Acute alcohol administration dampens central extended amygdala reactivity.

Alcohol use is common, imposes a staggering burden on public health, and often resists treatment. The central extended amygdala (EAc)-including the bed nucleus of the stria terminalis (BST) and the central nucleus of the amygdala (Ce)-plays a key role in prominent neuroscientific models of alcohol drinking, but the relevance of these regions to acute alcohol consumption in humans remains poorly understood. Using a single-blind, randomized-groups design, multiband fMRI data were acquired from 49 social drinkers while they performed a well-established emotional faces paradigm after consuming either alcohol or placebo. Relative to placebo, alcohol significantly dampened reactivity to emotional faces in the BST. To rigorously assess potential regional differences in activation, data were extracted from unbiased, anatomically predefined regions of interest. Analyses revealed similar levels of dampening in the BST and Ce. In short, alcohol transiently reduces reactivity to emotional faces and it does so similarly across the two major divisions of the human EAc. These observations reinforce the translational relevance of addiction models derived from preclinical work in rodents and provide new insights into the neural systems most relevant to the consumption of alcohol and to the initial development of alcohol abuse in humans

Middle pleistocene glaciation in Patagonia dated by cosmogenic-nuclide measurements on outwash gravels

The well-preserved glacial record in Argentine Patagonia offers a ~ 1 Ma archive of terrestrial climate extremes in southern South America. These glacial deposits remain largely undated beyond the range of radiocarbon dating at ca. 40 ka. Dating old glacial deposits (> several 105 a) by cosmogenic surface exposure methods is problematic because of the uncertainty in moraine degradation and boulder erosion rates. Here, we show that cobbles on outwash terraces can reliably date ‘old’ glacial deposits in the Lago Pueyrredón valley, 47.5° S, Argentina. Favorable environmental conditions (e.g., aridity and strong winds) have enabled continuous surface exposure of cobbles and preservation of outwash terraces. The data demonstrate that nuclide inheritance is negligible and we therefore use the oldest surface cobbles to date the deposit. 10Be concentrations in outwash cobbles reveal a major glacial advance at ca. 260 ka, concurrent with Marine Isotope Stage 8 (MIS 8) and dust peaks in Antarctic ice cores. A 10Be concentration depth-profile in the outwash terrace supports the age and suggests a low terrace erosion rate of ca. 0.5 mm ka− 1. We compare these data to exposure ages obtained from associated moraines and find that surface boulders underestimate the age of the glaciation by ~ 100 ka; thus the oldest boulders in this area do not date closely moraine deposition. The 10Be concentration in moraine cobbles help to constrain moraine degradation rates. These data together with constraints from measured 26Al/10Be ratios suggest that all moraine boulders were likely exhumed after original deposition. We determine the local Last Glacial Maximum (LGM) occurred at ~ 27–25 ka, consistent with the maximum LGM in other parts of Patagonia

Accuracy of the Cosmed K5 portable calorimeter

Purpose The purpose of this study was to assess the accuracy of the Cosmed K5 portable metabolic system dynamic mixing chamber (MC) and breath-by-breath (BxB) modes against the criterion Douglas bag (DB) method. Methods Fifteen participants (mean age±SD, 30.6±7.4 yrs) had their metabolic variables measured at rest and during cycling at 50, 100, 150, 200, and 250W. During each stage, participants were connected to the first respiratory gas collection method (randomized) for the first four minutes to reach steady state, followed by 3-min (or 5-min for DB) collection periods for the resting condition, and 2-min collection periods for all cycling intensities. Collection periods for the second and third methods were preceded by a washout of 1–3 min. Repeated measures ANOVAs were used to compare metabolic variables measured by each method, for seated rest and each cycling work rate. Results For ventilation (VE) and oxygen uptake (VO2), the K5 MC and BxB modes were within 2.1 l/min (VE) and 0.08 l/min (VO2) of the DB (p≥0.05). Compared to DB values, carbon dioxide production (VCO2) was significantly underestimated by the K5 BxB mode at work rates ≥150W by 0.12–0.31 l/min (p\u3c0.05). K5 MC and BxB respiratory exchange ratio values were significantly lower than DB at cycling work rates ≥100W by 0.03–0.08 (p\u3c0.05). Conclusion Compared to the DB method, the K5 MC and BxB modes are acceptable for measuring VE and VO2 across a wide range of cycling intensities. Both K5 modes provided comparable values to each other

