831 research outputs found
Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation
Activation of microglia is a common denominator and a pathophysiological hallmark of the central nervous system (CNS) disorders. Damage or CNS disorders can trigger inflammatory responses in resident microglia and initiate a systemic immune system response. Although a repertoire of inflammatory responses differs in those diseases, there is a spectrum of transcriptionally activated genes that encode various mediators such as growth factors, inflammatory cytokines, chemokines, matrix metalloproteinases, enzymes producing lipid mediators, toxic molocules, all of which contribute to neuroinflammation. The initiation, progression and termination of inflammation requires global activation of gene expression, postranscriptional regulation, epigenetic modifications, changes in chromatin structure and these processes are tightly regulated by specific signaling pathways. This review focuses on the function of "master regulators" and epigenetic mechanisms in microglia activation during neuroinflammation. We review studies showing impact of epigenetic enzyme inhibitors on microglia activation in vitro and in vivo, and critically discuss potential of such molecules to prevent/moderate pathological events mediated by microglia under brain pathologies.(1)
Faults Affecting Energy-Harvesting Circuits of Self-Powered Wireless Sensors and Their Possible Concurrent Detection
We analyze the effects of faults on an energy-harvesting circuit (EHC) providing power to a wireless biomedical multisensor node. We show that such faults may prevent the EHC from producing the power supply voltage level required by the multisensor node. Then, we propose a low-cost (in terms of power consumption and area overhead) additional circuit monitoring the voltage level produced by the EHC continuously, and concurrently with the normal operation of the device. Such a monitor gives an error indication if the generated voltage falls below the minimum value required by the sensor node to operate correctly, thus allowing the activation of proper recovery actions to guarantee system fault tolerance. The proposed monitor is self-checking with regard to the internal faults that can occur during its in-field operation, thus providing an error signal when affected by faults itself
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The Impact of QE on Liquidity: Evidence from the UK Corporate Bond Purchase Scheme
In August 2016, the Bank of England (BoE) announced a Corporate Bond Purchase Scheme (CBPS) to purchase up to $10bn of sterling corporate bonds. To investigate the impact of these purchases on liquidity, we create a novel dataset that combines transaction-level data from the secondary corporate bond market with proprietary offer-level data from the BoE's CBPS auctions. Identifying the impact of central bank asset purchases on liquidity is potentially impacted by reverse causality, because liquidity considerations might impact purchases. But the offer-level data allow us to construct proxy measures for the BoE's demand for bonds and auction participants' supply of bonds, meaning that we can control for the impact of liquidity on purchases. Across a range of liquidity measures, we find that CBPS purchases improved the liquidity of purchased bonds
Scientific Research In The Health Tourism Market: A Systematic Literature Review
The authors pay attention to bibliographic analysis in the field of health tourism. The primary purpose of the study is to find out which countries’ works predominate in scientific circles, and which nationalities have the most significant influence in the scientific community in terms of the number and content of their research. In particular, they do an in-depth analysis of researches in health tourism marketing. The authors put forward hypotheses about the growing popularity of marketing research in this category, which they confirmed during their investigation. Besides, the study concluded that most articles in health tourism marketing are analytical, systematizing data from secondary sources
Search for dark Higgsstrahlung in e+ e- -> mu+ mu- and missing energy events with the KLOE experiment
We searched for evidence of a Higgsstrahlung process in a secluded sector,
leading to a final state with a dark photon U and a dark Higgs boson h', with
the KLOE detector at DAFNE. We investigated the case of h' lighter than U, with
U decaying into a muon pair and h' producing a missing energy signature. We
found no evidence of the process and set upper limits to its parameters in the
range 2m_mu<m_U<1000 MeV, m_h'<m_U.Comment: 16 pages, 7 figures, submitted to Physics Letters
First-principles study of As interstitials in GaAs: Convergence, relaxation, and formation energy
Convergence of density-functional supercell calculations for defect formation
energies, charge transition levels, localized defect state properties, and
defect atomic structure and relaxation is investigated using the arsenic split
interstitial in GaAs as an example. Supercells containing up to 217 atoms and a
variety of {\bf k}-space sampling schemes are considered. It is shown that a
good description of the localized defect state dispersion and charge state
transition levels requires at least a 217-atom supercell, although the defect
structure and atomic relaxations can be well converged in a 65-atom cell.
Formation energies are calculated for the As split interstitial, Ga vacancy,
and As antisite defects in GaAs, taking into account the dependence upon
chemical potential and Fermi energy. It is found that equilibrium
concentrations of As interstitials will be much lower than equilibrium
concentrations of As antisites in As-rich, -type or semi-insulating GaAs.Comment: 10 pages, 5 figure
Precision measurement of the Dalitz plot distribution with the KLOE detector
Using fb of data collected with
the KLOE detector at DANE, the Dalitz plot distribution for the decay is studied with the world's largest sample of events. The Dalitz plot density is parametrized as a polynomial
expansion up to cubic terms in the normalized dimensionless variables and
. The experiment is sensitive to all charge conjugation conserving terms of
the expansion, including a term. The statistical uncertainty of all
parameters is improved by a factor two with respect to earlier measurements.Comment: 11 pages, 9 figures, supplement: an ascii tabl
Spatio-temporal Models of Lymphangiogenesis in Wound Healing
Several studies suggest that one possible cause of impaired wound healing is
failed or insufficient lymphangiogenesis, that is the formation of new
lymphatic capillaries. Although many mathematical models have been developed to
describe the formation of blood capillaries (angiogenesis), very few have been
proposed for the regeneration of the lymphatic network. Lymphangiogenesis is a
markedly different process from angiogenesis, occurring at different times and
in response to different chemical stimuli. Two main hypotheses have been
proposed: 1) lymphatic capillaries sprout from existing interrupted ones at the
edge of the wound in analogy to the blood angiogenesis case; 2) lymphatic
endothelial cells first pool in the wound region following the lymph flow and
then, once sufficiently populated, start to form a network. Here we present two
PDE models describing lymphangiogenesis according to these two different
hypotheses. Further, we include the effect of advection due to interstitial
flow and lymph flow coming from open capillaries. The variables represent
different cell densities and growth factor concentrations, and where possible
the parameters are estimated from biological data. The models are then solved
numerically and the results are compared with the available biological
literature.Comment: 29 pages, 9 Figures, 6 Tables (39 figure files in total
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