This thesis is being archived as a Digitized Shelf Copy for campus access to current students and staff only. We currently cannot provide this open access without the author's permission. If you are the author of this work and desire to provide it open access or wish access removed, please contact the Wahlstrom Library to discuss permission.The Clinical Potential of Calorie-Restricted and Ketogenic Diets in the Treatment of Alzheimer’s Disease in the Context of Hyperinsulinemia. The role of hyperinsulinemia in the context of hyperglycemia due to insulin resistance has been well studied in its role in the development of Type II Diabetes (T2D). A strong correlation exists between T2D and Alzheimer’s Disease (AD), and the mechanisms involved are multi-factorial. Derangement in key amyloid-related enzymes secondary to increased insulin levels, increased inflammation, and increased oxidative stress among other factors have been well studied. Calorie Restriction (CR), along with variations on the clinical approach, has been shown to increase overall lifespan and to improve insulin resistance, reduce inflammation, and reduce oxidative stress markers. This review assessed the connection between hyperinsulinemia and CR in the context of Alzheimer’s Disease. This approach, based on available evidence in human and animal studies, is a reasonable adjunct to treatment protocols for Alzheimer’s Disease. Based on projected patient compliance CR variations may be employed, though likely with slower and less drastic impact on Alzheimer’s Disease outcomes
