mRNAステムループ構造標的アンチセンスオリゴ核酸を用いたRegnase-1発現増強による炎症抑制法の開発

京都大学新制・課程博士博士(医学)甲第24192号医博第4886号京都大学大学院医学研究科医学専攻(主査)教授 萩原 正敏, 教授 森信 暁雄, 教授 遊佐 宏介学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

A content analysis of print advertising from the United States and Hong Kong

The purpose of this study was to extend the research in cross-cultural advertising by investigating the differences in cosmetics and fragrance advertising in Hong Kong and the United States

Print Advertising In The Us And Hong Kong: A Comparative Analysis

Given the static condition of the global economy marketers are cutting advertising budgets commensurate with dismal sales. It is a longstanding belief that utilizing a standardized advertising approach not only controls good ideas and provides for a consistent image but it also has the benefit of controlling expenses through economies of scale. With this in mind, the purpose of the study was to determine the degree of standardization or lack thereof in advertising strategies in the cosmetics and fragrances advertising industries in the United States and Hong Kong. The findings of this study suggest that there is a high level of standardization in the advertising for perfumes because Hong Kong belonged to the British for a long time and individuals’ needs and desires for love and acceptance are the same irrespective of geography. On the other hand only a moderate form of standardization was noted in the advertising for cosmetics. This may be attributed to the fact that different beauty concepts are held among different regions. Implications of the findings are also noted.print advertising, standardization, glocalization, cosmetics and fragrance industry

IoT-based Asset Management System for Healthcare-related Industries

The healthcare industry has been focusing efforts on optimizing inventory management procedures through the incorporation of Information and Communication Technology, in the form of tracking devices and data mining, to establish ideal inventory models. In this paper, a roadmap is developed towards a technological assessment of the Internet of Things (IoT) in the healthcare industry, 2010–2020. According to the roadmap, an IoT-based healthcare asset management system (IoT-HAMS) is proposed and developed based on Artificial Neural Network (ANN) and Fuzzy Logic (FL), incorporating IoT technologies for asset management to optimize the supply of resources

Key factors in encouraging and empowering undergraduates to practice service leadership through extra-curricular service-learning practicums

While internships bridge students\u27 academic major to the world of work, in this paper, we focus on practicums as vehicles for service leadership development. In the summers of 2013 and 2014, Lingnan University arranged 28 full-time practicums in 13 partner organizations, mainly not-for-profit organizations or social enterprises, for students with prior service-learning experience. Practicums lasted 6 weeks in 2013, and 8 weeks in 2014. Students attended a 3-hour preparatory workshop on service leadership, and an interim review meeting. Through interviews with 26 practicum students and site supervisors from 13 partner organizations, we identified three factors that enabled practicum students to develop as service leaders. The first factor was the availability of practicum tasks that required innovation to identify and meet hitherto unmet needs. Successful practicums allowed students to create or extend events or arrangements that made a clear difference to the achievement of the social mission of their respective host organizations. Students were empowered to initiate responsibility for service planning, organization and delivery, including the need to anticipate and respond to end -user contingencies and demands. The second broad factor was the availability of a supportive site supervisor, willing and able to provide timely briefings, guidance, coaching and feedback. The third factor was the developmental readiness of the practicum student. Developmentally -ready students were psychologically prepared to seek out new challenges, cared about both end-user service-recipients and other stakeholders, were committed to making a difference, and had sufficient skills, knowledge, and self-confidence to work things out independently and arrive at their own decisions. They found effective ways to approach their site supervisor whenever necessary, and by demonstrating their competence and integrity, they were able to build trust. We highlight four cases, which reveal differences between traditional internships and the innovation -oriented nature of successful service leadership practicums. The first features a supportive site supervisor and two developmentally-ready practicum students. The second involves a moderately-supportive site supervisor, one developmentally-ready practicum student, and one moderately-ready practicum student. The third features a supportive site supervisor, one developmentally-ready practicum student, and one moderately-ready practicum student. The fourth involves a less-supportive site supervisor and a less-ready practicum student

A handbook for using elder academy as a platform of other learning experiences

This handbook will discuss how school syllabus, Other Learning Experiences (OLE) and Elder Academy (EA) can be integrated. It will provide some structures for schools as a reference and help develop a comprehensive learning plan. Besides, the handbook will mention different roles and responsibilities of stakeholders, as well as the suggestions and guidelines for assessment. The programs and activities in the “Elder Academy at Lingnan” will be taken as examples to demonstrate the guidelines. This can provide a better understanding of the operation mode of the integration between school curricula, OLE and EA. Hence, interested stakeholders can perform their own plans more systematically and effectively.https://commons.ln.edu.hk/osl_book/1000/thumbnail.jp

