The young adults feelings after losing their parents to cancer in adolescence : a study based on the written records of the young adults fight against cancer

目的；青年期にがんで親を亡くした人の死別後の気持ちをあきらかにする． 方法；闘病記より，青年期にがんで親を亡くした人の死別後の気持ちが表現されている言動を，逐語録化し分析した．具体的には，前後の文脈と表現された言語の意味をコード化しカテゴリー化した． 結果；４つのカテゴリー，すなわち，１．親の死を受け止められない，２．親との生活を振り返る，３．進路や人生観が変化する，４．親のいない生活への適応，を抽出した．なお，それぞれのカテゴリーには複数のサブカテゴリーで構成されていた． 青年期に親と死別した人の気持ちは，学校（高校など）でも家でも感情の板挟みとなって葛藤を繰り返し，誰にも打ち明けられずに孤独に耐える．しかし，生前の親との時間や親の生きざまを想察することで，死と向き合い始める．また，その後の進路や人生観の変化も，生前の親からの学びが，対象者の気持ちに影響を及ぼしている．Objective : The Objective of this study identified the feeding of young adults after they lost their parents who died of cancer. Methods : Some of the young adult of these parents had recorded their fight against cancer in their own way, and we first extracted from their records the parts in which their feelings following their parents’ death were written down or the parts in which their feelings about their parents’ death were hinted in the form of what they said or did. We then transcribed these parts word for word, and made an analysis of them. Results : We have found that these parts consist of four categories ： １） being unable to accept their parents’ death, ２） looking back on the life they led with their parents, ３） the change of their career or their outlook on life, and ４） adapting to the life in which their parents no longer exist. Each category comprises more than one subcategory. Conclusions : It is important for nurses to understand and support the complicated feelings of those young adult whose parents died in young adult. It can be an effective suggestion in influencing the mental attitude the oung adult assume following their parents’ death

New methodological approaches for assessing thrombus formation in cardiovascular disease

Antiplatelet therapy is the mainstay preventive strategy for cardiovascular diseases, and dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor is the standard treatment for patients who underwent percutaneous coronary intervention. The Total Thrombus‑Formation Analysis System (T‑TAS) is a microchip flow‑chamber system developed to evaluate overall thrombus formation under flow conditions, which is reportedly able to assess single and combined antithrombotic therapy. Here, we focus on this new system, T‑TAS, and review its characteristics together with those of the conventional systems available for evaluation of antithrombotic therapies for cardiovascular diseases

IFN-γ is reciprocally involved in the concurrent development of organ-specific autoimmunity in the liver and stomach.

Interferon (IFN)-γ acts as a critical proinflammatory mediator in autoimmune processes, whereas it exerts regulatory functions to limit tissue damage associated with inflammation. However, a detailed understanding of the complex roles of IFN-γ in the development of organ-specific autoimmunity is still lacking. Recently, we found that programmed cell death 1-deficient mice thymectomized 3 days after birth (NTx-PD-1(- / - ) mice) concurrently developed autoimmune hepatitis (AIH) and autoimmune gastritis (AIG). In this study, we investigated the roles of IFN-γ in the development of AIH and AIG in this mouse model. In NTx-PD-1(- / - ) mice, serum levels of IFN-γ were markedly elevated. Neutralization of IFN-γ prevented the development of AIG. However, the same treatment exacerbated hepatic T-cell infiltration in AIH. Because of the loss of anti-proliferative effects by IFN-γ, neutralization of IFN-γ increased T-cell proliferation in the spleen and liver, resulting in exacerbated T-cell infiltration in the liver. On the other hand, in the development of AIG, CD4(+) T-cell migration into the gastric mucosa is essential for induction. CCL20 expression was up-regulated in the gastric mucosa, and anti-CCL20 suppressed CD4(+) T-cell infiltration into the gastric mucosa. Importantly, anti-IFN-γ suppressed CCL20 expression and infiltration of CD4(+) T cells in the gastric mucosa, whereas in vivo injection of recombinant IFN-γ up-regulated CCL20 expression in the stomach, suggesting that IFN-γ is critically involved in CD4(+) T-cell accumulation in AIG by up-regulating local CCL20 expression. In conclusion, IFN-γ is involved differently in the development of AIH and of AIG. IFN-γ negatively regulates T-cell proliferation in fatal AIH, whereas it initiates development of AIG. These findings imply that increased production of IFN-γ induced by an organ-specific autoimmunity may trigger the concurrent development of another organ-specific autoimmune disease

Essential Roles of Androgen Signaling in Wolffian Duct Stabilization and Epididymal Cell Differentiation

Epithelial androgen receptor has few functions for epithelial cell survival but is essential for cell differentiation in the epididymis