HYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB

Objective: A study on the hydrotropic solubility and linearity profile of Pazopanib was carried out by using Niacinamide as the solubilizing agent as Pazopanib is poorly soluble in water. Methods: Pazopanib was freely soluble in water when 2.8M Niacinamide was used as a solubilizing agent. Pazopanib shows an absorption maximum at 282 nm in First derivative mode of measurement using Shimazdu UV Spectrophotometer 1800 spectronic model. Results: At the absorption maximum of 282 nm, Pazopanib shows a linear response in the range of 5μg/ml to 15μg/ml concentration. Conclusion: The present study is useful for the aqueous solubilization and quantitative determination of Pazopanib in bulk drug and in pharmaceutical formulations thus avoiding toxic solvents

Optimized placement of multiple FACTS devices using PSO and CSA algorithms

This paper is an attempt to develop a multi-facts device placementin deregulated power system using optimization algorithms. The deregulated power system is the recent need in the power distribution as it has many independent sellers and buyers of electricity. The problem of deregulation is the quality of the power distribution as many sellers are involved. The placement of FACTS devices provides the solution for the above problem. There are researches available for multiple FACTS devices. The optimization algorithms like Particle Swarm Optimization (PSO) and Cuckoo Search Algorithm (CSA) are implemented to place the multiple FACTS devices in a power system. MATLAB based implementation is carried out for applying Optimal Power Flow (OPF) with variation in the bus power and the line reactance parameters. The cost function is used as the objective function. The cost reduction of FACTS as well as generation by placement of different compensators like, Static Var Compensator (SVC), Thyristor Controlled Series Compensator (TCSC) and Unified Power Flow Controller (UPFC). The cost calculation is done on the 3-seller scenario. The IEEE 14 bus is taken here as 3-seller system

Modeling of Power Generation using Municipal Solid Waste in India

Generation of Electrical Energy from Municipal Solid Waste (MSW) is acomplex process since the waste has to undergo various unit processes before it is put in to the process of energy production. The modeling of power generation from MSW, therefore has to include all these unit processes, waste flow paths etc. The modeling must also be capable of providing information on important issues like economical, environmental among many others. With the launching of new energy policy by Govt. of India, on liberalization of energy production, Independent power producers (IPP) are exploring Municipal Solid Waste (MSW) as a main source of energy in addition to other renewable sources like fuel cells, solar, wind etc. for production of energy at affordable rates. In this paper, a mathematical model of the power generation using MSW is examined, keeping in view, the composition of waste in India. Linear equations have been developed for the various waste flow paths and the mass balance equations are then solved for the main objective function of minimum cost.DOI:http://dx.doi.org/10.11591/ijece.v2i2.27

Prevalence of alexithymia and its association with anxiety and depression in a sample of Greek chronic obstructive pulmonary disease (COPD) outpatients

<p>Abstract</p> <p>Background</p> <p>Chronic obstructive pulmonary disease (COPD) is a major health problem, especially in adults over 40 years of age, and has a great social and economic impact. The psychological morbidity of COPD patients with regard to anxiety and depressive symptoms has been extensively studied in the past. However, few studies have investigated the prevalence of alexithymia in these patients, as well as its association with this comorbidity. Based on this fact, we studied the prevalence of alexithymia and its association with anxiety and depressive symptoms in COPD outpatients.</p> <p>Methods</p> <p>The present study included 167, randomly selected, outpatients diagnosed with COPD. Alexithymia, anxiety and depression were assessed using the Toronto Alexithymia Scale (TAS-20), Spielberger Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI), respectively.</p> <p>Results</p> <p>The mean BDI score was 12.88 (SD: 7.7), mean STAI score 41.8 (SD: 11.0) and mean TAS-20 score 48.2 (SD: 11.5). No differences were observed between genders regarding age and alexithymia (t test <it>P </it>> 0.05), while female patients presented higher depression and trait anxiety scores than males (t test <it>P </it>< 0.05). Clinically significant levels of anxiety were present in 37.1% of men, and in 45.7% of women. The mean depression score was also higher than the corresponding mean score in the general population (one-sample t test <it>P </it>< 0.01), while 27.7% and 30.5% of the sample presented mild and moderate to severe depression, respectively. Finally, a strong correlation was observed between alexithymia, depression and anxiety.</p> <p>Conclusions</p> <p>This study confirms the high prevalence of anxiety and depression symptoms in Greek outpatients with COPD. The prevalence of alexithymia in COPD patients, contrary to what has been observed in patients with other chronic respiratory diseases, seem to be lower. However, we observed a strong association between alexithymia, depression and anxiety levels. This observation suggests that alexithymia should be taken into consideration when drafting specific psychotherapeutic interventions for these patients.</p

Investigate the Stability and Control of the BD-5A Single Passenger Aircraft

The research is an attempt to investigate the stability and controls analysis of the BD-5A aircraft, and determine if any past incidents are caused due to an issue with the stability of the aircraft. Three different types of stability were determined: longitudinal, directional and lateral. For conducting the stability analysis the geometric, weight and physical parameters of the aircraft were determined and processed to be used by the three different stability and controls calculation method: Hand Calculation, USAF Digital DATCOM, and Surfaces (Vortex Lattice Method). Each of the stability and controls computation method was used to determine the stability coefficients of the aircraft, and then analyzed. The final findings were proved that the aircraft was longitudinally, directionally and laterally stable, and that no previously documented incidents were caused due to a lack of stability. The research helped the team ascertain that only an in depth aerodynamic and performance analysis would be able to give further insight about the various BD-5 incidents

Application of Heuristic Search Algorithm to Design Automatic Generation Control in Power System

This paper presents a Heuristic Search Algorithm, Conventional Particle Swarm Optimization (CPSO) which is employed to design Automatic Generation Control (AGC) for an isolated power system to minimize the variation in frequency due to changes in load demand. Further, Advanced Particle Swarm Optimization (APSO) with a velocity update strategy is introduced to ensure that the particles will orbit toward their optimum point quickly which guarantees faster convergence

Enhancement of Voltage Quality using D-STATCOM

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