Tenofovir-Associated Nephrotoxicity in Two HIV-Infected Adolescent Males

We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents. The first case, a 16-year-old African American male with an absolute CD4+ cell count of 314 cells/mm3, presented with an abrupt rise in serum creatinine leading to irreversible renal failure while on TDF-containing highly active antiretroviral therapy (HAART). While the patient had evidence of underlying kidney disease, the timing of his renal failure indicates that TDF played a central role. The second case, a 16-year-old African-American male with an absolute CD4+ cell count of 895 cells/mm3, presented with rickets and hypophosphatemia while receiving TDF-based HAART. To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients. We believe these cases highlight important and potentially irreversible side effects of this agent and emphasize the need for further studies of the renal safety of TDF in pediatric patients

Effective Field Theory, Black Holes, and the Cosmological Constant

Bekenstein has proposed the bound S < pi M_P^2 L^2 on the total entropy S in a volume L^3. This non-extensive scaling suggests that quantum field theory breaks down in large volume. To reconcile this breakdown with the success of local quantum field theory in describing observed particle phenomenology, we propose a relationship between UV and IR cutoffs such that an effective field theory should be a good description of Nature. We discuss implications for the cosmological constant problem. We find a limitation on the accuracy which can be achieved by conventional effective field theory: for example, the minimal correction to (g-2) for the electron from the constrained IR and UV cutoffs is larger than the contribution from the top quark.Comment: 5 pages, no figures minor clarifications, refs adde

Charge Neutrality of the Color-Flavor Locked Phase from the Low Energy Effective Theory

We investigate the issue of charge neutrality of the CFL$K^0$ phase of dense quark matter using the low energy effective theory of high density QCD. We show that the local electric and color charge neutrality of the ground state in a homogeneous color superconducting medium follows from its dynamics. We also consider the situation of a spatially inhomogeneous medium, such as may be found in a neutron star core. We find that spatial inhomogeneity results in the generation of electric fields, and positrons/electrons may be present in the ground state. We estimate the concentration of charged leptons in the ground state to be $n_{e}\sim{10^2}{cm}^{-3}$ and consider their influence on the opacity of the medium with respect to the modified photons.Comment: typos corrected, this version to appear in PR

Microscopic Entropy of N=2 Extremal Black Holes

String theory is used to compute the microscopic entropy for several examples of black holes in compactifications with $N=2$ supersymmetry. Agreement with the Bekenstein-Hawking entropy and the moduli-independent $N=2$ area formula is found in all cases.Comment: 9 pages, no figures, uses harvma

A Survey of UV Bright Sources Behind the Halo of M31

We have performed a wide-area ultraviolet (UV) imaging survey using the GALaxy Evolution eXplorer (GALEX) to search for bright, point-like UV sources behind M31's extended halo. Our survey consisted of 46 pointings covering an effective area of ~50 deg^2, in both the far-UV and near-UV channels. We combined these data with optical R-band observations acquired with the WIYN Mosaic-1 imager on the Kitt Peak National Observatory 0.9m WIYN telescope. An analysis of the brightness and colors of sources matched between our photometric catalogs yielded ~100 UV-bright quasar candidates. We have obtained discovery spectra for 76 of these targets with the Kast spectrometer on the Lick 3m telescope and confirm 30 active galactic nuclei and quasars, 29 galaxies at z > 0.02 including several early-type systems, 16 Galactic stars (hot main-sequence stars), and one featureless source previously identified as a BL Lac object. Future UV spectroscopy of the brightest targets with the Cosmic Origins Spectrograph on the Hubble Space Telescope will enable a systematic search for diffuse gas in the extended halo of M31.Comment: 10 pages, 10 figures. Accepted to MNRA

Kaon differential flow in relativistic heavy-ion collisions

Using a relativistic transport model, we study the azimuthal momentum asymmetry of kaons with fixed transverse momentum, i.e., the differential flow, in heavy-ion collisions at beam momentum of 6 GeV/c per nucleon, available from the Alternating Gradient Synchrotron (AGS) at the Brookhaven National Laboratory (BNL). We find that in the absence of kaon potential the kaon differential flow is positive and increases with transverse momentum as that of nucleons. The repulsive kaon potential as predicted by theoretical models, however, reduces the kaon differetnial flow, changing it to negative for kaons with low momenta. Cancellation between the negative differential flow at low mementa and the positive one at high momenta is then responsible for the experimentally observed nearly vanishing in-plane transverse flow of kaons in heavy ion experiments.Comment: Phys. Rev. C in pres

Hyperbolic quenching problem with damping in the micro-electro mechanical system device

[[abstract]]We study the initial boundary value problem for the damped hyperbolic equation arising in the micro-electro mechanical system device with local or nonlocal singular nonlinearity. For both cases, we provide some criteria for quenching and global existence of the solution. We also derive the existence of the quenching curve for the corresponding Cauchy problem with local source[[notice]]補正完畢[[journaltype]]國外[[incitationindex]]SCI[[ispeerreviewed]]Y[[countrycodes]]US