When a Pandemic Enters the Game: The Initial and Prolonged Impact of the COVID-19 Pandemic on Live-Stream Broadcasters on Twitch

The global COVID-19 pandemic has accelerated the popularity of video games and online-gaming platforms. However, little research is devoted to understanding how the pandemic has affected gamers, especially live-stream broadcasters. Therefore, our study aimed to evaluate the impact the COVID-19 pandemic has had on established streamers on Twitch. By using a longitudinal time-series design and focusing on a large sample (N = 23,019) of broadcasters, we were able to determine the initial as well as prolonged effects of the pandemic on their streaming behavior. Our results suggest that the pandemic was a "game changer" for the target group, especially in regard to their choice of game settings and their focus on non-gaming content. Relating the data obtained from the target group of established streamers to the general platform data, we discuss the pandemic-related platform dynamics

When a Pandemic Enters the Game: The Initial and Prolonged Impact of the COVID-19 Pandemic on Live-Stream Broadcasters on Twitch

The global COVID-19 pandemic has accelerated the popularity of video games and online-gaming platforms. However, little research is devoted to understanding how the pandemic has affected gamers, especially live-stream broadcasters. Therefore, our study aimed to evaluate the impact the COVID-19 pandemic has had on established streamers on Twitch. By using a longitudinal time-series design and focusing on a large sample (N = 23,019) of broadcasters, we were able to determine the initial as well as prolonged effects of the pandemic on their streaming behavior. Our results suggest that the pandemic was a game changer for the target group, especially in regard to their choice of game settings and their focus on non-gaming content. Relating the data obtained from the target group of established streamers to the general platform data, we discuss the pandemic-related platform dynamics

Lab-on-a-Chip Magneto-Immunoassays: How to Ensure Contact between Superparamagnetic Beads and the Sensor Surface

Lab-on-a-chip immuno assays utilizing superparamagnetic beads as labels suffer from the fact that the majority of beads pass the sensing area without contacting the sensor surface. Different solutions, employing magnetic forces, ultrasonic standing waves, or hydrodynamic effects have been found over the past decades. The first category uses magnetic forces, created by on-chip conducting lines to attract beads towards the sensor surface. Modifications of the magnetic landscape allow for additional transport and separation of different bead species. The hydrodynamic approach uses changes in the channel geometry to enhance the capture volume. In acoustofluidics, ultrasonic standing waves force µm-sized particles onto a surface through radiation forces. As these approaches have their disadvantages, a new sensor concept that circumvents these problems is suggested. This concept is based on the granular giant magnetoresistance (GMR) effect that can be found in gels containing magnetic nanoparticles. The proposed design could be realized in the shape of paper-based test strips printed with gel-based GMR sensors

ERNST: Demonstrating Advanced Infrared Detection from a 12U CubeSat

The ERNST mission will demonstrate complex infrared detection capabilities using a 12U CubeSat platform. ERNST’s main payload is an advanced cryogenically-cooled infrared imager that implicates demanding requirements in terms of power demand, heat dissipation, and vibration response for a nanosatellite. The optical bench that integrates optics, a filter-wheel for switching between spectral bands, and the detector-cooler system has been additively designed and manufactured, giving it a bionic appearance and combined with a highly efficient radiator. An onboard radiation monitor and a COTS camera complete the mission payloads. The ERNST 12U platform is based on high-performance CubeSat subsystems for avionics, UHF, and X-band communication, attitude control, and power management. The commercial components are made compatible through a backplane solution. In-house developments include a fast DPU and an autonomous de-orbit dragsail. The platform provides 30 Watt (OAP) and \u3e6U payload volume. After comprehensive environmental and functional testing of the Engineering Model, the Flight Model is currently being integrated. Starting operations in February 2023, ERNST will verify early warning concepts and technology

Bis(diethylamino)(pentafluorophenyl)phosphane – a Push–Pull Phosphane Available for Coordination

