je slučaj uspješnog opstanka i prilagodbe i bez premca je model za ostala poduzeća industrije hrane koja moraju predvladati geografske, društvene, političke i ekonomske izazove. Ovaj se članak bavi istraživanjem marketinškog sustava hrane i njegovog razvoja te omogućava pregled stupnja razvijenosti marketinškog sustava hrane u Hrvatskoj, posebice na primjeru poduzeća Gavrilović uspješnog poslovnog slučaja iz gospodarske prakse Hrvatske
Structural characterization of synthetic and biological carbonated hydroxyapatite
It is well known that inorganic part of bones and teeth are impure form of hydroxyapatite, (HAp) Ca10(PO4)6(OH) 2. During the past few decades, great efforts have been invested to develop synthetic equivalent of natural apatite. The major difference of natural bioapatites from hydroxyapatites is in the presence of certain content of 2- CO3 ions in the structure. The presence of the 2- CO3 ions in the HAp structure influences the reactivity and stability. Therefore, the exact content of 2- CO3 ions as well as their arrangement in the structure is very important. The aim of our work is comparative analysis of the biological carbonated hydroxyapatite extracted from human alveolar bone and synthesized carbonated hydroxyapatite (BCHAp). Structural and microstructural parameters were determined through Rietveld refinement of recorded XRPD data, and with transmission electron microscopy (TEM). Microstructure analysis showed anisotropic X-ray line broadening due to the small crystallite size (about 10 nm) as well as anisotropic growth of crystallites. The Raman spectroscopy confirmed the apatite structure and crystallinity
Regulated Dependence: Platform Workers’ Responses to New Forms of Organizing
Platform economy organizations often resolve fundamental organizing problems with novel solutions, thereby transforming their relationship with core stakeholders including regulators and workers. Despite the integral role played by platform workers, research on the interplay between platforms and regulatory conditions has yet to take workers into consideration. We investigate how Uber drivers engage with novel forms of organizing across different regulatory structures. Drawing on insights from resource dependence theory, we conduct a topic modeling analysis of drivers’ online forum posts and a complementary qualitative analysis of triangulated data sources. Our findings reveal that workers do not always succumb to organizing solutions imposed upon them; they also actively oppose or supplement them. Importantly, platform workers’ responses vary with the local regulatory structure, which affects the mutual dependency and balance of power between platforms and workers. We discuss implications for the literature on new forms of organizing and the platform economy
Synthetical bone-like and biological hydroxyapatites: a comparative study of crystal structure and morphology
Phase composition, crystal structure and morphology of biological hydroxyapatite (BHAp) extracted from human mandible bone, and carbonated hydroxyapatite (CHAp), synthesized by the chemical precipitation method, were studied by x-ray powder diffraction (XRD), Fourier transform infrared (FTIR) and Raman (R) spectroscopy techniques, combined with transmission electron microscopy (TEM). Structural and microstructural parameters were determined through Rietveld refinement of recorded XRD data, performed using the FullProf computing program, and TEM. Microstructural analysis shows anisotropic extension along the [0 0 l] crystallographic direction (i.e. elongated crystallites shape) of both investigated samples. The average crystallite sizes of 10 and 8 nm were estimated for BHAp and CHAp, respectively. The FTIR and R spectroscopy studies show that carbonate ions substitute both phosphate and hydroxyl ions in the crystal structure of BHAp as well as in CHAp, indicating that both of them are mixed AB-type of CHAp. The thermal behaviour and carbonate content were analysed using thermogravimetric and differential thermal analysis. The carbonate content of about 1 wt.% and phase transition, at near 790 °C, from HAp to β-tricalcium phosphate were determined in both samples. The quality of synthesized CHAp powder, particularly, the particle size distribution and uniformity of morphology, was analysed by a particle size analyser based on laser diffraction and field emission scanning electron microscopy, respectively. These data were used to discuss similarity between natural and synthetic CHAp. Good correlation between the unit cell parameters, average crystallite size, morphology, carbonate content and crystallographic positions of carbonate ions in natural and synthetic HAp samples was found
Polymeric cooper(II) complex with 2,2’-dipyrydilamine and terephthalate ions
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