A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism

Background: Distinctive types of iron deficiency have been accounted for patients with obvious hypothyroidism with a predominance of up to 47%. Regardless of the fact that vitamin B12, folic corrosive and iron fixations are ordinary, weakness that standardizes in light of thyroxine substitution is found in up to 25% of hypothyroid patients.Methods: Briefly, 50 women with SCH were enrolled in the study. Patients between 18 and 65 years old, with TSH levels more than 5.0 mIU/L, the patients selected has a history of hypothyroidism for more than a year and were on oral levothyroxine. A total of 50 participants were enrolled in the study. Blood samples were collected from 50 selected hypothyroid patients on the basis of a history of a hypothyroidism, persistent Anemia, of these patients all were females.Results: In present study 25 cases of age group 41-65 years  there were almost 10 patients having high thyroid stimulating factor (Tsh) that is more than (0.3-5.0U/Ml), Constitute to be 40% cases in this age category. Hence patients with high age may slower the response towards a levothyroxine hormone and hence have the high risk of developing anemia.Conclusions: Thyroid dysfunctions have an immediate impact on hemoglobin levels and these progressions should be considered in therapeutic consideration by medical practitioner

Effect of ovine luteinizing hormone antibodies on reproduction in rabbits

Call number: LD2668 .T4 1966 Q1Master of Scienc

Development and Evaluation of Palmyrah (Borassus Flabellifer L.) Fruit Pulp

Palmyrah(Borassus flabellifer L) fruit pulp is available abundantly and has high potential for food in rural areas, useful for pharmaceutical and cosmetic applications, however, the main hindrance for these pulp is lack of mechanisation and availability of pulp in sufficient quantity at one place. The pulp of this fruit is usually used by rural communities where the processors use manual pulping, which are not only time-consuming but yields seasonal during July and August in India. Therefore, the objective of this work was to develop and evaluate the efficiency of fruit pulp extractor. The pulper was developed to be compact and easy to operate, consisting of main housing with stainless steel teeth on rotating shaft and pulping performed by beating and shearing. The performance evaluation of the machine was carried out with different rpm (320, 360, 410) input capacity(8,10 and 12 kg) for fixed time of operation is 6 minutes.. The pulp weight was evaluated during the pulping process period. The highest pulping efficiency (84.78%) and pulp recovery (33.9%) was obtained rpm of 410, with 6 minutes of pulping, and batch capacity of 10 kg of fruits which resulted in a capacity of 50 kg fruits per hour. This high efficiency makes this mechanized effective for pulping palmyrah fruits and, thus, it can replace manual pulping, especially in rural communities involved with the palmyrah fruit pulping. &nbsp

Optimization of osmotic dehydration in dragon fruit (Hylocereus Polyrhizus) slices using response surface methodology

Dragon fruit (Hylocereus polyrhizus) is emerging as a super crop because of its several health and therapeutic benefits and ease of cultivation even in degraded land. Using response surface approach, the process parameters for osmotic dehydration of dragon fruit slices included process temperature, syrup concentration and process time. Slices of size 20 x 20 x 5 mm were dipped into sugar syrup with a syrup to dragon fruit slice ratio of 4:1 (w/w). After osmotic dehydration, the initial moisture content of dragon fruit samples was reduced to 27.5-68.49% (wb), demonstrating water loss, solid gain, and mass reduction in the range of 18.01-65.9%, 6.3-17.9% and 9.31-50.6%, respectively. After statistical analysis of the data on water loss, solid gain, and weight reduction, it was shown that regression equations of second order provided the greatest match for all the experimental data. With a syrup to fruit ratio of 4:1 and a syrup concentration of 65.3° Brix at a syrup temperature of 56.5°C, a maximum water loss of 58.2% and a minimum solid gain of 7.7% were expected to occur in 240 minutes of osmotic dehydration

Modelling and simulation of fluid flow through a circular cylinder with high reynolds number: a COMSOL multiphysics study

In this study, we intend to investigate the steady-state and laminar �ow of a viscous �uid through a circular cylinder �xed between two parallel plates keeping the aspect ratio of 1 : 5 from cylinder radius to height of the channel. �e two-dimensional, in�compressible �uid �ow problem has been simulated using COMSOL Multiphysics 5.4 which implements �nite element’s procedure. �e �ow pattern will be investigated by using the Reynolds number from 100 to 1000. �e reattachment length formed at the back of the cylinder and drag force when the �uid comes to strike with the front surface of the cylinder is expressed in terms of Reynolds numbers. We propose to calculate the velocity and the pressure before and after the cylinder. For this purpose, two�line graphs before and after the cylinder will be drawn to check the impact of cylinder on both velocity and pressure. It was found that the percentage change in the velocity as well as pressure before to after the cylinder is changing their behaviours at Re � 700. �e study is important because the empirical equations between the vortex’s lengths formed along the cylinder using the linear regression process obtained in this study may be used for future implementatio

Papillary Renal Cell Carcinoma: Demographics, Survival Analysis, Racial Disparities, and Genomic Landscape

