267 research outputs found
Modeling Distillers Dried Grains with Solubles (DDGS) Mass Flow Rate as Affected by Drying and Storage Conditions
Ethanol production in 2015 was over 15 million gallons in the United States, and it is projected to increase in the next few years to meet market demands. With the continued growth in the ethanol industry, there has been enormous expansion in distillers grains production. Because the local market for distillers dried grains with solubles (DDGS) is often saturated, it is essential to transport DDGS long distances, across the United States and to international markets. Caking and agglomeration of DDGS particles in hoppers and other storage structures are typical during transportation. The current study deals with DDGS prepared by combining condensed distillers solubles (CDS) with distillers wet grains and then drying at varying temperatures. DDGS was stored in conical hoppers under varying ambient temperature, consolidation pressure, and time conditions. We investigated the effects of CDS (10, 15, and 20% wb), drying temperature (100, 200, and 300°C), drying time (20, 40, and 60 min), cooling temperature (0, 25, and 50°C), consolidation pressure (0, 1.72, and 3.43 kPa), and consolidation time (0, 3, and 6 days) levels on various flow parameters. To examine these factors, Taguchi’s experimental design with an L18 orthogonal array was implemented. Response surface modeling yielded mass flow rate = f(Hausner ratio, angle of repose) with R2 = 0.99, and it predicted moisture content for good, fair, and poor flow. Results showed that drying temperature, drying time, and cooling type were the main factors in predicting mass flow rate. The Johansson model for predicted mass flow rate was calibrated with experimental data, and a new parameter, compressibility factor, with a value of 0.96 g2/(min cm3), was determined to quantify the divergence of compressible and cohesive materials (such as DDGS) for free-flowing bulk solids. Thus, the predicted models may be beneficial for quantitative understanding of DDGS flow
Hepatoblastoma in an Adult with Biliary Obstruction and Associated Portal Venous Thrombosis
We present a case of adult hepatoblastoma. This young female presented with severe acute
cholangitis. Preoperative diagnosis was common bile duct (CBD) obstruction with portal vein
thrombosis. On exploration she had a tumor mass in the CBD. The unusual features of this case
are discussed in this report
Correction due to finite speed of light in absolute gravimeters
Correction due to finite speed of light is among the most inconsistent ones
in absolute gravimetry. Formulas reported by different authors yield
corrections scattered up to 8 Gal with no obvious reasons. The problem,
though noted before, has never been studied, and nowadays the correction is
rather postulated than rigorously proven. In this paper we make an attempt to
revise the subject. Like other authors, we use physical models based on signal
delays and the Doppler effect, however, in implementing the models we
additionally introduce two scales of time associated with moving and resting
reflectors, derive a set of rules to switch between the scales, and establish
the equivalence of trajectory distortions as obtained from either time delay or
distance progression. The obtained results enabled us to produce accurate
correction formulas for different types of instruments, and to explain the
differences in the results obtained by other authors. We found that the
correction derived from the Doppler effect is accountable only for of
the total correction due to finite speed of light, if no signal delays are
considered. Another major source of inconsistency was found in the tacit use of
simplified trajectory models
Buccal soft tissue lipoma in an adult Nigerian: a case report and literature review
<p>Abstract</p> <p>Introduction</p> <p>Lipomas are benign mesenchymal neoplasms composed of mature adipocytes, usually surrounded by a thin fibrous capsule. They are uncommon intra-oral tumors with 1% to 4% occurring in this region. The literature is scanty on lipomas occurring in the buccal soft tissue, especially in our environment.</p> <p>Case presentation</p> <p>We present a case of a 35-year-old woman of the Tiv ethnic group of Nigeria who presented with a slow growing left cheek swelling that was treated by intra-oral local excision.</p> <p>Conclusion</p> <p>The purpose of this report is to highlight the existence of this rare but not uncommon disease even in our environment and to emphasize that a high index of suspicion is needed in making a diagnosis. Surgical excision as treatment is associated with an excellent outcome.</p
An Introduction to Statistical Issues and Methods in Metrology for Physical Science and Engineering
This article provides an overview of the interplay between statistics and measurement. Measurement quality affects inference from data collected and analyzed using statistical methods while appropriate data analysis quantifies the quality of measurements. This article brings material on statistics and measurement together in one place as a resource for practitioners. Both frequentist and Bayesian methods are discussed
Circular Economy Pathways for Municipal Wastewater Management in India: A Practitioner’s Guide
The 2030 Water Resources Group is a unique publicprivate-
civil society partnership that helps governments to
accelerate reforms that will ensure sustainable water resource
management for the long term development and economic
growth of their country. It does so by helping to change the
“political economy” for water reform in the country through
convening a wide range of actors and providing water resource
analysis in ways that are digestible for politicians and business
leaders. The 2030 WRG was launched in 2008 at the World
Economic Forum and has been hosted by the International
Finance Corporation (IFC) since 2012
Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: conformational analysis and binding mode of multisite inhibitors
The critical role of BACE-1 in the formation of neurotoxic ß-amyloid peptides in the brain makes it an attractive target for an efficacious treatment of Alzheimer’s disease. However, the development of clinically useful BACE-1 inhibitors has proven to be extremely challeng- ing. In this study we examine the binding mode of a novel potent inhibitor (compound 1, with IC50 80 nM) designed by synergistic combination of two fragments—huprine and rhein— that individually are endowed with very low activity against BACE-1. Examination of crystal structures reveals no appropriate binding site large enough to accommodate 1. Therefore we have examined the conformational flexibility of BACE-1 through extended molecular dynamics simulations, paying attention to the highly flexible region shaped by loops 8–14, 154–169 and 307–318. The analysis of the protein dynamics, together with studies of pocket druggability, has allowed us to detect the transient formation of a secondary binding site, which contains Arg307 as a key residue for the interaction with small molecules, at the edge of the catalytic cleft. The formation of this druggable “floppy” pocket would enable the bind- ing of multisite inhibitors targeting both catalytic and secondary sites. Molecular dynamics simulations of BACE-1 bound to huprine-rhein hybrid compounds support the feasibility of this hypothesis. The results provide a basis to explain the high inhibitory potency of the two enantiomeric forms of 1, together with the large dependence on the length of the oligo- methylenic linker. Furthermore, the multisite hypothesis has allowed us to rationalize the inhibitory potency of a series of tacrine-chromene hybrid compounds, specifically regarding the apparent lack of sensitivity of the inhibition constant to the chemical modifications intro- duced in the chromene unit. Overall, these findings pave the way for the exploration of novel functionalities in the design of optimized BACE-1 multisite inhibitors
- …