Religious Discrimination and the Role of Arbitration Under Title VII

One of the major thrusts of the Civil Rights Act of 1964, passed by the 88th Congress of the United States after much procrastination and debate, is title VII, the Equal Employment Opportunity Act, which prohibits selected forms of employment discrimination. In drafting title VII, the proponents of the Act were chiefly concerned with racial discrimination in employment. In fact, the entire Civil Rights Act was written with an eye toward the elimination of the glaring ... discrimination against Negroes which exists throughout our nation. Given this intent, it is not surprising that, during the hearings and debates preceding the passage of the Act, Congress focused its attention primarily on the race discrimination problem. The legislative history is replete with pronouncements, from friend and foe alike, concerning the impact of the proposed Act on existing patterns of racial prejudice in the United States

Deconstruction, Lattice Supersymmetry, Anomalies and Branes

We study the realization of anomalous Ward identities in deconstructed (latticized) supersymmetric theories. In a deconstructed four-dimensional theory with N=2 supersymmetry, we show that the chiral symmetries only appear in the infrared and that the anomaly is reproduced in the usual framework of lattice perturbation theory with Wilson fermions. We then realize the theory on the world-volume of fractional D-branes on an orbifold. In this brane realization, we show how deconstructed theory anomalies can be computed via classical supergravity. Our methods and observations are more generally applicable to deconstructed/latticized supersymmetric theories in various dimensions.Comment: 1+27 pages, 2 figures, references adde

Valuation of scleroderma and psoriatic arthritis health states by the general public

<p>Abstract</p> <p>Objective</p> <p>Psoriatic arthritis (PsA) and scleroderma (SSc) are chronic rheumatic disorders with detrimental effects on health-related quality of life. Our objective was to assess health values (utilities) from the general public for health states common to people with PsA and SSc for economic evaluations.</p> <p>Methods</p> <p>Adult subjects from the general population in a Midwestern city (N = 218) completed the SF-12 Health Survey and computer-assisted 0-100 rating scale (RS), time trade-off (TTO, range: 0.0-1.0) and standard gamble (SG, range: 0.0-1.0) utility assessments for several hypothetical PsA and SSc health states.</p> <p>Results</p> <p>Subjects included 135 (62%) females, 143 (66%) Caucasians, and 62 (28%) African-Americans. The mean (SD) scores for the SF-12 Physical Component Summary scale were 52.9 (8.3) and for the SF-12 Mental Component Summary scale were 49.0 (9.1), close to population norms. The mean RS, TTO, and SG scores for PsA health states varied with severity, ranging from 20.2 to 63.7 (14.4-20.3) for the RS 0.29 to 0.78 (0.24-0.31) for the TTO, and 0.48 to 0.82 (0.24-0.34) for the SG. The mean RS, TTO, and SG scores for SSc health states were 25.3-69.7 (15.2-16.3) for the RS, 0.36-0.80 (0.25-0.31) for the TTO, and 0.50-0.81 (0.26-0.32) for the SG, depending on disease severity.</p> <p>Conclusion</p> <p>Health utilities for PsA and SSc health states as assessed from the general public reflect the severity of the diseases. These descriptive findings could have implications regarding comparative effectiveness research for tests and treatments for PsA and SSc.</p

Deconstruction and other approaches to supersymmetric lattice field theories

This report contains both a review of recent approaches to supersymmetric lattice field theories and some new results on the deconstruction approach. The essential reason for the complex phase problem of the fermion determinant is shown to be derivative interactions that are not present in the continuum. These irrelevant operators violate the self-conjugacy of the fermion action that is present in the continuum. It is explained why this complex phase problem does not disappear in the continuum limit. The fermion determinant suppression of various branches of the classical moduli space is explored, and found to be supportive of previous claims regarding the continuum limit.Comment: 70 page

Fermions scattering in a three dimensional extreme black hole background

The absorption cross section for scattering of fermions off an extreme BTZ black hole is calculated. It is shown that, as in the case of scalar particles, an extreme BTZ black hole exhibits a vanishing absorption cross section, which is consistent with the vanishing entropy of such object. Additionally, we give a general argument to prove that the particle flux near the horizon is zero. Finally we show that the {\it reciprocal space} introduced previously in \cite{gm} gives rise to the same result and, therefore, it could be considered as the space where the scattering process takes place in an AdS spacetime.Comment: 15 pages, RevTex4. Revised version. To be published in Class. Quantum. Gra