Papillary renal cell carcinoma (PRCC) is the second most common histological subtype of renal cell cancer. This research aims to present a large database study highlighting the demographic, clinical, and pathological factors, racial disparities, prognosis, and survival of PRCC. The clinical and demographic data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database, and molecular data was cured from the Catalogue Of Somatic Mutations in Cancer (COSMIC) database. PRCC had a median age of diagnosis at 64 years, with a higher incidence in men (77%), and Whites (68%). 70.3% of cases were Grades I–IV (13, 53, 31, and 3%, respectively). In patients with known data, 85% were localized to the kidney, and 84% of cases were 7 cm in size. No metastasis occurred in 97% of the known data. The most common treatment offered was surgical resection (9%). The 5-year overall survival was 79%, with patients undergoing surgery having a 90.6% 5-year survival. Multivariable analysis revealed age > 60 years, Black race, poor histologic differentiation, distant metastases, and tumor size > 10 cm as independent risk factors for mortality. The most common mutations identified from the COSMIC database were MET, KMT2D, KMT2C, ARID1A, and SPEN. PRCC affects male individuals in the sixth decade of life. Increased age, Black race, distant metastases, and tumors > 10 cm are associated with a worse prognosis. Surgical resection offers a favorable survival outcome. Next-generation sequencing (NGS) could identify potentially targetable alterations and future personalized therapeutic approaches

Optimization of robust and LQR control parameters for half car model using genetic algorithm

To test the performance of the half car system, two types of controller are used, namely Robust H-infinity control and LQR control. Robust H-infinity and LQR controller is designed to control the suspension system and to reduce the vibrations in the car and to improve handling. A half car model is considered in this research to study the effects in passenger owing to different road profiles. The weights of Robust H-infinity and LQR controller are obtained using Genetic Algorithm on a half car model with two different types of usually existing road disturbance.The design parameters of both the active controller varies with various road profiles. This proves that particular design parameters in Robust and LQR controller do not have the ability to adapt to the variations in road surface. Furthermore, active controllers significantly improve the performance of the system in all aspects when compared to passive system. © 2019 SERSC

SMEs respond to climate change: Evidence from developing countries

Given the concerns stemming from climate change, it is important to investigate whether SMEs could become innovative (and thereby invest in technologies mitigating climate change) because of heightened climate change risk. This study explores the impact of climate change on SMEs' innovation from a resource-based view (RBV) standpoint. Using the generalized method of moments (GMM) estimation of panel data for 443 SMEs from 14 developing countries during the period 2007–2016, we found that climate change has a significant positive impact on SMEs' innovation performance. In economic terms, climate change of one standard deviation variation resulted in a 6.6 % increase in innovation investment. Interesting results emerged when the sample was divided into firms with high and low growth, high and low profit, and high and low slack resources, and industries with high and low vulnerability. The results show that SMEs' innovation response to climate change may vary substantially across firms and industries. In high-growth, high-slack-resources firms, and in highly profitable and non-vulnerable industries, SMEs' innovation responds positively to climate change. Our study contributes to the SME and climate change literature by being the first to examine the impact of climate change on SMEs' innovation. Managerial and policy implications are discussed

Effect of anti microbial and fluorescence on L-Alaninium maleate (LAM) macro and nano crystals

The Fluorescence (FL) and Anti Microbial (AM) effects of the L-Alaninium maleate which is Zwitter ionic in nature is studied and reported, XRD data reveals that it is orthorhombic and space group as P212121 and of NLO with SHG type. The FL emission wavelength of LAM is 399 nm for macro scale and 403 nm, 406 nm, 430 nm for nano scales of 50 nm, 29 nm and 27 nm of sample sizes. The Anti microbial analysis is also studied for macro scale and for nano scales of LAM for 4 species such as Staphylococcus sp., Pseudomonas sp., E. coli sp., Klebsiella sp., respectively

Bioequivalence evaluation of two different controlled release matrix formulations of ketoprofen tablets in healthy malaysian volunteers

The aim of this study was to evaluate the in vivo behavior of matrix tablets formulated with ketoprofen as a model drug after oral administrations in healthy Malaysian male volunteers and to compare its rate and extent of absorption with the commercially available tablet Apo-Keto SR® as a reference product. The test formulation containing 20 % HPC (GXF) as release retardant was selected in this regards. The bioequivalence study was conducted according to a single dose, randomized, 2-treatment, 2-sequence, 2-period crossover study design on six healthy non-smoking Malaysian adult male volunteers. Plasma concentrations of ketoprofen were determined by a high-performance liquid chromatographic method with UV detection. The pharmacokinetic parameters, Tmax , Cmax , AUC0–∞, Ke , and T1/2 were determined. The 90 % confidence intervals of the mean values for the test/reference ratios were 96.89-107.03 % for AUC0–∞ and 99.64-104.62 % for Cmax , respectively. The results of this study suggest that the two preparations, the test formulation of ketoprofen 200 mg tablets were bioequivalent to the marketed reference tablet of Apo-Keto SR® 200 mg in these healthy Malaysian male volunteers. However, this study results are to be further confirmed by carrying out a pivotal biostudy using more number of subjects.Colegio de Farmacéuticos de la Provincia de Buenos Aire