Strategic sourcing supplier selection misalignment with critical success factors:findings from multiple case studies in Germany and the United Kingdom

Strategic sourcing plays an important role in organisations' performance. Strategic sourcing has been researched extensively using empirical studies as well as review work, such as strategic sourcing importance, issues and challenges, processes, source selection criteria and framework. However, there is no research on critical success factors for strategic sourcing specific to industry and country. This research aims to qualitatively evaluate and understand the current role of strategic sourcing, the critical success factors for business performance and its relationship with strategic sourcing, and strategic supplier evaluation criteria from multiple stakeholders' perspectives specific to industry and country. This research studies twenty organisations from Germany and the United Kingdom (UK) covering two industry sectors - electronics manufacturing and construction. We consider five organisations from each industry sector and each country. The findings from twenty case studies reveal comparative analysis of strategic sourcing practices of two countries and two industries

Coordinated Ionospheric Reconstruction CubeSat Experiment (CIRCE), In situ and Remote Ionospheric Sensing (IRIS) suite

The UK’s Defence Science and Technology Laboratory (Dstl) is partnering with the US Naval Research Laboratory (NRL) on a joint mission to launch miniature sensors that will advance space weather measurement and modelling capabilities. The Coordinated Ionospheric Reconstruction Cubesat Experiment (CIRCE) comprises two 6U cube-satellites that will be launched into a near-polar low earth orbit (LEO), targeting 500 km altitude, in 2021. The UK contribution to CIRCE is the In situ and Remote Ionospheric Sensing (IRIS) suite, complementary to NRL sensors, and comprising three highly miniaturised payloads provided to Dstl by University College London (UCL), University of Bath, and University of Surrey/Surrey Satellite Technology Ltd (SSTL). One IRIS suite will be flown on each satellite, and incorporates an ion/neutral mass spectrometer, a tri-band global positioning system (GPS) receiver for ionospheric remote sensing, and a radiation environment monitor. From the US, NRL have provided two 1U Triple Tiny Ionospheric Photometers (Tri-TIPs) on each satellite (Nicholas et al., 2019), observing the ultraviolet 135.6 nm emission of atomic oxygen at night-time to characterize the two-dimensional distribution of electrons

Kefir consumption does not alter plasma lipid levels or cholesterol fractional synthesis rates relative to milk in hyperlipidemic men: a randomized controlled trial [ISRCTN10820810]

BACKGROUND: Fermented milk products have been shown to affect serum cholesterol concentrations in humans. Kefir, a fermented milk product, has been traditionally consumed for its potential health benefits but has to date not been studied for its hypocholesterolemic properties. METHODS: Thirteen healthy mildly hypercholesterolemic male subjects consumed a dairy supplement in randomized crossover trial for 2 periods of 4 wk each. Subjects were blinded to the dairy supplement consumed. Blood samples were collected at baseline and after 4 wk of supplementation for measurement of plasma total, low-density lipoprotein, and high-density lipoprotein cholesterol and triglyceride concentrations, as well as fatty acid profile and cholesterol synthesis rate. Fecal samples were collected at baseline and after 2 and 4 wk of supplementation for determination of fecal short chain fatty acid level and bacterial content. RESULTS: Kefir had no effect on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglyceride concentrations nor on cholesterol fractional synthesis rates after 4 wk of supplementation. No significant change on plasma fatty acid levels was observed with diet. However, both kefir and milk increased (p < 0.05) fecal isobutyric, isovaleric and propionic acids as well as the total amount of fecal short chain fatty acids. Kefir supplementation resulted in increased fecal bacterial content in the majority of the subjects. CONCLUSIONS: Since kefir consumption did not result in lowered plasma lipid concentrations, the results of this study do not support consumption of kefir as a cholesterol-lowering agent

π+\pi^+ photoproduction on the proton for photon energies from 0.725 to 2.875 GeV

Differential cross sections for the reaction $\gamma p \to n \pi^+$ have been measured with the CEBAF Large Acceptance Spectrometer (CLAS) and a tagged photon beam with energies from 0.725 to 2.875 GeV. Where available, the results obtained here compare well with previously published results for the reaction. Agreement with the SAID and MAID analyses is found below 1 GeV. The present set of cross sections has been incorporated into the SAID database, and exploratory fits have been made up to 2.7 GeV. Resonance couplings have been extracted and compared to previous determinations. With the addition of these cross sections to the world data set, significant changes have occurred in the high-energy behavior of the SAID cross-section predictions and amplitudes.Comment: 18 pages, 10 figure