Quasinormal Modes of Extremal BTZ Black Hole

Motivated by several pieces of evidence, in order to show that extreme black holes cannot be obtained as limits of non-extremal black holes, in this article we calculate explicitly quasinormal modes for Ba\~{n}ados, Teitelboim and Zanelli (BTZ) extremal black hole and we showed that the imaginary part of the frequency is zero. We obtain exact result for the scalar an fermionic perturbations. We also showed that the frequency is bounded from below for the existence of the normal modes (non-dissipative modes).Comment: 6 pp. Accepted Classical and Quantum Gravity. Typos corrected and some references was added. Final Versio

Perturbative renormalization of lattice N=4 super Yang-Mills theory

We consider N=4 super Yang-Mills theory on a four-dimensional lattice. The lattice formulation under consideration retains one exact supersymmetry at non-zero lattice spacing. We show that this feature combined with gauge invariance and the large point group symmetry of the lattice theory ensures that the only counterterms that appear at any order in perturbation theory correspond to renormalizations of existing terms in the bare lattice action. In particular we find that no mass terms are generated at any finite order of perturbation theory. We calculate these renormalizations by examining the fermion and auxiliary boson self energies at one loop and find that they all exhibit a common logarithmic divergence which can be absorbed by a single wavefunction renormalization. This finding implies that at one loop only a fine tuning of the finite parts is required to regain full supersymmetry in the continuum limit.Comment: v2. Minor corrections, references adde

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.

GSVD Comparison of Patient-Matched Normal and Tumor aCGH Profiles Reveals Global Copy-Number Alterations Predicting Glioblastoma Multiforme Survival

Despite recent large-scale profiling efforts, the best prognostic predictor of glioblastoma multiforme (GBM) remains the patient's age at diagnosis. We describe a global pattern of tumor-exclusive co-occurring copy-number alterations (CNAs) that is correlated, possibly coordinated with GBM patients' survival and response to chemotherapy. The pattern is revealed by GSVD comparison of patient-matched but probe-independent GBM and normal aCGH datasets from The Cancer Genome Atlas (TCGA). We find that, first, the GSVD, formulated as a framework for comparatively modeling two composite datasets, removes from the pattern copy-number variations (CNVs) that occur in the normal human genome (e.g., female-specific X chromosome amplification) and experimental variations (e.g., in tissue batch, genomic center, hybridization date and scanner), without a-priori knowledge of these variations. Second, the pattern includes most known GBM-associated changes in chromosome numbers and focal CNAs, as well as several previously unreported CNAs in 3% of the patients. These include the biochemically putative drug target, cell cycle-regulated serine/threonine kinase-encoding TLK2, the cyclin E1-encoding CCNE1, and the Rb-binding histone demethylase-encoding KDM5A. Third, the pattern provides a better prognostic predictor than the chromosome numbers or any one focal CNA that it identifies, suggesting that the GBM survival phenotype is an outcome of its global genotype. The pattern is independent of age, and combined with age, makes a better predictor than age alone. GSVD comparison of matched profiles of a larger set of TCGA patients, inclusive of the initial set, confirms the global pattern. GSVD classification of the GBM profiles of an independent set of patients validates the prognostic contribution of the pattern

Sample Reproducibility of Genetic Association Using Different Multimarker TDTs in Genome-Wide Association Studies: Characterization and a New Approach

Multimarker Transmission/Disequilibrium Tests (TDTs) are very robust association tests to population admixture and structure which may be used to identify susceptibility loci in genome-wide association studies. Multimarker TDTs using several markers may increase power by capturing high-degree associations. However, there is also a risk of spurious associations and power reduction due to the increase in degrees of freedom. In this study we show that associations found by tests built on simple null hypotheses are highly reproducible in a second independent data set regardless the number of markers. As a test exhibiting this feature to its maximum, we introduce the multimarker -Groups TDT (), a test which under the hypothesis of no linkage, asymptotically follows a distribution with degree of freedom regardless the number of markers. The statistic requires the division of parental haplotypes into two groups: disease susceptibility and disease protective haplotype groups. We assessed the test behavior by performing an extensive simulation study as well as a real-data study using several data sets of two complex diseases. We show that test is highly efficient and it achieves the highest power among all the tests used, even when the null hypothesis is tested in a second independent data set. Therefore, turns out to be a very promising multimarker TDT to perform genome-wide searches for disease susceptibility loci that may be used as a preprocessing step in the construction of more accurate genetic models to predict individual susceptibility to complex diseases