A facile large-scale synthesis of the “push–pull”-substituted ligand bis(diethylamino)(pentafluorophenyl)phosphane is reported. A selenophosphorane as well as complexes with CuI and PdCl2, can be formed almost quantitatively from suitable starting materials. The PdII complex shows a square-planar coordination with significant distortions of the Cl–Pd–Cl moiety in the solid state. In contrast, the phosphane ligand exhibits a large flexibility in the trigonal-planar coordination of the Cu salt, as proven by X-ray crystallography. C–C cross-coupling reactions and 1,3-dipolar cycloadditions have been tested for the PdII and CuI complexes, respectively. Whereas the reactivity of the PdII complex is good at low temperature, the CuI complex reveals remarkable reaction rates at temperatures up to 130 °C. Furthermore, the CuI-catalyzed azide/alkyne 1,3-dipolar cycloaddition was successfully adapted for flow conditions

Virosome-Formulated Plasmodium falciparum AMA-1 & CSP Derived Peptides as Malaria Vaccine: Randomized Phase 1b Trial in Semi-Immune Adults & Children

BACKGROUND\ud \ud This trial was conducted to evaluate the safety and immunogenicity of two virosome formulated malaria peptidomimetics derived from Plasmodium falciparum AMA-1 and CSP in malaria semi-immune adults and children.\ud \ud METHODS\ud \ud The design was a prospective randomized, double-blind, controlled, age-deescalating study with two immunizations. 10 adults and 40 children (aged 5-9 years) living in a malaria endemic area were immunized with PEV3B or virosomal influenza vaccine Inflexal®V on day 0 and 90.\ud \ud RESULTS\ud \ud No serious or severe adverse events (AEs) related to the vaccines were observed. The only local solicited AE reported was pain at injection site, which affected more children in the Inflexal®V group compared to the PEV3B group (p = 0.014). In the PEV3B group, IgG ELISA endpoint titers specific for the AMA-1 and CSP peptide antigens were significantly higher for most time points compared to the Inflexal®V control group. Across all time points after first immunization the average ratio of endpoint titers to baseline values in PEV3B subjects ranged from 4 to 15 in adults and from 4 to 66 in children. As an exploratory outcome, we found that the incidence rate of clinical malaria episodes in children vaccinees was half the rate of the control children between study days 30 and 365 (0.0035 episodes per day at risk for PEV3B vs. 0.0069 for Inflexal®V; RR  = 0.50 [95%-CI: 0.29-0.88], p = 0.02).\ud \ud CONCLUSION\ud \ud These findings provide a strong basis for the further development of multivalent virosomal malaria peptide vaccines.\ud \ud TRIAL REGISTRATION\ud \ud ClinicalTrials.gov NCT00513669

Ordnung im Informations-Chaos

Auch die Humboldt-Universität ist vom World Wide Web - Fieber erfaßt worden: Der Aufbau und die Nutzung von WWWDiensten haben explosionsartig an den verschiedenen Einrichtungen zugenommen. Von der TU Graz kommt jetzt ein interessanter Diskussionsbeitrag mit der Frage: Ist denn WWW das Informationssystem auch in der Zukunft? Oder wird das WWW auf Grund seiner Design-Schwächen einmal nicht mehr beherrschbar sein? Ist Hyper-G als sinnvoller Ersatz oder als Ergänzung zum World Wide Web nutzbar? Herr Frank Kappe von der TU Graz gibt mit diesem Artikel einen ersten Einblick in die Funktionalität und Kompatibilität zu WWW von Hyper-G

A Scalable Architecture for Maintaining Referential Integrity in Distributed Information Systems

One of the problems that we experience with today's most widespread Internet Information Systems (like WWW or Gopher) is the lack of support for maintaining referential integrity. Whenever a resource is (re)moved, dangling references from other resources may occur.This paper presents a scalable architecture for automatic maintenance of referential integrity in large (thousands of servers) distributed information systems. A central feature of the proposed architecture is the p-flood algorithm, which is a scalable, robust, prioritizable, probabilistic server-server protocol for efficient distribution of update information to a large collection of servers.The p-flood algorithm is now implemented in the Hyper-G system, but may in principle also be implemented as an add-on for existing WWW and Gopher servers.Keywords: Hypertext, Link Consistency, Distributed Information System, Internet, Gopher, WWW, Hyper-G, Scalability, p-flood