A study of the correlation between the serum Latexin levels and the mTORC subunits Raptor and Rictor in the molecular pathogenesis of chronic lymphocytic leukemia

Hematopoietic stem cells (HSCs) ensure the lifelong production of blood cells throughout a lifetime. Latexin (Lxn) is thought to have a tumor suppressor role and endogenously down-regulate the number of HSCs via increased apoptosis. Therewithal, Raptor, and Rictor are components of the mammalian target of rapamycin complex-1, and 2 (mTORC), which are the regulatory structures for cell growth. However, Lxn, Raptor, and Rictor-associated molecular mechanisms underlying leukemia-induced HSCs proliferation are largely unknown. Nowadays, chronic lymphocytic leukemia (CLL) remains the most common leukemia type in adults. Therefore, we investigated the serum levels of Lxn, Raptor, and Rictor in CLL patients. We randomized 40 patients with newly diagnosed, untreated CLL. Serum levels of Lxn, Raptor, and Rictor were examined using ELISA assay. The results showed that serum Lxn levels reduced in patients with CLL. Moreover, the Rictor level increased in association with the up-regulation of leukocytosis. Although there was a tendency for an increase of the Raptor levels, the differences did not reach statistical significance. The up-regulated Raptor and Rictor levels in CLL suggested that it was associated with cancer pathogenesis. However, decreased Lxn levels raised the question of whether the disease is secondary to epigenetic features or if it is caused by pathology related to Lxn. The negative correlation between Lxn and Raptor/Rictor levels can provide new methods for the treatment of CLL, which are likely to increase the quality of life and improve the prognosis of the disease. In conclusion, further clinical studies are needed to elucidate the role of Lxn and Raptor/Rictor with the newly defined molecular properties in hematological malignancies and the clinical implications of their use. [Med-Science 2021; 10(2.000): 511-5

Woe patient is purple

Aim: Our purpose in presenting this case is to review the management of traumatic asphyxia with blunt thoracic trauma patients. Case: A 47 year-old male patient due to accident at work were brought to the emergency department with chest and abdominal pain. On physical examination face, upper extremities, 1/3 of both the proximal and the body to the level of the nipple with cyanosis, subconjunctival hemorrhage in both eyes was seen. At bed side echocardiography it wasn't seen pericardial effusion. At chest computed tomography there were pneumomediastenium, sternum fracture and pulmonary contusion. Patient was entubated and admitted to intensive care unit and followed. Conclusion: Traumatic asphyxia is a clinical condition caused by blunt thoracoabdominal trauma, and with good trauma management patients can be discharged with less mortality and morbidity. [Cukurova Med J 2014; 39(4.000): 914-917

The effects of therapeutic X-ray doses on mechanical, chemical and physical properties of poly methyl methacrylate

Aim. The aim of this study was to investigate the effect of radiation doses very close to the human dose for oral cancers on mechanical, chemical and physical properties for poly methyl-methacrylate (PMMA). Methods. PMMA samples were divided into four different groups: no irradiated group, 25-Gy irradiated group, 50-Gy irradiated group and 75-Gy irradiated group. Each group contained nine samples. After 24 h, a three-point loading test was applied to each PMMA groups. The transverse strength and the elastic modulus were calculated using the test results. The results were analyzed statistically by using one-way analysis of variance. The structural characterizations of the PMMA samples were carried out by a Fourier Transform Infrared (FTIR) spectrophotometer to evaluate the chemical structure differences. Results. The transverse strength values of 25-Gy, 50-Gy and 75-Gy radiation groups were significantly higher than that of the no radiation group (p 0.05). The FTIR findings demonstrated that the irradiation process did not change the chemical structure of the PMMA polymeric materials. Conclusion. The therapeutic radiation doses increase the mechanical properties of the PMMA; however, the chemical and structural properties have no effect. When the findings of this study are taken into account, it can be said that patients can wear dentures during the radiotherapy. © 2013 Informa Healthcare

Analysis of quarry-blast-induced ground vibrations to mitigate their adverse effects on nearby structures

The Peak Particle Velocities (PPVs) were measured at several station points in the vicinity of a limestone quarry in Turkey, and a Scaled Distance (SD) value for each individual blast was calculated. A linear regression analysis was performed and results were plotted. An attenuation equation unique for the limestone quarry was statistically derived from the plotted graph, with an acceptable correlation coefficient. The safe charge weight per delay was calculated for given distances, based on the damage criteria developed by US Bureau of Mines (USBM), DIN 4150-3 and other international standards. A comparison was also performed between the predicted and measured PPV values to verify the accuracy of the attenuation equation

