Application of Raman spectroscopy to real-time monitoring of CO2 capture at PACT pilot plant; Part 1: Plant operational data

Process analyzers for in-situ monitoring give advantages over the traditional analytical methods such as their fast response, multi-chemical information from a single measurement unit, minimal errors in sample handing and ability to use for process control. This study discusses the suitability of Raman spectroscopy as a process analytical tool for in-situ monitoring of CO2 capture using aqueous monoethanolamine (MEA) solution by presenting its performance during a 3-day test campaign at PACT pilot plant in Sheffield, UK. Two Raman immersion probes were installed on lean and rich streams for real time measurements. A multivariate regression model was used to determine the CO2 loading. The plant performance is described in detail by comparing the CO2 loading in each solvent stream at different process conditions. The study shows that the predicted CO2 loading recorded an acceptable agreement with the offline measurements. The findings from this study suggest that Raman Spectroscopy has the capability to follow changes in process variables and can be employed for real time monitoring and control of the CO2 capture process. In addition, these predictions can be used to optimize process parameters; to generate data to use as inputs for thermodynamic models, plant design and scale-up scenarios

T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates.

Immune responses against multiple epitopes are required for the prevention of hepatitis C virus (HCV) infection, and the progression to phase I trials of candidates may be guided by comparative immunogenicity studies in non-human primates. Four vectors, DNA, SFV, human serotype 5 adenovirus (HuAd5) and Modified Vaccinia Ankara (MVA) poxvirus, all expressing hepatitis C virus Core, E1, E2 and NS3, were combined in three prime-boost regimen, and their ability to elicit immune responses against HCV antigens in rhesus macaques was explored and compared. All combinations induced specific T-cell immune responses, including high IFN-γ production. The group immunized with the SFV+MVA regimen elicited higher E2-specific responses as compared with the two other modalities, while animals receiving HuAd5 injections elicited lower IL-4 responses as compared with those receiving MVA. The IFN-γ responses to NS3 were remarkably similar between groups. Only the adenovirus induced envelope-specific antibody responses, but these failed to show neutralizing activity. Therefore, the two novel regimens failed to induce superior responses as compared with already existing HCV vaccine candidates. Differences were found in response to envelope proteins, but the relevance of these remain uncertain given the surprisingly poor correlation with immunogenicity data in chimpanzees, underlining the difficulty to predict efficacy from immunology studies.This work was supported by European Union contract QLK2-CT-1999- 00356, by the Biomedical Primate Research Centre, The Netherlands, and by the Swedish Research Council. We are grateful to Alexander van den Berg for technical assistance with the ICS, to our colleagues from Animal Science Department for technical assistance and expert care of the macaques, to the participants of the European HCVacc Cluster who provided help and support, and to Thomas Darton (Oxford Vaccine Group, UK) for input and advice on the manuscript. Christine Rollier is an Oxford Martin fellow and a Jenner Insitute Investigator.This is the author accepted manuscript. The final version is available from Nature Publishing Group at https://doi.org/10.1038/gt.2016.55

The Clinical Potential of Calorie-Restricted and Ketogenic Diets in the Treatment of Alzheimer’s Disease in the Context of Hyperinsulinemia

This thesis is being archived as a Digitized Shelf Copy for campus access to current students and staff only. We currently cannot provide this open access without the author's permission. If you are the author of this work and desire to provide it open access or wish access removed, please contact the Wahlstrom Library to discuss permission.The Clinical Potential of Calorie-Restricted and Ketogenic Diets in the Treatment of Alzheimer’s Disease in the Context of Hyperinsulinemia. The role of hyperinsulinemia in the context of hyperglycemia due to insulin resistance has been well studied in its role in the development of Type II Diabetes (T2D). A strong correlation exists between T2D and Alzheimer’s Disease (AD), and the mechanisms involved are multi-factorial. Derangement in key amyloid-related enzymes secondary to increased insulin levels, increased inflammation, and increased oxidative stress among other factors have been well studied. Calorie Restriction (CR), along with variations on the clinical approach, has been shown to increase overall lifespan and to improve insulin resistance, reduce inflammation, and reduce oxidative stress markers. This review assessed the connection between hyperinsulinemia and CR in the context of Alzheimer’s Disease. This approach, based on available evidence in human and animal studies, is a reasonable adjunct to treatment protocols for Alzheimer’s Disease. Based on projected patient compliance CR variations may be employed, though likely with slower and less drastic impact on Alzheimer’s Disease outcomes

In-line monitoring of solvents during CO₂ absorption using multivariate data analysis

Engineering Thermodynamic

Analysis of the re-denomination and its impact on the selected macroeconomic indicators on the example of the Belarusian ruble.

Cílem této bakalářské práce je analýza příčin provedení denominace a vymezení vztahu mezi denominací a vývojem vybraných makroekonomických veličin. První kapitola poskytuje teoretický popis pojmu denominace, vysvětluje důvody vedoucí k nutnosti reformu provést. Dále vykládá, jak ten proces probíhá a jaké má teoretické dopady na vybrané ukazatele. V druhé kapitole najdeme aplikaci teoretické části na příkladu běloruského rublu. Uvidíme, jaké skutečností povedly k potřebě v denominaci běloruského rublu a provedeme hodnocení její vlivů na vybrané makroekonomické ukazatele.The purpose of this work is to analyze the causes of implementation of re-denomination and to specify relations between re-denomination and the development of selected macroeconomic indicators. The first chapter provides a theoretical description of the concept of re-denomination as such, explains the reasons for the necessity of the reforms, telling how the process is done and what theoretical impacts on the selected indicators it has. In the second chapter we can find the application of the theoretical part on the example of the Belarusian ruble. We will see what facts lead to Belarusian ruble re-denomination and also evaluate its impact on selected macroeconomic indicators