Effects of amlodipine on ischaemia/reperfusion injury in the rat testis

CADIRCI, ELIF/0000-0003-0836-7205; Karakus, Emre/0000-0002-0822-0054; bayir, yasin/0000-0003-3562-6727WOS: 000374179400010PubMed: 26259852The aim of this study was to examine the effects of amlodipine (AML) in rat testicular torsion/detorsion damage. in this study, rats were divided into eight groups: (i) sham; (ii) testicular ischaemia, 2h of ischaemia; (iii) testicular ischaemia/reperfusion (I/R), 2h of ischaemia followed by 2h of reperfusion; (iv) ischaemia + AML (5mgkg(-1)) administered 30min before ischaemia; (v) ischaemia + AML (10mgkg(-1)) administered 30min before ischaemia; (vi) and (vii) I/R + AML (5mgkg(-1)) and I/R + AML (10mgkg(-1)) administered 1.5h after the induction of ischaemia, respectively, and at the end of a 2-h ischaemia period and a 2-h reperfusion period applied; and (viii) sham + AML (10mgkg(-1)). Significant decreases in levels of superoxide dismutase and glutathione were observed in ischaemia and reperfusion groups when compared with healthy controls. These antioxidant levels increased in AML groups while malondialdehyde levels significantly decreased. While increases in tumour necrosis factor-alpha and transforming growth factor-beta levels were found in the torsion and detorsion groups, significant decreases in the levels of these inflammatory cytokines were observed in the treatment groups. These results demonstrate that AML significantly produced protective effects on testis tissue damage that occurs in the torsion/detorsion model via biochemical, histopathological and molecular pathways

Adaption of Talent Management Scale into Turkish: Sinop University Case

As a result of globalization, talented employees have been needed in the workplace anymore. With being hired of talented employees, new understanding of management has appeared and talent management has gained importance due to this new understanding. Talent management is a kind of management understanding according to which employees feel motivated and have desire to move forward by taking the initiative, trust in their knowledge and expertise has increased, they believe that they can control the incidents and the conditions which enable them to fulfill the tasks which are suitable and meaningful for them for the sake of organizational purposes have been composed (Doğan, 2006). Talent management is composed of a five-step process, which these steps are hiring, keeping, improving, performance and strengthening personnel. The purpose of this study is to adapt the scale which was used by Oehley (2007) in the thesis of “The Development and Evaluation of a Partial Talent Management Competency Model” for prospective teachers in Turkey. The adaptation study was conducted with 133 prospective teachers who are continuing their education in the Faculty of Education of Sinop University. In the adaptation study, exploratory factor analysis and confirmatory factor analysis were conducted. The original scale is composed of 44 items. In the first step of the adaptation study, 40 items are included in the Turkish form with regard to expert opinions. As a result of exploratory factor analysis conducted, item 8 was excluded from the scale. The scale has come up with 8 sub-dimensions as it is in the original scale. To test its accuracy, confirmatory factor analysis was conducted for 39 items

Evaluation of effectiveness of erbium:yttrium-aluminum-garnet laser on atrophic facial acne scars with 22-MHz digital ultrasonography in a Turkish population

Scar formation due to acne is a common problem among the young population and significantly affects their quality of life. The aim of this study was to evaluate the efficacy of erbium:yttriumaluminumgarnet (Er:YAG) laser resurfacing for acne scars and to objectively demonstrate the altering of collagen density in the dermis by 22-MHz digital ultrasonography. Twenty-one patients, aged 1955 similar to years, with facial acne scars were treated with Er:YAG laser. The results of the laser resurfacing were evaluated for the degree of clinical improvement, alteration of the collagen density by 22-MHz digital ultrasonography and any adverse effects at 3 similar to months. At 3 similar to months after the treatment, good (in 12 patients) and near total (in four patients) clinical improvement was noted in most of the patients compared to baseline. Overall treatment results were 76% (both near total and good) in 16 patients. By ultrasonographic evaluation, the average density of dermal collagen (total density/number of patients) of 21 patients was 32.714 (right cheek) and 32.142 (left cheek) before laser facial resurfacing. At the third month after treatment, the average density of dermal collagen of 21 patients was 36.380 (right cheek) and 38.809 (left cheek). In conclusion, Er:YAG laser skin resurfacing was found to be a safe and effective treatment modality for treatment of atrophic facial acne scars. As public demand grows for less invasive modalities to approach clinical diagnosis and evaluation, digital ultrasonography seems to provide an easy and confidential method for collagen density evaluation

Assessment of diagnostic doses for widely used synthetic pyrethroids (Deltamethrin & Permethrin) in an endemic focus of leishmaniasis in Turkey

WOS: 000384846700007PubMed ID: 27688146Background: Leishmania is a group of parasitic flagellated protozoons, which are transmitted by female sand flies and produces health problems in humans and also in wild and domestic animals. So far, 25 Phlebotomus and 4 Sergentomyia species were recorded in Turkey including proven or possible vectors of Leishmania spp. As no single insecticide susceptibility test was conducted targeting the sand flies in Turkey, we aimed to determine the diagnostic dose against two commonly used synthetic pyrethroids (deltamethrin and permethrin) in a hyperendemic area for leishmaniasis. Methods: Sand flies were collected from villages of Adana in 2-4 September 2013 using Centers for Disease Control and Prevention (CDC) light traps and transferred to the laboratory. The World Health Organisation tube test method was conducted using self-prepared filter papers with different concentrations. In order to determine the diagnostic dose, lethal doses (LD) were calculated by EPA Probit Analysis. Sand flies used in the experiments were dissected, mounted and identified. Results: For the lowest (0.025 %) and highest dose of permethrin (0.5 %), the mortality rate was recorded as 52.6 % and 100 % by the end of 24-h period and the diagnostic dose was recorded as 0.36 %. The mortality rate for lowest (0.0025 %) and highest (0.05 %) doses of deltamethrin was recorded as 54.8 % and 100 %. The diagnostic dose of deltamethrin was determined as 0.9 %. Conclusion: An insecticide susceptibility study was conducted in Turkey for the first time and effective doses were determined by calculating the LDs. According to presented results, the wild population of sand flies collected from a hyper-endemic region of Adana Province is still susceptible to deltamethrin and permethrin.Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), United States; National Research Council (NRC); EUEuropean Union (EU) [FP7-261504 EDENext]This study was partially supported by The Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), United States (with Yvonne Marie-Linton as the principal investigator). This manuscript was prepared whilst YML held a National Research Council (NRC) Research Associateship Award at the Walter Reed Army Institute of Research. This research was performed in part under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The material to be published reflects the views of the authors and should not be construed to represent those of the US Department of the Army or the US Department of Defense.; This work was partially supported by EU grant FP7-261504 EDENext and is catalogued by the EDENext Steering Committee as EDENext451 (http://www.ede-next.eu). The contents of this publication are the sole responsibility of the authors and do not necessarily reflect the views of the European Commission

The effects of boron nitride/hydroxyapatite compounds on bone defects in osteoporotic rats

This study investigated the effects of poly-(lactide-co-glycolide) (PLGA) scaffolds containing different concentrations of boron nitride (BN) and/or hydroxyapatite (HA) on bone defects in osteoporotic rats. The control group consisted of healthy rats. A standard non-critical size defect was induced in the osteoporotic rat femurs 12 weeks post-ovariectomy. PLGA scaffolds containing different concentrations of BN+HA were then applied to the defect area. In one group, defect was induced but no PLGA was applied. Computed tomography images were obtained and tissue samples were collected in the first, second, and fourth weeks postoperatively. PLGA scaffolds were classified as no BN + HA, only 10% HA, 2.5% BN + 10% HA, 5% BN + 10% HA, 10% BN + 10% HA or only 2.5%, 5% or 10% BN. No healing was determined in the first and second weeks postoperatively. However, in the fourth week healing was observed in the groups treated with PLGA scaffolds containing 10% HA, 2.5% BN + 10% HA, 2.5% BN and 5% BN, and especially in the 2.5% BN + 10% HA group. The findings of this study suggest that BN may represent a novel target for treating osteoporotic bone defects for physicians and engineers

Evaluation of the efficacy of Olyset® Plus in a village-based cohort study in the Cukurova Plain, Turkey, in an area of hyperendemic cutaneous leishmaniasis

PubMed ID: 25424269ABSTRACT: The aim of this study was to measure the protective efficacy of Olyset® Plus, a new long-lasting factory-treated insecticidal net (LLIN) incorporated with 2% permethrin and 1% of the synergist piperonyl butoxide (PBO), against cutaneous leishmaniasis (CL) transmission under field conditions. A village-scale trial, promoting the use of LLIN by the local inhabitants of the study area was conducted as a pilot study in a new hyperendemic focus of CL caused by a Leishmania infantum/L. donovani hybrid parasite transmitted by proven vector species Phlebotomus tobbi in Cukurova Plain, Adana, Turkey, between May, 2013 and May, 2014. The study area comprised eight villages; two of them were selected as an intervention village with Olyset® Plus net (Kizillar) and a control village without net application (Malihidirli). Six villages with surrounding allopatric barriers were utilized as a buffer zone cluster between intervention and control villages. Monthly entomological surveys were performed in the intervention and control villages and Damyeri, representing the other six villages, to collect adults of Phlebotomus tobbi. Results showed a significant reduction in cutaneous leishmaniasis incidence in the intervention village from 4.78% to 0.37%. The protective efficacy rate of LLIN was 92.2%. In contrast, incidence rates increased in the control village from 3.67% to 4.69%. We also evaluated residual insecticide levels of used nets after six and 12 months of usage. It was determined that the nets had retained full insecticidal strength. These results highlight the value of real-world data on bed net effectiveness and longevity to guide decisions regarding sand fly control strategies. To the best of our knowledge, this is the first field study to evaluate Olyset® Plus efficacy in a hyperendemic cutaneous leishmaniasis area. © 2014